... : This signature reflects the HSF1 and DYRK2 gene expression profile that predicts in vivo efficacy to standard of care drugs tested in the Champions Oncology PDX models. This signature was calculated by correlating DYRK2 and HSF1 gene expression across PDX models with efficacy (tumour growth inhibition index...

... discovered ubiquitin-specific peptidase (USP) 52 (USP52) in NSCLC remained unclear. Here, our findings identify USP52 as a novel tumor suppressor of NSCLC, the low expression of USP52 predicts a poor prognosis for NSCLC patients. The present study demonstrates that USP52 inhibits cancer cell proliferation...

... demonstrate that considering allosteric inhibition of caspase 3 as a shift between discrete ‘off-state’ or ‘on-state’ conformations is insufficient. Although His 266 is accommodated in the interface, the structural defects are propagated to the active site through a helix on the protein surface. A more...

... within post-thaw culture. © 2007 The Biochemical Society 2007 Apoptosis Cryopreservation Embryonic Freezing Human Inhibition Stem cells ORI GI N A L P A PE R Caspase Inhibitor Z-VAD-FMK Enhances the Freeze-Thaw Survival Rate of Human Embryonic Stem Cells Boon Chin Heng Æ Marie Veronique...

... of entry into target cells. To correlate membrane merging and infectivity MDCK cells were used as targets for the viruses in both approaches. In either case pronounced inhibition of virus–cell interactions by dextran sulfate was only observed at low pH, even though Sendai virus fuses maximally at pH 7.4...

... was found to inhibit the activity of the liver microsomal Ca 2+ -ATPase to 50% to that of control rats. The specific activity of the enzyme in rats administered sodium arsenite with vitamin C pretreatment was not significantly different from that of control rats. © 1999 Plenum Publishing Corporation 1999...

...-stranded RNA high concentrations of C protein triggered the phosphorylation of the interferon-induced, double-stranded RNA-activated protein kinase, PKR. Activated PKR in turn phosphorylated its natural substrate, the α subunit of eukaryotic initiation factor 2 (eIF-2), thereby inhibiting initiation...