... distantly placed pathways: amyloid formation and developing cancers in the brain have similarities and are mechanistically intertwined together. Cancer amyloid neurodegeneration glioma proteostasis aging Bennett University India Seed grant 000000 Joshi Vibhuti ÿ ÿ 09 162ÿ 34...

... the Creative Commons Attribution License 4.0 (CC BY) . endoplasmic reticulum endosomes intracellular transport Lysosomes neurodegeneration neuronal ceroid lipofuscinosis First discovered by Christian de Duve, lysosomes perform several key cellular functions, and their dysfunction has been...

... of Mendelian disease genes in a diverse range of in vitro , in vivo and in silico models [ 20 , 21 ], substantial progress has been made in elucidating the molecular mechanisms of neurodegeneration in PD. Figure 1 The emerging genetic architecture of Parkinson’s disease Mutations and variants...

... 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alzheimer's disease disease models neurodegeneration tau protein...

.... Such understanding may have further implications in neurodegeneration and peripheral neuropathy. Correspondence: Chandan Goswami ( chandan@niser.ac.in ) 30 01 2020 03 05 2020 05 05 2020 28 09 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cystamine cysteamine celiac disease cardiac disease neurodegeneration tranglutaminase Cystamine is a symmetric organodisulphide commonly used as an inhibitor of transglutaminases. This disulphide is also reduced...

... of phosphatidylinositol 3,5-bisphosphate [PI(3,5) P 2 ]. PIKfyve function is required for homoeostasis of the endo/lysosomal system and is crucially implicated in neuronal function and integrity, as loss of function mutations in the PIKfyve complex lead to neurodegeneration in mouse models and human patients. Our recent...

... and Alzheimer's disease involve lysosome dysfunction and may similarly suffer from vitamin B 12 trapping. lysosome mitochondria neurodegeneration subcellular-fractionation vitamin B 12 Previous data indicated that treatment of fibroblasts with chloroquine (25 μM for 21 h) resulted in a dramatic...

... non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cognition diabetes energy homoeostasis ghrelin hormone insulin leptin neural circuitry neurodegeneration Food intake and energy expenditure, the key determinants...

... in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in neurodegeneration?” is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic...

.... Factors associated with predisposition and vulnerability to neurodegenerative disorders may be described usefully within the context of gene–environment interplay. There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human...

... involved in both neurodegeneration and cancer. An impairment of Wnt signals appears to be associated with aspects of neurodegenerative pathologies while overactivation of Wnt signaling is a common theme in several types of human tumors. Therefore, although therapeutic approaches aimed at modulating Wnt...

...+ . These results suggest that Aβ 25–35 can promote the PTP induced by Ca 2+ . © 2001 Plenum Publishing Corporation 2001 Amyloid β-peptide permeability transition pore brain mitochondria mitochondrial transmembrane potential calcium fluxes neurodegeneration Bioscience Reports, Vol. 21, No. 6...