...Valéria Sutti Nunes; Isabela M. Bensenor; Paulo A. Lotufo; Marisa Passarelli; Edna Regina Nakandakare; Eder Carlos Rocha Quintão It is controversial whether atherosclerosis is linked to increased intestinal cholesterol absorption or synthesis in humans. The aim of the present study was to relate...

...Hima Rani Sapa Cholesterol efflux capacity (CEC), an important functional step in reverse cholesterol transport, is the main anti-atherosclerotic function of high-density lipoprotein (HDL). Assays that improve the determination of CEC ex vivo for clinical applications are constantly explored...

...Anna-Maria Caridis; Richard J. Lightbody; Jamie M.R. Tarlton; Sharron Dolan; Annette Graham Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus. Cholesterol efflux to (apo...

...Eser J. Zerenturk; Laura J. Sharpe; Andrew J. Brown Cholesterol synthesis occurs in the ER (endoplasmic reticulum), where most of the cholesterogenic machinery resides. As membrane-bound proteins, their topology is difficult to determine, and thus their structures are largely unknown. To help...

...Lidia A. Daimiel; María E. Fernández-Suárez; Sara Rodríguez-Acebes; Lorena Crespo; Miguel A. Lasunción; Diego Gómez-Coronado; Javier Martínez-Botas DHCR24 (3β-hydroxysterol Δ 24 -reductase) catalyses the reduction of the C-24 double bond of sterol intermediates during cholesterol biosynthesis...

...-distearoyl- sn -glycero-3-phosphocholine) and variable amounts of cholesterol. The effects of cholesterol content on liposome size, percentage drug loading and in vitro drug release profiles were investigated. Differential scanning calorimetry and FTIR (Fourier-transform infrared) spectroscopy were used...

...Gerald Gimpl; Katja Gehrig-Burger Cholesterol is a major constituent of the membranes in most eukaryotic cells where it fulfills multiple functions. Cholesterol regulates the physical state of the phospholipid bilayer, affects the activity of several membrane proteins, and is the precursor...

... and composition of viral and cellular lipids can dramatically modulate the fusion reaction. Lipid rafts, which primarily consist of sphingolipids and cholesterol, have been implicated for infectious route of HIV-1 entry. Plasma membrane Glycosphingolipids (GSLs) have been proposed to support HIV-1 infection...

...Feride Severcan; Nadide Kazanci; Ülkü Baykal; Şefik Süzer Binary and tertiary mixture of α-tocophenol, cholesterol and dimyristoylphosphatidylcholine in the form of multilamellar liposomes were investigated by Fourier Transform Infrared and visible spectroscopy. Results of the FTIR and turbidity...

...Michael J. Bennett; Michael H. Nantz; Rajiv P. Balasubramaniam; Dieter C. Gruenert; Robert W. Malone Cationic liposome transfection reagents are useful for transferring polynucleotides into cells, and have been proposed for human pulmonary gene therapy. The effect of adding cholesterol to cationic...

... lipoprotein infusion. This caused a significant rise in cholesterol, phospholipid and bile salt secretions. However, only the percentage of cholesterol increased with respect to the other bile lipids. The changes observed in the cholesterol/phospholipid molar ratio values of liver membrane subfractions (i.e...

... technique. When in vitro experiments were carried out with both treated and untreated rats, an interesting lack of parallelism was found, which could indicate the development of a resistance to membrane disordering by lindane. The observed changes in cholesterol and phospholipid composition are also...

... polarization in a dose dependent manner. This effect, which is associated with an increased membrane fluidity, occurred in a very short period of time. Lindane also provoked a number of changes in lipid biosynthesis from acetate in the membrane. Less [1- 14 C]acetate was incorporated into cholesterol and more...

... to be of the classical type and to differ from that of platelets. 3 9 1990 © 1991 Plenum Publishing Corporation 1991 promegakaryoblast LDL cholesterol platelet Bioscience Reports, Vol. 11, No. 1, 1991 Characterization of the LDL Receptor in Rat Promegakaryoblasts in Culture Tracy J. Budd, 1 Frank...

...B. de Kruijff A mechanism is proposed for the way in which cholesterol facilitates channel formation by polyene antibiotics and bacterial protein toxins. Central elements of the model are: (i) interactions between the ring system of the sterol and rigid elements of the polyene or toxin molecule...

...G. Bruscalupi; L. Conti Devirgiliis; S. Leoni; F. Piemonte; A. Trentalance Acyl CoA: cholesterol acyl transferase (ACAT) activity presents marked oscillations and differential sensitivity to the “in vitro” stimulation of the kinase-phosphatase modulatory system in the perinatal rat liver...