...Yu Zhang; Xin Yang; Xiao-Lin Zhu; Jia-Qi Hao; Hao Bai; You-Chao Xiao; Zhuang-Zhuang Wang; Chun-Yan Hao; Hu-Bin Duan Background: Glioblastoma (GBM) has a high degree of malignancy, aggressiveness and recurrence rate. However, there are limited options available for the treatment of GBM...

...Zhenlin Wang; Chenting Ying; Anke Zhang; Houshi Xu; Yang Jiang; Meiqing Lou The hematopoietic cell kinase (HCK), a member of the Src family protein-tyrosine kinases (SFKs), is primarily expressed in cells of the myeloid and B lymphocyte lineages. Nevertheless, the roles of HCK in glioblastoma (GBM...

...Liang Xue; Haibing Liu; Yehuang Chen; Liangfeng Wei; Jingfang Hong Background: Glioblastoma (GBM) is the most common malignant brain tumor with a poor prognosis. The initial treatment for high-grade gliomas is surgical excision. However, even with concomitant use of radiation or chemotherapy...

...% CI: 1.53–5.89, P =0.002), but not in patients with glioblastoma (HR: 1.26, 95% CI: 0.76–2.08, P =0.47; P for subgroup difference = 0.03). Results were not statistically different between subgroups according to patient ethnicity, sample size, CD44 detection method, CD44 cutoff, HR estimation...

... glioblastoma multiforme (GBM) remain elusive and ill-defined. The current study was designed to highlight the functional role and disclose the underlying molecular mechanism by which DLEU1 regulated GBM development. We found that DLEU1 was up-regulated in GBM and DLEU1 knockdown significantly inhibited GBM...

...Claire Lailler; Christophe Louandre; Mony Chenda Morisse; Thomas Lhossein; Corinne Godin; Marine Lottin; Jean-Marc Constans; Bruno Chauffert; Antoine Galmiche; Zuzana Saidak The tumor microenvironment is an important determinant of glioblastoma (GBM) progression and response to treatment. How...

...Marko Gjorgjevski; Ricarda Hannen; Barbara Carl; Yu Li; Emilie Landmann; Malte Buchholz; Jörg W. Bartsch; Christopher Nimsky Due to poor prognosis of glioblastoma (GBM), there is an urgent need to develop new therapeutic strategies. Besides eliminating GBM tumor cells and stem cells, a novel...

...Qing Yuan; Hong-Qing Cai; Yi Zhong; Min-Jie Zhang; Zhi-Jian Cheng; Jia-Jie Hao; Ming-Rong Wang; Jing-Hai Wan The prognosis of patients with glioblastoma (GBM) is dismal. It has been reported that Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) is associated with the mobility...

...Zhixiao Li; Rongjun Qian; Jiadong Zhang; Xiwen Shi Glioblastoma (GBM) is a main subtype of high-grade gliomas with features in progressive brain tumor. Lipoma HMGIC fusion partner-like 3 (LHFPL3) is reported to be highly expressed in malignant glioma, but the relationship and mechanism between...

...Minjie Tian; Wenying Ma; Yueqiu Chen; Yue Yu; Donglin Zhu; Jingping Shi; Yingdong Zhang Background: Preclinical models have suggested a role for sex hormones in the development of glioblastoma multiforme (GBM). However, the impact of gender on the survival time of patients with GBM has not been...

... for studies related to mechanisms of drug responsiveness or the search for new therapeutic approaches. The purpose of our work was to identify the potential differences in drug resistance and response to treatment of glioblastoma with the use of three in vitro models: traditional adherent culture, serum-free...