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Keywords: diabetes
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Biosci Rep (2023) 43 (1): BSR20221699.
Published: 23 December 2022
...Kwamie K. Harris; Bradley A. Welch; Allie M. Smith; Yilianys Pride; Bernadette E. Grayson The lifetime risk for Type 2 diabetes mellitus remains higher in people with spinal cord injuries (SCIs) than in the able-bodied population. However, the mechanisms driving this disparity remain poorly...
Biosci Rep (2022) 42 (5): BSR20211297.
Published: 18 May 2022
...Shahab Hassan; Kenneth White; Cassandra Terry There are over 40 identified human disorders that involve certain proteins folding incorrectly, accumulating in the body causing damage to cells and organs and causing disease. Type 2 Diabetes Mellitus (T2DM) is one of these protein misfolding disorders...
Includes: Supplementary data
Biosci Rep (2022) 42 (3): BSR20212209.
Published: 02 March 2022
...Jennifer Matthews; Lakshini Herat; Jennifer Rooney; Elizabeth Rakoczy; Markus Schlaich; Vance B. Matthews Diabetes mellitus is a chronic metabolic disease that occurs when the pancreas is not producing enough insulin or when the insulin that it does produce is not able to be used effectively...
Includes: Supplementary data
Biosci Rep (2021) 41 (8): BSR-2018-1852_RET.
Published: 24 August 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Arterial injury Atherosclerosis Atherosclerotic inflammation Diabetes miR...
Biosci Rep (2021) 41 (7): BSR20210495.
Published: 12 July 2021
...Devesh Kesharwani; Amit Kumar; Mukta Poojary; Vinod Scaria; Malabika Datta For a global epidemic like Type 2 diabetes mellitus (T2DM), while impaired gene regulation is identified as a primary cause of aberrant cellular physiology; in the past few years, non-coding RNAs (ncRNAs) have emerged...
Includes: Supplementary data
Biosci Rep (2021) 41 (4): BSR-20181852_EOC.
Published: 31 March 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Arterial injury Atherosclerosis Atherosclerotic inflammation Diabetes miR...
Biosci Rep (2020) 40 (7): BSR20200507.
Published: 07 July 2020
...Weiwei Liang; FangFang Sun This research was carried out to reveal specific hub genes involved in diabetic heart failure, as well as remarkable pathways that hub genes locate. The GSE26887 dataset from the GEO website was downloaded. The gene co-expression network was generated and central modules...
Includes: Supplementary data
Biosci Rep (2020) 40 (6): BSR20192118.
Published: 04 June 2020
...Wenyuan Li; Wei Li; Yan Leng; Yonghong Xiong; Rui Xue; Rong Chen; Zhongyuan Xia Ischemic heart disease is the main cardiovascular complication of diabetes patients which is mainly caused by oxidative stress. DJ-1 is the key regulator for myocardial protection through inhibiting phosphatase...
Includes: Supplementary data
Biosci Rep (2019) 39 (11): BSR20190817.
Published: 13 November 2019
...Nanwen Zhang; Haixiang Wei; Weifang Wu; Peimin Lin; Yuan Chen; Zhiwei Liu; Honglin Wang; Yize Bian; Kai Yu; Shan Lin; Yanqi Cui; Renwei Luo; Jianming Lin; Xiaole Chen Objective To determine the effect of ropivacaine on peripheral neuropathy in diabetic rats and its possible mechanism. Methods Forty...
Biosci Rep (2019) 39 (7): BSR20181852.
Published: 02 July 2019
...Yang Liu; Ling-yun Liu; Ye Jia; Yan-yan Sun; Fu-zhe Ma The present study aims to investigate the mechanism of miR-15a-5p in the atherosclerotic (AS) inflammatory response and arterial injury improvement in diabetic rats by regulating fatty acid synthase (FASN). Initially, bioinformatics tools were...
Biosci Rep (2019) 39 (6): BSR20190328.
Published: 18 June 2019
...Edoardo Midena; Silvia Bini; Luisa Frizziero; Elisabetta Pilotto; Graziana Esposito; Alessandra Micera Purpose: To determine if aqueous humour (AH) concentrations of Retinal Pigment Epithelium (RPE)’s biomarkers are modified after subthreshold micropulse laser (SMPL) treatment of diabetic macular...
Biosci Rep (2019) 39 (5): BSR20182051.
Published: 21 May 2019
..., suggesting their potential application in future stem cell based therapy for the treatment of diabetes. Correspondence: Gyu-Jin Rho ( jinrho@gnu.ac.kr ) 08 11 2018 16 03 2019 10 04 2019 23 04 2019 © 2019 The Author(s). 2019 This is an open access article published...
Includes: Supplementary data
Biosci Rep (2019) 39 (4): BSR20181729.
Published: 30 April 2019
...Jing Cheng; Jia Zheng; Yanping Liu; Panpan Hao The morbidity of type 2 diabetes mellitus (T2DM) has been increasing rapidly worldwide. Tangminling pill, consisting of ten Chinese herbal medications, is usually prescribed for T2DM in mainland China. Whether treatment with Tangminling can improve...
Biosci Rep (2019) 39 (4): BSR20182144.
Published: 23 April 2019
...Meng Jiang; Shanya Huang; Wang Duan; Qiaoshu Liu; Minxiang Lei Acid sphingomyelinase (aSMase) plays an important role in endothelial dysfunction. Here, we show that elevated aSMase activity and ceramide content were reduced by desipramine treatment in diabetic animals. The inhibitor of aSMase...
Biosci Rep (2019) 39 (2): BSR20181995.
Published: 15 February 2019
...Qingguo Lu; Xuan Li; Jia Liu; Xiaodong Sun; Thomas Rousselle; Di Ren; Nanwei Tong; Ji Li Diabetics have higher morbidity and mortality in cardiovascular disease (CVD). A variety of antidiabetic agents are available for clinical choice. Cardiovascular (CV) safety assessment of these agents...
Biosci Rep (2019) 39 (1): BSR20181614.
Published: 15 January 2019
...Si Shi; Shaoqing Lei; Chaoliang Tang; Kai Wang; Zhongyuan Xia Background and aims: Diabetic kidney is more sensitive to ischemia/reperfusion (I/R) injury, which is associated with increased oxidative stress and impaired nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1...
Biosci Rep (2018) 38 (5): BSR20181042.
Published: 28 September 2018
...Qian Hou; Ke Hu; Xiaofeng Liu; Jiao Quan; Zehao Liu Vascular dysfunction is a common result of diabetes in humans. However, the mechanism underlying diabetic vascular dysfunction is not fully understood. Here in the present study, we showed that the histone deacetylase 2 (HDAC2) promoted...
Includes: Supplementary data
Biosci Rep (2018) 38 (4): BSR20180127.
Published: 03 July 2018
...Huajie Li; Dan Ye; Wei Xie; Fei Hua; Yilin Yang; Jian Wu; Aifang Gu; Yi Ren; Keshi Mao Diabetes is a risk factor for Alzheimer’s disease (AD) in humans. Branched-chain amino acids (BCAAs, namely valine, leucine, and isoleucine) metabolic defect is observed in human diabetes, which is associated...
Includes: Supplementary data
Biosci Rep (2018) 38 (2): BSR20171208.
Published: 21 March 2018
... in vascular endothelial injury. It is an important factor in the development of diabetes mellitus (DM). The aim of the present study was to screen out the potential candidate microRNAs (miRNAs) in DM patients with BSS by high-throughput sequencing (HTS) and bioinformatics analysis. Human umbilical vein...
Biosci Rep (2018) 38 (2): BSR20180059.
Published: 16 March 2018
...Qian Zhang; Xinhua Xiao; Jia Zheng; Ming Li; Miao Yu; Fan Ping; Tong Wang; Xiaojing Wang Increasing evidence shows that diabetes causes cardiac dysfunction. We hypothesized that a glucagon-like peptide-1 (GLP-1) analog, liraglutide, would attenuate cardiac dysfunction in diabetic rats. A total...
Biosci Rep (2017) 37 (5): BSR20170886.
Published: 17 October 2017
...Nattayaporn Apaijai; Narattaphol Charoenphandhu; Jitjiroj Ittichaichareon; Panan Suntornsaratoon; Nateetip Krishnamra; Ratchaneevan Aeimlapa; Siriporn C. Chattipakorn; Nipon Chattipakorn Both Type 2 diabetes mellitus (T2DM) and estrogen deprivation have been shown to be associated...
Biosci Rep (2017) 37 (4): BSR20171079.
Published: 31 August 2017
...), extracellular acidification rate (ECAR) and intracellular signalling. In addition, we assessed in vivo proliferation, cytokine production and cytolytic activity of cells in chemically induced diabetic C57BL/6 mice. Elevated levels of glucose in in vitro cultures had modest effects on proliferation and cytokine...
Includes: Supplementary data
Biosci Rep (2017) 37 (3): BSR20170289.
Published: 21 June 2017
...Yi-Min Zhang; Xin Jiang; Yan-Shan Sun The present study estimates the effect of rivaroxaban on preventing deep vein thrombosis (DVT) in aged diabetics with femoral neck fractures after hip replacement. Our study consisted of 236 aged diabetics with femoral neck fractures, which were divided...
Biosci Rep (2017) 37 (2): BSR20160557.
Published: 10 April 2017
...Zhi-da Wang; Yu-fei Xia; Yue Zhao; Li-ming Chen This meta-analysis was performed to evaluate the effect of cognitive behavioural therapy (CBT) in improving the depression symptoms of patients with diabetes. Literature search was conducted in PubMed and Embase up to October 2016 without the initial...
Biosci Rep (2016) 36 (6): e00421.
Published: 05 December 2016
...Martin Larsson; Grazyna Lietzau; David Nathanson; Claes-Göran Östenson; Carina Mallard; Maria E. Johansson; Thomas Nyström; Cesare Patrone; Vladimer Darsalia Type 2 diabetic (T2D) patients often develop early cognitive and sensorimotor impairments. The pathophysiological mechanisms behind...
Biosci Rep (2016) 36 (6): e00416.
Published: 29 November 2016
...María M. Adeva-Andany; Noemi Pérez-Felpete; Carlos Fernández-Fernández; Cristóbal Donapetry-García; Cristina Pazos-García Information about normal hepatic glucose metabolism may help to understand pathogenic mechanisms underlying obesity and diabetes mellitus. In addition, liver glucose metabolism...
Biosci Rep (2016) 36 (1): e00285.
Published: 15 January 2016
...Rachel L. Dods; Dan Donnelly Glucagon-like peptide-1 (7–36)amide (GLP-1) plays a central role in regulating blood sugar levels and its receptor, GLP-1R, is a target for anti-diabetic agents such as the peptide agonist drugs exenatide and liraglutide. In order to understand the molecular nature...
Includes: Supplementary data
Biosci Rep (2015) 35 (3): e00219.
Published: 22 June 2015
...Zheng Zhenzhong; Yu Yafa; Liang Jin Fibrinogen-like protein 2 (Fgl2) is involved in apoptosis, angiogenesis and inflammatory response. Diabetes is closely associated with apoptosis, angiogenesis and coagulation. So it allowed us to assume that Fgl2 plays an important role during the process...
Biosci Rep (2012) 32 (5): 423–432.
Published: 20 July 2012
...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cognition diabetes energy homoeostasis ghrelin hormone insulin leptin neural circuitry neurodegeneration Food intake...
Biosci Rep (2011) 31 (5): 411–419.
Published: 05 August 2011
...Geun Bae Rha; Guangteng Wu; Young-In Chi HNF4α (hepatocyte nuclear factor 4α) is a culprit gene product for a monogenic and dominantly inherited form of diabetes, referred to as MODY (maturity onset diabetes of the young). As a member of the NR (nuclear receptor) superfamily, HNF4α recruits...
Includes: Supplementary data
Biosci Rep (2009) 29 (6): 397–404.
Published: 02 September 2009
...Pei Lai; Francesco Michelangeli Diabetes mellitus-related vascular disease is often associated with both a dysregulation of Ca 2+ homoeostasis and enhanced secretory activity in VSMCs (vascular smooth muscle cells). Here, we employ a commonly used rat cell line for VSMCs (A7r5 cells) to investigate...
Biosci Rep (2003) 23 (5-6): 313–337.
Published: 01 October 2003
...Aya Sato; Hitoshi Endo; Kazuo Umetsu; Hideyuki Sone; Yoshiko Yanagisawa; Azusa Saigusa; Sayuri Aita; Yasuo Kagawa Mitochondrial DNA (mtDNA) is highly susceptible to mutations that result in polymorphisms and diseases including diabetes. We analyzed heteroplasmy, polymorphisms related to diabetes...
Biosci Rep (1999) 19 (6): 511–523.
Published: 01 December 1999
... by the glucose concentration by inducing locomotor activity in otherwise non-locomoting cells and by improving adhesion to the substratum. © 1999 Plenum Publishing Corporation 1999 Polymorphonuclear leukocytes motility locomotion diabetes adhesion Bioscience Reports, Vol. 19, No. 6, 1999...
Biosci Rep (1998) 18 (4): 187–198.
Published: 01 August 1998
... in streptozotocin (STZ)-diabetic rat retina (Kowluru et al. Diabetologia 35: 624–631, 1992). Since NDP kinase hasbeen implicated in direct interaction with and/or activation of various G-proteins, we quantitated both basal and magnesium-stimulated NDP kinase activity in soluble and particulate fractions of retina...
Biosci Rep (1995) 15 (1): 15–20.
Published: 01 February 1995
...M. E. Martin; A. M. Garcia; L. Blanco; E. Herrera; M. Salinas To study the effect of diabetes on hepatic protein synthesis and polysomal aggregation in pregnant rats, female rats were treated with streptozotocin prior to conception. Some animals were mated, and studied at day 20 of pregnancy...
Biosci Rep (1988) 8 (3): 233–240.
Published: 01 June 1988
...L. G. Guijarro; M. P. Lopez-Ruiz; J. C. Prieto; E. Arilla Diabetes was induced by administration of alloxan (150 mg/Kg) to 24 h-fasted rabbits. Somatostatinlike immunoreactivity (SLI) and cytosolic binding sites for somatostatin in gastric fundic mucosa were studied using radiolabelled Tyr 11...
Biosci Rep (1987) 7 (2): 129–133.
Published: 01 February 1987
...Evelyne Rouer; Patricia Rouet; Jean Paul Leroux Aldrin epoxidase activity in liver microsomes from streptozotocin-diabetic rats is only 40% of that from normal rats. Epoxidation of aldrin has also been assayed in freshly isolated hepatocytes from normal rats. Addition of 10 −7 M glucagon...