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Keywords: proteasomes
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Biosci Rep (2023) 43 (1): BSR20222102.
Published: 30 January 2023
...) is a key oncogenic kinase that directly activates the transcription factor heat-shock factor 1 (HSF1) and the 26S proteasome. Targeting DYRK2 has proven to be a tractable strategy to target cancers sensitive to proteotoxic stress; however, the development of HSF1 inhibitors remains in its infancy...
Includes: Supplementary data