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Keywords: hepatocellular carcinoma
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Articles
Biosci Rep (2022) 42 (7): BSR20221082.
Published: 14 July 2022
...Hui Liu; Songhao Jia; Kun Guo; Rongkuan Li The INK4 family is an important family of cyclin-dependent kinase inhibitors (CDKIs) and consists of CDKN2A, CDKN2B, CDKN2, and CDKN2D. Abnormal expression of CDKN2A has been reported in hepatocellular carcinoma (HCC) and is associated with the prognosis...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (6): BSR-2019-4026_RET.
Published: 27 June 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . DDP Exosome hepatocellular carcinoma Huh-7/DDP miR-199a-3p...
Articles
Biosci Rep (2022) 42 (6): BSR-2019-4026_EOC.
Published: 14 June 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . DDP Exosome hepatocellular carcinoma Huh-7/DDP miR-199a-3p...
Articles
Biosci Rep (2022) 42 (2): BSR20212560.
Published: 25 February 2022
...Jialu Liang; Wenhui Chen; Jianwen Ye; Chen Ni; Wenlong Zhai Hepatocellular carcinoma (HCC) tumors exhibit high heterogeneity. However, current understanding of tumor cell heterogeneity of HCC and the association with prognosis remains very limited. In the present study, we collected and examined...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (2): BSR20212304.
Published: 07 February 2022
...Xiaoqiang Yin; Tongchui Wu; Yadong Lan; Wulin Yang Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide. The onset of the disease is occult and develops rapidly. As a result, the disease is often detected when it is already in advanced stages, resulting in patients...
Articles
Biosci Rep (2022) 42 (1): BSR-2021-1103_COR.
Published: 06 January 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . CDKN2A Hepatocellular carcinoma Immune signature Prognostic biomarker...
Articles
Biosci Rep (2021) 41 (12): BSR20211420.
Published: 08 December 2021
...Beibei Zhu; Shanshan Gu; Xiaoting Wu; Wenyong He; Hongke Zhou Background: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies that seriously threaten global health. The primary reason for its grim prognosis is the lack of sensitive tools for early diagnosis. The purpose...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (10): BSR20211103.
Published: 06 October 2021
...Jun-peng Luo; Jing Wang; Jin-hua Huang Cyclin dependent kinase inhibitor 2A (CDKN2A) is an essential regulator of immune cell functionality, but the mechanisms whereby it drives immune infiltration in hepatocellular carcinoma (HCC) remain unclear. In the present study, we studied the association...
Articles
Biosci Rep (2021) 41 (9): BSR20211053.
Published: 31 August 2021
...Jian Xu; Xiaomin Shen; Bo Zhang; Rui Su; Mingxuan Cui; Lihua Yan; Yu Cao Purpose: To develop a lipoprotein receptor-related protein 1B ( LRP1B ) gene mutation-based prognostic model for hepatocellular carcinoma (HCC) patients risk prediction. Methods: The LRP1B gene mutation rate was calculated...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (8): BSR-2016-0532_RET.
Published: 24 August 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hepatocellular carcinoma Human ovarian cancer specific transcript 2 Long...
Articles
Biosci Rep (2021) 41 (7): BSR20210124.
Published: 26 July 2021
...Xu Chao; Jieqiong Wu; Wei Zhang; Xuesong Feng; Luyan Zhao; Feng Huang; Chao Jiang Background: Hepatocellular carcinoma (HCC) is a common fatal malignant tumor worldwide. Signal transducer and activator of transcription 4 (STAT4) is HCC susceptibility gene identified by genome-wide association study...
Articles
Biosci Rep (2021) 41 (7): BSR20211143.
Published: 12 July 2021
...Nan-Chieh Huang; Ru-Lai Huang; Xiao-Fan Huang; Kai-Fu Chang; Chien-Ju Lee; Chih-Yen Hsiao; Shan-Chih Lee; Nu-Man Tsai Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and accounts for the fourth leading cause of all cancer deaths. Scientific evidence has found...
Articles
Biosci Rep (2021) 41 (7): BSR20211241.
Published: 12 July 2021
...Zhihui Wang; Shuijun Zhang Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide, but effective immunotherapy is still limited for those affected. Therefore, there is an urgent need to explore the specific mechanisms governing tumor immunity to improve the survival rate for those...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (7): BSR20210126.
Published: 01 July 2021
...Meisi Huo; Kangkang Yu; Yahui Zheng; Lu Liu; Hao Zhao; Xiaoqi Li; Chong Huang; Jubo Zhang Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality, metastasis accounts for most of the cases. Angiogenesis plays an important role in cancer metastasis, but how tumor cells affect...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (6): BSR20204312.
Published: 18 June 2021
... infiltration of hepatocellular carcinoma (HCC) patients is unclear yet. Methods: Differentially expressed CXCLs between HCC and normal control were screened by Oncomine and GEPIA2. Genetic alternations of CXCLs in HCC were analyzed by cBioPortal. Clinicopathological relevance of CXCLs in HCC patients...
Articles
Biosci Rep (2021) 41 (6): BSR20210760.
Published: 08 June 2021
...Lili Li; Rongrong Xie; Guangrong Lu N6-methyladenosine (m6A) methyltransferase has been shown to be an oncogene in a variety of cancers. Nevertheless, the relationship between the long non-coding RNAs (lncRNAs) and hepatocellular carcinoma (HCC) remains elusive. We integrated the gene expression...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (5): BSR20210583.
Published: 27 May 2021
... 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hepatocellular carcinoma prognosis signature TCGA Hepatocellular carcinoma...
Articles
Biosci Rep (2021) 41 (4): BSR20210328.
Published: 16 April 2021
...Mingxing Li; Zhihui Wang; Lixu Zhu; Yifang Shui; Shuijun Zhang; Wenzhi Guo Recent research has indicated that metabolically related genes play crucial roles in the pathogenesis of hepatocellular carcinoma (HCC). We evaluated the associations between novel biomarkers and retinol-binding protein 4...
Articles
Biosci Rep (2021) 41 (3): BSR20204219.
Published: 17 March 2021
...Huan Ding; Huan Hu; Feifei Tian; Huaping Liang The 5-year survival of hepatocellular carcinoma (HCC) is difficult due to the high recurrence rate and metastasis. Tumor infiltrating immune cells (TICs) and immune-related genes (IRGs) bring hope to improve survival and treatment of HCC patients...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (3): BSR20204006.
Published: 15 March 2021
...Cheng Zhang; Yang Ke; Xuefen Lei; Xin Liu; Hai Li; Runjiao Shi; Lin Wang Objective: The aim of the present study was to explore the relationship among Girdin DNA methylation, its high expression, and immune infiltration in human hepatocellular carcinoma (HCC). Materials and methods: The Cancer...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (3): BSR20203945.
Published: 10 March 2021
...Xiang-Yong Hao; An-Qiang Li; Hao Shi; Tian-Kang Guo; Yan-Fei Shen; Yuan Deng; Li-Tian Wang; Tao Wang; Hui Cai Purpose: To build a novel predictive model for hepatocellular carcinoma (HCC) patients based on DNA methylation data. Methods: Four independent DNA methylation datasets for HCC were used...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (2): BSR20202063.
Published: 19 February 2021
...Junhui Chen; Jie Yang; Qingchun Xu; Zhenyu Wang; Jun Wu; Liukui Pan; Kai Huang; Chen Wang Liver hepatocellular carcinoma (LIHC) is one of the most frequently occurring primary malignant liver tumors and seriously harms people’s health in the world. Methylenetetrahydrofolate dehydrogenase 1-like...
Articles
Biosci Rep (2021) 41 (1): BSR20203231.
Published: 15 January 2021
...Wenfang Xu; Wenke Guo; Ping Lu; Duan Ma; Lei Liu; Fudong Yu The poor prognosis of hepatocellular carcinoma (HCC) calls for the development of accurate prognostic models. The growing number of studies indicating a correlation between autophagy activity and HCC indicates there is a commitment...
Articles
Biosci Rep (2021) 41 (1): BSR20203594.
Published: 07 January 2021
...Zhili Zeng; Zebiao Cao; Enxin Zhang; Haifu Huang; Ying Tang Background: Hepatocellular carcinoma (HCC) is a malignant tumor with rapid progression, high recurrence rate and poor prognosis. The objective of our investigation was to explore the prognostic value of CDK5R1 in HCC. Methods: The raw data...
Articles
Biosci Rep (2020) 40 (12): BSR20202054.
Published: 16 December 2020
...Yan-Tong Liu; Guo-Qing Liu; Jing-Min Huang Chemotherapy resistance is still a key hurdle in current hepatocellular carcinoma (HCC) treatment. Therefore, clarifying the molecular mechanisms contributing to this acquired resistance is urgent for the effective treatment of liver cancer...
Articles
Biosci Rep (2020) 40 (11): BSR20203263.
Published: 13 November 2020
...Xiaofei Wang; Jie Qiao; Rongqi Wang The present study aimed to construct a novel signature for indicating the prognostic outcomes of hepatocellular carcinoma (HCC). Gene expression profiles were downloaded from Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and the International...
Articles
Biosci Rep (2020) 40 (10): BSR20201761.
Published: 30 October 2020
...Xiaohui Duan; Wei Li; Peng Hu; Bo Jiang; Jianhui Yang; Lixue Zhou; Xianhai Mao; Bingzhang Tian Hepatocellular carcinoma (HCC) remains one of the most common malignant tumors worldwide. The present study aimed to investigate the biological role of microRNA-183-5p (miR-183-5p), a novel tumor-related...
Articles
Biosci Rep (2020) 40 (10): BSR20202603.
Published: 16 October 2020
... revealed that self-DNA from by-products of chromosome instability and tumors could activate the cGAS-STING pathway, and subsequently promote or inhibit tumor development. However, the prognostic value and correlations with immune infiltrates of the cGAS-STING pathway in hepatocellular carcinoma (HCC) have...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (10): BSR20192593.
Published: 05 October 2020
...Limin Zhen; Gang Ning; Lina Wu; Yongyuan Zheng; Fangji Yang; Tongtong Chen; Wenxiong Xu; Ying Liu; Chan Xie; Liang Peng Objectives: To identify the prognostic value of aberrantly methylated differentially expressed genes (DEGs) in hepatocellular carcinoma (HCC) and to explore the underlying...
Articles
Biosci Rep (2020) 40 (8): BSR20200894.
Published: 28 August 2020
...Kaifei Zhao; Lin Xu; Feng Li; Jin Ao; Guojun Jiang; Rongshu Shi; Fang Chen; Qing Luo Background: Due to the heterogeneity of hepatocellular carcinoma (HCC), hepatocelluarin-associated differentially expressed genes were analyzed by bioinformatics methods to screen the molecular markers for HCC...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (8): BSR-20160532_EOC.
Published: 25 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hepatocellular carcinoma Human ovarian cancer specific transcript 2 Long...
Articles
Biosci Rep (2020) 40 (7): BSR20201627.
Published: 30 July 2020
...Yunfei Duan; Jing Chen; Yu Yang; Zhen Qu; Yunjie Lu; Donglin Sun Drug resistance of Taxol leads to the treatment failure in hepatocellular carcinoma (HCC). LncRNA HOTAIR have drawn increasing attention in various diseases; its function and mechanism in Taxol-resistance in HCC remain unclear...
Articles
Biosci Rep (2020) 40 (7): BSR20193137.
Published: 27 July 2020
...Liang Yang; Yue Hu; Guanbao Zhou; Qi Chen; Zhenshun Song Background: Hepatocellular carcinoma (HCC) is the dominant pathological type of primary liver cancer and no effective methods are available for its treatment. Erianin is a natural product extracted from Dendrobium , which possesses multiple...
Articles
Biosci Rep (2020) 40 (7): BSR20201479.
Published: 22 July 2020
...Yuan Ding; Zhongquan Sun; Sitong Zhang; Qianhui Xu; Liuzhi Zhou; Dongkai Zhou; Yanjie Li; Xin Han; Hao Xu; Yang Bai; Chang Xu; Hao Ding; Yao Ge; Weilin Wang Background: For lack of accurate early diagnosis and prognostic assessment, hepatocellular carcinoma (HCC) becomes severe challenge...
Articles
Biosci Rep (2020) 40 (7): BSR20201001.
Published: 15 July 2020
...Runzhi Huang; Gaili Yan; Hanlin Sun; Jie Zhang; Dianwen Song; Rui Kong; Penghui Yan; Peng Hu; Aiqing Xie; Siqiao Wang; Juanwei Zhuang; Huabin Yin; Tong Meng; Zongqiang Huang As the most common neoplasm in digestive system, hepatocellular carcinoma (HCC) is one of the most important leading cause...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR20191418.
Published: 15 July 2020
... in hepatocellular carcinoma (HCC). We investigated hsa_circ_0026134 expression in 20 pairs of clinical tissues from HCC patients; expression of hsa_circ_0026134 in different cell lines; effect of hsa_circ_0026134 on proliferation and invasion of HCC cell lines; and the regulatory mechanisms and interactions among...
Articles
Biosci Rep (2020) 40 (7): BSR20194026.
Published: 06 July 2020
...Kun Zhang; Chu-xiao Shao; Jin-de Zhu; Xin-liang Lv; Chao-yong Tu; Chuan Jiang; Min-jie Shang Hepatocellular carcinoma (HCC) is a frequently seen malignant tumor globally. The occurrence of cisplatin (DDP) resistance is one of the main reasons for the high mortality of HCC patients. Therefore...
Articles
Biosci Rep (2020) 40 (6): BSR20192690.
Published: 16 June 2020
...Rong-Rui Huo; Xu Liu; Jing Cui; Liang Ma; Kun-Hua Huang; Cai-Yi He; Yang Yang; Xue-Mei You; Wei-Ping Yuan; Bang-De Xiang; Jian-Hong Zhong; Le-Qun Li Background and aim: Assessing the average survival rate of patients with hepatocellular carcinoma (HCC) after hepatectomy is important for making...
Articles
Biosci Rep (2020) 40 (6): BSR20194011.
Published: 10 June 2020
...-4651 (miR-4651) was involved in hepatocellular carcinoma (HCC) progression. The certain role of miRNA-4651 during the progression of HCC, however, remains unclear. Herein, we investigated the mRNA expression level of miR-4651 in HCC tissues and HCC cell lines and found miR-4651 was noticeably down...
Articles
Biosci Rep (2020) 40 (5): BSR20193295.
Published: 04 May 2020
...Jisiguleng Wu; Tong Zhang; Yubo Chen; Sigaowa Ha The microRNA, miR-139-5p, has been proved to play important roles in regulating tumor progression, including prostate cancer, osteosarcoma, esophageal cancer, and so on, but its correlation of hepatocellular carcinoma (HCC) still remains unclear...
Articles
Biosci Rep (2020) 40 (4): BSR20200219.
Published: 23 April 2020
... and subcellular localisations of the ACSL3 and ACSL4 isoforms in hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and hepatic metastases were assessed by immunohistochemical analyses of multiple tumour tissue arrays and by subcellular fractionation of cultured HepG2 cells. The expression of both enzymes...
Articles
Biosci Rep (2020) 40 (4): BSR20200232.
Published: 03 April 2020
...Xiaofei Li; Liwen Liu; Yongtao Hu Background: Association between statin use and prognosis in patients with hepatocellular carcinoma (HCC) remains unknown. We performed a meta-analysis of follow-up studies to systematically evaluate the influence of statin use on clinical outcome in HCC patients...
Articles
Biosci Rep (2020) 40 (3): BSR-20182466_RET.
Published: 13 March 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hepatocellular carcinoma MiR-367 PTEN PI3K/AKT pathway Bioscience...
Articles
Biosci Rep (2020) 40 (3): BSR20200297.
Published: 12 March 2020
...Qin-Liang Fang; Jian-Yin Zhou; Yu Xiong; Cheng-Rong Xie; Fu-Qiang Wang; Yun-Tong Li; Zhen-Yu Yin; Guo-Hui Luo A newly identified lncRNA designated as RP11-284P20.2 has been identified to be up-regulated in hepatocellular carcinoma (HCC), but its role in HCC remain poorly understood. Quantitative...
Articles
Biosci Rep (2020) 40 (3): BSR20192790.
Published: 09 March 2020
...Quan Zhang; Shujie Cheng; Liye Cao; Jihong Yang; Yu Wang; Yaqing Chen Objective : To study the role of long non-coding RNA (lncRNA) LINC00978 in hepatocellular carcinoma (HCC) carcinogenesis. Materials and methods : LINC00978 expression level was measured by reverse transcription quantitative real...
Articles
Biosci Rep (2020) 40 (2): BSR20194229.
Published: 20 February 2020
... 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hepatocellular carcinoma Meta-analysis MTHFR Polymorphism Susceptibility...
Articles
Biosci Rep (2020) 40 (2): BSR20200071.
Published: 20 February 2020
...Xiumei Wang; Yongqiang Liu; Qiong Qin; Ti Zheng Aim: To explore the prognostic value of clusterin ( CLU ) in hepatocellular carcinoma (HCC) patients treated with oxaliplatin (OXA). Methods: Relative expression of plasma CLU mRNA was examined via fluorescence quantitative real-time PCR (qRT-PCR...
Articles
Biosci Rep (2020) 40 (2): BSR20193212.
Published: 11 February 2020
...Ying Lü; Jing Zhang; Lei Li; Shun Li; Zongguo Yang This report aimed to investigate the carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma (HCC). E2F8 expression level was compared in Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and Oncomine...
Articles
Biosci Rep (2020) 40 (1): BSR20194019.
Published: 17 January 2020
...He Xu; Wenjie Wei; Mu Y.; Chengwei Dong Jinlong capsule (JLC), a type of herbal medicine, is considered to be a promising adjuvant therapy for hepatocellular carcinoma (HC). Although an analysis of the published literature has been performed, the exact effects and safety of JLC are yet...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (1): BSR20192727.
Published: 02 January 2020
...Yun Huang; Chen Liu; Wu-Cha Zeng; Guo-Yan Xu; Jian-Min Wu; Zhi-Wen Li; Xuan-Yu Huang; Rong-Jin Lin; Xi Shi The overall survival rate of patients with hepatocellular carcinoma (HCC) has remained unchanged over the last several decades. Therefore, novel drugs and therapies are required for HCC...