.../streptomycin solution, and maintained at 37°C under a 5% CO 2 atmosphere. Cell culture reagents were acquired from Sigma-Aldrich (St. Louis, MO/U.S.A.). chitosan gene therapy HEK293T cells IGFBP nuclear localization signals Gene therapy entails the transfer of therapeutic genetic material...

... The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . FGFR1 gastric cancer gene therapy miR-198 miRNA Gastric cancer (GC) is a prevalent...

... the Creative Commons Attribution License 4.0 (CC BY) . aberrant expression status chromosome remodeling gene therapy inhibitor of growth 4 mechanisms non-neoplastic diseases Tumor suppressor genes (TSGs) can oppose oncogene function and restrain cancer development, with inactivation of TSGs...

... © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy large intervening non-coding RNA microRNA oncogenesis gene therapy...

... and its induction was achieved with low Dox concentrations. Remarkably, the intracellular regulatory expression of 2LTRZFP significantly inhibited HIV-1 integration and replication in HIV-inoculated SupT1 cells. This approach could provide a potential tool for gene therapy applications, which efficiently...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cytoskeleton cell nucleus gene therapy intracellular transport microtubule nuclear protein transport Productive transfection and gene transfer require...

... and assess whether targeting this pathway has potential for reducing neointima formation. We utilized a gene therapy approach selectively targeting cells in which the β-catenin/TCF pathway is activated by using a recombinant adenovirus Ad-TOPTK, which carries a herpes simplex virus thymidine kinase (HSV-TK...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . endostatin gene therapy radiotherapy Conventional treatment modalities of cancer, such as surgery, radiotherapy and chemotherapy, have achieved...

... is a promising method that allows the targeting of gene therapy for heart failure. Furthermore, we found that the treated animals (liposomal magnetofection with shIGF1R) showed reduced septal and posterior wall thickness, reduced HW:BWs (heart weight-to-body weights) compared with controls. Moreover, we also...

.... © 2007 The Biochemical Society 2007 MNGIE Thymidine phosphorylase Thymidine Deoxyuridine Stem cells Gene therapy ORI GI N A L P A PE R Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE): Biochemical Features and Therapeutic Approaches M. C. Lara Æ M. L. Valentino Æ J. Torres...

... efficient in vivo gene delivery protocols. © 2006 Springer Science+Business Media, LLC 2006 Cationic lipid Cell uptake Endocytosis Gene therapy Gene delivery Nuclear import Plasmid DNA Stability Transfection Abstract Cationic lipids are conceptually and methodologically simple tools...

...-mediated transposition as a tool for gene transfer to chromosomes and ultimately for human gene therapy. Transfection of mouse 3T3 cells, HeLa cells, and human A549 lung carcinoma cells with a transposon containing the neomycin phosphotransferase ( NEO ) gene resulted in a several-fold increase in drug...

... Corporation 2002 Liposomes non-viral delivery systemic delivery gene therapy optimization Bioscience Reports, Vol. 22, No. 2, April 2002 ( 2002) MINI REVIEW Cationic Liposome-mediated Gene Delivery In vivo Nancy Smyth Templeton Receiûed Noûember 1, 2001 Several improvements have been made...

... attention to polyunsaturated lipids, membrane proteins and ion channels, surfactant additives in membranes, and lipid–DNA gene transfer complexes. © 2002 Plenum Publishing Corporation 2002 Biomembranes membrane proteins lipid–DNA complexes lipid–protein interactions gene therapy polyunsaturated...

... showed significantly less cytotoxicity compared to the commonly used cationic lipsomes or PEI mediated transfection and several cell lines were transfected with high efficiency. LPDII vectors avoid the use of toxic cationic lipids and may have potential application in gene therapy. © 2000 Plenum...