...Ying Jing; Donghai Li MicroRNAs (miRNAs) play important roles in a variety of human diseases, including breast cancer. A number of miRNAs are up- and down-regulated in breast cancer. However, little is known about miRNA similarity and similarity network in breast cancer. Here, a collection of 272...

...Fajuan Cheng; Bin Zheng; Jianwei Wang; Guiting Zhao; Zhongshun Yao; Zhihong Niu; Wei He Histone deacetylase (HDAC) 10, a class II family, has been implicated in various tumors and non-tumor diseases, which makes the discovery of biological functions and novel inhibitors a fundamental endeavor...

... in these pathways can result in diseases of the brain, skeletal muscle, heart and liver, affecting approximately 1 in 5000 live births. There are no effective therapies for these disorders, with quality of life severely reduced for most patients. The pathology underlying many aspects of these diseases is not well...

... disease states including cancer, atherosclerosis and blindness. This family of growth factors and receptors is an important model system for understanding human disease pathology and developing new therapeutics for treating such ailments. disease drugs isoforms membrane trafficking receptor...

.... These processes are closely related to substrates degradation, antigen presentation, cell signalling, cell survival and microbial pathogen infection. Consistently, mutations or dysfunctions of Rab7 result in traffic disorders, which cause various diseases, such as neuropathy, cancer and lipid metabolism disease...

... zebrafish development. Chemical genetics using zebrafish embryos may become an important step in the discovery of drugs and their targets. © 2005 Springer Science+Business Media, Inc. 2005 Chemical genetics zebrafish development compounds inhibitors drug target disease Chemical Genetics...

..., the importance of the composition of the aqueous layer of the tear film in proper structuring of the lipid layer has not been recognized. Finally, lipid layer abnormalities and their relationship to ocular disease are beginning to be clarified. © 2001 Plenum Publishing Corporation 2001 Ocular tear film...