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Articles

Mitochondrial DNA maintenance in Drosophila melanogaster

Ana P.C. Rodrigues, Audrey C. Novaes, Grzegorz L. Ciesielski, Marcos T. Oliveira

Biosci Rep (2022) 42 (11): BSR20211693.

DOI: https://doi.org/10.1042/BSR20211693

Published: 10 November 2022

... melanogaster mitochondria nucleic acids The mitochondrial DNA (mtDNA) in flies and humans is highly conserved in terms of gene content, as is in the vast majority of animal species, although genomic structure varies substantially ( Figure 1 ). Its 37 genes encode 24 RNA components...

View article titled, Mitochondrial DNA maintenance in Drosophila melanogaster

Includes: Supplementary data

Articles

Prescription drugs and mitochondrial metabolism

Cameron A. Schmidt

Biosci Rep (2022) 42 (4): BSR20211813.

DOI: https://doi.org/10.1042/BSR20211813

Published: 12 April 2022

...Cameron A. Schmidt Mitochondria are central to the physiology and survival of nearly all eukaryotic cells and house diverse metabolic processes including oxidative phosphorylation, reactive oxygen species buffering, metabolite synthesis/exchange, and Ca 2+ sequestration. Mitochondria...

View article titled, Prescription drugs and mitochondrial metabolism

Includes: Supplementary data

Articles

Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells

Gabriela Assis-de-Lemos, Jamila Monteiro, Viviane M. Oliveira-Valença, Guilherme A. Melo, Ricardo A. de Melo Reis, Stevens K. Rehen, Mariana S. Silveira, Antonio Galina

Biosci Rep (2021) 41 (12): BSR20211191.

DOI: https://doi.org/10.1042/BSR20211191

Published: 08 December 2021

... with the mitochondria (mt-HK), is a potent modulator of the generation of mitochondrial ROS in the brain. In the present study, we investigated whether dopamine could affect both the activity and redox function of mt-HK in human neural progenitor cells (NPCs). We found that dopamine signaling via D 1 R decreases mt-HK...

View article titled, Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells

Includes: Supplementary data

Articles

Mitochondria-related core genes and TF-miRNA-hub mrDEGs network in breast cancer

Li-rong Yan, Ang Wang, Zhi Lv, Yuan Yuan, Qian Xu

Biosci Rep (2021) 41 (1): BSR20203481.

DOI: https://doi.org/10.1042/BSR20203481

Published: 27 January 2021

...Li-rong Yan; Ang Wang; Zhi Lv; Yuan Yuan; Qian Xu Background: Mitochondria-nuclear cross-talk and mitochondrial retrograde regulation are involved in the genesis and development of breast cancer (BC). Therefore, mitochondria can be regarded as a promising target for BC therapeutic strategies...

View article titled, Mitochondria-related core genes and TF-miRNA-hub mrDEGs network in breast cancer

Includes: Supplementary data

Articles

Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response

Katsuhiko Sasaki, Takeshi Uchiumi, Takahiro Toshima, Mikako Yagi, Yura Do, Haruka Hirai, Ko Igami, Kazuhito Gotoh, Dongchon Kang

Biosci Rep (2020) 40 (11): BSR20201289.

DOI: https://doi.org/10.1042/BSR20201289

Published: 24 November 2020

... translation inhibition induced the ISR through ATF4 activation rather than the mtUPR. ATF4 integratad stress responce mitochondria mtUPR Mitochondria are important not only for ATP production by oxidative phosphorylation (OXPHOS), but also for lipid metabolism, iron–sulfur cluster biogenesis...

View article titled, Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response

Includes: Supplementary data

Articles

MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells

Yi-Huan Chen, Yi-Ju Wu, Wei-Cheng Chen, Tzong-Shyuan Lee, Tsui-Chun Tsou, Hsuan-Chia Chang, Sheng-Wen Lo, Shen-Liang Chen

Biosci Rep (2020) 40 (4): BSR20194404.

DOI: https://doi.org/10.1042/BSR20194404

Published: 17 April 2020

... differentiation of proliferating myoblasts (PMB) and confluent myoblasts (CMB) but had weak effect on this process once it had been initiated. The transition of mitochondria (MITO) morphology from high efficient filamentary network to low efficient vesicles was triggered by MEHP, implying its negative effects...

View article titled, MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells

Includes: Supplementary data

Articles

Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα

Iglika G. Ivanova, Neil D. Perkins

Biosci Rep (2019) 39 (9): BSR20192101.

DOI: https://doi.org/10.1042/BSR20192101

Published: 16 September 2019

... is its regulation of mitochondrial biology, including biogenesis, metabolism and apoptosis. In addition to regulating the expression of mitochondrial genes encoded in the nucleus, NF-κB signalling components are also found within mitochondria themselves and associated with mitochondrial DNA. However...

View article titled, Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα

Articles

Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity

Wessal Massalha, Mark Markovits, Edward Pichinuk, Yael Feinstein-Rotkopf, Mark Tarshish, Kumudesh Mishra, Victoria Llado, Miguel Weil, Pablo V. Escriba, Or Kakhlon

Biosci Rep (2019) 39 (1): BSR20181661.

DOI: https://doi.org/10.1042/BSR20181661

Published: 18 January 2019

... The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer glycolysis membrane lipid therapy Minerval (2-hydroxyoleic acid) mitochondria...

View article titled, Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity

Articles

Insights into the respiratory chain and oxidative stress

Véronique Larosa, Claire Remacle

Biosci Rep (2018) 38 (5): BSR20171492.

DOI: https://doi.org/10.1042/BSR20171492

Published: 02 October 2018

... radical (HOO∙). Their production sites in mitochondria are reviewed. Even though being highly toxic products, ROS seem important in transducing information from dysfunctional mitochondria. Evidences of signal transduction mediated by ROS in mitochondrial deficiency contexts are then presented in different...

View article titled, Insights into the respiratory chain and oxidative stress

Articles

Retraction of rod-like mitochondria during microtubule-dependent transport

María Cecilia De Rossi, Valeria Levi, Luciana Bruno

Biosci Rep (2018) 38 (3): BSR20180208.

DOI: https://doi.org/10.1042/BSR20180208

Published: 29 June 2018

...María Cecilia De Rossi; Valeria Levi; Luciana Bruno Molecular motors play relevant roles on the regulation of mitochondria size and shape, essential properties for the cell homeostasis. In this work, we tracked single rod-shaped mitochondria with nanometer precision to explore the performance...

View article titled, Retraction of rod-like mitochondria during microtubule-dependent transport

Includes: Multimedia, Supplementary data

Articles

Piperine functions as a tumor suppressor for human ovarian tumor growth via activation of JNK/p38 MAPK-mediated intrinsic apoptotic pathway

Lihui Si, Ruiqi Yang, Ruixin Lin, Shuli Yang

Biosci Rep (2018) 38 (3): BSR20180503.

DOI: https://doi.org/10.1042/BSR20180503

Published: 31 May 2018

... The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Caspase JNK Mitochondria p38 MARK Piperine Ovarian cancer remains the most...

View article titled, Piperine functions as a tumor suppressor for human ovarian tumor growth via activation of JNK/p38 MAPK-mediated intrinsic apoptotic pathway

Articles

The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation

Mir Hussain Nawaz, Juliana C. Ferreira, Lyudmila Nedyalkova, Haizhong Zhu, César Carrasco-López, Serdal Kirmizialtin, Wael M. Rabeh

Biosci Rep (2018) 38 (1): BSR20171666.

DOI: https://doi.org/10.1042/BSR20171666

Published: 21 February 2018

... of HK2 with the mitochondria through its N-half is proposed to facilitate higher stability on the mitochondria. The identification of structural and biochemical differences between HK2 and other human hexokinase isozymes could potentially be used in the development of new anticancer therapies...

View article titled, The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation

Includes: Supplementary data

Articles

Protein arginine methyltransferase expression and activity during myogenesis

Nicole Y. Shen, Sean Y. Ng, Stephen L. Toepp, Vladimir Ljubicic

Biosci Rep (2018) 38 (1): BSR20171533.

DOI: https://doi.org/10.1042/BSR20171533

Published: 10 January 2018

... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell differentiation Histone Methylarginine Mitochondria PGC-1a Skeletal muscle Protein arginine methyltransferases...

View article titled, Protein arginine methyltransferase expression and activity during myogenesis

Articles

Oxidative stress regulates cellular bioenergetics in esophageal squamous cell carcinoma cell

Xiaolong Zhang, Linhua Lan, Lili Niu, Juping Lu, Changxi Li, Miaomiao Guo, Shouyong Mo, Jing Lu, Yongzhang Liu, Bin Lu

Biosci Rep (2017) 37 (6): BSR20171006.

DOI: https://doi.org/10.1042/BSR20171006

Published: 12 December 2017

... hypoxia mitochondria oxidative stress reactive oxygen species All experiments were performed at least three times and the data obtained were analyzed using SPSS version 16.0 (SPSS, Chicago, U.S.A.). The values are presented as the mean ± S.D. For the evaluation of two groups, Student’s t test...

View article titled, Oxidative stress regulates cellular bioenergetics in esophageal squamous cell carcinoma cell

Includes: Supplementary data

Articles

Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM

Linhua Lan, Miaomiao Guo, Yong Ai, Fuhong Chen, Ya Zhang, Lei Xia, Dawei Huang, Lili Niu, Ying Zheng, Carolyn K. Suzuki, Yihua Zhang, Yongzhang Liu, Bin Lu

Biosci Rep (2017) 37 (3): BSR20170319.

DOI: https://doi.org/10.1042/BSR20170319

Published: 17 May 2017

... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Lon protease mitochondria mitochondrial DNA mitochondrial transcription factor A Tetramethylpyrazine Protein...

View article titled, Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM

Includes: Supplementary data

Articles

Amino acids trigger down-regulation of superoxide via TORC pathway in the midgut of Rhodnius prolixus

Ana Caroline P. Gandara, José Henrique M. Oliveira, Rodrigo D. Nunes, Renata L.S. Goncalves, Felipe A. Dias, Fabio Hecht, Denise C. Fernandes, Fernando A. Genta, Francisco R.M. Laurindo, Marcus F. Oliveira, Pedro L. Oliveira

Biosci Rep (2016) 36 (2): e00321.

DOI: https://doi.org/10.1042/BSR20160061

Published: 15 April 2016

... in the release of large quantities of amino acids, together with the haemoglobin prosthetic group, haem, which decomposes hydroperoxides and propagates oxygen-derived free radicals. Our previous studies demonstrated that reactive oxygen species (ROS) levels were diminished in the mitochondria and midgut...

View article titled, Amino acids trigger down-regulation of superoxide via TORC pathway in the midgut of Rhodnius prolixus

Articles

Combined defects in oxidative phosphorylation and fatty acid β-oxidation in mitochondrial disease

Abena Nsiah-Sefaa, Matthew McKenzie

Biosci Rep (2016) 36 (2): e00313.

DOI: https://doi.org/10.1042/BSR20150295

Published: 16 March 2016

...Abena Nsiah-Sefaa; Matthew McKenzie Mitochondria provide the main source of energy to eukaryotic cells, oxidizing fats and sugars to generate ATP. Mitochondrial fatty acid β-oxidation (FAO) and oxidative phosphorylation (OXPHOS) are two metabolic pathways which are central to this process. Defects...

View article titled, Combined defects in oxidative phosphorylation and fatty acid β-oxidation in mitochondrial disease

Articles

Review: can diet influence the selective advantage of mitochondrial DNA haplotypes?

J. William O. Ballard, Neil A. Youngson

Biosci Rep (2015) 35 (6): e00277.

DOI: https://doi.org/10.1042/BSR20150232

Published: 22 December 2015

... 3 11 2015 5 11 2015 5 11 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution Licence 3.0 . diet epigenetics flavin-adenine dinucleotide (FAD) mitochondria retrograde...

View article titled, Review: can diet influence the selective advantage of mitochondrial DNA haplotypes?

Articles

Role of tryptophan residues of Erv1: Trp 95 and Trp 183 are important for its folding and oxidase function

Qi Wang, Swee Kim Ang, Efrain Ceh-Pavia, Jiayun Pang, Hui Lu

Biosci Rep (2015) 35 (4): e00244.

DOI: https://doi.org/10.1042/BSR20150144

Published: 28 August 2015

... are not functionally important. flavin-adenine dinucleotide (FAD) binding mitochondria protein folding tryptophan residue thiol oxidase Erv1 (essential for respiration and viability 1) is an essential component of the mitochondrial import and assembly (MIA) pathway, playing a critical role during...

View article titled, Role of tryptophan residues of Erv1: Trp 95 and Trp 183 are important for its folding and oxidase function

Includes: Supplementary data

Articles

Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients

Philip A. Kramer, Balu K. Chacko, David J. George, Degui Zhi, Chih-Cheng Wei, Louis J. Dell'Italia, Spencer J. Melby, James F. George, Victor M. Darley-Usmar

Biosci Rep (2015) 35 (4): e00237.

DOI: https://doi.org/10.1042/BSR20150161

Published: 07 August 2015

... surgery cardiomyocytes mitochondria monocytes pericardial fluid oxidative stress Cardiac surgery is a common procedure with a significant incidence of post-operative complications associated with increased morbidity and several complications which have few effective therapies [ 1 – 4...

View article titled, Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients

Includes: Supplementary data

Articles

Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring

Brittany Beauchamp, A. Brianne Thrush, Jessica Quizi, Ghadi Antoun, Nathan McIntosh, Osama Y. Al-Dirbashi, Mary-Elizabeth Patti, Mary-Ellen Harper

Biosci Rep (2015) 35 (3): e00200.

DOI: https://doi.org/10.1042/BSR20150007

Published: 11 June 2015

... energetics and increased plasma short-chain acylcarnitines in adult mice. Findings suggest that in utero undernutrition is associated with maladaptive programming processes that have negative effects on the heart. energetics fetal programming heart metabolism mitochondria obesity...

View article titled, Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring

Includes: Supplementary data

Articles

Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition

Hua Zhao, Kalani Ruberu, Hongyun Li, Brett Garner

Biosci Rep (2014) 34 (1): e00092.

DOI: https://doi.org/10.1042/BSR20130130

Published: 31 January 2014

...Hua Zhao; Kalani Ruberu; Hongyun Li; Brett Garner Cbl (cobalamin) utilization as an enzyme cofactor is dependent on its efficient transit through lysosomes to the cytosol and mitochondria. We have previously proposed that pathophysiological perturbations in lysosomal function may inhibit...

View article titled, Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition

Articles

How does the metabolism of tumour cells differ from that of normal cells

Nívea Dias Amoêdo, Juan Perez Valencia, Mariana Figueiredo Rodrigues, Antonio Galina, Franklin David Rumjanek

Biosci Rep (2013) 33 (6): e00080.

DOI: https://doi.org/10.1042/BSR20130066

Published: 15 November 2013

..., and anabolic pathways that provide precursors for the synthesis of lipids, proteins and DNA. The review will discuss the original ideas of Otto Warburg and how they initially led to the notion that mitochondria of tumour cells were dysfunctional. Data will be presented to show that not only the organelles...

View article titled, How does the metabolism of tumour cells differ from that of normal cells

Articles

Proteome adaptations in Ethe1-deficient mice indicate a role in lipid catabolism and cytoskeleton organization via post-translational protein modifications

Tatjana M. Hildebrandt, Ivano Di Meo, Massimo Zeviani, Carlo Viscomi, Hans-Peter Braun

Biosci Rep (2013) 33 (4): e00052.

DOI: https://doi.org/10.1042/BSR20130051

Published: 25 July 2013

... encephalopathy hydrogen sulfide mitochondria redox regulation sulfur dioxygenase ETHE1 is a mitochondrial SDO (sulfur dioxygenase) [ 1 ], which takes part in sulfide detoxification by oxidizing persulfides to sulfite [ 2 ]. Animal cells produce H 2 S during the catabolism of sulfur-containing amino...

View article titled, Proteome adaptations in Ethe1-deficient mice indicate a role in lipid catabolism and cytoskeleton organization via post-translational protein modifications

Articles

The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction

Yana Chen, Kevork Hagopian, Douglas Bibus, José M. Villalba, Guillermo López-Lluch, Plácido Navas, Kyoungmi Kim, Roger B. McDonald, Jon J. Ramsey

Biosci Rep (2013) 33 (1): e00008.

DOI: https://doi.org/10.1042/BSR20120060

Published: 13 December 2012

... and three 40% CR groups) and the CR groups were fed diets containing soya bean oil (also in the control diet), fish oil or lard. The fatty acid composition of the major mitochondrial phospholipid classes, proton leak and H 2 O 2 production were measured in liver mitochondria following 1 month of CR...

View article titled, The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction

Articles

Two independent activities define Ccm1p as a moonlighting protein in Saccharomyces cerevisiae

J. Ignacio Moreno, Babu Patlolla, Kerry R. Belton, Brenita C. Jenkins, Polina V. Radchenkova, Marta A. Piva

Biosci Rep (2012) 32 (6): 549–557.

DOI: https://doi.org/10.1042/BSR20120066

Published: 19 September 2012

...J. Ignacio Moreno; Babu Patlolla; Kerry R. Belton; Brenita C. Jenkins; Polina V. Radchenkova; Marta A. Piva Ccm1p is a nuclear-encoded PPR (pentatricopeptide repeat) protein that localizes into mitochondria of Saccharomyces cerevisiae . It was first defined as an essential factor to remove the bI4...

View article titled, Two independent activities define Ccm1p as a moonlighting protein in Saccharomyces cerevisiae

Articles

Brown adipose tissue mitochondria: modulation by GDP and fatty acids depends on the respiratory substrates

Leopoldo De Meis, Luisa A. Ketzer, Juliana Camacho-Pereira, Antonio Galina

Biosci Rep (2012) 32 (1): 53–59.

DOI: https://doi.org/10.1042/BSR20100144

Published: 10 October 2011

...Leopoldo De Meis; Luisa A. Ketzer; Juliana Camacho-Pereira; Antonio Galina The UCP1 [first UCP (uncoupling protein)] that is found in the mitochondria of brown adipocytes [BAT (brown adipose tissue)] regulates the heat production, a process linked to non-shivering thermogenesis. The activity...

View article titled, Brown adipose tissue mitochondria: modulation by GDP and fatty acids depends on the respiratory substrates

Articles

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

Jie Cui, Mei Yu, Jingwen Niu, Zhenyu Yue, Zhiheng Xu

Biosci Rep (2011) 31 (5): 429–437.

DOI: https://doi.org/10.1042/BSR20100127

Published: 05 August 2011

... mutant form can suppress the processing of the immature form of uMtCK. LRRK2 expression keeps the uMtCK preprotein on the outer mitochondrial membrane instead of entering the mitochondria. In addition, the expression of both wild-type and mutant forms of LRRK2 promotes the interaction between ANT...

View article titled, Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

Includes: Supplementary data

Articles

Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection

Xianli Wang, Qian Wang, Wei Guo, Yi Zhun Zhu

Biosci Rep (2011) 31 (2): 87–98.

DOI: https://doi.org/10.1042/BSR20100003

Published: 29 October 2010

... protein from the mitochondria to the cytoplasm. Histological observation by TUNEL and EM proved that NaHS inhibited cardiac apoptosis in HF hearts and improved mitochondrial derangements, but that PAG aggravated those indices. Hence, H 2 S has protective effects in HF rats. 1 To whom correspondence...

View article titled, Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection

Articles

Characterization of non-cytosolic hexokinase activity in white skeletal muscle from goldfish ( Carassius auratus L.) and the effect of cold acclimation

Reinaldo Sousa dos Santos, Luan Pereira Diniz, Antonio Galina, Wagner Seixas da-Silva

Biosci Rep (2010) 30 (6): 413–423.

DOI: https://doi.org/10.1042/BSR20090128

Published: 27 September 2010

... the cold acclimation process. 1 To whom correspondence should be addressed (email wseixas@bioqmed.ufrj.br ). 16 10 2009 4 1 2010 7 1 2010 7 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 glycolysis goldfish hexokinase (HK) mitochondria...

View article titled, Characterization of non-cytosolic hexokinase activity in white skeletal muscle from goldfish ( Carassius auratus L.) and the effect of cold acclimation

Articles

Molecular and functional characterization of VDAC2 purified from mammal spermatozoa

Viviana A. Menzel, M. Carolina Cassará, Roland Benz, Vito De Pinto, Angela Messina, Vincenzo Cunsolo, Rosaria Saletti, Klaus-Dieter Hinsch, Elvira Hinsch

Biosci Rep (2009) 29 (6): 351–362.

DOI: https://doi.org/10.1042/BSR20080123

Published: 22 July 2009

... Journal compilation © 2009 Biochemical Society 2009 mitochondria porin isoform purification sequence analysis spermatozoa voltage-dependent anion channel 2 (VDAC2) VDACs (voltage-dependent anion channels), also known as mitochondrial porins, are the most abundant integral membrane...

View article titled, Molecular and functional characterization of VDAC2 purified from mammal spermatozoa

Articles

The mitochondrial pool of free amino acids reflects the composition of mitochondrial DNA-encoded proteins: indication of a post- translational quality control for protein synthesis

Catherine Ross-Inta, Chern-Yi Tsai, Cecilia Giulivi

Biosci Rep (2008) 28 (5): 239–249.

DOI: https://doi.org/10.1042/BSR20080090

Published: 11 September 2008

...Catherine Ross-Inta; Chern-Yi Tsai; Cecilia Giulivi Mitochondria can synthesize a limited number of proteins encoded by mtDNA (mitochondrial DNA) by using their own biosynthetic machinery, whereas most of the proteins in mitochondria are imported from the cytosol. It could be hypothesized...

View article titled, The mitochondrial pool of free amino acids reflects the composition of mitochondrial DNA-encoded proteins: indication of a post- translational quality control for protein synthesis

Includes: Supplementary data

Articles

Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential

Nadeene Parker, Antonio Vidal-Puig, Martin D. Brand

Biosci Rep (2008) 28 (2): 83–88.

DOI: https://doi.org/10.1042/BSR20080002

Published: 29 April 2008

... of proton leak by HNE in rat and mouse skeletal muscle mitochondria is dependent on incubation with respiratory substrate. In the presence of HNE, mitochondria energized with succinate became progressively more leaky to protons over time compared with mitochondria in the absence of either HNE or succinate...

View article titled, Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential

Articles

Mitochondria and Neurodegeneration

Lucia Petrozzi, Giulia Ricci, Noemi J. Giglioli, Gabriele Siciliano, Michelangelo Mancuso

Biosci Rep (2007) 27 (1-3): 87–104.

DOI: https://doi.org/10.1007/s10540-007-9038-z

Published: 13 June 2007

...Lucia Petrozzi; Giulia Ricci; Noemi J. Giglioli; Gabriele Siciliano; Michelangelo Mancuso Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities...

View article titled, Mitochondria and Neurodegeneration

Articles

Evaluating Mitochondrial Membrane Potential in Cells

Giancarlo Solaini, Gianluca Sgarbi, Giorgio Lenaz, Alessandra Baracca

Biosci Rep (2007) 27 (1-3): 11–21.

DOI: https://doi.org/10.1007/s10540-007-9033-4

Published: 13 June 2007

... of practical tips that should precede data acquisition and subsequent analysis. Furthermore, we discuss the application and feasibility of various techniques and discuss their respective strength and weakness. Membrane potential Mitochondria Cells Fluorescent probes © 2007 The Biochemical Society...

View article titled, Evaluating Mitochondrial Membrane Potential in Cells

Articles

The Role of Mitochondria in Stem Cell Biology

Claudia Nesti, Livia Pasquali, Francesca Vaglini, Gabriele Siciliano, Luigi Murri

Biosci Rep (2007) 27 (1-3): 165–171.

DOI: https://doi.org/10.1007/s10540-007-9044-1

Published: 13 June 2007

... disorders are also reported. © 2007 The Biochemical Society 2007 Mitochondria Stem cells Differentiation Mitochondrial localization ROS MNGIE MINI REVIEW The Role of Mitochondria in Stem Cell Biology Claudia Nesti Æ Livia Pasquali Æ Francesca Vaglini Æ Gabriele Siciliano Æ Luigi Murri...

View article titled, The Role of Mitochondria in Stem Cell Biology

Articles

Experimental Strategies Towards Treating Mitochondrial DNA Disorders

Julie L. Gardner, Lyndsey Craven, Douglass M. Turnbull, Robert W. Taylor

Biosci Rep (2007) 27 (1-3): 139–150.

DOI: https://doi.org/10.1007/s10540-007-9042-3

Published: 13 June 2007

... of exercise training for patients with mtDNA defects, and the prevention of mtDNA disease transmission. © 2007 The Biochemical Society 2007 Mitochondria mtDNA Mutation Heteroplasmy Treatment Exercise Satellite cell ORI GI N A L P A PE R Experimental Strategies Towards Treating Mitochondrial...

View article titled, Experimental Strategies Towards Treating Mitochondrial DNA Disorders

Articles

Genes and the Environment in Neurodegeneration

Fabio Coppedè, Michelangelo Mancuso, Gabriele Siciliano, Lucia Migliore, Luigi Murri

Biosci Rep (2006) 26 (5): 341–367.

DOI: https://doi.org/10.1007/s10540-006-9028-6

Published: 09 November 2006

... 2006 Alzheimer's disease Parkinson's disease Amyotrophic lateral Sclerosis Huntington's disease Prion diseases Neurodegeneration Genetics Mitochondria Environmental factors Abstract Neurodegenerative diseases are a heterogeneous group of pathologies which includes complex multifactorial...

View article titled, Genes and the Environment in Neurodegeneration

Articles

Targeting Dinitrophenol to Mitochondria: Limitations to the Development of a Self-limiting Mitochondrial Protonophore

Frances H. Blaikie, Stephanie E. Brown, Linda M. Samuelsson, Martin D. Brand, Robin A. J. Smith, Michael P. Murphy

Biosci Rep (2006) 26 (3): 231–243.

DOI: https://doi.org/10.1007/s10540-006-9018-8

Published: 18 August 2006

... methanesulfonate (MitoDNP). TPP cations accumulate within mitochondria driven by the membrane potential (Δ ψ ), the predominant component of Δ p . Our hypothesis was that MitoDNP would accumulate in mitochondria at high Δ ψ where it would act as a protonophore, but that at lower Δ ψ the accumulation and uncoupling...

View article titled, Targeting Dinitrophenol to Mitochondria: Limitations to the Development of a Self-limiting Mitochondrial Protonophore

Articles

Genomic Structure and Regulation of Mitochondrial Uncoupling Protein Genes in Mammals and Plants

Fábio T. S. Nogueira, Jiri Borecký, Aníbal E. Vercesi, Paulo Arruda

Biosci Rep (2005) 25 (3-4): 209–226.

DOI: https://doi.org/10.1007/s10540-005-2886-5

Published: 08 June 2005

...Fábio T. S. Nogueira; Jiri Borecký; Aníbal E. Vercesi; Paulo Arruda Uncoupling mitochondrial proteins (UCPs) belong to a discrete family within the mitochondrial anion carrier superfamily. Several uncoupling protein types have been found in mitochondria from mammals and plants, as well as in fishes...

View article titled, Genomic Structure and Regulation of Mitochondrial Uncoupling Protein Genes in Mammals and Plants

Articles

Plant Uncoupling Mitochondrial Protein and Alternative Oxidase: Energy Metabolism and Stress

Jiří Borecký, Aníbal E. Vercesi

Biosci Rep (2005) 25 (3-4): 271–286.

DOI: https://doi.org/10.1007/s10540-005-2889-2

Published: 08 June 2005

...Jiří Borecký; Aníbal E. Vercesi Energy-dissipation in plant mitochondria can be mediated by inner membrane proteins via two processes: redox potential-dissipation or proton electrochemical potential-dissipation. Alternative oxidases (AOx) and the plant uncoupling mitochondrial proteins (PUMP...

View article titled, Plant Uncoupling Mitochondrial Protein and Alternative Oxidase: Energy Metabolism and Stress

Articles

Bioenergetics of Yarrowia lipolytica Cells Grown at Alkaline Conditions

Renata A. Zvyagilskaya, Olga A. Parkhomenko, Anna V. Gordeeva, Yuliya I. Deryabina, Bengt L. Persson

Biosci Rep (2004) 24 (2): 117–125.

DOI: https://doi.org/10.1007/s10540-004-7192-0

Published: 01 April 2004

... respiratory activity. The oxidative phosphorylation system dominated in the energy budget of the cell. A procedure was specially design to isolate tightly coupled mitochondria from yeast cells grown at alkaline conditions. The isolated mitochondrial preparations met known criteria of physiological intactness...

View article titled, Bioenergetics of Yarrowia lipolytica Cells Grown at Alkaline Conditions

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Participation of Chloroplasts in Plant Apoptosis

Vitaly D. Samuilov, Elena M. Lagunova, Dmitry B. Kiselevsky, Elena V. Dzyubinskaya, Yana V. Makarova, Mikhail V. Gusev

Biosci Rep (2003) 23 (2-3): 103–117.

DOI: https://doi.org/10.1023/A:1025576307912

Published: 01 April 2003

...Vitaly D. Samuilov; Elena M. Lagunova; Dmitry B. Kiselevsky; Elena V. Dzyubinskaya; Yana V. Makarova; Mikhail V. Gusev Mitochondria are known to participate in the initiation of programmed cell death (PCD) in animals and in plants. The role of chloroplasts in PCD is still unknown. We describe a new...

View article titled, Participation of Chloroplasts in Plant Apoptosis

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Complex I and the cAMP Cascade in Human Physiopathology

S. Papa, S. Scacco, A.M. Sardanelli, V. Petruzzella, R. Vergari, A. Signorile, Z. Technikova-Dobrova

Biosci Rep (2002) 22 (1): 3–16.

DOI: https://doi.org/10.1023/A:1016004921277

Published: 01 February 2002

...S. Papa; S. Scacco; A.M. Sardanelli; V. Petruzzella; R. Vergari; A. Signorile; Z. Technikova-Dobrova A cAMP-dependent protein kinase (PKA) is localized in mammalian mitochondria with the catalytic site at the matrix side of the membrane where it phosphorylates a number of proteins. One...

View article titled, Complex I and the cAMP Cascade in Human Physiopathology

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Mitochondrial Dysfunction in Sepsis: Evidence from Bacteraemic Baboons and Endotoxaemic Rabbits

Frank Norbert Gellerich, Sonata Trumbeckaite, Jens Rüdiger Opalka, Johannes Frank Gellerich, Ying Chen, Stephan Zierz, Karl Werdan, Christiane Neuhof, Heinz Redl

Biosci Rep (2002) 22 (1): 99–113.

DOI: https://doi.org/10.1023/A:1016017224003

Published: 01 February 2002

...Frank Norbert Gellerich; Sonata Trumbeckaite; Jens Rüdiger Opalka; Johannes Frank Gellerich; Ying Chen; Stephan Zierz; Karl Werdan; Christiane Neuhof; Heinz Redl Mitochondria, that provide most of the ATP needed for cell work, and that play numerous specific functions in biosyntheses...

View article titled, Mitochondrial Dysfunction in Sepsis: Evidence from Bacteraemic Baboons and Endotoxaemic Rabbits

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Reconstitution of Novel Mitochondrial Uncoupling Proteins UCP2 and UCP3

Markéta Žáčkova, Petr Ježek

Biosci Rep (2002) 22 (1): 33–46.

DOI: https://doi.org/10.1023/A:1016009022186

Published: 01 February 2002

... Fatty acid mitochondria UCP2 & 3 uncoupling protein Bioscience Reports, Vol. 22, No. 1, February 2002 ( 2002) MINI REVIEW Reconstitution of Novel Mitochondrial Uncoupling Proteins UCP2 and UCP3 Marke´ta Z a´c kova1 and Petr Jez ek2,3 Receiûed September 13, 2001 Reconstitution of novel...

View article titled, Reconstitution of Novel Mitochondrial Uncoupling Proteins UCP2 and UCP3

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Bcl-2 Family of Proteins: Life-or-Death Switch in Mitochondria

Yoshihide Tsujimoto

Biosci Rep (2002) 22 (1): 47–58.

DOI: https://doi.org/10.1023/A:1016061006256

Published: 01 February 2002

... of cell survival and cell death signals. © 2002 Plenum Publishing Corporation 2002 Apoptosis Bcl-2 mitochondria permeability VDAC Bioscience Reports, Vol. 22, No. 1, February 2002 ( 2002) MINI REVIEW Bcl-2 Family of Proteins: Life-or-Death Switch in Mitochondria Yoshihide Tsujimoto...

View article titled, Bcl-2 Family of Proteins: Life-or-Death Switch in Mitochondria

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Barbara Cannon's Data on the UCP1-Ablated Mice: “Non-Cannonical” Point of View

Vladimir P. Skulachev

Biosci Rep (2001) 21 (2): 189–194.

DOI: https://doi.org/10.1023/A:1013600325266

Published: 01 April 2001

... mitochondria, which results in hypothermia. © 2001 Plenum Publishing Corporation 2001 Uncoupling proteins thermoregulation fatty acids mitochondria skeletal muscle brown fat Bioscience Reports, Vol. 21, No. 2, April 2001 ( 2001) MINI REVIEW Barbara Cannon s Data on the UCP1-Ablated Mice: Non...

View article titled, Barbara Cannon's Data on the UCP1-Ablated Mice: “Non-Cannonical” Point of View

Articles

Mitochondrial Uncoupling Proteins in Mammals and Plants

Jirí Borecký, Ivan G. Maia, Paulo Arruda

Biosci Rep (2001) 21 (2): 201–212.

DOI: https://doi.org/10.1023/A:1013604526175

Published: 01 April 2001

...Jirí Borecký; Ivan G. Maia; Paulo Arruda Uncoupling proteins (UCPs) belong to a distinct cluster of the mitochondrial anion carrier family. Up to five different uncoupling protein types were found in mitochondria of mammals and plants, and recently in fishes, fungi and protozoa. They exhibit...

View article titled, Mitochondrial Uncoupling Proteins in Mammals and Plants

Articles

Alternative Oxidase and Uncoupling Protein: Thermogenesis Versus Cell Energy Balance

Wieslawa Jarmuszkiewicz, Claudine M. Sluse-Goffart, Anibal E. Vercesi, Francis E. Sluse

Biosci Rep (2001) 21 (2): 213–222.

DOI: https://doi.org/10.1023/A:1013656510245

Published: 01 April 2001

... that thermogenesis is restricted not only by a lower-limit size but also by a kinetically-limited stimulation of the mitochondrial respiratory chain. © 2001 Plenum Publishing Corporation 2001 Alternative oxidase uncoupling protein mitochondria Bioscience Reports, Vol. 21, No. 2, April 2001 ( 2001) MINI...

View article titled, Alternative Oxidase and Uncoupling Protein: Thermogenesis Versus Cell Energy Balance

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