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Keywords: metabolism
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Biosci Rep (2024) 44 (3): BSR20231682.
Published: 21 March 2024
... pathways or by reactive oxygen species (ROS). Adenosine A1 receptors (ADORA1) are known to be involved in ethanol metabolism; however, underlying mechanism is not well understood. For investigating how the intrinsic ADORA1 function in ethanol metabolism in normal human hepatocytes without interference...
Includes: Supplementary data
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Biosci Rep (2023) 43 (7): BSR20222496.
Published: 19 July 2023
... metabolic diseases and their production pathways are for instance candidate therapeutic targets for cancer treatments. The fatty acid de novo synthesis (FADNS) occurs in the cytoplasm, while the microsomal modification of fatty acids (MMFA) happens at the surface of the endoplasmic reticulum (ER...
Articles
Biosci Rep (2023) 43 (1): BSR20221699.
Published: 23 December 2022
... (T2DM) is a metabolic disorder marked by high fasting and post-prandial circulating blood glucose, increased insulin resistance, and a progressive loss of pancreatic β-cell insulin secretion. The risk for T2DM is increased by obesity such that the high-calorie, high-carbohydrate diets generally consumed...
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Biosci Rep (2022) 42 (4): BSR20211813.
Published: 12 April 2022
...Cameron A. Schmidt Mitochondria are central to the physiology and survival of nearly all eukaryotic cells and house diverse metabolic processes including oxidative phosphorylation, reactive oxygen species buffering, metabolite synthesis/exchange, and Ca 2+ sequestration. Mitochondria...
Includes: Supplementary data
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Articles
Biosci Rep (2022) 42 (2): BSR20211215.
Published: 04 February 2022
... the burden of TB tremendously and new therapeutics to overcome the problem of drug resistance are urgently needed. Metabolism of Mtb and its interactions with the host is important for its survival and virulence; this is an important topic of research where there is growing interest in developing new...
Articles
Biosci Rep (2020) 40 (4): BSR20194404.
Published: 17 April 2020
...Yi-Huan Chen; Yi-Ju Wu; Wei-Cheng Chen; Tzong-Shyuan Lee; Tsui-Chun Tsou; Hsuan-Chia Chang; Sheng-Wen Lo; Shen-Liang Chen Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer frequently leached out from polyvinyl chloride (PVC) products and is quickly metabolized to its monoester equivalent mono(2...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (4): BSR20193325.
Published: 03 April 2020
...Lauren A. Mills; Alistair J. McCormick; David J. Lea-Smith Cyanobacteria are key organisms in the global ecosystem, useful models for studying metabolic and physiological processes conserved in photosynthetic organisms, and potential renewable platforms for production of chemicals. Characterizing...
Includes: Supplementary data
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Articles
Biosci Rep (2019) 39 (1): BSR20181215.
Published: 08 January 2019
... in pentose phosphate pathway, glycolysis, and tricarboxylic acid cycle as well as mitochondrial adenosine triphosphate biosynthesis. These findings may offer important insight into the metabolic alterations in THS-treated gut injury, which will be helpful for developing effective metabolites-based strategies...
Articles
Biosci Rep (2018) 38 (3): BSR20180520.
Published: 21 June 2018
... phenotypes or building genome-scale metabolic models. In this case, the mutation concerned appears to map to an enzyme in one of the little-known but essential metabolite repair pathways that have been discovered in recent years. However, the bioinformatic and experimental evidence presented suggests...
Articles
Biosci Rep (2018) 38 (2): BSR20171234.
Published: 13 April 2018
...Liyuan Zhou; Xinhua Xiao Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs an increased risk of the offspring developing metabolic disorders in addition to the adverse effects on the mother per se . Large numbers of human and animal studies have demonstrated...
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Biosci Rep (2016) 36 (4): e00367.
Published: 16 August 2016
... as far as the origin of life, which they facilitated by removal of atmospheric dihydrogen, H 2 . Moreover, as electron acceptors, antireductants equipped the first metabolic pathways, enabling lithoautotrophic microbial growth. When the Earth's atmosphere became more oxidizing, certain antireductants...
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Biosci Rep (2015) 35 (3): e00200.
Published: 11 June 2015
... undernutrition. Results reveal the negative impact of suboptimal maternal nutrition on adult offspring cardiac energy metabolism, which may have life-long implications for cardiovascular function and disease risk. 1 To whom correspondence should be addressed (email mharper@uottawa.ca ). 5 1 2015...
Includes: Supplementary data
Articles
Biosci Rep (2014) 34 (5): e00141.
Published: 02 October 2014
...–Seip Congenital lipodystrophy type 2), resulting from mutations in the BSCL2/seipin gene, exhibits the most severe lipodystrophic phenotype with loss of both metabolic and mechanical adipose depots. The majority of Seipin mutations cause C-terminal truncations, along with a handful of point mutations...
Articles
Biosci Rep (2013) 33 (4): e00058.
Published: 23 August 2013
...Eduardo Nunes Chini; Claudia C. S. Chini; Veronica Nin; Carlos Escande DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging ‘hallmark’ of cancer, it is possible that DBC1 may...
Articles
Biosci Rep (1992) 12 (1): 69–76.
Published: 01 February 1992
... the poor secretory response of HIT-T15 cells to KIC 17 12 1991 15 1 1992 © 1992 Plenum Publishing Corporation 1992 pancreatic islets HIT-T15 cells 2-ketoisocaproate transport metabolism Bioscience Reports, Vol. 12, No. I, 1992 2-Ketoisocaproate Transport in Insulin- Secreting...