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Keywords: insulin
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Biosci Rep (2024) 44 (1): BSR20231916.
Published: 31 January 2024
... metabolic hormones—including insulin, the incretins (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1), growth hormone, ghrelin, leptin, and adiponectin—signal throughout the hypothalamic–pituitary–gonadal axis to support or suppress reproduction. We synthesize current knowledge...
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Biosci Rep (2023) 43 (10): BSR20230946.
Published: 20 October 2023
...Angéline Geiser; Shannan Foylan; Peter W. Tinning; Nia J. Bryant; Gwyn W. Gould In adipose tissue, insulin stimulates glucose uptake by mediating the translocation of GLUT4 from intracellular vesicles to the plasma membrane. In 2010, insulin was revealed to also have a fundamental impact...
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Biosci Rep (2023) 43 (5): BSR20222594.
Published: 28 April 2023
...Jun Chen; Ziyan Wang; Tuanlao Wang; Jidong Cheng; Ruijuan Zhuang; Wei Wang SNAP25 is a core protein of the SNARE complex, which mediates stimulus-dependent secretion of insulin from the pancreatic β cells. SNAP23 is a SNAP25 homolog, however, the functional role of SNAP23 in the exocytic secretion...
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Biosci Rep (2021) 41 (4): BSR20204284.
Published: 14 April 2021
... into rats. Insulin can reduce the accumulation of pyruvate. To observe the insulin effect on pyruvate, cognitive and physical functions after acceleration, insulin administration or treatment of promoting insulin secretion was used. Physical and cognitive functions were assessed using open field test (OFT...
Includes: Supplementary data
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Biosci Rep (2020) 40 (4): BSR20193972.
Published: 07 April 2020
... glucose levels were determined by the glucose oxidase method. The experimental results revealed that ZnONPs suggestively ( p <0.001) declined the blood glucose levels (39.79%), while these reductions were 38.78% for the cotreatment of ZnONPs and insulin, and 48.60% for insulin, respectively...
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Biosci Rep (2018) 38 (2): BSR20171033.
Published: 05 March 2018
...) and insulin (Akt and p-Akt) signaling were evaluated. Glucose and leptin tolerance, peripheral insulin sensitivity, and plasma insulin, leptin and adiponectin were determined. Perigonadal and retroperitoneal fat depots were increased by diet but reduced by exercise despite lack of effect of exercise on body...
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Biosci Rep (2013) 33 (1): e00007.
Published: 13 December 2012
... in the adipocyte AMP:ATP ratio. Glucose decreased AMPK activity and effects of palmitate and glucose on AMPK activity were antagonistic. While insulin had no effect on basal AMPK activity insulin did decrease AMPK activity in the presence of palmitate and also decreased the percentage effectiveness of palmitate...
Includes: Supplementary data
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Biosci Rep (2012) 32 (5): 423–432.
Published: 20 July 2012
... non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cognition diabetes energy homoeostasis ghrelin hormone insulin leptin neural circuitry neurodegeneration Food intake and energy expenditure, the key determinants...
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Biosci Rep (2012) 32 (3): 229–239.
Published: 22 December 2011
.... The glucose effect was additive to the decrease in AMPK activity caused by insulin, was attenuated by adrenaline, was not mimicked by glucose analogues, lactate or pyruvate and was not due to changes in myocyte glycogen content. AMPK activity was decreased by xylitol and PMS (phenazine methosulfate...
Includes: Supplementary data
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Biosci Rep (2012) 32 (2): 197–209.
Published: 21 November 2011
... kinase) cascade inhibitor U0126 or by PTX (pertussis toxin). Adrenaline caused no measurable change in LKB1 activity. Adrenaline decreased AMPK activity through a process that was distinct from AMPK inactivation in response to insulin or PMA. Neither adrenaline nor PMA altered the myocyte AMP:ATP ratio...
Includes: Supplementary data
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Biosci Rep (2009) 29 (4): 229–235.
Published: 07 May 2009
...Patrick D. Lyons; Grantley R. Peck; Arminja N. Kettenbach; Scott A. Gerber; Liya Roudaia; Gustav E. Lienhard The signal transduction pathway leading from the insulin receptor to stimulate the fusion of vesicles containing the glucose transporter GLUT4 with the plasma membrane in adipocytes...
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Biosci Rep (2001) 21 (6): 755–763.
Published: 01 December 2001
...M. Esteve; P. Savall; J. Virgilli; J.A. Fernández-López; X. Remesar; M. Alemany Preadipocytes (3T3 L1) were used between 7 and 14 days after differentiation; they were incubated with 44 nM 3H-esterone. The medium was supplemented with 1 μM recombinant murine leptin, 10 nM recombinant human insulin...
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Biosci Rep (1997) 17 (6): 529–535.
Published: 01 December 1997
...L. Kőhidai; G. Csaba Mitochondrial dehydrogenase activity was measured in seven taxa of Tetrahymena (T. pyriformis G1, T. hegewishi, T. malaccensis, T. pigmentosa, T. shapiro, T. thermophila CU-399, T. thermophila MS-1). Enzyme activity was different in the taxa investigated. Insulin reduced enzyme...
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Biosci Rep (1995) 15 (6): 411–418.
Published: 01 December 1995
...John J. M. Bergeron; G. M. Di Guglielmo; Patricia C. Baass; François Authier; Barry I. Posner Upon the binding of insulin or epidermal growth factor to their cognate receptors on the liver parenchymal plasmalemma, signal transduction and receptor internalization are near co-incident. Indeed...
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Biosci Rep (1993) 13 (3): 127–142.
Published: 01 June 1993
... Publishing Corporation 1993 protein phosphorylation protein kinase phosphorylase glycogen metabolism normonal signaling cyclic AMP cyclic AMP-dependent protein kinase insulin growth factors Bioscience Reports, Vol. 13, No. 3, 1993 NOBEL LECTURE 9 DECEMBER 1992 Protein Phosphorylation...
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Biosci Rep (1993) 13 (2): 107–117.
Published: 01 April 1993
...Gerd Larsson-Nyrén; Janove Sehlin In order to elucidate the mechanisms responsible for the stimulatory effect of perchlorate (ClO 4 − ) on insulin secretion, we have investigated the interaction between this chaotropic anion and the organic calcium antagonist nifedipine. This drug, known...
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Biosci Rep (1992) 12 (2): 101–108.
Published: 01 April 1992
...Sandra Incerpi; Patrizia Baldini; Mario Lo Bello; Paolo Luly Insulin treatment of isolated liver plasma membranes induced the release of 5′-nucleotidase and alkaline phosphatase. This effect was maximal at physiological hormone concentrations, being 36% and 17% for 5′-nucleotidase and alkaline...
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Biosci Rep (1992) 12 (1): 23–27.
Published: 01 February 1992
...G. Csaba; Zsuzsa Darvas Histamine increased specifically the phagocytic activity of the unicellular Tetrahymena, whereas insulin had no influence on it. Insulin antagonized the phagocytosis stimulating action of histamine after simultaneous exposure and after preexposure two days earlier as well...
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Biosci Rep (1991) 11 (3): 147–157.
Published: 01 June 1991
.... In addition, when Ca 2+ -currents were recorded from intact β-cells, using the perforated patch whole-cell configuration, clonidine (1 μM) also failed to detectably affect the Ca 2+ -current. It is therefore suggested that the inhibition of β-cell electrical activity and insulin-secretion produced by α 2...
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Biosci Rep (1989) 9 (6): 721–725.
Published: 01 December 1989
...P. Kovács; Y. Okano; Y. Nozawa; G. Csaba The cells of the NIH 3T3 fibroblast line responded to primary interaction with insulin by a positive imprinting, i.e. by an increased binding capacity for the hormone on re-exposure. Positive imprinting, although to a lesser degree, was also induced...
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Biosci Rep (1986) 6 (5): 485–491.
Published: 01 May 1986
...R. M. Palmer; P. Bain; P. J. Reeds Insulin (100 μU/ml) stimulated protein synthesis and PGF 2α release in isolated rabbit muscle, but had little effect on the rate of protein degradation. The effect of insulin persisted for at least 5 h after removal of the hormone. Indomethacin, added at the start...
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