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Keywords: obesity
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Articles
Biosci Rep (2024) 44 (1): BSR20231916.
Published: 31 January 2024
...-pituitary-ovarian axis insulin metabolic disorders nutrient-sensing obesity polycystic ovary syndrome (PCOS) References 1. Schneider J. , Klingerman C. and Abdulhay A. ( 2012 ) Sense and nonsense in metabolic control of reproduction . Front Endocrinol. 3 , 26...
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Biosci Rep (2024) 44 (1): BSR20231846.
Published: 25 January 2024
... immunohistochemical markers to systematically evaluate the density of hypothalamic peptidergic neurons and glial cells. Results: We found that delivery of one specific preparation of AAV8-hSyn-Cre in the PVN led to the development of obesity, hyperphagia, and anxiety-like behaviors. This effect occurred independent...
Includes: Supplementary data
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Biosci Rep (2023) 43 (10): BSR20230114.
Published: 31 October 2023
... include branched-chain fatty acids (BCFAs). Recently, lowered BCFAs blood concentration was noticed in obese patients. An inverse correlation was found between serum concentrations of BCFAs and triglyceride levels, as well as C-reactive protein (CRP) concentration. Obesity is the most frequently observed...
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Biosci Rep (2023) 43 (7): BSR20230501.
Published: 04 July 2023
...Shengrong Wan; Ying An; Wei Fan; Fangyuan Teng; Zongzhe Jiang Obesity, characterized by accumulation of adipose, is usually accompanied by hyperlipidemia and abnormal glucose metabolism, which destroys the function and structure of islet β cells. However, the exact mechanism of islet deterioration...
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Biosci Rep (2022) 42 (3): BSR20212358.
Published: 08 March 2022
...Yue Qi; Xiaoyan Hui The adipose tissue (AT) has a major role in contributing to obesity-related pathologies through regulating systemic immunometabolism. The pathogenicity of the AT is underpinned by its remarkable plasticity to be reprogrammed during obesity, in the perspectives of tissue...
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Coronavirus
Biosci Rep (2021) 41 (8): BSR20210979.
Published: 20 August 2021
... become a significant concern for public health. Obesity is highly prevalent worldwide and is considered a risk factor for impairing the adaptive immune system. Although diabetes, hypertension, cardiovascular disease (CVD), and renal failure are considered the risk factors for COVID-19, obesity is not yet...
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Biosci Rep (2021) 41 (5): BSR20210029.
Published: 14 May 2021
...-recognised link between the ADAM17 substrate tumour necrosis factor α (TNF-α) and obesity, inflammation and diabetes. In addition, knocking out ADAM17 in mice leads to an extremely lean phenotype. Importantly, ADAM17-deficient mice exhibit one of the most pronounced examples of hypermetabolism in rodents...
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Biosci Rep (2020) 40 (6): BSR20194076.
Published: 09 June 2020
...Sunhye Shin; Asma S. El-Sabbagh; Brandon E. Lukas; Skylar J. Tanneberger; Yuwei Jiang Adipose tissue, the storage of excessive energy in the body, secretes various proteins called adipokines, which connect the body’s nutritional status to the regulation of energy balance. Obesity triggers...
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Biosci Rep (2020) 40 (1): BSR20192153.
Published: 06 January 2020
...Jinling Wang; Ningning Zhao; Xiaoting Mao; Feilong Meng; Ke Huang; Guanping Dong; Yanchun Ji; JunFen Fu A Chinese family with matrilineally inherited obesity was assessed and its clinical, genetic, and molecular profiling was conducted. Obesity was observed in matrilineal relatives (3 out of 7...
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Biosci Rep (2019) 39 (9): BSR20182042.
Published: 09 September 2019
...Rihua Zhang; Jing Bao Kan; Shan Lu; Pei Tong; Jie Yang; Ling Xi; Xiubing Liang; Dongming Su; Dong Li; Yun Liu The steadily increasing epidemic of obesity continues at alarming rates, is an important public health problem, and expression changes of S100A16 and 11 β-hydroxysteroid dehydrogenase type...
Includes: Supplementary data
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Biosci Rep (2018) 38 (4): BSR20180553.
Published: 06 July 2018
...Yan Zhou; Qi Pan; Xiaoxia Wang; Lina Zhang; Fei Xiao; Lixin Guo The study aimed to explore the prevalence of human adenovirus-36 (HAdV-36) infection and the association of HAdV-36 with obesity in Chinese Han population. A qualitative determination using ELISA was performed to determine...
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Biosci Rep (2018) 38 (4): BSR20180281.
Published: 06 July 2018
...Shabana; Saleem Ullah Shahid; Shahida Hasnain We aimed to identify the genetic causes of common forms of obesity in the Pakistani people and find out the mechanistic link by observing the relationship of genes and serum lipid traits. Four hundred and seventy-five subjects were genotyped for two...
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Biosci Rep (2017) 37 (4): BSR20171089.
Published: 31 August 2017
... accumulation in skeletal muscles and adipose tissue is widely associated with the impairment of insulin signalling. While the angiogenic role of VEGF-A and its increased circulating concentrations in obesity have been widely confirmed, the data related to the metabolic role of VEGF-B are diverse. However...
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Biosci Rep (2017) 37 (3): BSR20170286.
Published: 11 May 2017
...Jia Zheng; Sheng Zheng; Qianyun Feng; Qian Zhang; Xinhua Xiao Obesity is a growing public health problem, which has now been considered as a pandemic non-communicable disease. However, the efficacy of several approaches for weight loss is limited and variable. Thus, alternative anti-obesity...
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Biosci Rep (2017) 37 (1): BSR20160184.
Published: 03 February 2017
...Sara L. Pulit; Tugce Karaderi; Cecilia M. Lindgren Obesity is a chronic condition associated with increased morbidity and mortality and is a risk factor for a number of other diseases including type 2 diabetes and cardiovascular disease. Obesity confers an enormous, costly burden on both...
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Biosci Rep (2015) 35 (5): e00262.
Published: 30 October 2015
...Shaohai Xu; Peng Chen; Lei Sun BAT (brown adipose tissue) is specialized to burn fatty acids for heat generation and energy expenditure to defend against cold and obesity. Accumulating studies have demonstrated that manipulation of BAT activity through various strategies can regulate metabolic...
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Biosci Rep (2015) 35 (3): e00200.
Published: 11 June 2015
...Brittany Beauchamp; A. Brianne Thrush; Jessica Quizi; Ghadi Antoun; Nathan McIntosh; Osama Y. Al-Dirbashi; Mary-Elizabeth Patti; Mary-Ellen Harper Intrauterine growth restriction (IUGR) is associated with an increased risk of developing obesity, insulin resistance and cardiovascular disease...
Includes: Supplementary data
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Biosci Rep (2014) 34 (5): e00144.
Published: 22 October 2014
...Pawan Gulati; Edward Avezov; Marcella Ma; Robin Antrobus; Paul Lehner; Stephen O’Rahilly; Giles S. H. Yeo SNPs (single nucleotide polymorphisms) on a chromosome 16 locus encompassing FTO , as well as IRX3 , 5 , 6 , FTM and FTL are robustly associated with human obesity. FTO catalyses the Fe(II...
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Biosci Rep (2014) 34 (5): e00141.
Published: 02 October 2014
... metabolism obesity Aberrant expression of the AGPAT2 (1-acylglycerol-3-phosphate-O-acyl-transferase 2) gene, on chromosome 9q34, was identified as the cause of BSCL1 [ 10 , 11 ]. Expression of AGPAT2 is tissue specific, high in liver, pancreas, skeletal muscle and small intestine and highest...
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Biosci Rep (1987) 7 (11): 843–851.
Published: 01 November 1987
...Narinder Singh Shargill; Ibtisam Al-Baker; David A. York In an attempt to understand the hyper-responsiveness to glucocorticoids that is characteristic of genetically obese fa/fa rats, we have measured the levels of free corticosterone in serum from lean and obese rats as well as the number...