... emerged as an important mechanism by which TNBCs mediate drug resistance and occurs primarily due to overexpression of ATP-binding cassette (ABC) transporter proteins such as P-glycoprotein (Pgp). Pgp overexpression had been linked to poor outcome, reduced survival rates and chemoresistance in patients...

...)-based chemotherapy. Spearman correlation analysis showed a positive correlation between the levels of CRNDE and MDR1 in AML patients after ADR-based chemotherapy. Moreover, CRNDE was up-regulated in AML cells, especially in ADR-resistant AML cells. Multidrug resistance protein 1 (MDR1)/p-glycoprotein (P...

...Yan Xu; Feng Zhi; Guangming Xu; Xiaolei Tang; Sheng Lu; Jinhui Wu; Yiqiao Hu MDR (multidrug-resistance) represents a major obstacle to successful cancer chemotherapy and is usually accomplished by overexpression of P-gp (P-glycoprotein). Much effort has been devoted to developing P-gp inhibitors...

... of vitamins C and B12b was studied. It was found that this resistance in growing cells is suppressed by the disruption of intercellular contacts by EGTA and is related neither to the activity of P-glycoprotein nor to the content of intracellular glutathione and the activities of glutathione S-transferases...

...Luis F. Marques-Santos; José G. P. Oliveira; Raquel C. Maia; Vivian M. Rumjanek P -glycoprotein has a widespread expression on normal tissues. The protein has also been strongly associated with the multidrug resistance phenotype (MDR) on tumor cells. The employment of flow cytometry and confocal...

... in cell physiology, are reviewed in this study. The hypothesis is thus forwarded for the improper delivery of cellular ATP to the extracellular milieu by a dysfunctional CFTR, to be a relevant factor in the onset of cystic fibrosis. CFTR ABC transporters P-glycoprotein ATP channels ATP release...

... of disease. © 1991 Plenum Publishing Corporation 1991 membrane mitochondria transport chemiosmotics ATPase channels synaptic junctions neurotransmitters hormones P-glycoprotein multi-drug resistance antibiotics ionophores oxidative phosphorylation cardiac glycosides mitochondrial...

... the absence of the multidrug resistance associated membrane P-glycoprotein (P-gp). Neither Ver nor CsA had any acute or long term effects on cytoplasmic free Ca 2+ concentration (Ca 2+ i), except for a small Ver induced increase after 36 h of incubation. The results indicate that Ver and CsA may have...