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Keywords: polymorphism
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Articles
Biosci Rep (2022) 42 (9): BSR-2018-0177_RET.
Published: 12 September 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . allergic diseases FcεRIβ genetic model Meta-analysis polymorphism...
Articles
Biosci Rep (2021) 41 (4): BSR20210522.
Published: 22 April 2021
...Feifei Jiang; Aihui Yan Objective: The relationship between IL-4 rs2243250 polymorphism and the risk of allergic rhinitis is not clear at present. The present study aims to evaluate the exact association between IL-4 rs2243250 polymorphism and susceptibility to allergic rhinitis by a meta-analysis...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (2): BSR20201158.
Published: 17 February 2021
... nucleotide polymorphisms (SNPs) genotypic distributions were different in NSCLC cases and controls. However, the association of miR-196a-2 rs11614913 with a decreased risk of NSCLC was identified in the female subgroup (adjusted P =0.005, power = 0.809 for TC vs. TT, and adjusted P =0.004, power = 0.849...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (2): BSR20193877.
Published: 03 February 2021
...Bi-jun Wang; Jun-yi Chen; Yu Guan; Da-chao Liu; Zi-chuan Cao; Jin Kong; Zheng-Sheng Wu; Wen-Yong Wu Background: Both meta-analyses and systematic reviews were used to assess the relationship between purinergic receptor P2X ligand-gated ion channel 7 ( P2RX7 ) rs3751143 polymorphism and the risk...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20203461.
Published: 06 January 2021
...Guoxiang Rong; Yongping Zhu; Weifeng Tang; Hao Qiu; Sheng Zhang The relationship between rs3746444 T>C single-nucleotide polymorphism (SNP) in microRNA (mir)-499 and risk of gastric cancer (GC) has been widely investigated. However, the association was still unconfirmed. Here, we first recruited...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20191729.
Published: 04 January 2021
..., 7947 CRC cases and 12,168 controls were included. We found that miR-146a rs2910164 polymorphism did not influence the risk of CRC (G vs. C: P =0.537; GG vs. CC: P =0.517, CG/GG vs. CC: P =0.520 and GG vs. CC/CG: P =0.167). Our findings suggest that miR-146a rs2910164 C/G polymorphism is not correlated...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (10): BSR20192051.
Published: 23 October 2020
...Abdolkarim Moazeni-Roodi; Sahel Sarabandi; Shima Karami; Mohammad Hashemi; Saeid Ghavami Fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor tyrosine kinases (RTKs) for FGFs. Several studies have focused on the association between FGFR4 polymorphisms and cancer development...
Articles
Biosci Rep (2020) 40 (9): BSR20202275.
Published: 29 September 2020
...Wen-Ping Zhang; Xiao-Feng He; Xiang-Hua Ye Background: Many studies have been performed to explore the combined effects of glutathione-S-transferase M1 ( GSTM1 ) present/null and cytochrome P4501A1 ( CYP1A1 ) MspI polymorphisms with lung cancer (LC) risk, but the results are contradictory. Two...
Articles
Biosci Rep (2020) 40 (9): BSR20200027.
Published: 16 September 2020
...Yue-e Wu; Lan Ma; Hao Zhang; Xin-ran Chen; Xin-yi Xu; Ze-ping Hu Several studies have investigated a potential association between the endothelial lipase gene ( LIPG ) 584C/T polymorphism and susceptibility to coronary artery disease (CAD), but a uniform conclusion is yet to be reached. To better...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (8): BSR20201927.
Published: 25 August 2020
...Liang Song; Chen Yang; Xiao-Feng He Background. The presence or absence of glutathione S-transferase M1 gene ( GSTM1 ) and glutathione S-transferase T1 gene ( GSTT1 ) polymorphisms, and their combined effects have been suggested as a risk factor for colorectal cancer (CRC). However, the results...
Articles
Biosci Rep (2020) 40 (8): BSR20193895.
Published: 11 August 2020
... of single nucleotide polymorphisms (SNPs) in the interleukin-4 ( IL-4 ), IL-10 , and herpesvirus entry mediator ( HVEM ) genes in contributing to ESCC risk. IL-4, IL-10 , and HVEM SNPs were analyzed by employing an SNPscan method. After adjustment for body mass index (BMI), smoking, drinking, age and gender...
Articles
Biosci Rep (2020) 40 (8): BSR20200357.
Published: 03 August 2020
... the single-nucleotide polymorphisms (SNPs) in amyloid precursor-like protein (APLP) 2 ( APLP2 ) gene were associated with high lipid levels in Chinese population in Xinjiang, China. We recruited 1738 subjects (1187 men, 551 women) from the First Affiliated Hospital of Xinjiang Medical University...
Articles
Biosci Rep (2020) 40 (7): BSR20201414.
Published: 24 July 2020
... between AGT/EL gene polymorphism and CAD were collected through searching PubMed, Excerpta Medica Database (EMBASE), Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases up to 1 March 2020. Stata 15.0 software was used for analysis. Results: A total of 29 articles met...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR-20180177_EOC.
Published: 22 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . allergic diseases FcεRIβ genetic model Meta-analysis polymorphism...
Articles
Biosci Rep (2020) 40 (7): BSR20200068.
Published: 21 July 2020
... = 1.04–1.52, P =0.02) and was a genetic biomarker of severe manifestations after surgery. These findings indicate that the rs9690350 G allele is a PDGFA polymorphism associated with the risk of BA that may confer increased disease susceptibility. Correspondence: Ruizhong Zhang ( cowboy2006@163.com...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR20200995.
Published: 17 July 2020
...Ying Xiong; Ce Bian; Xiaojuan Lin; Xiaoli Wang; Kehui Xu; Xia Zhao Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) in hormone metabolism pathways might cause metabolic disturbances and contribute to the development of polycystic ovary syndrome (PCOS) and ovarian cancer...
Articles
Biosci Rep (2020) 40 (7): BSR20201200.
Published: 15 July 2020
...Bin Chen; Wang-fa Zhu; Yi-yang Mu; Biao Liu; Hong-zhuo Li; Xiao-feng He Background: Many studies have reported the association between vitamin D receptor ( VDR ) polymorphism and osteoporosis risk. However, their results were conflicting. Six previous meta-analyses have been published to analyze...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR20200860.
Published: 10 July 2020
...Miao Gao; Na Feng; Meixia Zhang; Xinyu Ti; Xiuping Zuo Recent years, it is a highly debated topic that whether methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and A1298C polymorphism could increase susceptibility to venous thromboembolism (VTE) in the Asian and Caucasian. Therefore...
Articles
Biosci Rep (2020) 40 (7): BSR20191825.
Published: 09 July 2020
...Guang-Hui Qi; Chun-Hui Wang; Hong-Ge Zhang; Jian-Guo Yu; Fei Ding; Zhi-Chao Song; Qing-Hua Xia There is still no conclusion on the potential effect of the rs2295080 and rs2536 polymorphisms of mTOR (mammalian target of rapamycin) gene on different cancers. Herein, we performed a comprehensive...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR20192313.
Published: 02 July 2020
...Ahu Soyocak; Merih Özgen; Didem Turgut Coşan; Hülyam Kurt; Fulya Doğaner; Onur Armağan; İrfan Değirmenci; Fezan Şahin Mutlu The present study was aimed to investigate the relationship between NOD1/CARD4 and NOD2/CARD15 gene polymorphisms and osteoporosis in the Turkish population. The first time we...
Articles
Biosci Rep (2020) 40 (6): BSR20192410.
Published: 26 June 2020
...Li-Fang Wu; Gui-Ping Xu; Qing Zhao; Ding Wang; Li-Jing Zhou; Bin Sun; Wei-Xian Chen Background: The evidence for an association between the adiponectin gene (ADIPOQ) polymorphism rs182052 and cancer risk is inconsistent. We performed a meta-analysis to obtain more precise conclusions. Methods...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (6): BSR20193779.
Published: 05 June 2020
... 6p24.1 (rs1223397, P =1.04e −07 ). The purpose of the present study was to investigate associations of PHACTR1 gene polymorphisms with PP in a Chinese population. We recruited 347 subjects with PP ≥ 65 mmHg as cases and 359 subjects with 30 ≤ PP ≤ 45 mmHg as controls. Seven single nucleotide...
Articles
Biosci Rep (2020) 40 (6): BSR20200321.
Published: 02 June 2020
...Hai Yuan; Lingling Du; Pingping Ge Complement receptor 1 (CR1) plays an important role in the development of sporadic Alzheimer’s disease (SAD) in Caucasians. However, the influence of CR1 (rs6656401A/G and rs3818361T/C) genetic polymorphisms on the risk of SAD remains controversial. A meta...
Articles
Biosci Rep (2020) 40 (5): BSR20193955.
Published: 28 May 2020
... and controls the specification, growth, and differentiation of the embryonic pancreas [ 9 ]. Although some studies have reported the relationship between IGF2BP2, HMG20A , and HNF1B polymorphisms and T2DM risk, the study on other polymorphisms in these genes is insufficient [ 10–12 ]. In the present...
Articles
Biosci Rep (2020) 40 (5): BSR20192513.
Published: 22 May 2020
...Ziyin Huang; Yufeng Jiang; Yafeng Zhou Background: CYP4A11 gene T8590C (rs1126742) is proved to be an important locus that is relevant to hypertension. Various research on the relationship between rs1126742 polymorphism and hypertension have been published, but due to small sample sizes...
Articles
Biosci Rep (2020) 40 (5): BSR20200854.
Published: 22 May 2020
...Yuan Fang; Xuemei Wu; Lin Li; Jinhong Zhu; Haiyan Wu; Haixia Zhou; Jing He; Yizhen Wang TP53 is a tumor suppressor gene that regulates cell growth, apoptosis and DNA repair. Previous studies have reported the contribution of TP53 Arg72Pro (rs1042522 C>G) polymorphism to pathogenesis of multiple...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (5): BSR20190629.
Published: 14 May 2020
...Anum Zehra Naqvi; Ishrat Mahjabeen; Saima Ameen; Malik Waqar Ahmed; Asad Ullah Khan; Zertashia Akram; Mahmood Akhtar Kayani The present study was designed to determine the association between the genetic polymorphisms/expression variations of RB1 and CCND1 genes and brain tumor risk...
Articles
Biosci Rep (2020) 40 (5): BSR20193989.
Published: 11 May 2020
...Yi Zheng; Tongyi Lu; Xiaoli Xie; Qiuming He; Lifeng Lu; Wei Zhong MicroRNAs (miRNAs) are endogenous non-coding small RNAs that play an important role in the development of many malignant tumors. In addition, recent studies have reported that single nucleotide polymorphisms (SNPs) located...
Articles
Biosci Rep (2020) 40 (5): BSR20191188.
Published: 05 May 2020
... to the patient, affecting speech, swallowing and respiratory skills. Smoking and alcohol abuse are principal risk factors linked to this disease. Genetic factors can be involved in carcinogenesis by controlling the cell cycle, cell survival, angiogenesis, and invasiveness. Single nucleotide polymorphisms (SNPs...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (4): BSR20200193.
Published: 21 April 2020
...Jin Li; Lifeng Jiang; Xindie Zhou; Lidong Wu; Dong Li; Gang Chen Expression of proinflammatory cytokines, such as interleukin (IL)-6 (IL-6) and metalloproteases, are elevated in patients with rotator cuff tear (RCT). In order to investigate the role of IL-6 gene polymorphisms on RCT risk, we...
Articles
Biosci Rep (2020) 40 (4): BSR20200406.
Published: 09 April 2020
...Qianqian Yu; Jing Zhu; Yong Yao; Chao Sun The complement factor I ( CFI ) gene polymorphisms have been reported to age-related macular degenerative (AMD) risk, nevertheless, above association is not consistent. We investigated a meta-analysis to evaluate the conclusions between CFI polymorphisms...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (3): BSR20191691.
Published: 13 March 2020
...Li Huang; Lunwen Wang Vascular endothelial growth factor ( VEGF ) plays a critical role in ovarian folliculogenesis and normal reproductive function. So far, several studies focusing on association between VEGF gene polymorphisms and polycystic ovary syndrome (PCOS). However, above association...
Articles
Biosci Rep (2020) 40 (3): BSR20192113.
Published: 12 March 2020
..., including leptin and/or GH signaling. Leptin is an adipose hormone that controls body weight. The objective of the present study is to evaluate the association between body measurement traits and SH2B2 gene polymorphisms as responsible mutations. For this purpose, we selected four single-nucleotide...
Articles
Biosci Rep (2020) 40 (2): BSR20193623.
Published: 28 February 2020
... is not entirely clear and a lot of possible pathogenic mechanisms have been proposed to explain the etiology of BA, including genetic, inflammatory, environmental and developmental abnormalities. As a transcription factor, USF2 gene rs916145 polymorphism has been shown to be related to the risk of BA. Methods: We...
Articles
Biosci Rep (2020) 40 (2): BSR20194202.
Published: 28 February 2020
... of TP53 mutations, the methylation of miR34b/c , and the interaction between these two molecules in tumorigenesis have been well documented. Due to the biological connection between p53 and miR34b/c , in the present study, we investigated the association between polymorphisms in these two molecules...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (2): BSR-20190744_COR.
Published: 28 February 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Gestational diabetes mellitus MTNR1B Polymorphism meta analysis Trial...
Articles
Biosci Rep (2020) 40 (2): BSR20200370.
Published: 28 February 2020
...Bo Huang; Yu-kun Wang; Lin-yuan Qin; Qin Wei; Nian Liu; Min Jiang; Hong-ping Yu; Xiang-yuan Yu Th authors of ‘A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus’ ( Bioscience Reports (2019) 39 , 12) have written a reply...
Articles
Biosci Rep (2020) 40 (2): BSR20191203.
Published: 24 February 2020
.... Myocardial infarction (MI) association transcript (MIAT) has demonstrated that it plays an important role in AMI. Purpose: To investigate the association between MIAT promoter polymorphisms and AMI in Chinese Han population. Methods: A total of 212 AMI patients and 218 healthy controls were recruited...
Articles
Biosci Rep (2020) 40 (2): BSR20194229.
Published: 20 February 2020
... polymorphism and the decreased risk of HCC in hepatitis/virus related patients (recessive model: OR, 0.85; 95%CI, 0.72–0.99; P = 0.035, and allele model: OR, 0.90; 95%CI, 0.81–0.99; P = 0.028). Subgroup analyses indicated that extreme heterogeneity existed in Asian population, larger sample size investigation...
Articles
Biosci Rep (2020) 40 (1): BSR20191449.
Published: 06 January 2020
...Menglei Yu; Jingyi Hou; Minghui Zheng; Yi Cao; Yamuhanmode Alike; Yuanyuan Mi; Jie Zhu Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous...
Articles
Biosci Rep (2019) 39 (12): BSR20190744.
Published: 20 December 2019
...Bo Huang; Yu-kun Wang; Lin-yuan Qin; Qin Wei; Nian Liu; Min Jiang; Hong-ping Yu; Xiang-yuan Yu The melatonin receptor 1B ( MTNR1B ) polymorphism rs10830963 C>G has been reported to be associated with the risk of gestational diabetes mellitus (GDM) with inconsistent results. To clarify the effect...
Articles
Biosci Rep (2019) 39 (12): BSR20190866.
Published: 17 December 2019
...Guowen Ding; Yu Chen; Huiwen Pan; Hao Qiu; Weifeng Tang; Shuchen Chen Background: Previous case–control studies have suggested that apurinic/apyrimidinic endonuclease 1 ( APE1 ) rs1760944 T>G polymorphism may be associated with cancer risk. Here, we carried out an updated meta-analysis to focus...
Articles
Biosci Rep (2019) 39 (12): BSR20191770.
Published: 13 December 2019
...Weifeng Tang; Shuchen Chen; Mingqiang Kang; Jun Liu; Chao Liu Background: Variants in B- and T-lymphocyte attenuator ( BTLA ) gene are likely to affect the function of BTLA protein. Methods: In the present case–control study, we selected BTLA tagging single-nucleotide polymorphisms (SNPs...
Articles
Biosci Rep (2019) 39 (12): BSR20190498.
Published: 28 November 2019
... to play important roles in cholesterol and triacylglycerol (TAG) metabolism. In the present study, our primary objective was to explore whether the single nucleotide polymorphisms (SNPs) in INSIG1 gene were associated with obesity in Uygur subjects, in Xinjiang, China. Methods: We designed a case–control...
Articles
Biosci Rep (2019) 39 (11): BSR20192517.
Published: 12 November 2019
...Sheng Zhang; Jing Lin; Jiakai Jiang; Yu Chen; Weifeng Tang; Longgen Liu Polymorphisms in one-carbon metabolism genes may influence the susceptibility to hepatocellular carcinoma (HCC). In the present study, we studied methylenetetrahydrofolate reductase ( MTHFR ) tagging polymorphisms in 584 HCC...
Articles
Biosci Rep (2019) 39 (10): BSR20191549.
Published: 21 October 2019
...Kaisong Miao; Lifeng Jiang; Xindie Zhou; Lidong Wu; Yong Huang; Nanwei Xu; Junjie Zhang; Jin Li An association of Matrix Metalloproteinases-1/3 (MMP-1/3) rs1799750/rs3025058 polymorphism with increased risk of rotator cuff tear (RCT) has been reported in a Brazilian population. However...
Articles
Biosci Rep (2019) 39 (10): BSR20192529.
Published: 18 October 2019
... life. The association between PHOX2B single nucleotide polymorphisms (SNPs) and Wilms tumor risk has not been investigated. Therefore, we conducted a case-control study involving 145 Wilms tumor patients and 531 controls to explore the association between the PHOX2B rs28647582 T>C polymorphism...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (9): BSR20190368.
Published: 13 September 2019
... for the degradation and transport of active vitamin D, play important role in many cancer-related cellular processes. Relationships between CYP27B1 and GC polymorphisms and cancer susceptibility have been widely investigated, whereas the results are inconsistent. We strictly searched EMBASE, PubMed, Web of Science...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (9): BSR20181025.
Published: 03 September 2019
...Kangpeng Yan; Kun Wu; Chao Lin; Zhigang Jie Previous studies have identified the prostate stem cell antigen ( PSCA ) gene rs2294008 C > T and rs2976392 G > A polymorphisms to be associated with the risk of gastric cancer, the results of which are inconsistent. The present study aimed...
Articles
Biosci Rep (2019) 39 (8): BSR20190741.
Published: 23 August 2019
...Xingliang Feng; Dan Ji; Chaozhao Liang; Song Fan Piles of evidence have supported the relationship between miR-618 rs2682818 polymorphism and tumorigenesis, but the conclusion remains inconsistent. In the present study, we conducted a meta-analysis to sniff out the potential risk between miR-618...
Includes: Supplementary data