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Keywords: inflammation
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Articles

Adipose tissue macrophages and their role in obesity-associated insulin resistance: an overview of the complex dynamics at play

Suktara Guria, Anupama Hoory, Snehasis Das, Dipanjan Chattopadhyay, Sutapa Mukherjee
Journal: Bioscience Reports
Biosci Rep (2023) 43 (3): BSR20220200.
DOI: https://doi.org/10.1042/BSR20220200
Published: 09 March 2023
... AT inflammation is prevalent during obesity. The adipose tissue macrophages (ATM) with astounding heterogeneity and complex regulation play a decisive role in mediating obesity-induced insulin resistance. Adipose-derived macrophages were broadly classified as proinflammatory M1 and anti-inflammatory M2 subtypes...
View article titled, Adipose tissue macrophages and their role in obesity-associated insulin resistance: an overview of the complex dynamics at play
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Articles

Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies

Alyson Deprez, Zakaria Orfi, Lupann Rieger, Nicolas Alexandre Dumont
Journal: Bioscience Reports
Biosci Rep (2023) 43 (1): BSR20220284.
DOI: https://doi.org/10.1042/BSR20220284
Published: 06 January 2023
... dystrophies that intrinsically compromise MuSC function and/or disturb their microenvironment leading to impaired muscle regeneration that contributes to disease progression. Alternatively, many acquired myopathies caused by comorbidities (e.g., cardiopulmonary or kidney diseases), chronic inflammation...
View article titled, Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies
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Articles

Retraction: Vitamin D ameliorates impaired wound healing in streptozotocin induced diabetic mice by suppressing NF-κB mediated inflammatory genes expression

Journal: Bioscience Reports
Biosci Rep (2022) 42 (12): BSR-2017-1294_RET.
DOI: https://doi.org/10.1042/BSR-2017-1294_RET
Published: 22 December 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . diabetic impaired wound healing inflammation NF-κB Vitamin D...
View article titled, Retraction: Vitamin D ameliorates impaired wound healing in streptozotocin induced diabetic mice by suppressing NF-κB mediated inflammatory genes expression
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Articles

Insights into mechanisms of graft-versus-host disease through humanised mouse models

Amal Elhage, Chloe Sligar, Peter Cuthbertson, Debbie Watson, Ronald Sluyter
Journal: Bioscience Reports
Biosci Rep (2022) 42 (9): BSR20211986.
DOI: https://doi.org/10.1042/BSR20211986
Published: 05 September 2022
... Antigen presenting cell Graft-versus-host disease Inflammation Lymphocyte Xenogeneic graft-versus-host disease Graft-versus-host disease (GVHD) is an inflammatory disorder that can occur following allogeneic haematopoietic stem cell transplantation (HSCT) [ 1 , 2 ]. Allogeneic HSCT...
View article titled, Insights into mechanisms of graft-versus-host disease through humanised mouse models
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Articles

TCF7 is highly expressed in immune cells on the atherosclerotic plaques, and regulating inflammatory signaling via NFκB/AKT/STAT1 signaling

Zhongnan Ma, Chuang Wang, Xiufeng Bai, Long Wang, Qianjing Wu, Zehong Cai, Wanxiang Wang, Zhuo Ma, Xinyu Liu, Jiaxuan Feng, Rui Feng
Journal: Bioscience Reports
Biosci Rep (2022) 42 (7): BSR20212064.
DOI: https://doi.org/10.1042/BSR20212064
Published: 18 July 2022
...-kB subunit) and AKT (AKT serine/threonine kinase 1) are important transcription factors in regulating inflammation. For instance, oxidized LDLs (oxLDLs) or LPS triggers vascular inflammation leading to atherosclerosis through activated NFκB. The study suggests that increased oxLDLs lead to sustained...
View article titled, TCF7 is highly expressed in immune cells on the atherosclerotic plaques, and regulating inflammatory signaling via NFκB/AKT/STAT1 signaling
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Includes: Supplementary data
Articles

Possible regulation of Toll-like receptor 4 by lysine acetylation through LPCAT2 activity in RAW264.7 cells

Victory Ibigo Poloamina, Wondwossen Abate, Gyorgy Fejer, Simon K. Jackson
Journal: Bioscience Reports
Biosci Rep (2022) 42 (7): BSR20220251.
DOI: https://doi.org/10.1042/BSR20220251
Published: 15 July 2022
...Victory Ibigo Poloamina; Wondwossen Abate; Gyorgy Fejer; Simon K. Jackson Inflammation is central to several diseases. TLR4 mediates inflammation by recognising and binding to bacterial lipopolysaccharides and interacting with other proteins in the TLR4 signalling pathway. Although...
View article titled, Possible regulation of Toll-like receptor 4 by lysine acetylation through LPCAT2 activity in RAW264.7 cells
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Includes: Supplementary data
Articles

Acanthopanax senticosus total flavonoids alleviate lipopolysaccharide-induced intestinal inflammation and modulate the gut microbiota in mice

Xiaoya Wang, Xinyu Zhang, Jianqing Su, Xiuling Chu
Journal: Bioscience Reports
Biosci Rep (2022) 42 (2): BSR20212670.
DOI: https://doi.org/10.1042/BSR20212670
Published: 07 February 2022
...Xiaoya Wang; Xinyu Zhang; Jianqing Su; Xiuling Chu Here, we study the therapeutic effect of Acanthopanax senticosus total flavonoids (ASTFs) using a mouse intestinal inflammation model. The inflammation model used in the present study was developed through lipopolysaccharide (LPS) treatment of mice...
View article titled, Acanthopanax senticosus total flavonoids alleviate lipopolysaccharide-induced intestinal <span class="search-highlight">inflammation</span> and modulate the gut microbiota in mice
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Includes: Supplementary data
Articles

Correction: Red Algae Natural Products for Prevention of Lipopolysaccharides (LPS)-induced liver and kidney inflammation and Injuries

Journal: Bioscience Reports
Biosci Rep (2021) 41 (10): BSR-2020-2022_COR.
DOI: https://doi.org/10.1042/BSR-2020-2022_COR
Published: 18 October 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . G. Oblongata red algae Natural products LPS Liver Kidney Inflammation...
View article titled, Correction: Red Algae Natural Products for Prevention of Lipopolysaccharides (LPS)-induced liver and kidney <span class="search-highlight">inflammation</span> and Injuries
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Articles

Exosomes derived from LPS-stimulated human thymic mesenchymal stromal cells enhance inflammation via thrombospondin-1

Qianru Li, Jing Li, Lei Sun, Yun Sun, Fei Zhao, Pingping Liu, Xin Peng, Xiaoyan Xuan, Yun Li, Peng Wang, Chen Tan, Ying Du
Journal: Bioscience Reports
Biosci Rep (2021) 41 (10): BSR20203573.
DOI: https://doi.org/10.1042/BSR20203573
Published: 12 October 2021
... that thrombospondin-1 (TSP-1) is highly expressed in response to inflammation. In this work, we isolated and identified human thymic mesenchymal stromal cells (tMSCs) and detected the expression of TSP-1. We found that tMSCs expressed TSP-1 and Poly (I:C) or LPS treatment promoted the expression of TSP-1. Further, we...
View article titled, Exosomes derived from LPS-stimulated human thymic mesenchymal stromal cells enhance <span class="search-highlight">inflammation</span> via thrombospondin-1
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Includes: Supplementary data
Articles

Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19

In Collection
Coronavirus
Aline H. de Nooijer, Inge Grondman, Simon Lambden, Emma J. Kooistra, Nico A.F. Janssen, Matthijs Kox, Peter Pickkers, Leo A.B. Joosten, Frank L. van de Veerdonk, Marc Derive, Sebastien Gibot, Mihai G. Netea, on behalf of RCI-COVID-19 study group
Journal: Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20210940.
DOI: https://doi.org/10.1042/BSR20210940
Published: 22 July 2021
... BY) . coronavirus disease 2019 (COVID-19) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) acute respiratory distress syndrome (ARDS) inflammation sTREM-1 mortality The current coronavirus disease 2019 (COVID-19) pandemic has, to date, led to almost three million deaths (World Health...
View article titled, Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19
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Includes: Supplementary data
Articles

Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males

Rob G.H. Driessen, Dorien Kiers, Casper G. Schalkwijk, Jean L.J.M. Scheijen, Jelle Gerretsen, Peter Pickkers, Marcel C.G. van de Poll, Iwan C.C. van der Horst, Dennis C.J.J. Bergmans, Matthijs Kox, Bas C.T. van Bussel
Journal: Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20210954.
DOI: https://doi.org/10.1042/BSR20210954
Published: 02 July 2021
...Rob G.H. Driessen; Dorien Kiers; Casper G. Schalkwijk; Jean L.J.M. Scheijen; Jelle Gerretsen; Peter Pickkers; Marcel C.G. van de Poll; Iwan C.C. van der Horst; Dennis C.J.J. Bergmans; Matthijs Kox; Bas C.T. van Bussel Background: Hypoxia and inflammation are hallmarks of critical illness, related...
View article titled, Systemic <span class="search-highlight">inflammation</span> down-regulates glyoxalase-1 expression: an experimental study in healthy males
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Articles

Correction: Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs

Journal: Bioscience Reports
Biosci Rep (2021) 41 (7): BSR-2019-2668_COR.
DOI: https://doi.org/10.1042/BSR-2019-2668_COR
Published: 02 July 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . adiponectin human periodontal ligament cells inflammation...
View article titled, Correction: Adiponectin inhibits lipoplysaccharide-induced <span class="search-highlight">inflammation</span> and promotes osteogenesis in hPDLCs
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Articles

Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12 , through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin

Waruni C. Dissanayake, Jin Kyo Oh, Brie Sorrenson, Peter R. Shepherd
Journal: Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20211066.
DOI: https://doi.org/10.1042/BSR20211066
Published: 29 June 2021
... was enabled by the participation of University Of Auckland in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. alpha catenin hexosamine biosynthesis pathway inflammation macrophages Macrophages are highly...
View article titled, Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12 , through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin
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Articles

The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia–reperfusion brain injury in mice

Maria E. Hammarlund, Vladimer Darsalia, Filip Mjörnstedt, Bagmi Pattanaik, Carina Mallard, Eridan Rocha-Ferreira, Cesare Patrone, Maria E. Johansson
Journal: Bioscience Reports
Biosci Rep (2021) 41 (6): BSR20210736.
DOI: https://doi.org/10.1042/BSR20210736
Published: 11 June 2021
...Maria E. Hammarlund; Vladimer Darsalia; Filip Mjörnstedt; Bagmi Pattanaik; Carina Mallard; Eridan Rocha-Ferreira; Cesare Patrone; Maria E. Johansson Inflammation plays a central role in stroke-induced brain injury. The alpha7 nicotinic acetylcholine receptor (α7nAChR) can modulate immune responses...
View article titled, The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia–reperfusion brain injury in mice
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Includes: Supplementary data
Articles

The role of the microbiome in gastrointestinal inflammation

David J. Sanders, Saskia Inniss, Gregory Sebepos-Rogers, Farooq Z. Rahman, Andrew M. Smith
Journal: Bioscience Reports
Biosci Rep (2021) 41 (6): BSR20203850.
DOI: https://doi.org/10.1042/BSR20203850
Published: 11 June 2021
... to preserve intestinal homoeostasis, promote protective immune responses, and limit excessive inflammation. The importance of the microbiome is further highlighted during dysbiosis where a loss of this finely balanced microbial population can lead to mucosal barrier dysfunction, aberrant immune responses...
View article titled, The role of the microbiome in gastrointestinal <span class="search-highlight">inflammation</span>
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Articles

Expression of Concern: Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs

Journal: Bioscience Reports
Biosci Rep (2021) 41 (5): BSR-20192668_EOC.
DOI: https://doi.org/10.1042/BSR-20192668_EOC
Published: 14 May 2021
... The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. adiponectin human periodontal ligament cells inflammation...
View article titled, Expression of Concern: Adiponectin inhibits lipoplysaccharide-induced <span class="search-highlight">inflammation</span> and promotes osteogenesis in hPDLCs
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Articles

Retraction: The protective effect of PPARγ in sepsis-induced acute lung injury via inhibiting PTEN/β-catenin pathway

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20192639_RET.
DOI: https://doi.org/10.1042/BSR-20192639_RET
Published: 19 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . acute lung injury apoptosis inflammation PPARγ PTEN/β-catenin pathway...
View article titled, Retraction: The protective effect of PPARγ in sepsis-induced acute lung injury via inhibiting PTEN/β-catenin pathway
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Articles

Expression of Concern: miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20193419_EOC.
DOI: https://doi.org/10.1042/BSR-20193419_EOC
Published: 31 March 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis inflammation miR-143-3p mycoplasmal pneumonia TLR4/MyD88/NF-κB...
View article titled, Expression of Concern: miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway
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Articles

Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

Xiao-Li Chen, Qing-Ling Xiao, Zhong-Hua Pang, Cheng Tang, Qi-Yong Zhu
Journal: Bioscience Reports
Biosci Rep (2021) 41 (3): BSR20204247.
DOI: https://doi.org/10.1042/BSR20204247
Published: 24 March 2021
... BY) . An-Chuan Granule Asthma Inflammation Network pharmacology Th17/Treg balance Asthma, the most common chronic respiratory disorder associated with a global morbidity rate, affects peoples of all age groups, with particular impact in children [ 1 , 2 ]. Increased smoking and allergy rates, severe...
View article titled, Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation
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Includes: Supplementary data
Articles

Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs

Huan-huan Wu, Yuan Guo, Yin-fei Pu, Zhi-hui Tang
Journal: Bioscience Reports
Biosci Rep (2021) 41 (3): BSR20192668.
DOI: https://doi.org/10.1042/BSR20192668
Published: 02 March 2021
...Huan-huan Wu; Yuan Guo; Yin-fei Pu; Zhi-hui Tang Periodontal diseases are infections of the structures that surround and support the teeth; they are characterized by local inflammation and alveolar bone loss. Most treatments focus on only one aspect, inhibiting inflammation, or promoting...
View article titled, Adiponectin inhibits lipoplysaccharide-induced <span class="search-highlight">inflammation</span> and promotes osteogenesis in hPDLCs
Click here to open pdf in another window PDF for Adiponectin inhibits lipoplysaccharide-induced <span class="search-highlight">inflammation</span> and promotes osteogenesis in hPDLCs
Articles

Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Asmaa Nabil-Adam, Mohamed A. Shreadah
Journal: Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20202022.
DOI: https://doi.org/10.1042/BSR20202022
Published: 15 January 2021
...Asmaa Nabil-Adam; Mohamed A. Shreadah Background: The liver and kidney inflammation due to bacterial infection is one of the most common pathological problems leading to tissue damage or disease. In many liver and kidney disorders, which represent serious global health burden with a high economic...
View article titled, Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney <span class="search-highlight">inflammation</span> and injuries
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Articles

Decoction of heat-clearing, detoxifying and blood stasis removing relieves acute soft tissue injury via modulating miR-26b-5p/COX2 axis to inhibit inflammation

Shunwan Jiang, Zhi Chen, Wenqiang Lai, Qingchun Mai, Dayu Chen, Shufen Sun, Yong Zhang
Journal: Bioscience Reports
Biosci Rep (2020) 40 (12): BSR20201981.
DOI: https://doi.org/10.1042/BSR20201981
Published: 21 December 2020
...Shunwan Jiang; Zhi Chen; Wenqiang Lai; Qingchun Mai; Dayu Chen; Shufen Sun; Yong Zhang Traditional Chinese medicine (TCM), such as Huanglian-Jie-Du-Tang, a heat-clearing and detoxifying decoction is beneficial for alleviation of inflammation-related diseases. The objective of the present study...
View article titled, Decoction of heat-clearing, detoxifying and blood stasis removing relieves acute soft tissue injury via modulating miR-26b-5p&#x2F;COX2 axis to inhibit <span class="search-highlight">inflammation</span>
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Articles

Icariin inhibits the inflammation through down-regulating NF-κB/HIF-2α signal pathways in chondrocytes

Pengzhen Wang, Qingqi Meng, Wen Wang, Shaoheng Zhang, Xifeng Xiong, Shengnan Qin, Jinli Zhang, Aiguo Li, Zhihe Liu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (11): BSR20203107.
DOI: https://doi.org/10.1042/BSR20203107
Published: 23 November 2020
...Pengzhen Wang; Qingqi Meng; Wen Wang; Shaoheng Zhang; Xifeng Xiong; Shengnan Qin; Jinli Zhang; Aiguo Li; Zhihe Liu Articular cartilage injury or defect is a common disease and is mainly characterized by cartilage degradation because of chondrocyte inflammation. By now, there are no effective drugs...
View article titled, Icariin inhibits the <span class="search-highlight">inflammation</span> through down-regulating NF-κB&#x2F;HIF-2α signal pathways in chondrocytes
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Articles

Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability

Tao Hu, Zhiwen Luo, Kai Li, Shanjin Wang, Desheng Wu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (10): BSR20201098.
DOI: https://doi.org/10.1042/BSR20201098
Published: 23 October 2020
... against this condition. The present study aims to investigate the protective effect of Zanthoxylum nitidum (ZN) on BMP-2-related hyperpermeability and inflammation on the human umbilical vein endothelial cells (HUVECs). The results revealed that, in a concentration-dependent manner, BMP-2 enhanced...
View article titled, Zanthoxylum nitidum extract attenuates BMP-2-induced <span class="search-highlight">inflammation</span> and hyperpermeability
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Articles

Amelioration of cyclophosphamide-induced myelosuppression during treatment to rats with breast cancer through low-intensity pulsed ultrasound

Wei Wang, Dong Luo, Junlin Chen, Jinyun Chen, Yi Xia, Wenzhi Chen, Yan Wang
Journal: Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20201350.
DOI: https://doi.org/10.1042/BSR20201350
Published: 24 September 2020
... License 4.0 (CC BY) . Breast cancer chemotherapy hematopoiesis inflammation low-intensity pulsed ultrasound myelosuppression Breast cancer is the most frequently diagnosed cancer in women worldwide and the leading cause of cancer-related deaths among women in less-developed countries...
View article titled, Amelioration of cyclophosphamide-induced myelosuppression during treatment to rats with breast cancer through low-intensity pulsed ultrasound
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Articles

Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III

Amal Ahmed Mohamed, Wafaa Gh. Shousha, Moushira Erfan Zaki, Hala T. El-Bassyouni, Hadeel El-Hanafi, Sara M. Abdo
Journal: Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20192910.
DOI: https://doi.org/10.1042/BSR20192910
Published: 21 September 2020
... of inflammation and endothelial dysfunction markers among Egyptian females with different obesity classes. Methods: Out of 130 females, 70 were categorized into three obesity groups: Class I, body mass index (BMI) 30–34.9 kg/m 2 ; Class II, BMI 35–39.9 kg/m 2 and Class III BMI ≥ 40 kg/m 2 , besides 60 control...
View article titled, Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III
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Articles

Statin-induced microRNAome alterations modulating inflammation pathways of peripheral blood mononuclear cells in patients with hypercholesterolemia

Hung-Ju Lin, Sung-Liang Yu, Ta-Chen Su, Hsiu-Ching Hsu, Ming-Fong Chen, Yuan-Teh Lee, Kuo-Liong Chien, Tzu-Pin Lu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20201885.
DOI: https://doi.org/10.1042/BSR20201885
Published: 21 September 2020
...Hung-Ju Lin; Sung-Liang Yu; Ta-Chen Su; Hsiu-Ching Hsu; Ming-Fong Chen; Yuan-Teh Lee; Kuo-Liong Chien; Tzu-Pin Lu Statins inhibit cholesterol biogenesis and modulate atheroma inflammation to reduce cardiovascular risks. Promoted by immune and non-immune cells, serum C-reactive protein (CRP) might...
View article titled, Statin-induced microRNAome alterations modulating <span class="search-highlight">inflammation</span> pathways of peripheral blood mononuclear cells in patients with hypercholesterolemia
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Includes: Supplementary data
Articles

MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2

Shijie Gao, Liang Liu, Shibo Zhu, Dawei Wang, Qiang Wu, Guangzhi Ning, Shiqing Feng
Journal: Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20192095.
DOI: https://doi.org/10.1042/BSR20192095
Published: 16 September 2020
...-regulate EIF4G2 expression in chondrocytes, while miR-197 knockdown could elevate EIF4G2 expression. Additionally, EIF4G2 overexpression reversed the effects of miR-197 mimics on chondrocytes proliferation, migration, and inflammation. Taken together, our study demonstrated that miR-197 promotes...
View article titled, MicroRNA-197 regulates chondrocyte proliferation, migration, and <span class="search-highlight">inflammation</span> in pathogenesis of osteoarthritis by targeting EIF4G2
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Articles

Retraction: Downregulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting Nuclear factor-kappa B signaling

Journal: Bioscience Reports
Biosci Rep (2020) 40 (9): BSR-20190700_RET.
DOI: https://doi.org/10.1042/BSR-20190700_RET
Published: 01 September 2020
... The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Inflammation MicroRNA-142-3p Nuclear factor-kappa B Proliferation Tumor necrosis factor α...
View article titled, Retraction: Downregulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting Nuclear factor-kappa B signaling
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Articles

Up-regulation of CXCL8 expression is associated with a poor prognosis and enhances tumor cell malignant behaviors in liver cancer

Song Yang, Han Wang, Chundi Qin, Hongmei Sun, Yupeng Han
Journal: Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20201169.
DOI: https://doi.org/10.1042/BSR20201169
Published: 20 August 2020
... <0.05 was considered as statistical significance. CXCL8 ERK Inflammation liver cancer malignant progression Liver cancer, the predominant primary malignancy, ranks as the fifth most commonly diagnosed cancer in male and the seventh in female around the world [ 1 ]. In the year...
View article titled, Up-regulation of CXCL8 expression is associated with a poor prognosis and enhances tumor cell malignant behaviors in liver cancer
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Articles

Correction: Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Journal: Bioscience Reports
Biosci Rep (2020) 40 (7): BSR-20193431_COR.
DOI: https://doi.org/10.1042/BSR-20193431_COR
Published: 30 July 2020
... The original article “Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway” ( Biosci Rep (2019) 40 (3), DOI: 10.1042/BSR20193431) contained an image error and an incorrect description of the data presented. The authors state that they had...
View article titled, Correction: Naringin protects endothelial cells from apoptosis and <span class="search-highlight">inflammation</span> by regulating the Hippo-YAP Pathway
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Articles

miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway

Yongjun Wang, Huan Li, Yongsheng Shi, Shuying Wang, Yan Xu, Hanyi Li, Donghai Liu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (7): BSR20193419.
DOI: https://doi.org/10.1042/BSR20193419
Published: 07 July 2020
... in mycoplasmal pneumonia mice by inhibiting TLR4/MyD88/NF-κB signaling pathway. apoptosis inflammation miR-143-3p mycoplasmal pneumonia TLR4/MyD88/NF-κB signaling pathway As a non-coding RNA, microRNA (miRNA) can regulate and control multiple life activities by regulating the transcription...
View article titled, miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway
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Articles

Correction: Sub-chronic toxicity evaluation of top-three commercial herbal anti-malarial preparations in the Kumasi metropolis, Ghana

Journal: Bioscience Reports
Biosci Rep (2020) 40 (7): BSR-20192536_COR.
DOI: https://doi.org/10.1042/BSR-20192536_COR
Published: 03 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biochemical haemolysis histology inflammation safety Surveillance...
View article titled, Correction: Sub-chronic toxicity evaluation of top-three commercial herbal anti-malarial preparations in the Kumasi metropolis, Ghana
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Articles

Expression of Concern: Downregulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting Nuclear factor-kappa B signaling

Journal: Bioscience Reports
Biosci Rep (2020) 40 (6): BSR-20190700_EOC.
DOI: https://doi.org/10.1042/BSR-20190700_EOC
Published: 25 June 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . MicroRNA-142-3p Inflammation Proliferation Tumor necrosis factor α...
View article titled, Expression of Concern: Downregulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting Nuclear factor-kappa B signaling
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Articles

Expression of Concern: The protective effect of PPARγ in sepsis-induced acute lung injury via inhibiting PTEN/β-catenin pathway

Journal: Bioscience Reports
Biosci Rep (2020) 40 (6): BSR-20192639_EOC.
DOI: https://doi.org/10.1042/BSR-20192639_EOC
Published: 24 June 2020
... inflammation The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. ...
View article titled, Expression of Concern: The protective effect of PPARγ in sepsis-induced acute lung injury via inhibiting PTEN/β-catenin pathway
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Articles

WITHDRAWN: Curcumin against imiquimod-induced psoriasis of mice through IL-6/STAT3 signaling pathway

Yibin Zeng, Hongying Zhao, Tong Zhang, Chao Zhang, Yanni He, Lingbo Du, Fuguo Zuo, Wuqing Wang
Journal: Bioscience Reports
Biosci Rep (2020) BSR20192842.
DOI: https://doi.org/10.1042/BSR20192842
Published: 18 June 2020
... Commons licence. Curcumin Imiquimod Psoriasis IL-6 STAT3 Inflammation WITHDRAWN ARTICLE WITHDRAWN: Curcumin against imiquimod-induced psoriasis of mice through IL-6/STAT3 signaling pathway Yibin Zeng; Hongying Zhao; Tong Zhang; Chao Zhang; Yanni He; Lingbo Du; Fuguo Zuo; Wuqing Wang Biosci...
View article titled, WITHDRAWN: Curcumin against imiquimod-induced psoriasis of mice through IL-6/STAT3 signaling pathway
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Articles

Inhibition of lncRNA DILC attenuates neuropathic pain via the SOCS3/JAK2/STAT3 pathway

Yujie Liu, Lu Feng, Shichao Ren, Yingxiu Zhang, Jing Xue
Journal: Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20194486.
DOI: https://doi.org/10.1042/BSR20194486
Published: 17 June 2020
... the Creative Commons Attribution License 4.0 (CC BY) . inflammation lncRNA DILC neuropathic pain SOCS3 the JAK2/STAT3 pathway Neuropathic pain occurs from lesions or diseases affecting the somatosensory pathways within the peripheral or central nervous system (CNS). It is reported...
View article titled, Inhibition of lncRNA DILC attenuates neuropathic pain via the SOCS3/JAK2/STAT3 pathway
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Includes: Supplementary data
Articles

Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway

Aimin Liu, Wei Zhao, Buxin Zhang, Yuanhui Tu, Qingxing Wang, Jing Li
Journal: Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20200471.
DOI: https://doi.org/10.1042/BSR20200471
Published: 17 June 2020
...) and MAPK (JNK, ERK, and p38) signaling pathways. Similar alterations for oxidative stress and inflammation parameters were also detected in TNF-α-treated HaCaT cells. In addition, cimifugin-induced down-regulation of ICAM-1 were observed in TNF-α-treated cells. Altogether, our findings suggest...
View article titled, Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and <span class="search-highlight">inflammation</span> via NF-κB&#x2F;MAPK pathway
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Articles

Sub-chronic toxicity evaluation of top three commercial herbal antimalarial preparations in the Kumasi metropolis, Ghana

Frank Adusei-Mensah, Carina Tikkanen-Kaukanen, Jussi Kauhanen, Isaac Tabiri Henneh, Phyllis Elsie Owusu Agyei, Patrick Kafui Akakpo, Martins Ekor
Journal: Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20192536.
DOI: https://doi.org/10.1042/BSR20192536
Published: 05 June 2020
.... The lungs showed alveolar with evidence of inflammation and foci of epithelial sloughing. Alveolar spaces were also obscured by debris and inflammatory cells. HPA and HPC produced scattered intensely congested heart vessels while HPB(10) produced haemorrhage and amorphous exudates within the heart. All HMPs...
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Includes: Supplementary data
Articles

Extracts of Thai Perilla frutescens nutlets attenuate tumour necrosis factor-α-activated generation of microparticles, ICAM-1 and IL-6 in human endothelial cells

Narisara Paradee, Niramon Utama-ang, Chairat Uthaipibull, John B. Porter, Maciej W. Garbowski, Somdet Srichairatanakool
Journal: Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20192110.
DOI: https://doi.org/10.1042/BSR20192110
Published: 29 May 2020
...Narisara Paradee; Niramon Utama-ang; Chairat Uthaipibull; John B. Porter; Maciej W. Garbowski; Somdet Srichairatanakool Elevation of endothelial microparticles (EMPs) play an important role in the progression of inflammation-related vascular diseases such as cardiovascular diseases (CVDs). Thai...
View article titled, Extracts of Thai Perilla frutescens nutlets attenuate tumour necrosis factor-α-activated generation of microparticles, ICAM-1 and IL-6 in human endothelial cells
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Articles

Dysregulation of miR-192-5p in acute pancreatitis patients with nonalcoholic fatty liver and its functional role in acute pancreatitis progression

Yang Hu, Yongming Yu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20194345.
DOI: https://doi.org/10.1042/BSR20194345
Published: 28 May 2020
... pancreatitis diagnosis inflammation microRNA-192-5p nonalcoholic fatty liver disease proliferation Acute pancreatitis (AP) is an inflammatory disease occurring in pancreas, which can progress to multiple organ failure with increasing morbidity and high mortality rate [ 1 ]. Abdominal pain...
View article titled, Dysregulation of miR-192-5p in acute pancreatitis patients with nonalcoholic fatty liver and its functional role in acute pancreatitis progression
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Articles

The protective effect of PPARγ in sepsis-induced acute lung injury via inhibiting PTEN/β-catenin pathway

Lili Liu, Junyi Chen, Xiaofang Zhang, Xue Cui, Nana Qiao, Yun Zhang, Jie Yang
Journal: Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20192639.
DOI: https://doi.org/10.1042/BSR20192639
Published: 28 May 2020
.... Compared with Sham group, the mRNA and protein expression levels of PPARγ were down-regulated, the inflammation levels were elevated, and the apoptosis was increased in CLP group. After treatment with rosiglitazone, the protein expression level of PPARγ was significantly up-regulated, the phosphorylation...
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Articles

Per2 attenuates LPS-induced chondrocyte injury through the PTEN/PI3K/Akt signalling pathway

Yu Zhao, Ding Ma, Bingchen Dong, Ming Li
Journal: Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20200417.
DOI: https://doi.org/10.1042/BSR20200417
Published: 28 May 2020
... lipopolysaccharide (LPS) for 12 h. Then, pcDNA3.1-Per2 and si-Per2 were recruited to boost and reduce the expression of Per2, respectively. MTT assay, apoptosis analysis and enzyme-linked immunosorbent assay (ELISA) results showed that Per2 increased cell proliferation, while inhibited apoptosis and inflammation...
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Articles

MiR-124-3p helps to protect against acute respiratory distress syndrome by targeting p65

Yufeng Liang, Junjie Xie, Di Che, Chunmin Zhang, Yongmin Lin, Lin Feng, Jinlu Chen, Jie Chen, Lihe Chen, Zhiyuan Wu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20192132.
DOI: https://doi.org/10.1042/BSR20192132
Published: 27 May 2020
... (miR-124-3p) helps to suppress inflammation during a pulmonary injury. However, its mechanism of action is largely unknown, and its role in ARDS remains to be determined. Methods: Mice and NR8383 cells were exposed to lipopolysaccharides (LPS) to induce ARDS, and their miR-124-3p levels were determined...
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Articles

MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3

Li Wang, Hua Li
Journal: Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20193653.
DOI: https://doi.org/10.1042/BSR20193653
Published: 29 April 2020
..., TIMP3 was a target of miR-770-5p in HG-treated podocytes. TIMP3 inhibited cell apoptosis and inflammation in HG-treated podocytes. Moreover, TIMP3 knockdown alleviated the inhibitory effect of miR-770-5p silencing on podocyte apoptosis and inflammatory response. Conclusion: Knockdown of miR-770-5p...
View article titled, MiR-770-5p facilitates podocyte apoptosis and <span class="search-highlight">inflammation</span> in diabetic nephropathy by targeting TIMP3
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Includes: Supplementary data
Articles

Stigmasterol alleviates cerebral ischemia/reperfusion injury by attenuating inflammation and improving antioxidant defenses in rats

Qilong Liang, Jun Yang, Jiaji He, Xiaoling Chen, Hong Zhang, Maolin Jia, Kai Liu, Chuangchuang Jia, Yanhong Pan, Jinwang Wei
Journal: Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20192133.
DOI: https://doi.org/10.1042/BSR20192133
Published: 15 April 2020
... and cleaved caspase-3 expression, and up-regulate Bcl-Xl expression. Conclusion: Stigmasterol protects the brain from brain I/R damage by reducing oxidative stress and inflammation. Figure 1 The investigation of Stigmasterol in cerebral ischemia/reperfusion injury ( A ) Stigmasterol (chemical formula...
View article titled, Stigmasterol alleviates cerebral ischemia&#x2F;reperfusion injury by attenuating <span class="search-highlight">inflammation</span> and improving antioxidant defenses in rats
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Articles

The effect of different concentrations of gold nanoparticles on growth performance, toxicopathological and immunological parameters of broiler chickens

Eman I. Hassanen, Eman A. Morsy, Ahmed M. Hussien, Marwa A. Ibrahim, Khaled Y. Farroh
Journal: Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20194296.
DOI: https://doi.org/10.1042/BSR20194296
Published: 27 March 2020
... nanoparticles histopathology inflammation performance Nanotechnology is defined as the comprehension and control of matter at the nano scale, at measurements between roughly 1 and 100 nanometers [ 1 , 2 ]. In the ongoing years, nanotechnology had been advance and had the most impact on all parts...
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Articles

ALK5 deficiency inhibits macrophage inflammation and lipid loading by targeting KLF4

Wenyan Li, Junhua Wang, Zhaofeng Li
Journal: Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20194188.
DOI: https://doi.org/10.1042/BSR20194188
Published: 04 March 2020
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ALK5 foam cell inflammation KLF4 macrophage Atherosclerosis is well recognized as a chronic inflammatory disease [ 1 ] and accounts for the development...
View article titled, ALK5 deficiency inhibits macrophage <span class="search-highlight">inflammation</span> and lipid loading by targeting KLF4
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Articles

Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Hui Zhao, Meirong Liu, Hui Liu, Rong Suo, Chengzhi Lu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20193431.
DOI: https://doi.org/10.1042/BSR20193431
Published: 04 March 2020
...Hui Zhao; Meirong Liu; Hui Liu; Rong Suo; Chengzhi Lu Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial–mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular...
View article titled, Naringin protects endothelial cells from apoptosis and <span class="search-highlight">inflammation</span> by regulating the Hippo-YAP Pathway
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Articles

Comparative analysis of inflammatory signature profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyposis

Yao Yao, Chunguang Yang, Xing Yi, Shaobing Xie, Hong Sun
Journal: Bioscience Reports
Biosci Rep (2020) 40 (2): BSR20193101.
DOI: https://doi.org/10.1042/BSR20193101
Published: 24 February 2020
... polyposis endotype eosinophil inflammation Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a complex inflammatory condition characterized by the presence of edematous masses of inflamed mucosa in the upper airways [ 1 , 2 ]. CRSwNP has a considerable impact on patients’ quality of life...
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Includes: Supplementary data