... further studies. In this sense, the present study aims to review the current knowledge on venous endothelial function and dysfunction, and the general state of the venous tone in two important cardiovascular diseases of high incidence and morbimortality worldwide: hypertension and heart failure...

... are associated with ACE/ACE2 imbalance in the lungs. Experiments were conducted in male and female Wistar rats and spontaneously hypertensive rats (SHRs). Lung ACE and ACE2 gene expression was also evaluated in normotensive and hypertensive humans using the Genotype-Tissue Expression (GTEx) project. Compared...

... (50 mg/dl) in females; 4) Elevated fasting glucose > 5.6 mmol/l (100 mg/dl) (due to insulin resistance) and/or 5) Elevated blood pressure > 130/85 mmHg. Correspondence: Vance B. Matthews ( vance.matthews@uwa.edu.au ) * Equal first authorship. ADAM17 hypertension...

... demonstrated to be associated with a worse prognosis: Radiologic Brixia score higher than 8, presence at baseline of hypertension, diabetes, chronic obstructive pulmonary disease, heart disease, cancer, previous treatment with ACE-inhibitors or anti-platelet drugs. Anticoagulant treatment during hospital...

...Tingwei Li; Jiahui Jin; Zhaowei Meng; Wenjuan Zhang; Yongle Li; Xuefang Yu; Xin Du; Ming Liu; Qing Zhang; Ying Gao; Kun Song; Xing Wang; Yaguang Fan; Yan Wang The prevalence of hypertension has increased rapidly in recent years. Currently, increasing attention has been paid to the relationship...

...Ziyin Huang; Yufeng Jiang; Yafeng Zhou Background: CYP4A11 gene T8590C (rs1126742) is proved to be an important locus that is relevant to hypertension. Various research on the relationship between rs1126742 polymorphism and hypertension have been published, but due to small sample sizes...

... the randomized controlled trials using nebivolol to treat essential hypertension. The primary end points included a measurement of peripheral endothelial function by brachial flow mediated vasodilatation (FMD) or forearm blood flow (FBF). A random-effect model was used to perform the meta-analysis when...

... to homocysteine (Hcy) level and are of great significance for hypertension. We aimed to evaluate the associations of MTHFR (rs1801133, rs1801131, rs9651118), TCN2 (rs117353193) and RNF213 (rs9916351) with hypertension and blood pressure (BP). A total of 953 patients with hypertension and 1103 controls were...

...Liuping Zhang; Jinwei Liu; Peng Cheng; Fangchao Lv We aimed to study the relationship between rs11174811 and rs3803107 single nucleotide polymorphisms (SNPs) in miRNA target sites of the 3′ UTR in the arginine vasopressin receptor 1a gene ( AVPR1A ) and the risk of hypertension in the Chinese Han...

...Miao Zhang; Jianping Zhang; Lifeng Li; Qiang Wang; Limin Feng Previous studies investigate the relationship between peroxisome proliferator-activated receptor γ-2 ( PPAR ) gene Pro12Ala polymorphisms and risk of hypertension. However, the number of available studies was extremely limited. We...

... therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hypertension and many other diseases, but also provides insights into understanding critical physiological and pathophysiological roles mediated by AGT. Correspondence: Hong S. Lu ( Hong.Lu...

...Xiaoyi Zhang; Xiaoyan Wang; Jian Wu; Juan Peng; Xin Deng; Yi Shen; Chunjie Yang; Jie Yuan; Yunzeng Zou Few studies have compared the performances of those reported miRNAs as biomarkers for hypertension in a same cohort, we aimed to comprehensively examine the performances of those reported miRNAs...

...Ellen E. Gillis; Krystal N. Brinson; Olga Rafikova; Wei Chen; Jacqueline B. Musall; David G. Harrison; Jennifer C. Sullivan We previously published that female spontaneously hypertensive rats (SHR) have significantly greater nitric oxide (NO) bioavailability and NO synthase (NOS) enzymatic activity...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chloride hypertension intracellular signaling molecular basis of health and disease renal physiology transport Hypertension is a major worldwide public health problem associated with a variety...

...Qingbin Zhao; Junfang Zhang; Huifang Wang Increasing evidences have accumulated that endothelial dysfunction is involved in the pathogenesis of hypertension. Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) has been identified as an essential factor that protects against...

...Daiei Takahashi; Takayasu Mori; Naohiro Nomura; Muhammad Zakir Hossain Khan; Yuya Araki; Moko Zeniya; Eisei Sohara; Tatemitsu Rai; Sei Sasaki; Shinichi Uchida By analysing the pathogenesis of a hereditary hypertensive disease, PHAII (pseudohypoaldosteronism type II), we previously discovered...

...O. O. Olorunsogo; F. O. Agbolade; S. O. Owojuyigbe; J. A. Adebisi; A. O. Adebayo; W. G. Okunade Calpain, a calcium-dependent, neutral cysteine-protease was purified from the erythrocyte cytosol of subjects having essential hypertension (HTN), sickle cell anaemia, (SCA), or kwashiorkor (KWA...