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Keywords: hexokinase II
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Articles

The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression

Nelson Ho, Jodi Morrison, Andreza Silva, Brenda L. Coomber
Journal: Bioscience Reports
Biosci Rep (2016) 36 (1): e00299.
DOI: https://doi.org/10.1042/BSR20150267
Published: 19 February 2016
...Nelson Ho; Jodi Morrison; Andreza Silva; Brenda L. Coomber Cancer cells heavily rely on the glycolytic pathway regardless of oxygen tension. Hexokinase II (HKII) catalyses the first irreversible step of glycolysis and is often overexpressed in cancer cells. 3-Bromopyruvate (3BP) has been shown...
View article titled, The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not <span class="search-highlight">hexokinase</span> <span class="search-highlight">II</span> expression
Click here to open pdf in another window PDF for The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not <span class="search-highlight">hexokinase</span> <span class="search-highlight">II</span> expression
Articles

Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II

Nadezda Bryan, Kevin P. Raisch
Journal: Bioscience Reports
Biosci Rep (2015) 35 (3): e00205.
DOI: https://doi.org/10.1042/BSR20150047
Published: 12 June 2015
...Nadezda Bryan; Kevin P. Raisch Hexokinase II (HKII) is responsible for the first step in the glycolysis pathway by adding a phosphate on to the glucose molecule so it can proceed down the pathway to produce the energy for continuous cancer cell growth. Tumour cells overexpress the HKII enzyme...
View article titled, Identification of a mitochondrial-binding site on the N-terminal end of <span class="search-highlight">hexokinase</span> <span class="search-highlight">II</span>
Click here to open pdf in another window PDF for Identification of a mitochondrial-binding site on the N-terminal end of <span class="search-highlight">hexokinase</span> <span class="search-highlight">II</span>