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Keywords: methylation
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Biosci Rep (2024) 44 (3): BSR20232063.
Published: 21 March 2024
...Catherine Mezzacappa; Zhanwei Wang; Lingeng Lu; Harvey Risch; Tamar Taddei; Herbert Yu Background: Alterations to DNA methylation have been identified in both hepatocellular carcinoma (HCC) tumor and circulating DNA from affected individuals. These markers have potential utility in HCC screening...
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Biosci Rep (2022) 42 (12): BSR20220998.
Published: 06 December 2022
... differential gene expression in normal and disease phenotypes. DNA methylation is a significant epigenetic process, guided by DNMT1, one of the most important maintenance methylating agents. However, the relationship between DNMT1 and NTDs had always been inconclusive and poorly understood. In the present...
Includes: Supplementary data
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Biosci Rep (2022) 42 (10): BSR20212624.
Published: 28 October 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EMT glioma immune checkpoint immune infiltration methylation RAB34 Glioma is the most frequent primary brain tumor, exhibiting high morbidity, a low rate of healing, and a high relapse rate [ 1...
Includes: Supplementary data
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Biosci Rep (2021) 41 (12): BSR20211719.
Published: 17 December 2021
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . endometrial carcinoma MCM methylation multiomics mutation Endometrial carcinoma (EC) is one of the most lethal malignant tumors of the female reproductive system worldwide [ 1–3 ]. According to the pathophysiological...
Includes: Supplementary data
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Biosci Rep (2021) 41 (5): BSR-20160523_RET.
Published: 14 May 2021
... duplicated within the Bioscience Reports article, in Figures 2F and 4B. This Retraction follows an Expression of Concern relating to this article previously published by Portland Press. autophagy CRISPR/Caspase-9 glioma methylation TET1 © 2021 The Author(s). 2021 This is an open access...
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Biosci Rep (2020) 40 (12): BSR20201482.
Published: 21 December 2020
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . deep learning methylation miRNA multi-omics data Colorectal cancer (CRC) is the fourth most prevalent cancer and the second primary cause of cancer...
Includes: Supplementary data
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Biosci Rep (2020) 40 (11): BSR20202571.
Published: 17 November 2020
... range of ageing-related pathologies. An electrochemical approach, which adopted three analytical techniques, was used to investigate DNA methylation in the engrailed-1 ( EN1 ) gene promoter. Using synthetic single-stranded DNA, one technique was able to detect DNA at concentrations as low as 10 nM...
Includes: Supplementary data
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Biosci Rep (2020) 40 (10): BSR20192593.
Published: 05 October 2020
...Limin Zhen; Gang Ning; Lina Wu; Yongyuan Zheng; Fangji Yang; Tongtong Chen; Wenxiong Xu; Ying Liu; Chan Xie; Liang Peng Objectives: To identify the prognostic value of aberrantly methylated differentially expressed genes (DEGs) in hepatocellular carcinoma (HCC) and to explore the underlying...
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Biosci Rep (2020) 40 (7): BSR20193468.
Published: 03 July 2020
... predicted via miRNet database, and methylation status of promoters of DEGs was determined through UALCAN database. Results: A total of 375 DEGs, including 105 and 270 up-regulated and down-regulated genes in LUAD, were commonly appeared in three datasets. These DEGs were significantly enriched...
Includes: Supplementary data
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Biosci Rep (2020) 40 (7): BSR-20160523_EOC.
Published: 02 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy CRISPR/Caspase-9 glioma methylation TET1 The Editorial...
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Biosci Rep (2020) 40 (2): BSR20191985.
Published: 28 February 2020
.... Further, though survival analysis, methylation analysis, pivot analysis, and enrichment analysis, some important molecules and related function or pathway were identified to elucidate potential mechanism in esophageal cancer. Results: A total of 7457 DEGs and 14 gene interaction modules were identified...
Includes: Supplementary data
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Biosci Rep (2020) 40 (1): BSR20191953.
Published: 31 January 2020
... was initially identified as a critical transcription factor in various normal tissues, which interacted with serum response factor (SRF) or other substance to regulate normal physiological function. However, HOPX is at a low expression or methylation level in tumors. These data indicated that HOPX may play...
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Biosci Rep (2018) 38 (5): BSR20180731.
Published: 23 October 2018
...: changes in the broad range, overlaps with that of blood, and negatively correlates with the increasing tumor grade. Because the amount of m 5 C in tumor tissue and blood is almost identical, the genomic DNA methylation can be a useful marker for brain metastases detection and differentiation. Our research...
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Biosci Rep (2018) 38 (5): BSR20180482.
Published: 14 September 2018
... content by HPLC, and methylation levels using BSP+Miseq sequencing in ‘Huangjinlun’ variety during different developmental stages including flower-bud stage (S1), initiating bloom (S2), bloom stage (S3), and withering stage (S4). Results showed that the expression level of CHI gene at S2 stage...
Includes: Supplementary data
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Biosci Rep (2017) 37 (6): BSR20160523.
Published: 06 November 2017
...Rui Fu; Yan Ding; Jie Luo; Li Yu; Cheng Lin Li; Dong Sheng Li; Shi Wen Guo DNA methylation and demethylation play a critical role in the regulation of the molecular pathogenesis of gliomas. Tet methylcytosine dioxygenase 1 (TET1) catalyses the sequential oxidation of 5-methylcytosine (5mC) to 5...
Includes: Supplementary data
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Biosci Rep (2016) 36 (4): e00362.
Published: 05 August 2016
...Hao Zhang; Aimei Li; Wei Zhang; Zhijun Huang; Jianwen Wang; Bin Yi Connective tissue growth factor (CTGF) plays an essential role in the pathogenesis of diabetic nephropathy and we have previously identified that high glucose induced the expression of CTGF by decreasing DNA methylation. The aim...
Includes: Supplementary data
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Biosci Rep (1987) 7 (8): 637–643.
Published: 01 August 1987
...Yasahiro Deguchi; Shigeru Negoro; Susumu Kishimoto The degree of methylation at the c-myc proto-oncogene was found to change in human lymphoproliferative diseases, when examined using a methylation-sensitive restriction enzyme. In peripheral blood mononuclear cells (PBMC) c-myc DNA showed...