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Articles

N6-methyladenosine (m6A)-connected lncRNAs are linked to survival and immune infiltration in glioma patients

Wei Jun Wu, Feng Xiao, Yaping Xiong, Gu Feng Sun, Yun Guo, Xiang Zhou, Guo Wen Hu, Kai Huang, Hua Guo

Biosci Rep (2023) 43 (5): BSR20222100.

DOI: https://doi.org/10.1042/BSR20222100

Published: 05 May 2023

...Wei Jun Wu; Feng Xiao; Yaping Xiong; Gu Feng Sun; Yun Guo; Xiang Zhou; Guo Wen Hu; Kai Huang; Hua Guo Background: The connection between m6A-assiociateed lncRNAs and prognosis has been demonstrated in multiple types of tumors. However, potential roles of m6A-assiociateed lncRNAs in glioma is still...

View article titled, N6-methyladenosine (m6A)-connected lncRNAs are linked to survival and immune infiltration in glioma patients

Includes: Supplementary data

Articles

A DCS-related lncRNA signature predicts the prognosis and chemotherapeutic response of patients with gastric cancer

Yang Zhang, Leyan Li, Yi Tu, Zongfeng Feng, Zhengrong Li, Yi Cao, Yong Li

Biosci Rep (2022) 42 (9): BSR20220989.

DOI: https://doi.org/10.1042/BSR20220989

Published: 02 September 2022

...Yang Zhang; Leyan Li; Yi Tu; Zongfeng Feng; Zhengrong Li; Yi Cao; Yong Li The combination of docetaxel, cisplatin, and S-1 (DCS) is a common chemotherapy regimen for patients with gastric cancer (GC). However, studies on long noncoding RNAs (lncRNAs) associated with the chemotherapeutic response...

View article titled, A DCS-related lncRNA signature predicts the prognosis and chemotherapeutic response of patients with gastric cancer

Includes: Supplementary data

Articles

A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus

Yoshiaki Kanemoto, Koichi Nishimura, Akira Hayakawa, Takahiro Sawada, Rei Amano, Jinichi Mori, Tomohiro Kurokawa, Yoshinori Murakami, Shigeaki Kato

Biosci Rep (2022) 42 (5): BSR20220321.

DOI: https://doi.org/10.1042/BSR20220321

Published: 27 May 2022

... and pathological settings. However, the known target genes of VDR appear unlikely to account for all VD actions. We used in silico and transcriptomic approaches in human cell lines to search for non-coding RNAs transcriptionally regulated by VD directly. Four long non-coding RNAs (lncRNAs), but no microRNAs...

View article titled, A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus

Articles

Retraction: LncRNA AWPPH promotes the growth of triple-negative breast cancer by up-regulating frizzled homolog 7 (FZD7)

Biosci Rep (2022) 42 (5): BSR-2018-1223_RET.

DOI: https://doi.org/10.1042/BSR-2018-1223_RET

Published: 10 May 2022

... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . AWPPH frizzled homolog 7 LncRNA proliferation Triple-negative breast...

View article titled, Retraction: LncRNA AWPPH promotes the growth of triple-negative breast cancer by up-regulating frizzled homolog 7 (FZD7)

Articles

Urinary exosomal long noncoding RNAs serve as biomarkers for early detection of non-small cell lung cancer

Quan Lin, Danli Xie, Liangliang Pan, Yongliang Lou, Mengru Shi

Biosci Rep (2021) 41 (10): BSR20210908.

DOI: https://doi.org/10.1042/BSR20210908

Published: 12 October 2021

...)-related long noncoding RNAs (lncRNAs) in urinary exosomes in NSCLC patients and normal controls to diagnose lung cancer. Methods: A differential expression analysis between NSCLC patients and healthy controls was performed using microarrays. Gene ontology (GO) term and Kyoto Encyclopedia of Genes...

View article titled, Urinary exosomal long noncoding RNAs serve as biomarkers for early detection of non-small cell lung cancer

Includes: Supplementary data

Articles

Circulating lncRNA UCA1 and lncRNA PGM5-AS1 act as potential diagnostic biomarkers for early-stage colorectal cancer

Minghui Wang, Zhijun Zhang, Deng Pan, Zhigang Xin, Fan Bu, Yue Zhang, Qingwu Tian, Xiaodong Feng

Biosci Rep (2021) 41 (7): BSR20211115.

DOI: https://doi.org/10.1042/BSR20211115

Published: 12 July 2021

...Minghui Wang; Zhijun Zhang; Deng Pan; Zhigang Xin; Fan Bu; Yue Zhang; Qingwu Tian; Xiaodong Feng Background: Colorectal cancer (CRC) is one of the most common and significant malignant diseases worldwide. In the present study, we evaluated two long non-coding RNAs (lncRNAs) in CRC patients...

View article titled, Circulating lncRNA UCA1 and lncRNA PGM5-AS1 act as potential diagnostic biomarkers for early-stage colorectal cancer

Includes: Supplementary data

Articles

Expression of Concern: Long non coding RNA FAM3D-AS1 inhibits development of colorectal cancer through NF-kB signaling pathway

Biosci Rep (2021) 41 (4): BSR-20190724_EOC.

DOI: https://doi.org/10.1042/BSR-20190724_EOC

Published: 07 April 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Colorectal cancer EMT lncRNA The Editorial Office has been made aware...

View article titled, Expression of Concern: Long non coding RNA FAM3D-AS1 inhibits development of colorectal cancer through NF-kB signaling pathway

Articles

XIST knockdown suppresses vascular smooth muscle cell proliferation and induces apoptosis by regulating miR-1264/WNT5A/β-catenin signaling in aneurysm

Liang Zou, Peng-fei Xia, Lei Chen, Yan-yan Hou

Biosci Rep (2021) 41 (3): BSR20201810.

DOI: https://doi.org/10.1042/BSR20201810

Published: 15 March 2021

...Liang Zou; Peng-fei Xia; Lei Chen; Yan-yan Hou Long non-coding RNAs (lncRNAs) have been ascertained as vital modulators in abdominal aortic aneurysm (AAA) development. In this research, the function and molecular mechanisms of the lncRNA X-inactive specific transcript ( XIST ) in the evolution...

View article titled, XIST knockdown suppresses vascular smooth muscle cell proliferation and induces apoptosis by regulating miR-1264/WNT5A/β-catenin signaling in aneurysm

Articles

Explore prognostic biomarker of bladder cancer based on competing endogenous network

Faping Li, Hui Guo, Bin Liu, Nian Liu, Zhixiang Xu, Yishu Wang, Honglan Zhou

Biosci Rep (2020) 40 (12): BSR20202463.

DOI: https://doi.org/10.1042/BSR20202463

Published: 02 December 2020

...Faping Li; Hui Guo; Bin Liu; Nian Liu; Zhixiang Xu; Yishu Wang; Honglan Zhou Bladder cancer (BC) is the most common tumor of the urinary tract. Increasing evidence showed that long non-coding RNA (lncRNA) is a critical regulator in cancer development and progression. However, the functions...

View article titled, Explore prognostic biomarker of bladder cancer based on competing endogenous network

Includes: Supplementary data

Articles

LncRNA NEAT1 promotes malignant phenotypes and TMZ resistance in glioblastoma stem cells by regulating let-7g-5p/MAP3K1 axis

Chang-Long Bi, Jin-Fang Liu, Ming-Yu Zhang, Song Lan, Zhuan-Yi Yang, Jia-Sheng Fang

Biosci Rep (2020) 40 (10): BSR20201111.

DOI: https://doi.org/10.1042/BSR20201111

Published: 30 October 2020

... The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Glioma stem cells let-7g-5p lncRNA MAP3K1 NEAT1 Temozolomide As the most common...

View article titled, LncRNA NEAT1 promotes malignant phenotypes and TMZ resistance in glioblastoma stem cells by regulating let-7g-5p/MAP3K1 axis

Articles

Relationship between lncRNA-Ang362 and prognosis of patients with coronary heart disease after percutaneous coronary intervention

Hui Wang, Huichao Gong, Yingwu Liu, Limin Feng

Biosci Rep (2020) 40 (7): BSR20201524.

DOI: https://doi.org/10.1042/BSR20201524

Published: 24 July 2020

...Hui Wang; Huichao Gong; Yingwu Liu; Limin Feng The severity and complexity evaluation of coronary artery disease in patients with coronary heart disease (CHD) require objective and accurate prognosis indexes. We assessed the relationship between lncRNA-Ang362 and prognosis of CHD patients after...

View article titled, Relationship between lncRNA-Ang362 and prognosis of patients with coronary heart disease after percutaneous coronary intervention

Articles

High lncSNHG15 expression may predict poor cancer prognosis: a meta-analysis based on the PRISMA and the bio-informatics analysis

Shi Xu Fang, Cheng Chen, Qiang Guo, Xi Xian Ke, Hong Ling Lu, Gang Xu

Biosci Rep (2020) 40 (7): BSR20194468.

DOI: https://doi.org/10.1042/BSR20194468

Published: 17 July 2020

... as long non-coding RNA (lncRNA). LncRNA does not have a single and pre-defined biological function [ 9 ]. Decades of lncRNA researches showed the involvement of lncRNA in the activation and silencing of genes, nuclear transfer and chromatin modification [ 10 ]. More evidences have confirmed...

View article titled, High lncSNHG15 expression may predict poor cancer prognosis: a meta-analysis based on the PRISMA and the bio-informatics analysis

Includes: Supplementary data

Articles

Fifteen mRNA-lncRNA expression-based signature predicted the survival of late-staged head and neck squamous cell carcinoma

He Ren, Huaping Li, Ping Li, Yuhui Xu, Gang Liu, Liping Sun

Biosci Rep (2020) 40 (7): BSR20200442.

DOI: https://doi.org/10.1042/BSR20200442

Published: 30 June 2020

... coefficients indicate that these genes were tumor suppressor genes. Correspondence: Liping Sun ( 1480390@sumhs.edu.cn ) or Gang Liu ( liugang@fudan.edu.cn ) head and neck squamous cell carcinoma lncRNA mRNA signature survival * These authors contributed equally to this work. 24...

View article titled, Fifteen mRNA-lncRNA expression-based signature predicted the survival of late-staged head and neck squamous cell carcinoma

Articles

β-Elemene suppresses tumor growth of diffuse large B-cell lymphoma through regulating lncRNA HULC-mediated apoptotic pathway

Tonglin Hu, Yu Gao

Biosci Rep (2020) 40 (2): BSR20190804.

DOI: https://doi.org/10.1042/BSR20190804

Published: 11 February 2020

... were assessed and in vivo study were performed to determine the tumor suppressive effect of β-elemene and explore the molecular mechanisms. Results: β-Elemene significantly suppressed the viability of DLBCL cells, and β-elemene down-regulated the lncRNA HULC expression and regulated key pro-apoptotic...

View article titled, β-Elemene suppresses tumor growth of diffuse large B-cell lymphoma through regulating lncRNA HULC-mediated apoptotic pathway

Articles

A susceptibility biomarker identification strategy based on significantly differentially expressed ceRNA triplets for ischemic cardiomyopathy

Yuqing Zou, Yahui Wang, Zherou Rong, Benliang Wei, Yang Liu, Zhaona Song, Wenshuai Li, Erqiang Hu, Gui Deng, Yuehan He, Junjie Lv, Lina Chen, Wan Li

Biosci Rep (2020) 40 (1): BSR20191731.

DOI: https://doi.org/10.1042/BSR20191731

Published: 24 January 2020

... constructed using permutation tests and differentially expressed mRNAs, miRNAs and lncRNAs. Candidate ICM susceptible genes were screened out as differentially expressed genes in significantly differentially expressed ceRNA triplets enriched in ICM-related functional classes. Finally, eight ICM susceptibility...

View article titled, A susceptibility biomarker identification strategy based on significantly differentially expressed ceRNA triplets for ischemic cardiomyopathy

Articles

The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma

Tang Ying, Jin-ling Dong, Cen Yuan, Peng Li, Qingshan Guo

Biosci Rep (2020) 40 (1): BSR20191251.

DOI: https://doi.org/10.1042/BSR20191251

Published: 06 January 2020

... RNAs (lncRNAs) are essential in osteosarcoma processes and development, and here we report significant lncRNAs to aid in earlier diagnosis of osteosarcoma. Methods: A univariate Cox proportional hazards regression analysis and a multivariate Cox regression analysis were used to analyze osteosarcoma...

View article titled, The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma

Includes: Supplementary data

Articles

RNA-sequencing analysis reveals the potential contribution of lncRNAs in palmitic acid-induced insulin resistance of skeletal muscle cells

Mei Han, Lianghui You, Yanting Wu, Nan Gu, Yan Wang, Xiaodan Feng, Lanlan Xiang, Yajun Chen, Yu Zeng, Tianying Zhong

Biosci Rep (2020) 40 (1): BSR20192523.

DOI: https://doi.org/10.1042/BSR20192523

Published: 02 January 2020

...Mei Han; Lianghui You; Yanting Wu; Nan Gu; Yan Wang; Xiaodan Feng; Lanlan Xiang; Yajun Chen; Yu Zeng; Tianying Zhong Insulin resistance (IR) has been considered as the common pathological basis and developmental driving force for most metabolic diseases. Long noncoding RNAs (lncRNAs) have emerged...

View article titled, RNA-sequencing analysis reveals the potential contribution of lncRNAs in palmitic acid-induced insulin resistance of skeletal muscle cells

Includes: Supplementary data

Articles

Long non-coding RNA TCONS_00000200 as a non-invasive biomarker in patients with intracranial aneurysm

Chenghan Wu, Hailong Song, Yinzhou Wang, Lili Gao, Yali Cai, Qiong Cheng, Yanru Chen, Zheng Zheng, Yuansheng Liao, Jushan Lin, Buni Xie, Weiwu Cai, Shiju Li, Lianming Liao, Xiaohua Yan

Biosci Rep (2019) 39 (11): BSR20182224.

DOI: https://doi.org/10.1042/BSR20182224

Published: 22 November 2019

...Chenghan Wu; Hailong Song; Yinzhou Wang; Lili Gao; Yali Cai; Qiong Cheng; Yanru Chen; Zheng Zheng; Yuansheng Liao; Jushan Lin; Buni Xie; Weiwu Cai; Shiju Li; Lianming Liao; Xiaohua Yan We performed long non-coding RNA (lncRNA) microarray assay to identify lncRNAs with differential expression...

View article titled, Long non-coding RNA TCONS_00000200 as a non-invasive biomarker in patients with intracranial aneurysm

Includes: Supplementary data

Articles

The molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism

Ting Tao, Shiyuan Wu, Zheng Sun, Wei Ma, Sichun Zhou, Jun Deng, Qiongli Su, Mei Peng, Gaosheng Xu, Xiaoping Yang

Biosci Rep (2019) 39 (11): BSR20192453.

DOI: https://doi.org/10.1042/BSR20192453

Published: 12 November 2019

...), is considered to be an important marker of metabolic reprogramming and one of the key enzymes. Recently, through the continuous development of genome-wide analysis and functional studies, accumulating evidence has demonstrated that long non-coding RNAs (LncRNAs) play vital regulatory roles in cancer progression...

View article titled, The molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism

Articles

LINC00511 is associated with the malignant status and promotes cell proliferation and motility in cervical cancer

Chun-Ling Yu, Xiao-Ling Xu, Fang Yuan

Biosci Rep (2019) 39 (9): BSR20190903.

DOI: https://doi.org/10.1042/BSR20190903

Published: 13 September 2019

...Chun-Ling Yu; Xiao-Ling Xu; Fang Yuan LINC00511 is a newly identified lncRNA that is up-regulated in many types of human cancers and may serve as an oncogenic lncRNA. However, there was no report about the role of LINC00511 in cervical cancer. Therefore, we investigated the clinical value...

View article titled, LINC00511 is associated with the malignant status and promotes cell proliferation and motility in cervical cancer

Articles

LncRNA LUCAT1 facilitates tumorigenesis and metastasis of triple-negative breast cancer through modulating miR-5702

Exian Mou, Hao Wang

Biosci Rep (2019) 39 (9): BSR20190489.

DOI: https://doi.org/10.1042/BSR20190489

Published: 03 September 2019

...Exian Mou; Hao Wang Triple-negative breast cancer (TNBC) is a subtype of aggressive breast cancer with high recurrence and poor survival. Emerging evidence has indicated that long non-coding RNAs (lncRNAs) play pivotal roles in the development and progression of multiple cancers. Although...

View article titled, LncRNA LUCAT1 facilitates tumorigenesis and metastasis of triple-negative breast cancer through modulating miR-5702

Articles

Molecular mechanisms of lncRNAs in regulating cancer cell radiosensitivity

Jiamin Zhu, Shusen Chen, Baixia Yang, Weidong Mao, Xi Yang, Jing Cai

Biosci Rep (2019) 39 (8): BSR20190590.

DOI: https://doi.org/10.1042/BSR20190590

Published: 28 August 2019

... years, long non-coding RNAs (lncRNAs), which affect the occurrence and development of tumors through a variety of mechanisms, have become a popular research topic. LncRNAs have been found to influence radiosensitivity by regulating various mechanisms, including DNA damage repair, cell cycle arrest...

View article titled, Molecular mechanisms of lncRNAs in regulating cancer cell radiosensitivity

Articles

Long noncoding RNA FAM3D-AS1 inhibits development of colorectal cancer through NF-κB signaling pathway

Ying Meng, Feng Yu

Biosci Rep (2019) 39 (7): BSR20190724.

DOI: https://doi.org/10.1042/BSR20190724

Published: 05 July 2019

...Ying Meng; Feng Yu Although numerous differential long noncoding RNAs (IncRNAs) have been identified, the relationship between lncRNA and colorectal cancer (CRC) still remains largely unclear. In the present study, we investigated the function and provided a possible mechanism of lncRNA FAM3D-AS1...

View article titled, Long noncoding RNA FAM3D-AS1 inhibits development of colorectal cancer through NF-κB signaling pathway

Articles

FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies

Changlong Shi, Li Sun, Yongsheng Song

Biosci Rep (2019) 39 (6): BSR20191202.

DOI: https://doi.org/10.1042/BSR20191202

Published: 25 June 2019

...Changlong Shi; Li Sun; Yongsheng Song Long noncoding RNAs (LncRNAs) refer to the RNA with a length of >200 nucleotides, which lack or have no open reading coding frame and have higher tissue and organ specificity compared with the protein coding genes. A surging number of studies have shown...

View article titled, FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies

Articles

SOX21-AS1 is associated with clinical stage and regulates cell proliferation in nephroblastoma

Jingxiu Zhang, Tianzhao Hou, Xueliang Qi, Jihong Wang, Xiangguo Sun

Biosci Rep (2019) 39 (5): BSR20190602.

DOI: https://doi.org/10.1042/BSR20190602

Published: 17 May 2019

...Jingxiu Zhang; Tianzhao Hou; Xueliang Qi; Jihong Wang; Xiangguo Sun LncRNA SOX21 antisense RNA 1 (SOX21-AS1) dysregulated in many types of human cancer, and functioned as tumor suppressor or promoter depending on tumor types. However, there was no report about the role of SOX21-AS1...

View article titled, SOX21-AS1 is associated with clinical stage and regulates cell proliferation in nephroblastoma

Articles

GHET1 acts as a prognostic indicator and functions as an oncogenic lncRNA in cervical cancer

Qunchang Zhang, Yongtao Zhang, Ying Wang

Biosci Rep (2019) 39 (4): BSR20182506.

DOI: https://doi.org/10.1042/BSR20182506

Published: 30 April 2019

...Qunchang Zhang; Yongtao Zhang; Ying Wang Gastric carcinoma proliferation enhancing transcript 1 (GHET1) has been suggested to serve as a promising oncogenic lncRNA in various types of human cancer. However, the role of GHET1 remained unknown in cervical cancer. In our study, we found GHET1...

View article titled, GHET1 acts as a prognostic indicator and functions as an oncogenic lncRNA in cervical cancer

Articles

LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma

Si Chen, Weiguo Li, Ai Guo

Biosci Rep (2019) 39 (4): BSR20190447.

DOI: https://doi.org/10.1042/BSR20190447

Published: 30 April 2019

...Si Chen; Weiguo Li; Ai Guo lncRNA LOXL1 antisense RNA 1 (lncRNA LOXL1-AS1) was recently found to function as oncogenic lncRNA in glioblastoma, prostate cancer, and medulloblastoma. The role of LOXL1-AS1 in osteosarcoma was still unknown. In our study, we found LOXL1-AS1 expression levels were...

View article titled, LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma

Articles

Long noncoding RNA UCA1 as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis

Congmin Liu, Jing Jin, Jin Shi, Liqun Wang, Zhaoyu Gao, Tiantian Guo, Yutong He

Biosci Rep (2019) 39 (4): BSR20180995.

DOI: https://doi.org/10.1042/BSR20180995

Published: 26 April 2019

...Congmin Liu; Jing Jin; Jin Shi; Liqun Wang; Zhaoyu Gao; Tiantian Guo; Yutong He Background: Urothelial carcinoma associated 1 (UCA1), a novel long noncoding RNA (lncRNA) which is first discovered in 2006 in human bladder cancer and has become a hot spot in recent years. UCA1 has been demonstrated...

View article titled, Long noncoding RNA UCA1 as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis

Articles

Integrated analyses of lncRNAs microarray profiles and mRNA–lncRNA coexpression in smooth muscle cells under hypoxic and normoxic conditions

Qinshuo Zhao, Dating Sun, Yuanyuan Li, Jin Qin, JiangTao Yan

Biosci Rep (2019) 39 (4): BSR20181783.

DOI: https://doi.org/10.1042/BSR20181783

Published: 02 April 2019

... of the aberrant expression of long noncoding RNAs (lncRNAs) with the development and progression of atherosclerosis is well known; however, it is not well investigated in hypoxic VSMCs. Using a microarray approach, we identified 1056 and 2804 differentially expressed lncRNAs and mRNAs, respectively, in hypoxic...

View article titled, Integrated analyses of lncRNAs microarray profiles and mRNA–lncRNA coexpression in smooth muscle cells under hypoxic and normoxic conditions

Includes: Supplementary data

Articles

LncRNA TP73-AS1 sponges miR-141-3p to promote the migration and invasion of pancreatic cancer cells through the up-regulation of BDH2

Xian-Ping Cui, Chuan-Xi Wang, Zhi-Yi Wang, Jian Li, Ya-Wen Tan, Song-Tao Gu, Cheng-Kun Qin

Biosci Rep (2019) 39 (3): BSR20181937.

DOI: https://doi.org/10.1042/BSR20181937

Published: 15 March 2019

...Xian-Ping Cui; Chuan-Xi Wang; Zhi-Yi Wang; Jian Li; Ya-Wen Tan; Song-Tao Gu; Cheng-Kun Qin LncRNA TP73 antisense RNA 1T (TP73-AS1) plays an important role in human malignancies. However, the levels of TP73-AS1 and its functional mechanisms in pancreatic cancer metastasis remain unknown...

View article titled, LncRNA TP73-AS1 sponges miR-141-3p to promote the migration and invasion of pancreatic cancer cells through the up-regulation of BDH2

Includes: Supplementary data

Articles

Long non-coding RNA MALAT1 regulates BLCAP mRNA expression through binding to miR-339-5p and promotes poor prognosis in breast cancer

Liuhong Zheng, Yuhan Zhang, Yajun Fu, Hangdi Gong, Jianjun Guo, Kangjing Wu, Qiaojun Jia, Xianfeng Ding

Biosci Rep (2019) 39 (2): BSR20181284.

DOI: https://doi.org/10.1042/BSR20181284

Published: 15 February 2019

...Liuhong Zheng; Yuhan Zhang; Yajun Fu; Hangdi Gong; Jianjun Guo; Kangjing Wu; Qiaojun Jia; Xianfeng Ding The human genome transcribes a large amount of non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs. LncRNAs and microRNAs have been shown to play a critical regulatory role...

View article titled, Long non-coding RNA MALAT1 regulates BLCAP mRNA expression through binding to miR-339-5p and promotes poor prognosis in breast cancer

Includes: Supplementary data

Articles

LncRNA AWPPH promotes the growth of triple-negative breast cancer by up-regulating frizzled homolog 7 (FZD7)

Kainan Wang, Xuelu Li, Chen Song, Man Li

Biosci Rep (2018) 38 (6): BSR20181223.

DOI: https://doi.org/10.1042/BSR20181223

Published: 28 November 2018

...Kainan Wang; Xuelu Li; Chen Song; Man Li Background: LncRNA AWPPH is a recently identified critical player in the development of several types of human malignancies, our study aimed to investigate the role of AWPPH in triple-negative breast cancer. Methods: In the present study, expression of AWPPH...

View article titled, LncRNA AWPPH promotes the growth of triple-negative breast cancer by up-regulating frizzled homolog 7 (FZD7)

Articles

ANRIL promotes chemoresistance via disturbing expression of ABCC1 by regulating the expression of Let-7a in colorectal cancer

Zhen Zhang, Lifeng Feng, Pengfei Liu, Wei Duan

Biosci Rep (2018) 38 (6): BSR20180620.

DOI: https://doi.org/10.1042/BSR20180620

Published: 21 November 2018

...Zhen Zhang; Lifeng Feng; Pengfei Liu; Wei Duan Increasing evidence indicates that long non-coding RNAs (lncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) has been involved in various diseases and promotes tumorigenesis and cancer progression as an oncogenic gene. However, the effect...

View article titled, ANRIL promotes chemoresistance via disturbing expression of ABCC1 by regulating the expression of Let-7a in colorectal cancer

Includes: Supplementary data

Articles

Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by up-regulating lncRNA GAS5

Guoqing Li, Ying Liu, Fanru Meng, Zhongbin Xia, Xia Wu, Yuxuan Fang, Chunwang Zhang, Dan Liu

Biosci Rep (2018) 38 (5): BSR20180626.

DOI: https://doi.org/10.1042/BSR20180626

Published: 05 October 2018

... the mechanisms of the Tanshinone IIA (Tan IIA)-induced apoptosis of FLS from patients with RA (termed RAFLS). Cell Counting Kit-8 (CCK-8) assay and Annexin V staining revealed that RAFLS viability decreased and apoptosis increased after Tan IIA treatment. Long non-coding RNA (lncRNA) GAS5 expression...

View article titled, Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by up-regulating lncRNA GAS5

Includes: Supplementary data

Articles

TUG1 promotes prostate cancer progression by acting as a ceRNA of miR-26a

Bin Yang, Xiaodi Tang, Zhixin Wang, Daju Sun, Xin Wei, Youpeng Ding

Biosci Rep (2018) 38 (5): BSR20180677.

DOI: https://doi.org/10.1042/BSR20180677

Published: 02 October 2018

... prediction revealed putative miR-26a-binding sites within TUG1 transcripts. In conclusion, our study suggests that long non-coding RNA (lncRNA) TUG1 acts as a functional oncogene in PCa development. Correspondence : Zhixin Wang ( zhangtang1617@163.com ) * These authors contributed equally...

View article titled, TUG1 promotes prostate cancer progression by acting as a ceRNA of miR-26a

Articles

Long non-coding RNA HOTTIP promotes prostate cancer cells proliferation and migration by sponging miR-216a-5p

Bin Yang, Ge Gao, Zhixin Wang, Daju Sun, Xin Wei, Yanan Ma, Youpeng Ding

Biosci Rep (2018) 38 (5): BSR20180566.

DOI: https://doi.org/10.1042/BSR20180566

Published: 28 September 2018

...Bin Yang; Ge Gao; Zhixin Wang; Daju Sun; Xin Wei; Yanan Ma; Youpeng Ding Long non-coding RNAs (lncRNAs) are a class of ncRNAs with >200 nts in length that regulate gene expression. The HOXA transcript at the distal tip (HOTTIP) lncRNA plays an important role in carcinogenesis, however...

View article titled, Long non-coding RNA HOTTIP promotes prostate cancer cells proliferation and migration by sponging miR-216a-5p

Articles

LncRNA PROX1-AS1 promotes proliferation, invasion, and migration in papillary thyroid carcinoma

Yanyan Shen, Erjie Xia, Adheesh Bhandari, Xiaohui Wang, Guilong Guo

Biosci Rep (2018) 38 (5): BSR20180862.

DOI: https://doi.org/10.1042/BSR20180862

Published: 12 September 2018

...Yanyan Shen; Erjie Xia; Adheesh Bhandari; Xiaohui Wang; Guilong Guo Evidence has been provided that long noncoding RNAs (LncRNAs) play major roles in affecting essential physiological processes, and many of which seem to have functional roles in tumorigenesis and progression. However, the intrinsic...

View article titled, LncRNA PROX1-AS1 promotes proliferation, invasion, and migration in papillary thyroid carcinoma

Articles

Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis

Xin Huang, Weiyue Zhang, Zengwu Shao

Biosci Rep (2018) 38 (4): BSR20180365.

DOI: https://doi.org/10.1042/BSR20180365

Published: 31 July 2018

...Xin Huang; Weiyue Zhang; Zengwu Shao Several studies have suggested that long non-coding RNA (lncRNA) gene polymorphisms are associated with cancer risk. In the present study, we conducted a meta-analysis related to studies on the association between lncRNA single-nucleotide polymorphisms (SNPs...

View article titled, Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis

Includes: Supplementary data

Articles

Long non-coding RNA XIST predicts worse prognosis in digestive system tumors: a systemic review and meta-analysis

Xuefang Liu, Xinliang Ming, Wei Jing, Ping Luo, Nandi Li, Man Zhu, Mingxia Yu, Chunzi Liang, Jiancheng Tu

Biosci Rep (2018) 38 (3): BSR20180169.

DOI: https://doi.org/10.1042/BSR20180169

Published: 21 June 2018

...Xuefang Liu; Xinliang Ming; Wei Jing; Ping Luo; Nandi Li; Man Zhu; Mingxia Yu; Chunzi Liang; Jiancheng Tu Increasing studies are indicating that long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is associated with the prognosis of cancer patients. However, the results have been...

View article titled, Long non-coding RNA XIST predicts worse prognosis in digestive system tumors: a systemic review and meta-analysis

Articles

ZFAS1 functions as an oncogenic long non-coding RNA in bladder cancer

Haifan Yang, Ge Li, Bo Cheng, Rui Jiang

Biosci Rep (2018) 38 (3): BSR20180475.

DOI: https://doi.org/10.1042/BSR20180475

Published: 15 May 2018

...Haifan Yang; Ge Li; Bo Cheng; Rui Jiang Long non-coding RNA (lncRNA) ZFAS1 (zinc finger antisense 1) has been suggested to have an oncogenic role in the tumorigenesis of human malignant tumors. However, the expression status and biological function of ZFAS1 in bladder cancer is still unknown. Thus...

View article titled, ZFAS1 functions as an oncogenic long non-coding RNA in bladder cancer

Articles

Genome-wide differential expression profiling of mRNAs and lncRNAs associated with prolificacy in Hu sheep

Xu Feng, Fengzhe Li, Feng Wang, Guomin Zhang, Jing Pang, Caifang Ren, Tingting Zhang, Hua Yang, Ziyu Wang, Yanli Zhang

Biosci Rep (2018) 38 (2): BSR20171350.

DOI: https://doi.org/10.1042/BSR20171350

Published: 27 April 2018

..., and year-round estrus. However, little is known about the molecular mechanisms underlying HP in Hu sheep. To explore the potential mRNAs and long non-coding RNAs (lncRNAs) involved in Hu sheep prolificacy, we performed an ovarian genome-wide analysis of mRNAs and lncRNAs during the follicular stage using...

View article titled, Genome-wide differential expression profiling of mRNAs and lncRNAs associated with prolificacy in Hu sheep

Includes: Supplementary data

Articles

The pseudogene-derived long non-coding RNA SFTA1P suppresses cell proliferation, migration, and invasion in gastric cancer

Hongwei Ma, Tianshi Ma, Miao Chen, Zigui Zou, Zhihong Zhang

Biosci Rep (2018) 38 (2): BSR20171193.

DOI: https://doi.org/10.1042/BSR20171193

Published: 20 April 2018

...Hongwei Ma; Tianshi Ma; Miao Chen; Zigui Zou; Zhihong Zhang Pseudogenes were once regarded as transcriptionally inactive and without specific molecular function. However, current evidence shows that pseudogene-derived long non-coding RNAs (lncRNAs) may be crucial regulators of human cancer...

View article titled, The pseudogene-derived long non-coding RNA SFTA1P suppresses cell proliferation, migration, and invasion in gastric cancer

Articles

LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma

Dawei Xu, Jian Yu, Guojun Gao, Guangjian Lu, Yi Zhang, Pengju Ma

Biosci Rep (2018) 38 (1): BSR20171664.

DOI: https://doi.org/10.1042/BSR20171664

Published: 02 February 2018

...Dawei Xu; Jian Yu; Guojun Gao; Guangjian Lu; Yi Zhang; Pengju Ma Long noncoding RNA (lncRNA) differentiation antagonizing nonprotein coding RNA (DANCR) plays important regulatory roles in many solid tumors. However, the effect of DANCR in glioma progression and underlying molecular mechanisms were...

View article titled, LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma

Articles

Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling

Shanyang He, Yunhe Zhao, Xiaoping Wang, Yalan Deng, Zhiyong Wan, Shuzhong Yao, Hongwei Shen

Biosci Rep (2018) 38 (1): BSR20170681.

DOI: https://doi.org/10.1042/BSR20170681

Published: 05 January 2018

...Shanyang He; Yunhe Zhao; Xiaoping Wang; Yalan Deng; Zhiyong Wan; Shuzhong Yao; Hongwei Shen Long non-coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to play crucial regulatory roles in many types of cancer. However, the biological function of long ncRNA (lncRNA) SNHG20...

View article titled, Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling

Includes: Supplementary data

Articles

Regulatory networks of non-coding RNAs in brown/beige adipogenesis

Shaohai Xu, Peng Chen, Lei Sun

Biosci Rep (2015) 35 (5): e00262.

DOI: https://doi.org/10.1042/BSR20150155

Published: 30 October 2015

... homoeostasis and lead to a healthy phenotype. Two classes of ncRNA (non-coding RNA), miRNA and lncRNA (long non-coding RNA), play crucial roles in gene regulation during tissue development and remodelling. In the present review, we summarize recent findings on regulatory role of distinct ncRNAs in brown/beige...

View article titled, Regulatory networks of non-coding RNAs in brown/beige adipogenesis

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