... the Creative Commons Attribution License 4.0 (CC BY) . endoplasmic reticulum endosomes intracellular transport Lysosomes neurodegeneration neuronal ceroid lipofuscinosis First discovered by Christian de Duve, lysosomes perform several key cellular functions, and their dysfunction has been...

... roles in lipid metabolism, calcium homeostasis, cell differentiation amongst many other processes (reviewed in [ 18 , 19 ]); a correct positioning of these organelles is essential for relevant processes such as cell division and migration [ 20 ]. intracellular transport mitochondria molecular...

..., but with the development of a number of model systems and approaches, great progress is being made. Correspondence: David A. Dean ( david_dean@urmc.rochester.edu ) 14 09 2017 13 10 2017 17 10 2017 20 10 2017 cytoskeleton cell nucleus gene therapy intracellular transport microtubule...

... dimerization and contains the binding sites for two ICs and two LICs. The two ICs also interact with three pairs of light chains: Tctex, LC7 and LC8 (adapted from [ 24 ]). dynein FIP-1 gene transfer intracellular transport microtubules non-viral vector The relative non-immunogenicity...