... Attribution License 4.0 (CC BY) . endothelial dysfunction extracellular vesicles placenta preeclampsia vascular function Preeclampsia (PE) is a pregnancy disorder occurring in 5–7% of pregnancies worldwide [ 1 ]. It is a major cause of maternal and neonatal mortality and a risk factor...

... against miR-335-5p-induced endothelial dysfunction. Furthermore, the direct binding of miR-335-5p to SIRT7 was observed in human embryonic kidney cells 293T (HEK 293T). Therefore, it can be inferred that miR-335-5p down-regulates the expression of SIRT7 in human cells. Current findings may provide deeper...

... of inflammation and endothelial dysfunction markers among Egyptian females with different obesity classes. Methods: Out of 130 females, 70 were categorized into three obesity groups: Class I, body mass index (BMI) 30–34.9 kg/m 2 ; Class II, BMI 35–39.9 kg/m 2 and Class III BMI ≥ 40 kg/m 2 , besides 60 control...

...Bingwei Li; Qiuju Zhang; Honggang Zhang; Chunxiao Wang; Ruijuan Xiu We aim to determine whether nebivolol has a better effect on endothelial dysfunction compared with other β-blockers or other classes of antihypertensive drugs. Searches of the PubMed, Embase etc. were performed to analyze all...

...Meng Jiang; Shanya Huang; Wang Duan; Qiaoshu Liu; Minxiang Lei Acid sphingomyelinase (aSMase) plays an important role in endothelial dysfunction. Here, we show that elevated aSMase activity and ceramide content were reduced by desipramine treatment in diabetic animals. The inhibitor of aSMase...

... 17 04 2018 19 06 2018 19 06 2018 © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . endothelial dysfunction...

..., such as diabetes and atherosclerosis. Irisin levels have been associated with diabetes, endothelial dysfunction and atherosclerosis. The objective of the present study was to investigate whether circulating irisin levels are correlated with skin AF values in type 2 diabetes patients. A total of 362 Chinese type 2...

.... In the present study, we try to explore the impact of TMAO on endothelial dysfunction. After TMAO treatment, human umbilical vein endothelial cells (HUVECs) showed significant impairment in cellular proliferation and HUVECs-extracellular matrix (ECM) adhesion compared with control. Likewise, TMAO markedly...

...Qingbin Zhao; Junfang Zhang; Huifang Wang Increasing evidences have accumulated that endothelial dysfunction is involved in the pathogenesis of hypertension. Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) has been identified as an essential factor that protects against...