... of seizures, which substantially results in neurodevelopmental impairments with long-lasting outcomes and is one of the main causes of death in neonates. We aimed to investigate the correlation between miRNA-210 and SCN1B, a voltage-gated sodium channel gene, in brain tissue of fetal rats with hypoxic...

... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . AKT3 breast cancer metastasis miRNA NF-κB This article is being...

... to be fully elucidated. In the present study, we established a HPH rat model with 8 h of hypoxia exposure (10% O 2 ) per day for 21 days. High-throughput sequencing identified 60 differentially expressed (DE) lncRNAs, 20 DE miRNAs and 695 DE mRNAs in rat lung tissue. qRT-PCR verified the accuracy...

... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell invasion cell migration EMT miRNA TBXT Although much progress has been made in cancer research, breast cancer remains a major public health concern, as it is the most diagnosed cancer in women...

... the needs of clinical practice because of DLBCL heterogeneity, a problem that might be improved by selection of miRNAs as biomarkers. Methods: Twelve patients with DLBCLs were used to screen out the aberrant miRNA profile using miRNA microarray technology in two patient subtypes (six germinal center B-like...

... survival analysis and constructed transcription factor (TF)-miRNA-hub mrDEGs network. Results: A total of 23 up-regulated and 71 down-regulated mrDEGs were identified and validated in BC cell lines and tissues. Enrichment analyses indicated that mrDEGs were associated with several cancer-related biological...

... independent confirmation cohorts. Differential expression analysis, Pearson’s correlation analysis, construction of miRNA–target gene network, and function enrichment analysis were performed. Two risk groups with significant survival differences were identified in TCGA set using the autoencoder-based model...

...YunZhong Shi; DongMei Xi; XiaoNi Zhang; Zhen Huang; Na Tang; YongMin Liu; LaMei Wang; Yan Tang; Hua Zhong; Fang He Introduction: Multiple studies have suggested an association between cytomegalovirus (CMV) infection and essential hypertension (EH). MicroRNAs (miRNAs) play a critical role...

.... In the present study, we aimed to establish and validate a miRNA signature to predict TMB level in endometrial cancer using The Cancer Genome Atlas (TCGA) database. MiRNA expression and somatic mutation profiles of uterine corpus endometrial carcinoma (UCEC) were downloaded from TCGA database. Total 518 patients...

... signaling are mediated in association with other signaling pathways involving microRNAs (miRNAs), PI3K/AKT/PTEN/GSK-3β, retinoic acid receptors (RARs), dickkopf-1 (DKK1), protein kinase A regulatory subunit 1 α (PRKAR1A/PKAI), (SLAP), liver kinase B1 (LKB1) and CXCR4. The selective inhibitors of Wnt/β...

..., which is detrimental to the in-depth study of this disease. In the present study, ICM susceptibility biomarkers were identified using a proposed strategy based on RNA-Seq and miRNA-Seq data of ICM and normal samples. Significantly differentially expressed competing endogenous RNA (ceRNA) triplets were...

... © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Argonaute miRNA recurrent implantation failure RISC Human reproduction...

...Liwei Ruan; Xiaojun Qian Background: Breast cancer endangers the life of women and has become the major cause of deaths among them. MiRNAs are found to exert a regulatory effect on the migration, proliferation and apoptosis of breast cancer cells. This research aims at investigating the miR-16-5p...

...Junxia Gu; Xiaozhen Li; Hui Li; Zhe Jin; Jianjun Jin MicroRNAs (miRNAs) are increasingly recognized as important therapeutic targets in cancer. Here we aim to investigate the role of miR-198, a broad-spectrum tumor suppressor, in gastric cancer (GC). MiR-198 overexpression was achieved...

..., and decreased PTPN1 level. The effect was obviously post pristimerin treatment and miR-542-5p suppression. In conclusion, pristimerin inhibited glioma progression through AGO2 and PTPN1 expression via a canonical miRNA-mediated mechanism. Correspondence: Xianglin Chen ( xianglinchen007@163.com...

... License 4.0 (CC BY) . α-pinene anti-hepatoma carcinoma apoptosis in vitro miR-221 miRNA The incidence of hepatocellular carcinoma (HCC), a highly malignant cancer, is increasing dramatically with annual new cases estimated at 600,000 worldwide [ 1 , 2 ]. Relatively, few cases can...

... BY) . Colorectal carcinoma Chemoresistance LncRNA MiRNA Colorectal cancer (CRC) is the third most common human cancer and the fourth most common cause of cancer deaths in global and its incidence has increased in recent years [ 1 ]. Although encouraging advances in diagnosis and cancer therapy...

...Ben-Gang Wang; Li-Yue Jiang; Qian Xu MiRNA polymorphisms had potential to be biomarkers for hepatocellular cancer (HCC) susceptibility. Recently, miRNA single nucleotide polymorphisms (SNPs) were reported to be associated with HCC risk, but the results were inconsistent. We performed a systematic...

...Jing Wen; Zhi Lv; Hanxi Ding; Xinxin Fang; Mingjun Sun Single nucleotide polymorphisms (SNPs) in miRNA biosynthesis genes DROSHA and DGCR8 were indicated to be correlated with cancer risk. We comprehensively reviewed and analyzed the effect of DROSHA and DGCR8 polymorphisms on cancer risk. Eligible...

...Li Sun; Sen Wu; Chao-Hui Dai; Shou-Yong Sun; Guo-Qiang Zhu; Sheng-Long Wu; Wen-Bin Bao MicroRNAs (miRNAs) have important roles in many cellular processes, including cell proliferation, growth and development, and disease control. Previous study demonstrated that the expression of two highly...

... are a pressing need for this disease. miRNAs profiling is an innovative method of identifying biomarkers for many diseases and could be proven as a powerful tool in the diagnosis and treatment of CAD. We performed miRNA microarray analysis from the plasma of three CAD patients and three healthy controls...

... homoeostasis and lead to a healthy phenotype. Two classes of ncRNA (non-coding RNA), miRNA and lncRNA (long non-coding RNA), play crucial roles in gene regulation during tissue development and remodelling. In the present review, we summarize recent findings on regulatory role of distinct ncRNAs in brown/beige...