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Keywords: prognosis
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Biosci Rep (2023) 43 (7): BSR20230733.
Published: 19 July 2023
... of proliferation essential genes (PLEGs) on the prognosis and chemotherapy response of colon cancer patients, as well as identifying the expression and cellular functions of important PLEG. Methods: The DepMap database was utilized for identification of PLEG in colon cancer cells. Through DEGs screening, WGCNA...
Includes: Supplementary data
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Biosci Rep (2023) 43 (5): BSR20222100.
Published: 05 May 2023
...Wei Jun Wu; Feng Xiao; Yaping Xiong; Gu Feng Sun; Yun Guo; Xiang Zhou; Guo Wen Hu; Kai Huang; Hua Guo Background: The connection between m6A-assiociateed lncRNAs and prognosis has been demonstrated in multiple types of tumors. However, potential roles of m6A-assiociateed lncRNAs in glioma is still...
Includes: Supplementary data
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Biosci Rep (2023) 43 (4): BSR20222627.
Published: 06 April 2023
... for determining whether MYB could serve as a biomarker for cancer screening, prognosis prediction and accurate therapy design in various human cancers. Methods: In the present study, we performed qRT-PCR, wound healing assay and transwell assay to validate the expression level and biological function of MYB...
Includes: Supplementary data
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Biosci Rep (2023) 43 (2): BSR-2019-2298_RET.
Published: 10 February 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Breast cancer FOXA2 MicroRNA-942 Prognosis Progression...
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Biosci Rep (2023) 43 (2): BSR20221659.
Published: 02 February 2023
... of different TAMs markers and histologic locations on the prognosis of LCa. Methods: Searches of Web of Science, PubMed, and EMBASE databases were performed up to 28 February 2022. The pooled analysis was conducted in random-effect or fixed-effects model with hazard risk (HR) and 95% confidence interval (CI...
Includes: Supplementary data
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Biosci Rep (2023) 43 (1): BSR20222230.
Published: 16 January 2023
... cancers either at the mRNA or protein level, which might be caused by genetic mutations, DNA methylation, and protein phosphorylation. Additionally, EZH2 expression was correlated with clinical prognosis, and its up-regulation usually indicated poor survival outcomes in cancer patients. Subsequent...
Includes: Supplementary data
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Biosci Rep (2022) 42 (12): BSR20222171.
Published: 22 December 2022
... in the monitoring of patient response to chemotherapy, with potential prognosis value. Several highly sensitive biosensors have been developed for the quantification of cyt c levels in human serum. Moreover, the delivery of exogenous cyt c to the cytoplasm of cancer cells is an effective approach for inducing...
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Biosci Rep (2022) 42 (10): BSR20221128.
Published: 18 October 2022
... and quantitative PCR (q-PCR) analysis found that down-regulation of MT1X reduced the accumulation of hypoxia-associated factors. Bioinformatic analysis associated increased MT1X expression with a worse prognosis. Laboratory experiments confirmed bioinformatic findings. MT1X was also found to be an independent...
Includes: Supplementary data
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Biosci Rep (2022) 42 (7): BSR20220078.
Published: 20 July 2022
... a favorable response to immunotherapy. Finally, the result of qPCR revealed that most IRlncRNAs were differently expressed between normal and tumor cell lines. Conclusion: The constructed 9-IRlncRNA signature has potential to predict the prognosis of CRC patients and may be helpful to guide personalized...
Articles
Biosci Rep (2022) 42 (7): BSR20221030.
Published: 20 July 2022
... remodeling. The molecular docking simulation validated strong binding affinity between the core targets and core ingredients. Furthermore, 62-gene signature may be used for determining the prognosis in cirrhotic patients based on the results of ssGSEA-Cox analysis. In conclusion, the present study revealed...
Includes: Supplementary data
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Biosci Rep (2022) 42 (7): BSR20221082.
Published: 14 July 2022
...Hui Liu; Songhao Jia; Kun Guo; Rongkuan Li The INK4 family is an important family of cyclin-dependent kinase inhibitors (CDKIs) and consists of CDKN2A, CDKN2B, CDKN2, and CDKN2D. Abnormal expression of CDKN2A has been reported in hepatocellular carcinoma (HCC) and is associated with the prognosis...
Includes: Supplementary data
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Biosci Rep (2022) 42 (5): BSR20211653.
Published: 10 May 2022
...-analyses based on existing evidence to ascertain the value of miRNA-21 in diagnosis and clinical prognosis of lung cancer have been documented. Methods: We comprehensively searched all the literature pertaining to ‘miRNA-21’ and ‘lung cancer’ from four databases from the period of inception of each...
Includes: Supplementary data
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Biosci Rep (2022) 42 (5): BSR20220647.
Published: 10 May 2022
... changes in the inflammatory microenvironment also have regulatory effects on AML. Exploring the relationship between inflammatory response and pathological features of AML has implications for clinical diagnosis, treatment and prognosis evaluation. We analyzed the expression variation landscape...
Includes: Supplementary data
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Biosci Rep (2022) 42 (2): BSR20212119.
Published: 18 February 2022
... Omicshare3.0 ( http://www.omicshare.com/tools ) was performed to discover the overlapping genes among different profiles. Finally, IGF2BP2 was selected as the subject of the present study based on the association between the expression of overlapping genes and the prognosis of OSCC ( P <0.01). OSCC...
Includes: Supplementary data
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Biosci Rep (2022) 42 (2): BSR20212035.
Published: 04 February 2022
... higher in breast carcinoma tissue than in Para cancerous tissues analyzed by Gene Expression Profiling Interactive Analysis (GEPIA) and ONCOMINE. Overexpression ofCD24, MMP1, SDC1, and SPP1 indicated the poor prognosis in breast carcinoma patients analyzed by Kaplan–Meier (KM) Plotter...
Includes: Supplementary data
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Biosci Rep (2022) 42 (1): BSR20212378.
Published: 18 January 2022
..., 1p/19q non-codeletion, O (6)-methylguanine-DNA methyltransferase (MGMT) unmethylated gliomas. Gliomas with higher DNAJC10 expression present poorer prognosis compared with low-DNAJC10 gliomas. The predictive accuracy of 1/3/5-OS of DNAJC10 is found to be stable and robust using time-dependent ROC...
Includes: Supplementary data
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Biosci Rep (2022) 42 (1): BSR20212446.
Published: 11 January 2022
... and clinical significance in osteosarcoma remain unknown. The aim of the present study was to investigate SMARCB1 expression in osteosarcoma and its clinical significance with respect to chemosensitivity and prognosis. Methods: We obtained 114 specimens from 70 osteosarcoma patients to construct a tissue...
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Biosci Rep (2021) 41 (12): BSR20212026.
Published: 08 December 2021
... was determined in patients with OV. The low expression of ZNF76 was associated with worse survival in OV. Multivariable analysis showed that the low expression of ZNF76 was an independent factor predicting poor outcome in OV. The prognosis value of ZNF76 in pan-cancer was validated from multiple cohorts using...
Includes: Supplementary data
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Biosci Rep (2021) 41 (12): BSR20212300.
Published: 07 December 2021
..., we analyzed the expression profiles and prognostic value of THUMPD1 in pan-cancer and gained insights into the correlation between THUMPD1 expression level and immunotherapy efficacy. Methods: Gene expression pattern and its correlation with prognosis, immune cell infiltration in pan-cancer were...
Includes: Supplementary data
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Biosci Rep (2021) 41 (8): BSR20211451.
Published: 27 August 2021
... the Creative Commons Attribution License 4.0 (CC BY) . clear cell renal cell carcinoma (ccRCC) glycolysis long noncoding RNAs (lncRNAs) prognosis risk model Renal cell carcinoma (RCC) is a common lethal urologic malignancy with over 430000 new cases and approximately 180000 deaths per year...
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Biosci Rep (2021) 41 (8): BSR20181627.
Published: 12 August 2021
...Wei Liu; Qin-Peng Wang; Jia Guo Several studies demonstrated that lncRNA differentiation antagonizing non-protein coding RNA (lncRNA DANCR) expression might have the potential capacity to predict the cancer prognosis; however, definite conclusion has not been obtained. The aim of this meta-analysis...
Includes: Supplementary data
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Biosci Rep (2021) 41 (8): BSR20203531.
Published: 05 August 2021
...Anze Yu; Kai Guo; Qilin Qin; Changsheng Xing; Xiongbing Zu Background: Evaluation of the feasibility for osteopontin (OPN) to serve as a biomarker in the prognosis and clinical-pathological features of prostate cancer (PCA) patients. Methods: The original publications related to OPN and PCA were...
Includes: Supplementary data
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Biosci Rep (2021) 41 (8): BSR20204401.
Published: 02 August 2021
...-analysis was used to explore the correlation between SII and prognosis in pancreatic carcinoma patients. Methods: PubMed, Embase and Cochrane Library databases were screened from inception to May 2020. Studies describing the prognostic role of SII in pancreatic carcinoma were then retrieved. The pooled...
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Biosci Rep (2021) 41 (8): BSR20210866.
Published: 02 August 2021
.... Objective: We aimed to assess the level of serum NSE to predict prognosis and treatment response in patients with advanced or metastatic non-neuroendocrine NSCLC. Methods: We retrospectively analyzed 363 patients with advanced and metastatic NSCLC between January 2011 and October 2016. The serum NSE level...
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Biosci Rep (2021) 41 (7): BSR20210158.
Published: 28 July 2021
..., guide individualized treatment, and improve the prognosis of HNSC patients. Therefore, there is still an urgent need to explore the effective biomarkers and underlie the molecular mechanism in the development and progression of HNSC. Forkhead box D1 ( FOXD1 ), also known as FKHL8, FREAC-4...
Includes: Supplementary data
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Biosci Rep (2021) 41 (7): BSR20211175.
Published: 28 July 2021
...Yurong Zhu; Zhifa Zhang; Hui Peng; Weiping Li; Shaowei Hu; Min Zhao; Weifeng Lin Background: We conducted this research to investigate the relationship between long intergenic non-protein coding RNA 673 (linc00673) expression and prognosis and clinicopathological parameters in human malignancies...
Includes: Supplementary data
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Biosci Rep (2021) 41 (7): BSR-2018-0617_COR.
Published: 01 July 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gastric cancer Inhibitory kappa B Kinases nuclear factor kappa B prognosis...
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Biosci Rep (2021) 41 (7): BSR20210055.
Published: 28 June 2021
... with the poor prognosis of GC patients, the prognostic model was established in TCGA-STAD cohort, and validated in Gene Expression Omnibus (GEO) cohorts, with effectiveness in both HER2 positive and negative patients. DNA methylation was involved in the impact on prognosis. Cell cycle, immune-associated...
Includes: Supplementary data
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Biosci Rep (2021) 41 (7): BSR20201551.
Published: 28 June 2021
... rates of patients. Results: miR-208a-5p, miR-296-5p and miR-1304-5p were screened as potential biomarkers. miR-208a-5p and miR-296-5p were shown to be associated with better survival of patients after Kaplan–Meier analysis, whereas miR-1304-5p overexpression indicated a poor survival prognosis...
Includes: Supplementary data
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Biosci Rep (2021) 41 (6): BSR20210012.
Published: 08 June 2021
...Yongfeng Li; Xinmiao Rui; Daobao Chen; Haojun Xuan; Hongjian Yang; Xuli Meng Background: Long non-coding RNA associated with poor prognosis of hepatocellular carcinoma (AWPPH) is dysregulated in a variety of human cancers. However, the prognostic value of AWPPH in various cancers remains unclear...
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Biosci Rep (2021) 41 (5): BSR20204148.
Published: 27 May 2021
... identified, CDK1 and CDC45 were associated with unfavorable HNSCC prognosis, and three potential small molecule drugs for treating HNSCC were identified. Increased CDK1 expression was confirmed in HNSCC cells, and menadione, the top predicted potential drug, exerted significant inhibitory effects against...
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Biosci Rep (2021) 41 (5): BSR20210527.
Published: 27 May 2021
... associated with the prognosis may be used as independent prognostic factors for the overall survival time of NSCLC patients. The pathways enriched with DEGs in low-risk and high-risk groups were analyzed, and the enriched pathways were correlated significantly with immunosuppressive status...
Includes: Supplementary data
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Biosci Rep (2021) 41 (5): BSR20210231.
Published: 21 May 2021
...Ding Zhou; Mengmeng Wang; Yu Zhang; Kai Wang; Min Zhao; Yan Wang; Xu Wang; Rutong Yu; Xiuping Zhou Glioma is the most common primary cancer in the central nervous system. Despite advances in surgery, radiotherapy and chemotherapy over the past decades, the prognosis of glioblastoma patients remains...
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Biosci Rep (2021) 41 (5): BSR20203431.
Published: 14 May 2021
...Ke Han; Kun Qian; Teng Zhao; Xing Sheng Liu; Yi Zhang Purpose: The host’s immune response to malignant tumor is fundamental to tumorigenesis and tumor development. The immune score is currently used to assess prognosis and to guide immunotherapy; however, its association with lung cancer prognosis...
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Biosci Rep (2021) 41 (4): BSR20204008.
Published: 30 April 2021
... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . enhancer FOXP4 FOXP4-AS1 OV prognosis Ovarian cancer (OV) is the fifth malignant reproductive tumor in women leading...
Includes: Supplementary data
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Biosci Rep (2021) 41 (4): BSR-20192298_EOC.
Published: 07 April 2021
... Breast cancer FOXA2 MicroRNA-942 Prognosis Progression The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. © 2021...
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Biosci Rep (2021) 41 (4): BSR-20180617_EOC.
Published: 06 April 2021
... factor κB prognosis The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. ...
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Biosci Rep (2021) 41 (4): BSR-20193515_EOC.
Published: 06 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . DOT1L EPZ5676 Gastric cancer Prognosis The Editorial Office has been...
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Biosci Rep (2021) 41 (3): BSR20203945.
Published: 10 March 2021
...-based prognosis predictive model is effective and reliable in predicting prognosis for patients with HCC. Correspondence: Xiang-Yong Hao ( haoxy2007@lzu.edu.cn , haoxy-2008@163.com ) or Tao Wang ( wtdoctor831030@sina.com ) or Hui Cai ( goodcaihui@163.com ) * These authors contributed equally...
Includes: Supplementary data
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Biosci Rep (2021) 41 (2): BSR20203336.
Published: 26 February 2021
... than that in TMB-low group and high macrophage infiltration was correlated with inferior survival outcome of GC patients. Lastly, the TMBPRS was constructed and GC patients with high TMBPRS had poor prognosis. Correspondence: ChunHui Cui ( drcuich@126.com ) or JinLong Yu ( yujinlong640506@163.com...
Includes: Supplementary data