Skip Nav Destination
1-21 of 21
Keywords: nucleus pulposusClose
Biosci Rep (2020) 40 (2): BSR20191726.
Published: 04 February 2020
...Jingjing Xie; Bo Li; Bing Yao; Pingchao Zhang; Lixin Wang; Hua Lu; Xuan Song Background: During disc degeneration, inflammatory cytokine tumor necrosis factor (TNF)-α is correlated with nucleus pulposus (NP) cell apoptosis. Transforming growth factor (TGF)-β1 has the potential to regenerate...
Biosci Rep (2019) 39 (9): BSR20191711.
Published: 20 September 2019
...Jiawei Xu; Haopeng Li; Kai Yang; Shuai Guo; Jie Wang; Chaoshuai Feng; Huayou Chen Nucleus pulposus (NP) cell senescence is involved in disc degeneration. The in situ osmolarity within the NP region is an important regulator of disc cell’s biology. However, its effects on NP cell senescence remain...
Biosci Rep (2019) 39 (5): BSR20190126.
Published: 10 May 2019
... with disc cell senescence. Resveratrol has a protective role against inflammation in some cells. However, its biological effects on disc cells remain largely unclear. The present study was aimed to study the effects of resveratrol on disc nucleus pulposus (NP) cell senescence in an inflammation environment...
Ziming Liu, Zhiwen Zhang, Ali Zhang, Fan Zhang, Wennan Du, Yongqiang Zhang, Rongfeng Zhang, Jiagang Xu, Xiangkun Wu, Chengmin Zhang, Ning Li, Qi Tan, Wei Huang
Biosci Rep (2019) 39 (4): BSR20190170.
Published: 02 April 2019
... growth factor, osteogenic protein-1 (OP-1) has lots of protective effects on the healthy disc cell’s biology. The present study was aimed to investigate the effects of OP-1 on degenerative changes of nucleus pulposus (NP) cells in a high glucose culture. Rat NP cells were cultured in the baseline medium...
Biosci Rep (2019) 39 (3): BSR20182462.
Published: 29 March 2019
... of chondrocytes. The present study is aimed to investigate whether MGF can attenuate mechanical overload-induced nucleus pulposus (NP) cell apoptosis and the possible signaling transduction pathway. Rat NP cells were cultured and subjected to mechanical overload for 7 days. The control NP cells did not experience...
Biosci Rep (2019) 39 (3): BSR20190043.
Published: 26 March 2019
...Yanhai Jiang; Zhijie Xie; Jinying Yu; Lianqiang Fu Nucleus pulposus (NP) cell apoptosis is a classical cellular character during intervertebral disc degeneration (IDD). Previous studies have shown that inflammatory cytokine-induced NP cell apoptosis plays an important role in disc degeneration...
Biosci Rep (2019) 39 (3): BSR20182312.
Published: 19 March 2019
... senescence of human disc cells during cell subculture is important for TE-based strategy to regenerate degenerative disc tissue. Objective: The present study was aimed to investigate whether bone morphogenetic protein-7 (BMP-7) can alleviate subculture-induced senescence of human nucleus pulposus (NP) cells...
Biosci Rep (2018) 38 (6): BSR20181708.
Published: 14 December 2018
... intervertebral disc degeneration nucleus pulposus osteogenic protein-1 PI3K/Akt/mTOR Low back pain is a common and costly physical disease around the world, generating enormous socioeconomic burden and seriously affecting patient’s life quality [ 1 ]. Its global prevalence is estimated to reach 12...
Biosci Rep (2018) 38 (6): BSR20181530.
Published: 21 November 2018
...Wei Yu; Jiabin Fu; Yan Liu; Yuchi Wu; Dianming Jiang Background: Intervertebral disc degeneration is a pathological process that involves an inflammation response. As a classical cellular feature, several studies have demonstrated that inflammation can promote nucleus pulposus (NP) cell apoptosis...
Biosci Rep (2018) 38 (6): BSR20181451.
Published: 14 November 2018
...Jiabin Fu; Wei Yu; Dianming Jiang Background: Nucleus pulposus (NP) cell senescence is an important cellular feature within the degenerative disc. It is known that a very acidic niche exists in the degenerative disc, which participates in regulating disc cell viability and matrix metabolism...
Biosci Rep (2018) 38 (5): BSR20181176.
Published: 10 October 2018
...Shouguo Jiao; Jingxiang Li; Binbin Liu; Ming Yang; Jiangli Xiu; Daokui Qu Disc nucleus pulposus (NP) cell experiences periodic osmolarity alterations during daily activities, which has been proved to affect cell biology in vitro . The present study was aimed to investigate the effects of cartilage...
Biosci Rep (2018) 38 (4): BSR20180544.
Published: 06 July 2018
...Jinlou Gao; Qingyun Zhang; Lin Song The decrease in nucleus pulposus (NP) matrix production is a classic feature during disc degeneration. Resveratrol (RSV) is reported to play protective effects under many pathological factors.The present study aims to study the effects of RSV on NP matrix...
Biosci Rep (2018) 38 (4): BSR20180670.
Published: 06 July 2018
... nucleus pulposus (NP) cell senescence in vitro and the potential mechanism. The isolated rat NP cells were seeded in the decalcified bone matrix (DBM) and cultured under non-compression (control) and compression (20% deformation, 1.0 Hz, 6 h/day) for 5 days using the mechanically active bioreactor...
Wenping Wang, Pei Li, Jiagang Xu, Xiangkun Wu, Zhiliang Guo, Lijing Fan, Ruipeng Song, Jianli Wang, Li Wei, Haijun Teng
Biosci Rep (2018) 38 (2): BSR20171454.
Published: 13 April 2018
...Wenping Wang; Pei Li; Jiagang Xu; Xiangkun Wu; Zhiliang Guo; Lijing Fan; Ruipeng Song; Jianli Wang; Li Wei; Haijun Teng Background: Diabetes mellitus is closely correlated with disc degeneration. Nucleus pulposus (NP) cell apoptosis and senescence are typical cellular features within...
Biosci Rep (2018) 38 (2): BSR20180018.
Published: 16 March 2018
...Haolin Fang; Xianzhou Li; Haiming Shen; Buwei Sun; Haijun Teng; Pei Li Disc degeneration is correlated with mechanical load. Osteogenic protein-1 (OP-1) is potential to regenerate degenerative disc. To investigate whether OP-1 can protect against high magitude compression-induced nucleus pulposus...
Biosci Rep (2018) 38 (2): BSR20180064.
Published: 09 March 2018
...Jianmin Shi; Lianglong Pang; Shouguo Jiao Mechanical stimuli obviously affect disc nucleus pulposus (NP) biology. Previous studies have indicated that static compression exhibits detrimental effects on disc biology compared with dynamic compression. To study disc NP cell senescence under static...
Biosci Rep (2018) 38 (2): BSR20171703.
Published: 09 March 2018
...Zhiwen Zhang; Feng Wen; Chengjian He; Jun Yu Background: Nucleus pulposus (NP) cell apoptosis is a typical feature within the degenerative disc. High magnitude compression significantly promotes NP cell apoptosis. Several studies have indicated that resveratrol has protective effects on disc cell’s...
Biosci Rep (2018) 38 (1): BSR20171551.
Published: 08 February 2018
...Haibo Zhou; Jianmin Shi; Chao Zhang; Pei Li Mechanical compression often induces degenerative changes of disc nucleus pulposus (NP) tissue. It has been indicated that N-cadherin (N-CDH)-mediated signaling helps to preserve the NP cell phenotype. However, N-CDH expression and the resulting NP...
Biosci Rep (2017) 37 (6): BSR20171319.
Published: 23 November 2017
...Xiaorui Han; Xiaoming Leng; Man Zhao; Mei Wu; Amei Chen; Guoju Hong; Ping Sun Disc nucleus pulposus (NP) matrix homeostasis is important for normal disc function. Mechanical overloading seriously decreases matrix synthesis and increases matrix degradation. The present study aims to investigate...
Biosci Rep (2017) 37 (5): BSR20170718.
Published: 11 October 2017
...Lianglong Pang; Pei Li; Ruijie Zhang; Yuan Xu; Lei Song; Qiang Zhou Nucleus pulposus (NP) cell senescence is a typical pathological feature within the degenerative intervertebral disc. As a potential inducing and aggregating factor of disc degeneration, mechanical overloading affects disc biology...
Pei Li, Ruijie Zhang, Liyuan Wang, Yibo Gan, Yuan Xu, Lei Song, Lei Luo, Chen Zhao, Chengmin Zhang, Bin Ouyang, Bing Tu, Qiang Zhou
Biosci Rep (2017) 37 (2): BSR20160582.
Published: 28 April 2017
...Pei Li; Ruijie Zhang; Liyuan Wang; Yibo Gan; Yuan Xu; Lei Song; Lei Luo; Chen Zhao; Chengmin Zhang; Bin Ouyang; Bing Tu; Qiang Zhou Long-term exposure to a mechanical load causes degenerative changes in the disc nucleus pulposus (NP) tissue. A previous study demonstrated that N-cadherin (N-CDH...