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Articles

Nutritional strategies for intervention of diabetes and improvement of β-cell function

Siying Wei, Chenchen Li, Zinan Wang, Yan Chen

Biosci Rep (2023) 43 (2): BSR20222151.

DOI: https://doi.org/10.1042/BSR20222151

Published: 16 February 2023

...Siying Wei; Chenchen Li; Zinan Wang; Yan Chen Diabetes mellitus, especially Type 2 diabetes (T2D), is caused by multiple factors including genetics, diets, and lifestyles. Diabetes is a chronic condition and is among the top 10 causes of death globally. Nutritional intervention is one of the most...

View article titled, Nutritional strategies for intervention of diabetes and improvement of β-cell function

Articles

Altered chronic glycemic control in a clinically relevant model of rat thoracic spinal contusion

Kwamie K. Harris, Bradley A. Welch, Allie M. Smith, Yilianys Pride, Bernadette E. Grayson

Biosci Rep (2023) 43 (1): BSR20221699.

DOI: https://doi.org/10.1042/BSR20221699

Published: 23 December 2022

...Kwamie K. Harris; Bradley A. Welch; Allie M. Smith; Yilianys Pride; Bernadette E. Grayson The lifetime risk for Type 2 diabetes mellitus remains higher in people with spinal cord injuries (SCIs) than in the able-bodied population. However, the mechanisms driving this disparity remain poorly...

View article titled, Altered chronic glycemic control in a clinically relevant model of rat thoracic spinal contusion

Articles

Linking hIAPP misfolding and aggregation with type 2 diabetes mellitus: a structural perspective

Shahab Hassan, Kenneth White, Cassandra Terry

Biosci Rep (2022) 42 (5): BSR20211297.

DOI: https://doi.org/10.1042/BSR20211297

Published: 18 May 2022

...Shahab Hassan; Kenneth White; Cassandra Terry There are over 40 identified human disorders that involve certain proteins folding incorrectly, accumulating in the body causing damage to cells and organs and causing disease. Type 2 Diabetes Mellitus (T2DM) is one of these protein misfolding disorders...

View article titled, Linking hIAPP misfolding and aggregation with type 2 diabetes mellitus: a structural perspective

Includes: Supplementary data

Articles

Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy

Jennifer Matthews, Lakshini Herat, Jennifer Rooney, Elizabeth Rakoczy, Markus Schlaich, Vance B. Matthews

Biosci Rep (2022) 42 (3): BSR20212209.

DOI: https://doi.org/10.1042/BSR20212209

Published: 02 March 2022

...Jennifer Matthews; Lakshini Herat; Jennifer Rooney; Elizabeth Rakoczy; Markus Schlaich; Vance B. Matthews Diabetes mellitus is a chronic metabolic disease that occurs when the pancreas is not producing enough insulin or when the insulin that it does produce is not able to be used effectively...

View article titled, Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy

Includes: Supplementary data

Articles

Retraction: Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN

Biosci Rep (2021) 41 (8): BSR-2018-1852_RET.

DOI: https://doi.org/10.1042/BSR-2018-1852_RET

Published: 24 August 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Arterial injury Atherosclerosis Atherosclerotic inflammation Diabetes miR...

View article titled, Retraction: Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN

Articles

RNA sequencing reveals potential interacting networks between the altered transcriptome and ncRNome in the skeletal muscle of diabetic mice

Devesh Kesharwani, Amit Kumar, Mukta Poojary, Vinod Scaria, Malabika Datta

Biosci Rep (2021) 41 (7): BSR20210495.

DOI: https://doi.org/10.1042/BSR20210495

Published: 12 July 2021

...Devesh Kesharwani; Amit Kumar; Mukta Poojary; Vinod Scaria; Malabika Datta For a global epidemic like Type 2 diabetes mellitus (T2DM), while impaired gene regulation is identified as a primary cause of aberrant cellular physiology; in the past few years, non-coding RNAs (ncRNAs) have emerged...

View article titled, RNA sequencing reveals potential interacting networks between the altered transcriptome and ncRNome in the skeletal muscle of diabetic mice

Includes: Supplementary data

Articles

Expression of Concern: Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN

Biosci Rep (2021) 41 (4): BSR-20181852_EOC.

DOI: https://doi.org/10.1042/BSR-20181852_EOC

Published: 31 March 2021

... Arterial injury Atherosclerosis Atherosclerotic inflammation Diabetes miR-15a-5p The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office...

View article titled, Expression of Concern: Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN

Articles

Weighted gene co-expression network analysis to define pivotal modules and genes in diabetic heart failure

Weiwei Liang, FangFang Sun

Biosci Rep (2020) 40 (7): BSR20200507.

DOI: https://doi.org/10.1042/BSR20200507

Published: 07 July 2020

...Weiwei Liang; FangFang Sun This research was carried out to reveal specific hub genes involved in diabetic heart failure, as well as remarkable pathways that hub genes locate. The GSE26887 dataset from the GEO website was downloaded. The gene co-expression network was generated and central modules...

View article titled, Weighted gene co-expression network analysis to define pivotal modules and genes in diabetic heart failure

Includes: Supplementary data

Articles

Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1

Wenyuan Li, Wei Li, Yan Leng, Yonghong Xiong, Rui Xue, Rong Chen, Zhongyuan Xia

Biosci Rep (2020) 40 (6): BSR20192118.

DOI: https://doi.org/10.1042/BSR20192118

Published: 04 June 2020

...Wenyuan Li; Wei Li; Yan Leng; Yonghong Xiong; Rui Xue; Rong Chen; Zhongyuan Xia Ischemic heart disease is the main cardiovascular complication of diabetes patients which is mainly caused by oxidative stress. DJ-1 is the key regulator for myocardial protection through inhibiting phosphatase...

View article titled, Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1

Includes: Supplementary data

Articles

Effect of ropivacaine on peripheral neuropathy in streptozocin diabetes-induced rats through TRPV1-CGRP pathway

Nanwen Zhang, Haixiang Wei, Weifang Wu, Peimin Lin, Yuan Chen, Zhiwei Liu, Honglin Wang, Yize Bian, Kai Yu, Shan Lin, Yanqi Cui, Renwei Luo, Jianming Lin, Xiaole Chen

Biosci Rep (2019) 39 (11): BSR20190817.

DOI: https://doi.org/10.1042/BSR20190817

Published: 13 November 2019

...Nanwen Zhang; Haixiang Wei; Weifang Wu; Peimin Lin; Yuan Chen; Zhiwei Liu; Honglin Wang; Yize Bian; Kai Yu; Shan Lin; Yanqi Cui; Renwei Luo; Jianming Lin; Xiaole Chen Objective To determine the effect of ropivacaine on peripheral neuropathy in diabetic rats and its possible mechanism. Methods Forty...

View article titled, Effect of ropivacaine on peripheral neuropathy in streptozocin diabetes-induced rats through TRPV1-CGRP pathway

Articles

Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN

Yang Liu, Ling-yun Liu, Ye Jia, Yan-yan Sun, Fu-zhe Ma

Biosci Rep (2019) 39 (7): BSR20181852.

DOI: https://doi.org/10.1042/BSR20181852

Published: 02 July 2019

...Yang Liu; Ling-yun Liu; Ye Jia; Yan-yan Sun; Fu-zhe Ma The present study aims to investigate the mechanism of miR-15a-5p in the atherosclerotic (AS) inflammatory response and arterial injury improvement in diabetic rats by regulating fatty acid synthase (FASN). Initially, bioinformatics tools were...

View article titled, Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN

Articles

Aqueous humour concentrations of PEDF and Erythropoietin are not influenced by subthreshold micropulse laser treatment of diabetic macular edema

Edoardo Midena, Silvia Bini, Luisa Frizziero, Elisabetta Pilotto, Graziana Esposito, Alessandra Micera

Biosci Rep (2019) 39 (6): BSR20190328.

DOI: https://doi.org/10.1042/BSR20190328

Published: 18 June 2019

...Edoardo Midena; Silvia Bini; Luisa Frizziero; Elisabetta Pilotto; Graziana Esposito; Alessandra Micera Purpose: To determine if aqueous humour (AH) concentrations of Retinal Pigment Epithelium (RPE)’s biomarkers are modified after subthreshold micropulse laser (SMPL) treatment of diabetic macular...

View article titled, Aqueous humour concentrations of PEDF and Erythropoietin are not influenced by subthreshold micropulse laser treatment of diabetic macular edema

Articles

In vitro differentiation of single donor derived human dental mesenchymal stem cells into pancreatic β cell-like cells

Sharath B. Shivakumar, Hyeon-Jeong Lee, Young-Bum Son, Dinesh Bharti, Sun A. Ock, Sung-Lim Lee, Young-Hoon Kang, Bong-Wook Park, Gyu-Jin Rho

Biosci Rep (2019) 39 (5): BSR20182051.

DOI: https://doi.org/10.1042/BSR20182051

Published: 21 May 2019

..., suggesting their potential application in future stem cell based therapy for the treatment of diabetes. Correspondence: Gyu-Jin Rho ( jinrho@gnu.ac.kr ) 08 11 2018 16 03 2019 10 04 2019 23 04 2019 © 2019 The Author(s). 2019 This is an open access article published...

View article titled, In vitro differentiation of single donor derived human dental mesenchymal stem cells into pancreatic β cell-like cells

Includes: Supplementary data

Articles

Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

Jing Cheng, Jia Zheng, Yanping Liu, Panpan Hao

Biosci Rep (2019) 39 (4): BSR20181729.

DOI: https://doi.org/10.1042/BSR20181729

Published: 30 April 2019

...Jing Cheng; Jia Zheng; Yanping Liu; Panpan Hao The morbidity of type 2 diabetes mellitus (T2DM) has been increasing rapidly worldwide. Tangminling pill, consisting of ten Chinese herbal medications, is usually prescribed for T2DM in mainland China. Whether treatment with Tangminling can improve...

View article titled, Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

Articles

Inhibition of acid sphingomyelinase activity ameliorates endothelial dysfunction in db/db mice

Meng Jiang, Shanya Huang, Wang Duan, Qiaoshu Liu, Minxiang Lei

Biosci Rep (2019) 39 (4): BSR20182144.

DOI: https://doi.org/10.1042/BSR20182144

Published: 23 April 2019

...Meng Jiang; Shanya Huang; Wang Duan; Qiaoshu Liu; Minxiang Lei Acid sphingomyelinase (aSMase) plays an important role in endothelial dysfunction. Here, we show that elevated aSMase activity and ceramide content were reduced by desipramine treatment in diabetic animals. The inhibitor of aSMase...

View article titled, Inhibition of acid sphingomyelinase activity ameliorates endothelial dysfunction in db/db mice

Articles

AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases

Qingguo Lu, Xuan Li, Jia Liu, Xiaodong Sun, Thomas Rousselle, Di Ren, Nanwei Tong, Ji Li

Biosci Rep (2019) 39 (2): BSR20181995.

DOI: https://doi.org/10.1042/BSR20181995

Published: 15 February 2019

...Qingguo Lu; Xuan Li; Jia Liu; Xiaodong Sun; Thomas Rousselle; Di Ren; Nanwei Tong; Ji Li Diabetics have higher morbidity and mortality in cardiovascular disease (CVD). A variety of antidiabetic agents are available for clinical choice. Cardiovascular (CV) safety assessment of these agents...

View article titled, AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases

Articles

Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

Si Shi, Shaoqing Lei, Chaoliang Tang, Kai Wang, Zhongyuan Xia

Biosci Rep (2019) 39 (1): BSR20181614.

DOI: https://doi.org/10.1042/BSR20181614

Published: 15 January 2019

...Si Shi; Shaoqing Lei; Chaoliang Tang; Kai Wang; Zhongyuan Xia Background and aims: Diabetic kidney is more sensitive to ischemia/reperfusion (I/R) injury, which is associated with increased oxidative stress and impaired nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1...

View article titled, Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

Articles

HADC regulates the diabetic vascular endothelial dysfunction by targetting MnSOD

Qian Hou, Ke Hu, Xiaofeng Liu, Jiao Quan, Zehao Liu

Biosci Rep (2018) 38 (5): BSR20181042.

DOI: https://doi.org/10.1042/BSR20181042

Published: 28 September 2018

...Qian Hou; Ke Hu; Xiaofeng Liu; Jiao Quan; Zehao Liu Vascular dysfunction is a common result of diabetes in humans. However, the mechanism underlying diabetic vascular dysfunction is not fully understood. Here in the present study, we showed that the histone deacetylase 2 (HDAC2) promoted...

View article titled, HADC regulates the diabetic vascular endothelial dysfunction by targetting MnSOD

Includes: Supplementary data

Articles

Defect of branched-chain amino acid metabolism promotes the development of Alzheimer’s disease by targeting the mTOR signaling

Huajie Li, Dan Ye, Wei Xie, Fei Hua, Yilin Yang, Jian Wu, Aifang Gu, Yi Ren, Keshi Mao

Biosci Rep (2018) 38 (4): BSR20180127.

DOI: https://doi.org/10.1042/BSR20180127

Published: 03 July 2018

...Huajie Li; Dan Ye; Wei Xie; Fei Hua; Yilin Yang; Jian Wu; Aifang Gu; Yi Ren; Keshi Mao Diabetes is a risk factor for Alzheimer’s disease (AD) in humans. Branched-chain amino acids (BCAAs, namely valine, leucine, and isoleucine) metabolic defect is observed in human diabetes, which is associated...

View article titled, Defect of branched-chain amino acid metabolism promotes the development of Alzheimer’s disease by targeting the mTOR signaling

Includes: Supplementary data

Articles

Bioinformatics analysis of microRNAs related to blood stasis syndrome in diabetes mellitus patients

Ruixue Chen, Minghao Chen, Ya Xiao, Qiuer Liang, Yunfei Cai, Liguo Chen, Meixia Fang

Biosci Rep (2018) 38 (2): BSR20171208.

DOI: https://doi.org/10.1042/BSR20171208

Published: 21 March 2018

... in vascular endothelial injury. It is an important factor in the development of diabetes mellitus (DM). The aim of the present study was to screen out the potential candidate microRNAs (miRNAs) in DM patients with BSS by high-throughput sequencing (HTS) and bioinformatics analysis. Human umbilical vein...

View article titled, Bioinformatics analysis of microRNAs related to blood stasis syndrome in diabetes mellitus patients

Articles

Liraglutide protects cardiac function in diabetic rats through the PPARα pathway

Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang

Biosci Rep (2018) 38 (2): BSR20180059.

DOI: https://doi.org/10.1042/BSR20180059

Published: 16 March 2018

...Qian Zhang; Xinhua Xiao; Jia Zheng; Ming Li; Miao Yu; Fan Ping; Tong Wang; Xiaojing Wang Increasing evidence shows that diabetes causes cardiac dysfunction. We hypothesized that a glucagon-like peptide-1 (GLP-1) analog, liraglutide, would attenuate cardiac dysfunction in diabetic rats. A total...

View article titled, Liraglutide protects cardiac function in diabetic rats through the PPARα pathway

Articles

Estrogen deprivation aggravates cardiac hypertrophy in nonobese Type 2 diabetic Goto–Kakizaki (GK) rats

Nattayaporn Apaijai, Narattaphol Charoenphandhu, Jitjiroj Ittichaichareon, Panan Suntornsaratoon, Nateetip Krishnamra, Ratchaneevan Aeimlapa, Siriporn C. Chattipakorn, Nipon Chattipakorn

Biosci Rep (2017) 37 (5): BSR20170886.

DOI: https://doi.org/10.1042/BSR20170886

Published: 17 October 2017

...Nattayaporn Apaijai; Narattaphol Charoenphandhu; Jitjiroj Ittichaichareon; Panan Suntornsaratoon; Nateetip Krishnamra; Ratchaneevan Aeimlapa; Siriporn C. Chattipakorn; Nipon Chattipakorn Both Type 2 diabetes mellitus (T2DM) and estrogen deprivation have been shown to be associated...

View article titled, Estrogen deprivation aggravates cardiac hypertrophy in nonobese Type 2 diabetic Goto–Kakizaki (GK) rats

Articles

Hyperglycaemia does not affect antigen-specific activation and cytolytic killing by CD8 + T cells in vivo

Asha Recino, Kerry Barkan, F. Susan Wong, Graham Ladds, Anne Cooke, Maja Wallberg

Biosci Rep (2017) 37 (4): BSR20171079.

DOI: https://doi.org/10.1042/BSR20171079

Published: 31 August 2017

...), extracellular acidification rate (ECAR) and intracellular signalling. In addition, we assessed in vivo proliferation, cytokine production and cytolytic activity of cells in chemically induced diabetic C57BL/6 mice. Elevated levels of glucose in in vitro cultures had modest effects on proliferation and cytokine...

View article titled, Hyperglycaemia does not affect antigen-specific activation and cytolytic killing by CD8 + T cells in vivo

Includes: Supplementary data

Articles

Effect of rivaroxaban on preventing deep vein thrombosis in aged diabetics with femoral neck fractures after hip replacement

Yi-Min Zhang, Xin Jiang, Yan-Shan Sun

Biosci Rep (2017) 37 (3): BSR20170289.

DOI: https://doi.org/10.1042/BSR20170289

Published: 21 June 2017

...Yi-Min Zhang; Xin Jiang; Yan-Shan Sun The present study estimates the effect of rivaroxaban on preventing deep vein thrombosis (DVT) in aged diabetics with femoral neck fractures after hip replacement. Our study consisted of 236 aged diabetics with femoral neck fractures, which were divided...

View article titled, Effect of rivaroxaban on preventing deep vein thrombosis in aged diabetics with femoral neck fractures after hip replacement

Articles

Cognitive behavioural therapy on improving the depression symptoms in patients with diabetes: a meta-analysis of randomized control trials

Zhi-da Wang, Yu-fei Xia, Yue Zhao, Li-ming Chen

Biosci Rep (2017) 37 (2): BSR20160557.

DOI: https://doi.org/10.1042/BSR20160557

Published: 10 April 2017

...Zhi-da Wang; Yu-fei Xia; Yue Zhao; Li-ming Chen This meta-analysis was performed to evaluate the effect of cognitive behavioural therapy (CBT) in improving the depression symptoms of patients with diabetes. Literature search was conducted in PubMed and Embase up to October 2016 without the initial...

View article titled, Cognitive behavioural therapy on improving the depression symptoms in patients with diabetes: a meta-analysis of randomized control trials

Articles

Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4

Martin Larsson, Grazyna Lietzau, David Nathanson, Claes-Göran Östenson, Carina Mallard, Maria E. Johansson, Thomas Nyström, Cesare Patrone, Vladimer Darsalia

Biosci Rep (2016) 36 (6): e00421.

DOI: https://doi.org/10.1042/BSR20160437

Published: 05 December 2016

...Martin Larsson; Grazyna Lietzau; David Nathanson; Claes-Göran Östenson; Carina Mallard; Maria E. Johansson; Thomas Nyström; Cesare Patrone; Vladimer Darsalia Type 2 diabetic (T2D) patients often develop early cognitive and sensorimotor impairments. The pathophysiological mechanisms behind...

View article titled, Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4

Articles

Liver glucose metabolism in humans

María M. Adeva-Andany, Noemi Pérez-Felpete, Carlos Fernández-Fernández, Cristóbal Donapetry-García, Cristina Pazos-García

Biosci Rep (2016) 36 (6): e00416.

DOI: https://doi.org/10.1042/BSR20160385

Published: 29 November 2016

...María M. Adeva-Andany; Noemi Pérez-Felpete; Carlos Fernández-Fernández; Cristóbal Donapetry-García; Cristina Pazos-García Information about normal hepatic glucose metabolism may help to understand pathogenic mechanisms underlying obesity and diabetes mellitus. In addition, liver glucose metabolism...

View article titled, Liver glucose metabolism in humans

Articles

The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling

Rachel L. Dods, Dan Donnelly

Biosci Rep (2016) 36 (1): e00285.

DOI: https://doi.org/10.1042/BSR20150253

Published: 15 January 2016

...Rachel L. Dods; Dan Donnelly Glucagon-like peptide-1 (7–36)amide (GLP-1) plays a central role in regulating blood sugar levels and its receptor, GLP-1R, is a target for anti-diabetic agents such as the peptide agonist drugs exenatide and liraglutide. In order to understand the molecular nature...

View article titled, The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling

Includes: Supplementary data

Articles

Fibrinogen-like protein 2 gene silencing inhibits cardiomyocytes apoptosis, improves heart function of streptozotocin-induced diabetes rats and the molecular mechanism involved

Zheng Zhenzhong, Yu Yafa, Liang Jin

Biosci Rep (2015) 35 (3): e00219.

DOI: https://doi.org/10.1042/BSR20150078

Published: 22 June 2015

...Zheng Zhenzhong; Yu Yafa; Liang Jin Fibrinogen-like protein 2 (Fgl2) is involved in apoptosis, angiogenesis and inflammatory response. Diabetes is closely associated with apoptosis, angiogenesis and coagulation. So it allowed us to assume that Fgl2 plays an important role during the process...

View article titled, Fibrinogen-like protein 2 gene silencing inhibits cardiomyocytes apoptosis, improves heart function of streptozotocin-induced diabetes rats and the molecular mechanism involved

Articles

Regulation of synaptic functions in central nervous system by endocrine hormones and the maintenance of energy homoeostasis

Zhiping P. Pang, Weiping Han

Biosci Rep (2012) 32 (5): 423–432.

DOI: https://doi.org/10.1042/BSR20120026

Published: 20 July 2012

..., distribution and reproduction in any medium, provided the original work is properly cited. cognition diabetes energy homoeostasis ghrelin hormone insulin leptin neural circuitry neurodegeneration Besides the hypothalamus, LepRb is present in several brain regions related to cognition [ 42...

View article titled, Regulation of synaptic functions in central nervous system by endocrine hormones and the maintenance of energy homoeostasis

Articles

Probing the effect of MODY mutations near the co-activator-binding pocket of HNF4α

Geun Bae Rha, Guangteng Wu, Young-In Chi

Biosci Rep (2011) 31 (5): 411–419.

DOI: https://doi.org/10.1042/BSR20110013

Published: 05 August 2011

...Geun Bae Rha; Guangteng Wu; Young-In Chi HNF4α (hepatocyte nuclear factor 4α) is a culprit gene product for a monogenic and dominantly inherited form of diabetes, referred to as MODY (maturity onset diabetes of the young). As a member of the NR (nuclear receptor) superfamily, HNF4α recruits...

View article titled, Probing the effect of MODY mutations near the co-activator-binding pocket of HNF4α

Includes: Supplementary data

Articles

Changes in expression and activity of the secretory pathway Ca 2+ ATPase 1 (SPCA1) in A7r5 vascular smooth muscle cells cultured at different glucose concentrations

Pei Lai, Francesco Michelangeli

Biosci Rep (2009) 29 (6): 397–404.

DOI: https://doi.org/10.1042/BSR20090058

Published: 02 September 2009

...Pei Lai; Francesco Michelangeli Diabetes mellitus-related vascular disease is often associated with both a dysregulation of Ca 2+ homoeostasis and enhanced secretory activity in VSMCs (vascular smooth muscle cells). Here, we employ a commonly used rat cell line for VSMCs (A7r5 cells) to investigate...

View article titled, Changes in expression and activity of the secretory pathway Ca 2+ ATPase 1 (SPCA1) in A7r5 vascular smooth muscle cells cultured at different glucose concentrations

Articles

Polymorphism, Heteroplasmy, Mitochondrial Fusion and Diabetes

Aya Sato, Hitoshi Endo, Kazuo Umetsu, Hideyuki Sone, Yoshiko Yanagisawa, Azusa Saigusa, Sayuri Aita, Yasuo Kagawa

Biosci Rep (2003) 23 (5-6): 313–337.

DOI: https://doi.org/10.1023/B:BIRE.0000019189.35983.b9

Published: 01 October 2003

...Aya Sato; Hitoshi Endo; Kazuo Umetsu; Hideyuki Sone; Yoshiko Yanagisawa; Azusa Saigusa; Sayuri Aita; Yasuo Kagawa Mitochondrial DNA (mtDNA) is highly susceptible to mutations that result in polymorphisms and diseases including diabetes. We analyzed heteroplasmy, polymorphisms related to diabetes...

View article titled, Polymorphism, Heteroplasmy, Mitochondrial Fusion and Diabetes

Articles

The Glucose Concentration Modulates N -Formyl-Methionyl-Leucyl-Phenylalanine (fMet-Leu-Phe)-Stimulated Chemokinesis in Normal Human Neutrophils

Per-Arne Oldenborg, Janove Sehlin

Biosci Rep (1999) 19 (6): 511–523.

DOI: https://doi.org/10.1023/A:1020286010551

Published: 01 December 1999

... by the glucose concentration by inducing locomotor activity in otherwise non-locomoting cells and by improving adhesion to the substratum. © 1999 Plenum Publishing Corporation 1999 Polymorphonuclear leukocytes motility locomotion diabetes adhesion Bioscience Reports, Vol. 19, No. 6, 1999...

View article titled, The Glucose Concentration Modulates N -Formyl-Methionyl-Leucyl-Phenylalanine (fMet-Leu-Phe)-Stimulated Chemokinesis in Normal Human Neutrophils

Articles

Subcellular Localization and Characterization of Nucleoside Diphosphate Kinase in Rat Retina: Effect of Diabetes

Anjaneyulu Kowluru, Renu A. Kowluru

Biosci Rep (1998) 18 (4): 187–198.

DOI: https://doi.org/10.1023/A:1020100813818

Published: 01 August 1998

... in streptozotocin (STZ)-diabetic rat retina (Kowluru et al. Diabetologia 35: 624–631, 1992). Since NDP kinase hasbeen implicated in direct interaction with and/or activation of various G-proteins, we quantitated both basal and magnesium-stimulated NDP kinase activity in soluble and particulate fractions of retina...

View article titled, Subcellular Localization and Characterization of Nucleoside Diphosphate Kinase in Rat Retina: Effect of Diabetes

Articles

Effect of streptozotocin diabetes on polysomal aggregation and protein synthesis rate in the liver of pregnant rats and their offspring

M. E. Martin, A. M. Garcia, L. Blanco, E. Herrera, M. Salinas

Biosci Rep (1995) 15 (1): 15–20.

DOI: https://doi.org/10.1007/BF01200211

Published: 01 February 1995

...M. E. Martin; A. M. Garcia; L. Blanco; E. Herrera; M. Salinas To study the effect of diabetes on hepatic protein synthesis and polysomal aggregation in pregnant rats, female rats were treated with streptozotocin prior to conception. Some animals were mated, and studied at day 20 of pregnancy...

View article titled, Effect of streptozotocin diabetes on polysomal aggregation and protein synthesis rate in the liver of pregnant rats and their offspring

Articles

Effects of alloxan-induced diabetes on somatostatin binding to cytosolic components of rabbit gastric fundic mucosa

L. G. Guijarro, M. P. Lopez-Ruiz, J. C. Prieto, E. Arilla

Biosci Rep (1988) 8 (3): 233–240.

DOI: https://doi.org/10.1007/BF01115040

Published: 01 June 1988

...L. G. Guijarro; M. P. Lopez-Ruiz; J. C. Prieto; E. Arilla Diabetes was induced by administration of alloxan (150 mg/Kg) to 24 h-fasted rabbits. Somatostatinlike immunoreactivity (SLI) and cytosolic binding sites for somatostatin in gastric fundic mucosa were studied using radiolabelled Tyr 11...

View article titled, Effects of alloxan-induced diabetes on somatostatin binding to cytosolic components of rabbit gastric fundic mucosa

Articles

Aldrin epoxidase activity in liver microsomes from normal or streptozotocin-diabetic rats: Comparison with activity in isolated hepatocytes from normal rats incubated with glucagon

Evelyne Rouer, Patricia Rouet, Jean Paul Leroux

Biosci Rep (1987) 7 (2): 129–133.

DOI: https://doi.org/10.1007/BF01121876

Published: 01 February 1987

...Evelyne Rouer; Patricia Rouet; Jean Paul Leroux Aldrin epoxidase activity in liver microsomes from streptozotocin-diabetic rats is only 40% of that from normal rats. Epoxidation of aldrin has also been assayed in freshly isolated hepatocytes from normal rats. Addition of 10 −7 M glucagon...

View article titled, Aldrin epoxidase activity in liver microsomes from normal or streptozotocin-diabetic rats: Comparison with activity in isolated hepatocytes from normal rats incubated with glucagon

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