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Articles

PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma

Feng Xiao, Xinfang Jie, Xiang Zhou, Yun Guo, Gu Feng Sun, Li Lin, Guo Wen Hu, Kai Huang, Hua Guo

Biosci Rep (2023) 43 (5): BSR20230028.

DOI: https://doi.org/10.1042/BSR20230028

Published: 05 May 2023

..., immune checkpoint genes (ICPGs), copy number alterations (CNA), and tumor mutation burden (TMB) were also closely associated with PPP1R81 expression in LGG. In vitro experiments demonstrated that PPP1R81 was up-regulated and closely interrelated with cell proliferation and cell cycle in LGG. Conclusion...

View article titled, PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma

Includes: Supplementary data

Articles

Retraction: Long non-coding RNA PSMA3-AS1 enhances cell proliferation, migration and invasion by regulating miR-302a-3p/RAB22A in glioma

Biosci Rep (2023) 43 (3): BSR-2019-1571_RET.

DOI: https://doi.org/10.1042/BSR-2019-1571_RET

Published: 01 March 2023

... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell proliferation glioma miR-302a-3p PSMA-AS1 RAB22A ...

View article titled, Retraction: Long non-coding RNA PSMA3-AS1 enhances cell proliferation, migration and invasion by regulating miR-302a-3p/RAB22A in glioma

Articles

Expression of Concern: LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation

Biosci Rep (2023) 43 (2): BSR-2017-1150_EOC.

DOI: https://doi.org/10.1042/BSR-2017-1150_EOC

Published: 09 February 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell proliferation growth arrest-specific 5 inflammasome long...

View article titled, Expression of Concern: LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation

Articles

Expression of Concern: Long non-coding RNA PSMA3-AS1 enhances cell proliferation, migration and invasion by regulating miR-302a-3p/RAB22A in glioma

Biosci Rep (2023) 43 (1): BSR-2019-1571_EOC.

DOI: https://doi.org/10.1042/BSR-2019-1571_EOC

Published: 19 January 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell proliferation glioma miR-302a-3p PSMA-AS1 RAB22A The Editorial...

View article titled, Expression of Concern: Long non-coding RNA PSMA3-AS1 enhances cell proliferation, migration and invasion by regulating miR-302a-3p/RAB22A in glioma

Articles

Retraction: Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targeting miR-532-5p

Biosci Rep (2022) 42 (7): BSR-2018-0538_RET.

DOI: https://doi.org/10.1042/BSR-2018-0538_RET

Published: 14 July 2022

... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell proliferation gastric cancer Hsa_circ_0000673 Invasion miR-532-5p...

View article titled, Retraction: Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targeting miR-532-5p

Articles

USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer

Maoshu Zhu, Hui Zhang, Fuhua Lu, Zhaowei Wang, Yulong Wu, Huoshu Chen, Xin Fan, Zhijiang Yin, Fulong Liang

Biosci Rep (2021) 41 (10): BSR20210486.

DOI: https://doi.org/10.1042/BSR20210486

Published: 04 October 2021

... discovered ubiquitin-specific peptidase (USP) 52 (USP52) in NSCLC remained unclear. Here, our findings identify USP52 as a novel tumor suppressor of NSCLC, the low expression of USP52 predicts a poor prognosis for NSCLC patients. The present study demonstrates that USP52 inhibits cancer cell proliferation...

View article titled, USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer

Articles

Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway

Yonggang Xu, Rong Fang, Jie Shao, Zihao Cai

Biosci Rep (2021) 41 (6): BSR20210093.

DOI: https://doi.org/10.1042/BSR20210093

Published: 10 June 2021

... mechanism. Methods: After treatment with erianin, MTT assay was employed to determine the MDA-MB-231 and EFM-192A cell proliferation, the nucleus morphological changes were observed by DAPI staining. The cell cycle and apoptotic proportion were detected by flow cytometry. Western blot was performed...

View article titled, Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway

Articles

Retraction: Effects of microRNA-136 on melanoma cell proliferation, apoptosis and epithelial mesenchymal transition by targeting PMEL through the Wnt signaling pathway

Biosci Rep (2021) 41 (4): BSR-20170743_RET.

DOI: https://doi.org/10.1042/BSR-20170743_RET

Published: 23 April 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell proliferation Epithelial-mesenchymal transition Melanoma cells...

View article titled, Retraction: Effects of microRNA-136 on melanoma cell proliferation, apoptosis and epithelial mesenchymal transition by targeting PMEL through the Wnt signaling pathway

Articles

Retraction: MicroRNA-505-5p functions as a tumor suppressor by targeting Cyclin-Dependent Kinase 5 in cervical cancer

Biosci Rep (2021) 41 (4): BSR-20191221_RET.

DOI: https://doi.org/10.1042/BSR-20191221_RET

Published: 14 April 2021

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cervical cancer cell invasion cell migration cell proliferation CDK5 miR-505-5p ...

View article titled, Retraction: MicroRNA-505-5p functions as a tumor suppressor by targeting Cyclin-Dependent Kinase 5 in cervical cancer

Articles

Expression of Concern: PAR-2 promotes cell proliferation, migration and invasion through activating PI3K/AKT signaling pathway in oral squamous cell carcinoma

Biosci Rep (2021) 41 (4): BSR-20182476_EOC.

DOI: https://doi.org/10.1042/BSR-20182476_EOC

Published: 06 April 2021

... Cell proliferation Invasion Migration Oral squamous cell carcinoma PAR-2 PI3K/AKT pathway The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial...

View article titled, Expression of Concern: PAR-2 promotes cell proliferation, migration and invasion through activating PI3K/AKT signaling pathway in oral squamous cell carcinoma

Articles

Expression of Concern: The silencing of long non-coding RNA ANRIL suppresses invasion, and promotes apoptosis of retinoblastoma cells through ATM-E2F1 signaling pathway

Biosci Rep (2021) 41 (3): BSR-20180558_EOC.

DOI: https://doi.org/10.1042/BSR-20180558_EOC

Published: 26 March 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ATM-E2F1 signaling pathway Cell apoptosis Cell proliferation Long-non...

View article titled, Expression of Concern: The silencing of long non-coding RNA ANRIL suppresses invasion, and promotes apoptosis of retinoblastoma cells through ATM-E2F1 signaling pathway

Articles

Expression of Concern: Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targeting miR-532-5p

Biosci Rep (2021) 41 (2): BSR-20180538_EOC.

DOI: https://doi.org/10.1042/BSR-20180538_EOC

Published: 16 February 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell proliferation gastric cancer Hsa_circ_0000673 Invasion miR-532-5p...

View article titled, Expression of Concern: Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targeting miR-532-5p

Articles

Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells

Jonathan J. Sheard, Andrew D. Southam, Hannah L. MacKay, Max A. Ellington, Martyn D. Snow, Farhat L. Khanim, Christopher M. Bunce, William E. Johnson

Biosci Rep (2021) 41 (1): BSR20202505.

DOI: https://doi.org/10.1042/BSR20202505

Published: 05 January 2021

... enzymes were measured by immunoblotting cell extracts. These drug treatments inhibited the growth and survival of SAOS2 and MG63 cells most effectively when used in combination (termed V-BAP). In contrast, V-BAP treated MSCs remained viable with only moderately reduced cell proliferation. V-BAP treatment...

View article titled, Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells

Includes: Supplementary data

Articles

Regulation of circGOLPH3 and its binding protein CBX7 on the proliferation and apoptosis of prostate cancer cells

Lifeng Gong, Yu Tang, Li Jiang, Wei Tang, Shengjun Luo

Biosci Rep (2020) 40 (12): BSR20200936.

DOI: https://doi.org/10.1042/BSR20200936

Published: 14 December 2020

... cell proliferation and inhibit apoptosis. If the OD value wouldn’t be measured immediately, 10 μl of a 0.1 M HCl solution or a 1% w/v SDS solution was added to each well, and the culture plates were covered with a culture plate and stored under room temperature in a dark place. There won’t be any...

View article titled, Regulation of circGOLPH3 and its binding protein CBX7 on the proliferation and apoptosis of prostate cancer cells

Articles

MicroRNA-223 decreases cell proliferation, migration, invasion, and enhances cell apoptosis in childhood acute lymphoblastic leukemia via targeting Forkhead box O 1

Chunyu Li, Tana Zhao, Lei Nie, Yanhong Zou, Quan Zhang

Biosci Rep (2020) 40 (10): BSR20200485.

DOI: https://doi.org/10.1042/BSR20200485

Published: 06 October 2020

... proliferation, migration and invasion, but also induced cell apoptosis. Importantly, FOXO1 was a target gene of miR-223 in ALL cells. Silencing of FOXO1 reversed the effects of miR-223 inhibitor on cell proliferation, migration, invasion and apoptosis in ALL. Conclusions: miR-223 could inhibit cell...

View article titled, MicroRNA-223 decreases cell proliferation, migration, invasion, and enhances cell apoptosis in childhood acute lymphoblastic leukemia via targeting Forkhead box O 1

Articles

Long non-coding RNA PSMA3-AS1 enhances cell proliferation, migration and invasion by regulating miR-302a-3p/RAB22A in glioma

Li-li Zhou, Meng Zhang, Yan-zhen Zhang, Mei-fen Sun

Biosci Rep (2020) 40 (9): BSR20191571.

DOI: https://doi.org/10.1042/BSR20191571

Published: 21 September 2020

... Attribution License 4.0 (CC BY) . cell migration cell proliferation glioma miR-302a-3p PSMA3-AS1 RAB22A As the most common solid tumor, glioma is the most common solid tumor in the central nervous system (CNS) [ 1 , 2 ]. Glioma in the CNS has been classified into the low and high grade...

View article titled, Long non-coding RNA PSMA3-AS1 enhances cell proliferation, migration and invasion by regulating miR-302a-3p/RAB22A in glioma

Articles

Expression of Concern: Effects of microRNA-136 on melanoma cell proliferation, apoptosis and epithelial mesenchymal transition by targeting PMEL through the Wnt signaling pathway

Biosci Rep (2020) 40 (8): BSR-20170743_EOC.

DOI: https://doi.org/10.1042/BSR-20170743_EOC

Published: 28 August 2020

... Cell proliferation Epithelial-mesenchymal transition Melanoma cells microRNA-136 PMEL Wnt signaling pathway The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers...

View article titled, Expression of Concern: Effects of microRNA-136 on melanoma cell proliferation, apoptosis and epithelial mesenchymal transition by targeting PMEL through the Wnt signaling pathway

Articles

Retraction: Role of Microvascular endothelial cells on proliferation, migration and adhesion of hematopoietic stem cells

Biosci Rep (2020) 40 (7): BSR-20192104_RET.

DOI: https://doi.org/10.1042/BSR-20192104_RET

Published: 09 July 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell adhesion Cell migration Cell proliferation Chemotaxis Hematopoietic...

View article titled, Retraction: Role of Microvascular endothelial cells on proliferation, migration and adhesion of hematopoietic stem cells

Articles

Expression of Concern: MicroRNA-505-5p functions as a tumor suppressor by targeting Cyclin-Dependent Kinase 5 in cervical cancer

Biosci Rep (2020) 40 (7): BSR-20191221_EOC.

DOI: https://doi.org/10.1042/BSR-20191221_EOC

Published: 02 July 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cervical cancer cell invasion cell migration cell proliferation CDK5 miR...

View article titled, Expression of Concern: MicroRNA-505-5p functions as a tumor suppressor by targeting Cyclin-Dependent Kinase 5 in cervical cancer

Articles

Expression of Concern: MicroRNA-144-3p inhibits High Glucose induced Cell proliferation through Suppressing FGF16

Biosci Rep (2020) 40 (7): BSR-20181788_EOC.

DOI: https://doi.org/10.1042/BSR-20181788_EOC

Published: 02 July 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell proliferation diabetic retinopathy FGF16 miR-144-3p...

View article titled, Expression of Concern: MicroRNA-144-3p inhibits High Glucose induced Cell proliferation through Suppressing FGF16

Articles

Expression of Concern: Role of Microvascular endothelial cells on proliferation, migration and adhesion of hematopoietic stem cells

Biosci Rep (2020) 40 (7): BSR-20192104_EOC.

DOI: https://doi.org/10.1042/BSR-20192104_EOC

Published: 02 July 2020

View article titled, Expression of Concern: Role of Microvascular endothelial cells on proliferation, migration and adhesion of hematopoietic stem cells

Articles

mTOR up-regulation of SNRPA1 contributes to hepatocellular carcinoma development

Jing Feng, Jian Guo, Pengyu Zhao, Jing Shen, Baofeng Chai, Junping Wang

Biosci Rep (2020) 40 (6): BSR20193815.

DOI: https://doi.org/10.1042/BSR20193815

Published: 15 June 2020

... of SNPRA1 inhibited the cell proliferation, colony formation and xenografted tumorigenesis of HCC cells. Apoptosis was induced by SNPRA1 down-regulation. Mechanistically, SNPRA1 was stimulated by mTOR activation. In addition, whole-genome microarray analysis identified that 262 genes were up-regulated...

View article titled, mTOR up-regulation of SNRPA1 contributes to hepatocellular carcinoma development

Articles

Molecular mechanism of targeted inhibition of HMGA2 via miRNAlet-7a in proliferation and metastasis of laryngeal squamous cell carcinoma

Li-Juan Ma, Jun Wu, En Zhou, Juan Yin, Xu-Ping Xiao

Biosci Rep (2020) 40 (6): BSR20193788.

DOI: https://doi.org/10.1042/BSR20193788

Published: 03 June 2020

...Li-Juan Ma; Jun Wu; En Zhou; Juan Yin; Xu-Ping Xiao MiRNAlet-7a is associated with the tumorigenesis of laryngeal squamous cell carcinoma (LSCC). Our study was designed to infer whether let-7a targets high-mobility AT-hook 2 (HMGA2) and suppresses laryngeal carcinoma cell proliferation, invasion...

View article titled, Molecular mechanism of targeted inhibition of HMGA2 via miRNAlet-7a in proliferation and metastasis of laryngeal squamous cell carcinoma

Includes: Supplementary data

Articles

Tanshinone II A enhances pyroptosis and represses cell proliferation of HeLa cells by regulating miR-145/GSDMD signaling pathway

Wenjuan Tong, Jianghong Guo, Chunfen Yang

Biosci Rep (2020) 40 (4): BSR20200259.

DOI: https://doi.org/10.1042/BSR20200259

Published: 15 April 2020

... in inflammation and cancer. Our study identified microRNA (miR) 145 (miR-145)/gasdermin D (GSDMD) signaling pathway as critical mediators in the effect of tanshinone II A on HeLa cells. In the present study, we found that treatment of tanshinone II A led to an obvious repression of cell proliferation...

View article titled, Tanshinone II A enhances pyroptosis and represses cell proliferation of HeLa cells by regulating miR-145/GSDMD signaling pathway

Includes: Supplementary data

Articles

Role of microvascular endothelial cells on proliferation, migration and adhesion of hematopoietic stem cells

Fanli Lin, Shuyue Wang, Hao Xiong, Yang Liu, Xiaoming Li, Chunlan Huang

Biosci Rep (2020) 40 (3): BSR20192104.

DOI: https://doi.org/10.1042/BSR20192104

Published: 20 March 2020

... the Creative Commons Attribution License 4.0 (CC BY) . Cell adhesion Cell migration Cell proliferation Chemotaxis Hematopoietic stem cells Microvascular endothelial cells Four- to six-week-old GFP mice (C57BL/6 line) were killed, and after cervical spinal cord dissection, the bone marrow...

View article titled, Role of microvascular endothelial cells on proliferation, migration and adhesion of hematopoietic stem cells

Articles

MicroRNA-505-5p functions as a tumor suppressor by targeting cyclin-dependent kinase 5 in cervical cancer

Elena Kapora, Shujun Feng, Wei Liu, Indira Sakhautdinova, Bo Gao, Wenhua Tan

Biosci Rep (2019) 39 (7): BSR20191221.

DOI: https://doi.org/10.1042/BSR20191221

Published: 26 July 2019

...Elena Kapora; Shujun Feng; Wei Liu; Indira Sakhautdinova; Bo Gao; Wenhua Tan MicroRNAs (miRs) are considered to be tumor suppressors or oncogenes as they regulate cell proliferation, migration, invasion, and differentiation. Recently, microRNA-505 (miR-505) has been reported as being involved...

View article titled, MicroRNA-505-5p functions as a tumor suppressor by targeting cyclin-dependent kinase 5 in cervical cancer

Articles

MiRNA-144-3p inhibits high glucose induced cell proliferation through suppressing FGF16

Cuimin Chen, Chunyan Zhao, Cao Gu, Xiao Cui, Jinhui Wu

Biosci Rep (2019) 39 (7): BSR20181788.

DOI: https://doi.org/10.1042/BSR20181788

Published: 26 July 2019

.... In the present study, we focussed on a significantly down-regulated miRNA, miR-144-3p, and investigated its role in high glucose (HG) induced cell proliferation. Our data showed that miR-144-3p mimics significantly inhibited HG induced cell proliferation and reduced the percentage of cells in S phase. HG induced...

View article titled, MiRNA-144-3p inhibits high glucose induced cell proliferation through suppressing FGF16

Articles

Overexpression of long non-coding RNA LINC00982 suppresses cell proliferation and tumor growth of papillary thyroid carcinoma through PI3K-ATK signaling pathway

Debin Xu, Jichun Yu, Shimin Zhuang, Shuyong Zhang, Zhengdong Hong, Chunlei Yuan

Biosci Rep (2019) 39 (7): BSR20191210.

DOI: https://doi.org/10.1042/BSR20191210

Published: 12 July 2019

... to detect the effects of LINC00982 on the cell proliferation and migration in PTC cells. Furthermore, western blot assay was used to measure the alteration expression levels of apoptosis relative proteins and the relative protein involved phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. Finally...

View article titled, Overexpression of long non-coding RNA LINC00982 suppresses cell proliferation and tumor growth of papillary thyroid carcinoma through PI3K-ATK signaling pathway

Articles

DEPDC1 promotes cell proliferation and suppresses sensitivity to chemotherapy in human hepatocellular carcinoma

Chao Zhou, Pu Wang, Mengtian Tu, Yi Huang, Fei Xiong, Yue Wu

Biosci Rep (2019) 39 (7): BSR20190946.

DOI: https://doi.org/10.1042/BSR20190946

Published: 10 July 2019

...: DEPDC1 was significantly up-regulated in HCC tissues compared with para-cancerous tissues. Besides, patients with high DEPDC1 expression experienced a significantly shorter overall survival. Functional investigations demonstrated that DEPDC1 overexpression facilitated HCC cell proliferation...

View article titled, DEPDC1 promotes cell proliferation and suppresses sensitivity to chemotherapy in human hepatocellular carcinoma

Articles

PAR-2 promotes cell proliferation, migration, and invasion through activating PI3K/AKT signaling pathway in oral squamous cell carcinoma

Kai-Liang Tang, Han-Ying Tang, Yi Du, Tian Tian, Shi-Jiang Xiong

Biosci Rep (2019) 39 (7): BSR20182476.

DOI: https://doi.org/10.1042/BSR20182476

Published: 05 July 2019

... 06 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell proliferation Invasion Migration PAR-2 Oral squamous cell...

View article titled, PAR-2 promotes cell proliferation, migration, and invasion through activating PI3K/AKT signaling pathway in oral squamous cell carcinoma

Articles

Ribophorin II promotes cell proliferation, migration, and invasion in esophageal cancer cells in vitro and in vivo

Yongshun Li, Changrong Huang, Qizhou Bai, Jun Yu

Biosci Rep (2019) 39 (5): BSR20182448.

DOI: https://doi.org/10.1042/BSR20182448

Published: 07 May 2019

... positively associated with differentiation and tumor node metastasis (TNM) stage. Furthermore, the expression of RPN2 was increased significantly in esophageal cancer cell lines compared with normal cells. The effect of RPN2 down-regulation on cell proliferation, cell migration, and cell invasion...

View article titled, Ribophorin II promotes cell proliferation, migration, and invasion in esophageal cancer cells in vitro and in vivo

Includes: Supplementary data

Articles

USP39 regulates the cell cycle, survival, and growth of human leukemia cells

Chunxia Liu, Xiaojian Yao, Ming Li, Yaming Xi, Li Zhao

Biosci Rep (2019) 39 (4): BSR20190040.

DOI: https://doi.org/10.1042/BSR20190040

Published: 05 April 2019

... transduction and cell proliferation assay was performed. The results showed that USP39 knockdown markedly repressed the proliferation rate of HL-60 and Jurkat cells since day 3 ( Figure 2 C,D). Colony formation is a key feature of stem cells and cancer cells [ 14 ]. We next investigated the effects of USP39...

View article titled, USP39 regulates the cell cycle, survival, and growth of human leukemia cells

Includes: Supplementary data

Articles

LncRNA SNHG20 predicts a poor prognosis and promotes cell progression in epithelial ovarian cancer

Dandan Wang, Jianrong Dai, Shunyu Hou, Yonghong Qian

Biosci Rep (2019) 39 (4): BSR20182186.

DOI: https://doi.org/10.1042/BSR20182186

Published: 02 April 2019

... that in adjacent tissues and closely correlated with histological grade and lymph node (LN) status. Patients with high SNHG20 showed a shorter overall survival (OS) and SNHG20 was an independent risk factor for the prognosis of serous EOC. Knockdown of SNHG20 remarkably inhibited EOC cell proliferation, migration...

View article titled, LncRNA SNHG20 predicts a poor prognosis and promotes cell progression in epithelial ovarian cancer

Articles

TIMP-1 inhibits proliferation and osteogenic differentiation of hBMSCs through Wnt/β-catenin signaling

Tangzhao Liang, Wenling Gao, Lei Zhu, Jianhua Ren, Hui Yao, Kun Wang, Dehai Shi

Biosci Rep (2019) 39 (1): BSR20181290.

DOI: https://doi.org/10.1042/BSR20181290

Published: 08 January 2019

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell proliferation Mesenchymal stem cells Osteogenic differentiation Tissue inhibitor of metalloproteinase-1 Wnt/β-catenin signaling Bone...

View article titled, TIMP-1 inhibits proliferation and osteogenic differentiation of hBMSCs through Wnt/β-catenin signaling

Articles

The silencing of long non-coding RNA ANRIL suppresses invasion, and promotes apoptosis of retinoblastoma cells through the ATM-E2F1 signaling pathway

Yang Yang, Xiao-Wei Peng

Biosci Rep (2018) 38 (6): BSR20180558.

DOI: https://doi.org/10.1042/BSR20180558

Published: 11 December 2018

... the Creative Commons Attribution License 4.0 (CC BY) . ATM-E2F1 signaling pathway Cell apoptosis Cell proliferation Long-non coding RNA ANRIL Negative feedback regulation Retinoblastoma Retinoblastoma is an aggressive form of an intraocular cancer usually occurring during childhood...

View article titled, The silencing of long non-coding RNA ANRIL suppresses invasion, and promotes apoptosis of retinoblastoma cells through the ATM-E2F1 signaling pathway

Articles

HADC regulates the diabetic vascular endothelial dysfunction by targetting MnSOD

Qian Hou, Ke Hu, Xiaofeng Liu, Jiao Quan, Zehao Liu

Biosci Rep (2018) 38 (5): BSR20181042.

DOI: https://doi.org/10.1042/BSR20181042

Published: 28 September 2018

... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell proliferation diabetes endothelial cells HDAC2 MnSOD Diabetes is a serious and increasing global health burden, and estimates of prevalence...

View article titled, HADC regulates the diabetic vascular endothelial dysfunction by targetting MnSOD

Includes: Supplementary data

Articles

Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p

Peng Chang, Furong Wang, Yumin Li

Biosci Rep (2018) 38 (5): BSR20180538.

DOI: https://doi.org/10.1042/BSR20180538

Published: 19 September 2018

... 04 2018 13 07 2018 30 07 2018 30 07 2018 © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell proliferation...

View article titled, Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p

Includes: Supplementary data

Articles

miRNA-1284, a regulator of HMGB1, inhibits cell proliferation and migration in osteosarcoma

Shuai Lv, Meng Guan

Biosci Rep (2018) 38 (4): BSR20171675.

DOI: https://doi.org/10.1042/BSR20171675

Published: 13 July 2018

... elevated in tumor tissues and negatively correlated with miR-1284 expression. MiR-1284 exerted its function by directly binding to 3′-UTR of HMGB1 and regulates expression of HMGB1. The overexpression of miR-1284 inhibited the cell proliferation and migration, and altered the protein expression...

View article titled, miRNA-1284, a regulator of HMGB1, inhibits cell proliferation and migration in osteosarcoma

Articles

Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes

Nazim Hussain, Wenhua Zhu, Congshan Jiang, Jing Xu, Manman Geng, Xiaoying Wu, Safdar Hussain, Bo Wang, Muhammad Shahid Riaz Rajoka, Yue Li, Juan Tian, Liesu Meng, Shemin Lu

Biosci Rep (2018) 38 (2): BSR20180003.

DOI: https://doi.org/10.1042/BSR20180003

Published: 13 April 2018

.... The miR-10a-5p mimic treatment showed a decline in cell proliferation while the increased rate of cell apoptosis as compared with control. Moreover, knockdown of TBX5 favored the apoptosis and reduced the cell proliferation as compared with control group. We conclude that down-regulation of miR-10a-5p...

View article titled, Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes

Articles

LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation

Jie Li, Chen Yang, Yinguang Li, Aiyue Chen, Li Li, Zeshan You

Biosci Rep (2018) 38 (2): BSR20171150.

DOI: https://doi.org/10.1042/BSR20171150

Published: 16 March 2018

... the cellular mechanism and clinical value of lncRNA GAS5 in ovarian cancer. Methods: Quantitative real-time PCR was used to detect mRNA level of lncRNA GAS5 in 20 ovarian cancer tissues. The effect of lncRNA GAS5 on cell proliferation was performed using CCK-8 assay. Cell apoptosis was evaluated by flow...

View article titled, LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation

Articles

miR-6743-5p , as a direct upstream regulator of GRIM-19, enhances proliferation and suppresses apoptosis in glioma cells

Fang Cao, Qiang Zhang, Wei Chen, Feng Zheng, Qishan Ran, Yang He, Yang Gao, Shengtao Yao

Biosci Rep (2017) 37 (6): BSR20171038.

DOI: https://doi.org/10.1042/BSR20171038

Published: 12 December 2017

... specimens and cell lines. Moreover, the inhibition of miR-6743-5p caused a significant inhibition of cell proliferation and a marked promotion of cell apoptosis in glioma cells, and this phenotype was rescued by GRIM-19 knockdown. Finally, the inhibition of miR-6743-5p expression suppressed...

View article titled, miR-6743-5p , as a direct upstream regulator of GRIM-19, enhances proliferation and suppresses apoptosis in glioma cells

Includes: Supplementary data

Articles

Dysregulation of POPDC1 promotes breast cancer cell migration and proliferation

Johanna Ndamwena Amunjela, Steven John Tucker

Biosci Rep (2017) 37 (6): BSR20171039.

DOI: https://doi.org/10.1042/BSR20171039

Published: 21 November 2017

... 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancer cAMP cell migration cell proliferation POPDC1...

View article titled, Dysregulation of POPDC1 promotes breast cancer cell migration and proliferation

Articles

A novel long noncoding RNA linc00460 up-regulated by CBP/P300 promotes carcinogenesis in esophageal squamous cell carcinoma

Yan Liang, Yuanyuan Wu, Xuedan Chen, Shixin Zhang, Kai Wang, Xingying Guan, Kang Yang, Juan Li, Yun Bai

Biosci Rep (2017) 37 (5): BSR20171019.

DOI: https://doi.org/10.1042/BSR20171019

Published: 17 October 2017

... lines. Linc00460 expression was positively correlated with ESCC TNM stage, lymph node metastasis, and predicted poor prognosis. In vitro experiments showed that linc00460 depletion suppressed ESCC cell growth through regulating cell proliferation and cell cycle; in additional, linc00460 depletion...

View article titled, A novel long noncoding RNA linc00460 up-regulated by CBP/P300 promotes carcinogenesis in esophageal squamous cell carcinoma

Includes: Supplementary data

Articles

Effects of microRNA-136 on melanoma cell proliferation, apoptosis, and epithelial–mesenchymal transition by targetting PMEL through the Wnt signaling pathway

Jiu-Jiang Wang, Zhi-Feng Li, Xiao-Jing Li, Zhao Han, Ling Zhang, Zhi-Jun Liu

Biosci Rep (2017) 37 (5): BSR20170743.

DOI: https://doi.org/10.1042/BSR20170743

Published: 07 September 2017

... inhibitors, siRNA-PMEL, and miR-136 inhibitors + siRNA-PMEL, LiC1 (Wnt signaling pathway activator), and siRNA-PMEL+ LiCl groups. MTT, Scratch test, Transwell assay, and flow cytometry were performed to measure cell proliferation, migration, invasion, and apoptosis. Quantitative real-time PCR (qRT-PCR...

View article titled, Effects of microRNA-136 on melanoma cell proliferation, apoptosis, and epithelial–mesenchymal transition by targetting PMEL through the Wnt signaling pathway

Articles

Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival

Aytug Kizilors, Mark R. Pickard, Cathleen E. Schulte, Kiren Yacqub-Usman, Nicola J. McCarthy, Shu-Uin Gan, David Darling, Joop Gäken, Gwyn T. Williams, Farzin Farzaneh

Biosci Rep (2017) 37 (4): BSR20170843.

DOI: https://doi.org/10.1042/BSR20170843

Published: 14 August 2017

..., potentially through interaction with PML nuclear bodies and/or epigenetic control of gene expression. Our study is the first to demonstrate a critical role for RNF168 in the mechanisms regulating cell proliferation and survival, in addition to its well-established role in DNA repair. Correspondence...

View article titled, Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival

Includes: Supplementary data

Articles

Long noncoding RNA HEIH promotes melanoma cell proliferation, migration and invasion via inhibition of miR-200b/a/429

Haiying Zhao, Guoping Xing, Yingying Wang, Zengxiang Luo, Guoyan Liu, Huijuan Meng

Biosci Rep (2017) 37 (3): BSR20170682.

DOI: https://doi.org/10.1042/BSR20170682

Published: 21 June 2017

... expression of lncRNA-HEIH promotes melanoma cell proliferation, migration and invasion. Knockdown of lncRNA-HEIH inhibits melanoma cell proliferation, migration and invasion. Mechanistically, we revealed that lncRNA-HEIH directly binds to miR-200b/a/429 promoter and represses miR-200b/a/429 transcription...

View article titled, Long noncoding RNA HEIH promotes melanoma cell proliferation, migration and invasion via inhibition of miR-200b/a/429

Articles

CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells

Wei Deying, Geng Feng, Liang Shumei, Zhao Hui, Liu Ming, Wang Hongqing

Biosci Rep (2017) 37 (2): BSR20160470.

DOI: https://doi.org/10.1042/BSR20160470

Published: 10 April 2017

... into the tumour microenvironment. In the present study, we firstly isolated CAFs from tumour tissues of the patients with ovarian cancer and demonstrated that the hepatocyte growth factor (HGF) was highly expressed in the supernatants of CAFs. CAF-derived HGF or human recombinant HGF promoted cell proliferation...

View article titled, CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells

Articles

SIN1 promotes the proliferation and migration of breast cancer cells by Akt activation

Deqiang Wang, Ping Wu, Hui Wang, Lei Zhu, Wei Zhao, Yuqin Lu

Biosci Rep (2016) 36 (6): e00424.

DOI: https://doi.org/10.1042/BSR20160192

Published: 09 December 2016

... functional role in breast cancer has not been well characterized. In the present study, SIN1 is associated with the progression and survival of breast cancer patients, as well as human breast cancer cell proliferation and migration. SIN1 mRNA level was significantly up-regulated in human breast cancer...

View article titled, SIN1 promotes the proliferation and migration of breast cancer cells by Akt activation

Articles

Role of miRNA-146 in proliferation and differentiation of mouse neural stem cells

Wei-Zhong Xiao, An-Qing Lu, Xin-Wei Liu, Zhe Li, Ying Zi, Zhi-Wei Wang

Biosci Rep (2015) 35 (5): e00245.

DOI: https://doi.org/10.1042/BSR20150088

Published: 10 September 2015

.... In the present study, miR-146 promoted spontaneous differentiation of neural stem cells (NSCs), and this mechanism was influenced by miR-146 , as well as its target (notch 1) and downstream gene. cell proliferation differentiation microRNA neural stem cells miRNAs are a fundamental class...

View article titled, Role of miRNA-146 in proliferation and differentiation of mouse neural stem cells

Articles

The down-regulation of GNAO1 and its promoting role in hepatocellular carcinoma

Xiaoyu Pei, Jun Zhang, Lijun Wu, Bin Lü, Xiaojiao Zhang, Dongqin Yang, Jie Liu

Biosci Rep (2013) 33 (5): e00069.

DOI: https://doi.org/10.1042/BSR20130001

Published: 17 September 2013

... by which it took effects. The expression of GNAO1 was detected by IHC (immunohistochemistry) and real-time qPCR (quantitative PCR). Cell proliferation test and cell senescence test were then performed to explore the role of GNAO1 in the occurrence and development of HCC. It was revealed that the level...

View article titled, The down-regulation of GNAO1 and its promoting role in hepatocellular carcinoma

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