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Keywords: microRNA
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Biosci Rep (2023) 43 (9): BSR20230014.
Published: 05 September 2023
...Xinyu Wang; Tingting Zhang; Jianlong Zhai; Zhongli Wang; Yan Wang; Lili He; Sai Ma; Hanying Xing; Yifang Guo MicroRNA-21 (miR‐21) plays an anti-apoptotic role following ischemia–reperfusion (I/R) injury (IRI) in vivo ; however, its underlying mechanism remains unclear. The present study explored...
Includes: Supplementary data
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Biosci Rep (2022) 42 (7): BSR20212355.
Published: 15 July 2022
...). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis endothelial cells microRNA non-coding RNA vascular smooth muscle Cardiovascular...
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Biosci Rep (2022) 42 (1): BSR20211972.
Published: 11 January 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . meta analysis microRNA miR-21 prognostic prostate cancer systematic Prostate cancer (PCa) is the most commonly diagnosed cancer for males in 105 countries including North and South America...
Includes: Supplementary data
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Biosci Rep (2021) 41 (12): BSR20211420.
Published: 08 December 2021
... of the present study was to apply bioinformatics analysis to explore tumor-educated platelet (TEP) microRNA (miRNA) expression and its potential diagnostic utility in HCC. Methods: Twenty-five HCC patients and 25 healthy controls were included. RNA sequencing was utilized to screen miRNA alterations in platelets...
Includes: Supplementary data
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Biosci Rep (2021) 41 (10): BSR20211123.
Published: 19 October 2021
...Ying Jing; Donghai Li MicroRNAs (miRNAs) play important roles in a variety of human diseases, including breast cancer. A number of miRNAs are up- and down-regulated in breast cancer. However, little is known about miRNA similarity and similarity network in breast cancer. Here, a collection of 272...
Includes: Supplementary data
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Biosci Rep (2021) 41 (9): BSR20211325.
Published: 17 September 2021
... study, we sequenced the whole miRNome in leukocytes and plasma of the family members and results were validated using real-time PCR. Our results highlighted the role of miR-409-3p, miR-424-5p, miR-144-3p as microRNAs that show correlation with the extent of severity of muscular weakness and can be used...
Includes: Supplementary data
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Biosci Rep (2021) 41 (8): BSR20210874.
Published: 12 August 2021
... endothelial growth factor (VEGF) pathway is essential in the placentation process and VEGF expression is regulated through post-transcriptional modification by microRNAs (miRNAs). We investigated the expression of VEGF-related circulating miR-16, miR-29b, miR-126, miR-155 and miR-200c in PE vs healthy...
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Biosci Rep (2021) 41 (7): BSR20210126.
Published: 01 July 2021
... the function of endothelial cells by dictating their microRNA (miRNA) expression remains largely unknown. Differentially expressed miRNAs (DEMs) were identified through dataset downloaded from the Gene Expression Omnibus (GEO) database and analyzed by GEO2R. We then used online tools to obtain potential...
Includes: Supplementary data
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Biosci Rep (2021) 41 (1): BSR20203559.
Published: 07 January 2021
...Mengqiu Xiong; Ping Wang; Bei Pan; Junjie Nie; Shukui Wang; Bangshun He MicroRNA-196a (miR-196a) was previously reported to be up-regulated in cancers, and it has the diagnostic and prognostic values in cancers. Whereas, the conclusion was still unclear according to the published data. To assess...
Includes: Supplementary data
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Biosci Rep (2020) 40 (11): BSR20201820.
Published: 17 November 2020
...Bo Ma; Hui Li; Jia Qiao; Tao Meng; Riyue Yu Background: Head and neck squamous cell carcinoma (HNSCC) is recognised as an immune active cancer, but little is known about the role of microRNAs (miRNAs) in it. In the present study, we aim to determine a prognostic and immune-related miRNAs signature...
Includes: Supplementary data
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Biosci Rep (2020) 40 (9): BSR20201885.
Published: 21 September 2020
... be a biomarker suboptimal to assess inflammation status. Although it has been reported that statins modulated inflammation via microRNAs (miRNAs), evidence remains lacking on comprehensive profiling of statin-induced miRNAome alterations in immune cells. We recruited 19 hypercholesterolemic patients receiving 2...
Includes: Supplementary data
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Biosci Rep (2020) 40 (9): BSR20193974.
Published: 18 September 2020
...Peng Lv; Zhenzhu Zhang; Li Hou; Yayue Zhang; Lingeng Lu; Chong Wang; Fengqin Shi Low expression of tumor suppressor microRNA (miRNA) and high expression of carcinogenic miRNA promote the occurrence and progression of human cancer. Most studies show that miR-145 is a tumor suppressor miRNA...
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Biosci Rep (2020) 40 (5): BSR20191028.
Published: 07 May 2020
...Daniel Lee; Wei Tang; Tiffany H. Dorsey; Stefan Ambs BACKGROUND: microRNAs (miRs) regulate the expression of protein-coding genes and play key roles in various biological processes, including development and immunity. However, dysregulation of miR expression is also involved in disease biology...
Includes: Supplementary data
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Biosci Rep (2020) 40 (4): BSR20182458.
Published: 21 April 2020
...Tingting Jia; Yipeng Ren; Fengze Wang; Rui Zhao; Bo Qiao; Lejun Xing; Long Ou; Bin Guo Objective: The current study aimed to investigate the functional roles and clinical significance of microRNA-148a ( miR-148a ) in the progression of oral squamous cell carcinoma (OSCC). Methods: Relative...
Includes: Supplementary data
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Biosci Rep (2020) 40 (1): BSR20190303.
Published: 17 January 2020
...Ying Xin; Xueqiang Wang; Kexin Meng; Chao Ni; Zhenye Lv; Dandan Guan Accumulated evidence has demonstrated exosomes of cancer cells carry microRNAs (miRNAs) to non-malignant cells to induce metastasis. The present study aimed to identify crucial exosomal miRNAs for breast cancer (BC) using...
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Biosci Rep (2019) 39 (12): BSR20193094.
Published: 13 December 2019
...) and 40 μg/ml gentamycin (PanEco) in the atmosphere containing 5% CO 2 at 37°C. cell cycle microRNA SCP/CTDSP phosphatases tumor suppressors Lung cancer is the most commonly diagnosed cancer in the world, with high mortality [ 1 ]. Alterations in many cellular processes and signaling...
Includes: Supplementary data
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Biosci Rep (2019) 39 (12): BSR20181404.
Published: 13 December 2019
... of microRNAs (miRNAs) play an important role in developing the disease which can be considered as early stage biomarkers. Since, selective, sensitive, simple and rapid method for detection of these miRNAs in a single test is critical for early diagnosis and efficient therapy of the disease, herein, we report...
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Biosci Rep (2019) 39 (11): BSR20170080.
Published: 15 November 2019
... Republic of China). After treatments, mice were killed and tumours were isolated for the downstream analysis. Immunohistochemistry was performed as described previously [ 16 ]. The HIF-1α antibody was diluted as 1:200 for immunohistochemical staining. cisplatin sensitivity HIF-1α microRNA...
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Biosci Rep (2019) 39 (7): BSR20190955.
Published: 23 July 2019
.... , Ma L. and Wang Q. ( 2017 ) MicroRNA-802 plays a tumour suppressive role in tongue squamous cell carcinoma through directly targeting MAP2K4 . Cell Prolif. 50 , e12336 , Epub 2017/03/21 10.1111/cpr.12336 8. Chen H. and Dai J. ( 2018 ) miR-409-3p suppresses...
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Biosci Rep (2019) 39 (7): BSR20190280.
Published: 19 July 2019
...-coding RNA microRNA Idiopathic pulmonary fibrosis (IPF), the most common idiopathic interstitial pneumonia, is characterized by cell proliferation, interstitial inflammation, fibrosis, or a combination of these symptoms not caused by infection or cancer [ 1 ]. Due to the high mortality rate...
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Biosci Rep (2019) 39 (7): BSR20190298.
Published: 19 July 2019
...Yingqi Xiao; Hui Liu; Li Chen; Yang Wang; Xiang Yao; Xiaolian Jiang Objective: To investigate whether microRNAs genes’ polymorphisms are associated with arthritis. Methods: The PubMed, Cochrane Library et al. were systematically searched to identify case–control studies, systematic reviews and meta...
Includes: Supplementary data
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Biosci Rep (2019) 39 (7): BSR20190996.
Published: 05 July 2019
.... and Wang X. ( 2015 ) miRDB: an online resource for microRNA target prediction and functional annotations . Nucleic Acids Res. 43 , D146 – D152 10.1093/nar/gku1104 25378301 16. Fromm B. , Billipp T. , Peck L.E. et al . ( 2015 ) A uniform system for the annotation...
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Biosci Rep (2019) 39 (7): BSR20180695.
Published: 02 July 2019
...Siwen Tang; Hongyu Fu; Qihua Xu; Ying Zhou Colorectal cancer (CRC) is one of the leading cancer-related causes of deaths in the world. Recently, microRNAs have been reported to regulate the tumor growth, invasion and the immunosuppression. In the present study, we found that miR-20a was increased...
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Biosci Rep (2019) 39 (1): BSR20180395.
Published: 03 January 2019
... to wash away the shed cells. An optical microscope was used for the observation and imaging of cells at 0 and 48 h of incubation in the culture medium. The experiment was repeated three times to obtain mean values. glioma Invasion Long noncoding RNA microRNA Migration Proliferation...
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Biosci Rep (2018) 38 (6): BSR20181386.
Published: 14 December 2018
... cancer large intervening non-coding RNA microRNA tumorigenesis Colorectal cancer (CRC) is the most common digestive system malignancy worldwide and caused by various factors such as environmental, genetic, and epigenetic ones [ 1 ]. Although surgery, chemotherapy, radiotherapy, targeted...
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Biosci Rep (2018) 38 (6): BSR20180961.
Published: 07 December 2018
... the Creative Commons Attribution License 4.0 (CC BY) . cytomegalovirus immediate early protein 2 microRNA tissues Human cytomegalovirus (HCMV) replication can cause serious harm in solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) recipients [ 1–3...
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Biosci Rep (2018) 38 (6): BSR20180646.
Published: 21 November 2018
..., the purpose of the present study was to explore the levels of miR-1297 over various time points in post-aSAH patients and determine the optimal prognostic thresholds of the indicator in aSAH. MicroRNAs (miRNAs) are an abundant class of highly conserved non-coding RNA molecules, consisting approximately 22...
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Biosci Rep (2018) 38 (6): BSR20181578.
Published: 14 November 2018
... in detail the proximal tubule megalin expression in IgAN. cell transfection IgA nephropathy megalin microRNA renal proximal tubule Significant increases in miR-21, miR-146a, and miR-192 have been reported in kidney tissue from patients with IgAN [ 16 , 18 , 19 ]. These three miRNAs...
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Biosci Rep (2018) 38 (5): BSR20180516.
Published: 23 October 2018
... and inhibited Beclin1, which further inhibited chemotherapy-induced autophagy and enhanced the chemosensitivity of colon cancer cells. autophagy large intervening non-coding RNA microRNA oncogenesis gene therapy Autophagy is a process of sustaining metabolism and homeostasis by capturing...
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Biosci Rep (2018) 38 (5): BSR20180915.
Published: 10 October 2018
... resistance hepatocellular carcinoma HCC long non-coding RNA microRNA Hepatocellular carcinoma (HCC) is one of the most frequently diagnosed cancers and the second leading cause of cancer-related deaths amongst males worldwide, which is largely caused by chronic hepatitis B virus (HBV) infection...
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Biosci Rep (2018) 38 (4): BSR20180448.
Published: 03 July 2018
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bone remodeling compression fluid shear stress mechanical cyclical stretch microgravity microRNA Bone remodeling, which involves a cross-talk between osteoclasts and osteoblasts, is regulated...
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Biosci Rep (2018) 38 (3): BSR20180453.
Published: 21 June 2018
... be the underlying mechanisms that link genetic and environmental factors with increased risks of osteoporosis and bone fracture. MicroRNA (miRNA), a major category of small noncoding RNA with 20–22 bases in length, is recognized as one important epigenetic modification. It can mediate post-transcriptional...
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Biosci Rep (2018) 38 (3): BSR20180668.
Published: 21 June 2018
... histological grade, and poor prognosis. Down-regulation of MCM5 inhibited cervical adenocarcinoma cell proliferation. The purpose of the present study is to search and confirm valuable microRNAs (miRNAs), which target MCM5 to modulate cervical adenocarcinoma cell proliferation. In our results, we found...
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Biosci Rep (2018) 38 (2): BSR20171208.
Published: 21 March 2018
... in vascular endothelial injury. It is an important factor in the development of diabetes mellitus (DM). The aim of the present study was to screen out the potential candidate microRNAs (miRNAs) in DM patients with BSS by high-throughput sequencing (HTS) and bioinformatics analysis. Human umbilical vein...
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Biosci Rep (2018) 38 (1): BSR20171265.
Published: 08 February 2018
...(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarkers cancer metastases microRNA miR-29a proliferation Initially, Gebeshuber et...
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Biosci Rep (2017) 37 (6): BSR20171157.
Published: 29 November 2017
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . diabetic retinopathy dysregulation long noncoding RNA molecular mechanisms microRNA Diabetes mellitus (DM...
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Biosci Rep (2017) 37 (5): BSR20171111.
Published: 31 October 2017
... lead exposure diagnosis microRNA The complete information on the final 1130 participants is shown in Table 1 , including gender, age, marital status, educational background, smoking and alcohol consumption, eating and drinking behavior at work, and BLL. The majority of these workers were...
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Biosci Rep (2017) 37 (5): BSR20170768.
Published: 11 October 2017
.... microRNA miRNA sequence analysis osteoclasts peri-implantitis Over the past decade, implant therapy has been widely accepted and chosen as a routine procedure for the reconstruction of fully or partially edentulous individuals. However, peri-implantitis has been shown to affect long-term success...
Includes: Supplementary data
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Biosci Rep (2017) 37 (4): BSR20170149.
Published: 31 August 2017
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . B lymphocyte IL-10 microRNA Figure 1 Evaluation of peripheral TSP1 expression B cells ( A , B ) The gated dot plots show representatives of peripheral TSP1 + B cells in PBMCs of healthy subjects ( n =20) and asthma...
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Biosci Rep (2016) 36 (3): e00351.
Published: 30 June 2016
... was re-calculated using each of these as a covariate in a linear regression model according the formula: miRNA ∼ group + covariate. The linear regression model was used as implemented in the lm function in R version 3.2.3. coronary artery disease diagnosis biomarker microRNA Troponin...
Includes: Supplementary data
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Biosci Rep (2015) 35 (5): e00245.
Published: 10 September 2015
... and distributed under the Creative Commons Attribution License 3.0. cell proliferation differentiation microRNA neural stem cells 9 4 2015 16 6 2015 22 6 2015 21 7 2015 In the present study, miR-146 promoted spontaneous differentiation of neural stem cells (NSCs...