... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Intervertebral disc degeneration Nucleus pulposus cells p53 signaling...

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Intervertebral disc degeneration Nucleus pulposus cells p53 signaling...

...Lianglong Pang; Keshi Yang; Zhi Zhang Diabetes mellitus (DM) is an important risk factor of intervertebral disc degeneration. However, how DM affects annulus fibrosus (AF) biology remains unclear. The present study was aimed to investigate the effects and mechanism of high glucose on AF cell...

... Attribution License 4.0 (CC BY) . inflammation intervertebral disc degeneration LPS Moracin Nrf-2 Recently, growing evidences have shown that the mechanism of pain induced by degeneration of intervertebral disc is still not very clear, and the clinical efficacy is not good. Intervertebral...

... in their lives [ 2 , 3 ]. It has been reported that approximately 20% of annual healthcare costs caused in the U.S.A. are related to LBP [ 4 , 5 ]. One of the most common etiologies of LBP is intervertebral disc degeneration (IVDD) [ 6 ]. © 2019 The Author(s). 2019 This is an open access article published...

...Jiangwei Chen; Zunwen Lin; Kui Deng; Bin Shao; Dong Yang Background: Intervertebral disc degeneration is a common degenerative disease. The present study aimed to explore the role and mechanism of tension-induced endoplasmic reticulum stress in intervertebral disc degeneration. Methods...

...Lizhen Shan; Di Yang; Danjie Zhu; Fabo Feng; Xiaolin Li Diabetes mellitus (DM) is an important risk factor of intervertebral disc degeneration. A high glucose niche-mediated disc cell apoptosis is an implicate causative factor for the spine degenerative diseases related with DM. However...

...Xiaoliang Bai; Wenyuan Ding; Sidong Yang; Xiaohui Guo Intervertebral disc degeneration (IDD) is a natural progression of the aging process associated with inflammation. Higenamine, a plant-based alkaloid, has been identified to possess various pharmacological properties, including anti-inflammatory...

...Xiaoming Li; Feixiang Lin; Yaohong Wu; Ning Liu; Jun Wang; Rongchun Chen; Zhijun Lu Intervertebral disc degeneration is a disease identified as an inflammation response-participated pathological process. As a classical cellular feature, disc cell senescence is reported to be closely related...

... protective effects. The concentration of OP-1 is determined according to a previous study [ 29 ]. apoptosis high glucose intervertebral disc degeneration nucleus pulposus osteogenic protein-1 Low back pain is a common musculoskeletal disease around the world. Intervertebral disc...

.... and Reis R.L. ( 2017 ) Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities . Biomater. Res. 21 , 22 10.1186/s40824-017-0106-6 3. Roberts S. ( 2002 ) Disc morphology in health and disease . Biochem. Soc. Trans. 30...

...Yanhai Jiang; Zhijie Xie; Jinying Yu; Lianqiang Fu Nucleus pulposus (NP) cell apoptosis is a classical cellular character during intervertebral disc degeneration (IDD). Previous studies have shown that inflammatory cytokine-induced NP cell apoptosis plays an important role in disc degeneration...

... for treatment of intervertebral disc degeneration: substitution and regeneration possibilities . Biomater. Res. 21 , 22 10.1186/s40824-017-0106-6 29085662 5. Boos N. , Weissbach S. , Rohrbach H. , Weiler C. , Spratt K.F. and Nerlich A.G. ( 2002 ) Classification...

... stem cell therapies . Cell Transplant. 24 , 2197 – 2208 10.3727/096368915X688650 26223943 21. Ding F. , Shao Z.W. and Xiong L.M. ( 2013 ) Cell death in intervertebral disc degeneration . Apoptosis 18 , 777 – 785 10.1007/s10495-013-0839-1 23512131 22...

... intervertebral disc degeneration nucleus pulposus osteogenic protein-1 PI3K/Akt/mTOR Low back pain is a common and costly physical disease around the world, generating enormous socioeconomic burden and seriously affecting patient’s life quality [ 1 ]. Its global prevalence is estimated to reach 12...

....) according to the manufacturer’s instructions. After gray value analysis using the Quantity One software (Bio-Rad, U.S.A.), protein expression of one target molecule was expressed as the ratio of its gray value to that of β-actin. apoptosis CDMP-2 intervertebral disc degeneration nucleus pulposus...

... by the one-way ANOVA. The post hoc test was determined by the LSD test. A statistical significance was regarded when P <0.05. autophagy intervertebral disc degeneration nucleus pulposus resveratrol We analyzed matrix protein deposition using the method of immunocytochemical (ICC...

...Yimin Chen; Haitao Ma; Dawei Bi; Binsong Qiu Intervertebral disc degeneration (IDD) is a major pathological process implicated in low back pain and is a prerequisite to disk herniation. Interleukin-1 α (IL-1α) was thought to be involved in the pathogenesis of disc degeneration by increasing...

...Liu-Zhong Jin; Ji-Shou Lu; Jian-Wen Gao Objective: Intervertebral disc degeneration (IDD), as a common cause of back pain, is related to the promotion of cellular senescence and reduction in proliferation. Based on recent studies, small ubiquitin-related modifier (SUMO) proteins have been...

... intervertebral disc degeneration nucleus pulposus resveratrol senescence Intervertebral disc degeneration (IDD) is a worldwide disease with multipathogenesis [ 1 ]. It can lead to stenosis, spine instability, and neurothlipsis [ 2 ]. Due to these complications, IDD is a main contributor to low back...

... and in the intact disc organ culture system [ 11 ]. Based on the above statements, we speculate that attenuation of NP cell apoptosis may be an effective strategy to attenuate high magnitude compression-induced disc degeneration. apoptosis intervertebral disc degeneration nucleus pulposus resveratrol...