... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . exercise obesity hepatic physiology skeletal muscle fat Obesity and its associated comorbidities represent major challenges to human health in the 21 st century [ 1 ]. The increasing prevalence...

... hepatic physiology insulin resistance MECR mitochondrial dysfunction Mitochondria provide intermediate metabolites (such as acetyl-CoA) to the glucose production pathway (gluconeogenesis) in hepatocytes in the maintenance of blood glucose by liver in the fasting conditions. The gluconeogenesis...