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Keywords: diabetes
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Biosci Rep (2023) 43 (2): BSR20222151.
Published: 16 February 2023
...Siying Wei; Chenchen Li; Zinan Wang; Yan Chen Diabetes mellitus, especially Type 2 diabetes (T2D), is caused by multiple factors including genetics, diets, and lifestyles. Diabetes is a chronic condition and is among the top 10 causes of death globally. Nutritional intervention is one of the most...
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Biosci Rep (2023) 43 (1): BSR20221699.
Published: 23 December 2022
...Kwamie K. Harris; Bradley A. Welch; Allie M. Smith; Yilianys Pride; Bernadette E. Grayson The lifetime risk for Type 2 diabetes mellitus remains higher in people with spinal cord injuries (SCIs) than in the able-bodied population. However, the mechanisms driving this disparity remain poorly...
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Biosci Rep (2022) 42 (5): BSR20211297.
Published: 18 May 2022
...Shahab Hassan; Kenneth White; Cassandra Terry There are over 40 identified human disorders that involve certain proteins folding incorrectly, accumulating in the body causing damage to cells and organs and causing disease. Type 2 Diabetes Mellitus (T2DM) is one of these protein misfolding disorders...
Includes: Supplementary data
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Biosci Rep (2022) 42 (3): BSR20212209.
Published: 02 March 2022
...Jennifer Matthews; Lakshini Herat; Jennifer Rooney; Elizabeth Rakoczy; Markus Schlaich; Vance B. Matthews Diabetes mellitus is a chronic metabolic disease that occurs when the pancreas is not producing enough insulin or when the insulin that it does produce is not able to be used effectively...
Includes: Supplementary data
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Biosci Rep (2020) 40 (7): BSR20200507.
Published: 07 July 2020
...Weiwei Liang; FangFang Sun This research was carried out to reveal specific hub genes involved in diabetic heart failure, as well as remarkable pathways that hub genes locate. The GSE26887 dataset from the GEO website was downloaded. The gene co-expression network was generated and central modules...
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Biosci Rep (2019) 39 (4): BSR20181729.
Published: 30 April 2019
...Jing Cheng; Jia Zheng; Yanping Liu; Panpan Hao The morbidity of type 2 diabetes mellitus (T2DM) has been increasing rapidly worldwide. Tangminling pill, consisting of ten Chinese herbal medications, is usually prescribed for T2DM in mainland China. Whether treatment with Tangminling can improve...
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Biosci Rep (2019) 39 (4): BSR20182144.
Published: 23 April 2019
...Meng Jiang; Shanya Huang; Wang Duan; Qiaoshu Liu; Minxiang Lei Acid sphingomyelinase (aSMase) plays an important role in endothelial dysfunction. Here, we show that elevated aSMase activity and ceramide content were reduced by desipramine treatment in diabetic animals. The inhibitor of aSMase...
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Biosci Rep (2019) 39 (2): BSR20181995.
Published: 15 February 2019
...Qingguo Lu; Xuan Li; Jia Liu; Xiaodong Sun; Thomas Rousselle; Di Ren; Nanwei Tong; Ji Li Diabetics have higher morbidity and mortality in cardiovascular disease (CVD). A variety of antidiabetic agents are available for clinical choice. Cardiovascular (CV) safety assessment of these agents...
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Biosci Rep (2018) 38 (5): BSR20181042.
Published: 28 September 2018
...Qian Hou; Ke Hu; Xiaofeng Liu; Jiao Quan; Zehao Liu Vascular dysfunction is a common result of diabetes in humans. However, the mechanism underlying diabetic vascular dysfunction is not fully understood. Here in the present study, we showed that the histone deacetylase 2 (HDAC2) promoted...
Includes: Supplementary data
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Biosci Rep (2018) 38 (4): BSR20180127.
Published: 03 July 2018
...Huajie Li; Dan Ye; Wei Xie; Fei Hua; Yilin Yang; Jian Wu; Aifang Gu; Yi Ren; Keshi Mao Diabetes is a risk factor for Alzheimer’s disease (AD) in humans. Branched-chain amino acids (BCAAs, namely valine, leucine, and isoleucine) metabolic defect is observed in human diabetes, which is associated...
Includes: Supplementary data
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Biosci Rep (2018) 38 (2): BSR20171208.
Published: 21 March 2018
... in vascular endothelial injury. It is an important factor in the development of diabetes mellitus (DM). The aim of the present study was to screen out the potential candidate microRNAs (miRNAs) in DM patients with BSS by high-throughput sequencing (HTS) and bioinformatics analysis. Human umbilical vein...
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Biosci Rep (2018) 38 (2): BSR20180059.
Published: 16 March 2018
...Qian Zhang; Xinhua Xiao; Jia Zheng; Ming Li; Miao Yu; Fan Ping; Tong Wang; Xiaojing Wang Increasing evidence shows that diabetes causes cardiac dysfunction. We hypothesized that a glucagon-like peptide-1 (GLP-1) analog, liraglutide, would attenuate cardiac dysfunction in diabetic rats. A total...
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Biosci Rep (2017) 37 (4): BSR20171079.
Published: 31 August 2017
...), extracellular acidification rate (ECAR) and intracellular signalling. In addition, we assessed in vivo proliferation, cytokine production and cytolytic activity of cells in chemically induced diabetic C57BL/6 mice. Elevated levels of glucose in in vitro cultures had modest effects on proliferation and cytokine...
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Biosci Rep (2016) 36 (6): e00416.
Published: 29 November 2016
...María M. Adeva-Andany; Noemi Pérez-Felpete; Carlos Fernández-Fernández; Cristóbal Donapetry-García; Cristina Pazos-García Information about normal hepatic glucose metabolism may help to understand pathogenic mechanisms underlying obesity and diabetes mellitus. In addition, liver glucose metabolism...
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Biosci Rep (2016) 36 (1): e00285.
Published: 15 January 2016
...Rachel L. Dods; Dan Donnelly Glucagon-like peptide-1 (7–36)amide (GLP-1) plays a central role in regulating blood sugar levels and its receptor, GLP-1R, is a target for anti-diabetic agents such as the peptide agonist drugs exenatide and liraglutide. In order to understand the molecular nature...
Includes: Supplementary data
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Biosci Rep (2012) 32 (5): 423–432.
Published: 20 July 2012
..., distribution and reproduction in any medium, provided the original work is properly cited. cognition diabetes energy homoeostasis ghrelin hormone insulin leptin neural circuitry neurodegeneration Besides the hypothalamus, LepRb is present in several brain regions related to cognition [ 42...
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Biosci Rep (2011) 31 (5): 411–419.
Published: 05 August 2011
...Geun Bae Rha; Guangteng Wu; Young-In Chi HNF4α (hepatocyte nuclear factor 4α) is a culprit gene product for a monogenic and dominantly inherited form of diabetes, referred to as MODY (maturity onset diabetes of the young). As a member of the NR (nuclear receptor) superfamily, HNF4α recruits...
Includes: Supplementary data
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Biosci Rep (2003) 23 (5-6): 313–337.
Published: 01 October 2003
...Aya Sato; Hitoshi Endo; Kazuo Umetsu; Hideyuki Sone; Yoshiko Yanagisawa; Azusa Saigusa; Sayuri Aita; Yasuo Kagawa Mitochondrial DNA (mtDNA) is highly susceptible to mutations that result in polymorphisms and diseases including diabetes. We analyzed heteroplasmy, polymorphisms related to diabetes...
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Biosci Rep (1998) 18 (4): 187–198.
Published: 01 August 1998
... in streptozotocin (STZ)-diabetic rat retina (Kowluru et al. Diabetologia 35: 624–631, 1992). Since NDP kinase hasbeen implicated in direct interaction with and/or activation of various G-proteins, we quantitated both basal and magnesium-stimulated NDP kinase activity in soluble and particulate fractions of retina...
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