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The effect of epigenetic reprogramming using MI192 HDAC inhibitor on enhancing the osteogenesis of human adipose-derived stem cells in vitro

Wei Lu, Kun Ji, Liam Lawlor, Sushmita Saha, Aiden Hempshall, Yan Jin, Xuebin B. Yang

Biosci Rep (2023) 43 (5): BSR20221635.

DOI: https://doi.org/10.1042/BSR20221635

Published: 28 April 2023

... of epigenetic reprogramming of hADSCs via HDAC inhibition for controlling the cell cycle, resulting in enhancing hADSCs osteogenic differentiation, which indicates the potential of using MI192 for promoting bone tissue regeneration. Figure 1 Morphological changes of hADSCs after 5 d MI192 treatment MI192...

View article titled, The effect of epigenetic reprogramming using MI192 HDAC inhibitor on enhancing the osteogenesis of human adipose-derived stem cells in vitro

Includes: Supplementary data

Articles

Retraction: Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Biosci Rep (2023) 43 (4): BSR-2015-0258_RET.

DOI: https://doi.org/10.1042/BSR-2015-0258_RET

Published: 21 April 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . TMEM14A cell cycle metastasis ovarian cancer This Retraction follows...

View article titled, Retraction: Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Articles

Retraction: Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR–NF-κB signalling pathway in human epidermoid carcinoma A431 cells

Biosci Rep (2023) 43 (4): BSR-2015-0002_RET.

DOI: https://doi.org/10.1042/BSR-2015-0002_RET

Published: 06 April 2023

... BY) . apoptosis cell cycle epidermal growth factor receptor–nuclear factor-kappa B signalling pathway human epidermoid carcinoma cells shikonin ...

View article titled, Retraction: Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR–NF-κB signalling pathway in human epidermoid carcinoma A431 cells

Articles

Retraction: Stromal interaction molecule 1 (STIM1) regulates growth, cell cycle and apoptosis of human tongue squamous carcinoma cells

Biosci Rep (2023) 43 (3): BSR-2016-0519_RET.

DOI: https://doi.org/10.1042/BSR-2016-0519_RET

Published: 02 March 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell cycle STIM1 Tca-8113 cells tongue squamous carcinoma...

View article titled, Retraction: Stromal interaction molecule 1 (STIM1) regulates growth, cell cycle and apoptosis of human tongue squamous carcinoma cells

Articles

Expression of Concern: Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Biosci Rep (2023) 43 (2): BSR-2015-0258_EOC.

DOI: https://doi.org/10.1042/BSR-2015-0258_EOC

Published: 09 February 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell cycle metastasis ovarian cancer THEM14A The Editorial Office has...

View article titled, Expression of Concern: Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Articles

Retraction: FEZF1-AS1 is a key regulator of cell cycle, epithelial-mesenchymal transition and Wnt/β-catenin signaling in nasopharyngeal carcinoma cells

Biosci Rep (2023) 43 (1): BSR-2018-0906_RET.

DOI: https://doi.org/10.1042/BSR-2018-0906_RET

Published: 30 January 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell cycle EMT FEZF1-AS1 nasopharyngeal carcinoma Wnt/β-catenin signaling...

View article titled, Retraction: FEZF1-AS1 is a key regulator of cell cycle, epithelial-mesenchymal transition and Wnt/β-catenin signaling in nasopharyngeal carcinoma cells

Articles

Expression of Concern: Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-κB signalling pathway in human epidermoid carcinoma A431 cells

Biosci Rep (2023) 43 (1): BSR-2015-0002_EOC.

DOI: https://doi.org/10.1042/BSR-2015-0002_EOC

Published: 19 January 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell cycle epidermal growth factor receptor–nuclear factor-kappa...

View article titled, Expression of Concern: Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-κB signalling pathway in human epidermoid carcinoma A431 cells

Articles

Jolkinolide B induces cell cycle arrest and apoptosis in MKN45 gastric cancer cells and inhibits xenograft tumor growth in vivo

Hao Zhang, Jiayi Qian, Ming Jin, Li Fan, SongJie Fan, Hong Pan, Yang Li, Ningning Wang, Baiyu Jian

Biosci Rep (2022) 42 (6): BSR20220341.

DOI: https://doi.org/10.1042/BSR20220341

Published: 27 June 2022

... 04 06 2022 07 06 2022 08 06 2022 © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Cell Cycle...

View article titled, Jolkinolide B induces cell cycle arrest and apoptosis in MKN45 gastric cancer cells and inhibits xenograft tumor growth in vivo

Includes: Supplementary data

Articles

Expression of Concern: Effect of microRNA-495 on lower extremity deep vein thrombosis through the TLR4 signaling pathway by regulation of IL1R1

Biosci Rep (2022) 42 (6): BSR-2018-0598_EOC.

DOI: https://doi.org/10.1042/BSR-2018-0598_EOC

Published: 30 May 2022

... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell cycle Femoral vein IL1R1 Lower extremity deep vein thrombosis...

View article titled, Expression of Concern: Effect of microRNA-495 on lower extremity deep vein thrombosis through the TLR4 signaling pathway by regulation of IL1R1

Articles

Correction: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin

Biosci Rep (2021) 41 (10): BSR-2019-0503_COR.

DOI: https://doi.org/10.1042/BSR-2019-0503_COR

Published: 29 October 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis bladder cancer cell cycle ENO1 This Correction follows...

View article titled, Correction: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin

Articles

Retraction: RNAi-mediated TCF-3 gene silencing inhibits proliferation of Eca-109 esophageal cancer cells by inducing apoptosis

Biosci Rep (2021) 41 (9): BSR-20170799_RET.

DOI: https://doi.org/10.1042/BSR-20170799_RET

Published: 13 September 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell cycle Eca-109 cell Esophageal cancer SiRNA Transcription factor 3...

View article titled, Retraction: RNAi-mediated TCF-3 gene silencing inhibits proliferation of Eca-109 esophageal cancer cells by inducing apoptosis

Articles

Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo

Nan-Chieh Huang, Ru-Lai Huang, Xiao-Fan Huang, Kai-Fu Chang, Chien-Ju Lee, Chih-Yen Hsiao, Shan-Chih Lee, Nu-Man Tsai

Biosci Rep (2021) 41 (7): BSR20211143.

DOI: https://doi.org/10.1042/BSR20211143

Published: 12 July 2021

... of J. communis extract (JCo extract) on HCC in vitro and in vivo . In the present study, we found that JCo extract inhibited the growth of human HCC cells by inducing cell cycle arrest at the G 0 /G 1 phase, extensive apoptosis and suppressing metastatic protein expressions in HCC cells. Moreover...

View article titled, Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo

Articles

Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer

Qing Wang, Jiahong Liang, Xianyu Hu, Songgang Gu, Qiaodong Xu, Jiang Yan

Biosci Rep (2021) 41 (7): BSR20210055.

DOI: https://doi.org/10.1042/BSR20210055

Published: 28 June 2021

... with the poor prognosis of GC patients, the prognostic model was established in TCGA-STAD cohort, and validated in Gene Expression Omnibus (GEO) cohorts, with effectiveness in both HER2 positive and negative patients. DNA methylation was involved in the impact on prognosis. Cell cycle, immune-associated...

View article titled, Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer

Includes: Supplementary data

Articles

Incaspitolide A extracted from Carpesium cernuum induces apoptosis in vitro via the PI3K/AKT pathway in benign prostatic hyperplasia

Xiaoyue Chen, Jingrui Song, Dongbo Yuan, Qing Rao, Kehua Jiang, Shuhui Feng, Guohua Zhu, Chen Yan, Yanmei Li, Jianguo Zhu

Biosci Rep (2021) 41 (6): BSR20210477.

DOI: https://doi.org/10.1042/BSR20210477

Published: 21 June 2021

... investigated the molecular mechanisms underlying the suppressive effect of TMJ-12 specifically on BPH-1 cells. A cytotoxicity assay indicated that TMJ-12 inhibited BPH-1 cell proliferation, while flow cytometry assays showed that TMJ-12 induced G 2 /M phase cell cycle arrest and the apoptosis of BPH-1 cells...

View article titled, Incaspitolide A extracted from Carpesium cernuum induces apoptosis in vitro via the PI3K/AKT pathway in benign prostatic hyperplasia

Includes: Supplementary data

Articles

A new chapter for a better Bioscience Reports

Christopher D.O. Cooper, Weiping Han

Biosci Rep (2021) 41 (5): BSR20211016.

DOI: https://doi.org/10.1042/BSR20211016

Published: 17 May 2021

... of the molecular life sciences, both basic and applied. biochemical techniques and resources biomarkers cell cycle genomics molecular basis of health and disease © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society...

View article titled, A new chapter for a better Bioscience Reports

Articles

Expression of Concern: Stromal interaction molecule 1 (STIM1) regulates growth, cell cycle and apoptosis of human tongue squamous carcinoma cells

Biosci Rep (2021) 41 (4): BSR-20160519_EOC.

DOI: https://doi.org/10.1042/BSR-20160519_EOC

Published: 19 April 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell cycle STIM1 Tca-8113 cells tongue squamous carcinoma...

View article titled, Expression of Concern: Stromal interaction molecule 1 (STIM1) regulates growth, cell cycle and apoptosis of human tongue squamous carcinoma cells

Articles

Expression of Concern: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin

Biosci Rep (2021) 41 (2): BSR-20190503_EOC.

DOI: https://doi.org/10.1042/BSR-20190503_EOC

Published: 16 February 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . β-catenin apoptosis bladder cancer cell cycle ENO1 The Editorial...

View article titled, Expression of Concern: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin

Articles

Suppression of oral cancer by induction of cell cycle arrest and apoptosis using Juniperus communis extract

Ching-Chang Lee, Chih-Yen Hsiao, Shan-Chih Lee, Xiao-Fan Huang, Kai-Fu Chang, Ming-Shih Lee, Ming-Chang Hsieh, Nu-Man Tsai

Biosci Rep (2020) 40 (9): BSR20202083.

DOI: https://doi.org/10.1042/BSR20202083

Published: 07 September 2020

...-fluorouracil (5-FU). We found that JCo inhibited oral cancer cell growth, and that JCo might be less cytotoxic to normal cells than to cancer cells. After JCo treatment, cell cycle arrest was observed at the G 0 /G 1 phase through modulation of p53/p21 and Rb signaling. JCo also caused an increase in the sub-G...

View article titled, Suppression of oral cancer by induction of cell cycle arrest and apoptosis using Juniperus communis extract

Articles

Discovery of novel isoliquiritigenin analogue ISL-17 as a potential anti-gastric cancer agent

Fengchang Huang, Jin Wang, Yi Xu, Yunfei Zhang, Ning Xu, Liang Yin

Biosci Rep (2020) 40 (6): BSR20201199.

DOI: https://doi.org/10.1042/BSR20201199

Published: 19 June 2020

... effective anti-gastric cancer agents based on ISL, aldol condensation reaction was applied to synthesize the ISL analogues. MTS assay was used to evaluate the inhibitory activities of ISL analogues against SGC-7901, BGC-823 and GES-1 cells in vitro . Cell cycle distribution, apoptosis and reactive oxygen...

View article titled, Discovery of novel isoliquiritigenin analogue ISL-17 as a potential anti-gastric cancer agent

Includes: Supplementary data

Articles

Tumor suppressor properties of the small C-terminal domain phosphatases in non-small cell lung cancer

George S. Krasnov, Grigory A. Puzanov, Marina A. Afanasyeva, Erdem B. Dashinimaev, Khava S. Vishnyakova, Artemy D. Beniaminov, Alexei A. Adzhubei, Tatiana T. Kondratieva, Yegor E. Yegorov, Vera N. Senchenko

Biosci Rep (2019) 39 (12): BSR20193094.

DOI: https://doi.org/10.1042/BSR20193094

Published: 13 December 2019

...). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell cycle microRNA SCP/CTDSP phosphatases tumor suppressors Lung cancer is the most commonly...

View article titled, Tumor suppressor properties of the small C-terminal domain phosphatases in non-small cell lung cancer

Includes: Supplementary data

Articles

A novel benzoxazinone derivative YLT-LL-11 inhibits diffuse large B-cell lymphoma growth via inducing cell cycle arrest and apoptosis

Cuiting Peng, Changzhen Sun, Ningyu Wang, Yuanmin He, Jixiang Xu, Yongqiong Deng, Lanyang Gao, Jianqiao Zhong, Xia Xiong, Li Liu

Biosci Rep (2019) 39 (10): BSR20190828.

DOI: https://doi.org/10.1042/BSR20190828

Published: 11 October 2019

... that YLT-LL-11 inhibited the proliferation of a DLBCL cell line OCI-LY10 via inducing G0/G1 cell cycle arrest with regulation of the cyclin-dependent kinases (CDKs) expression. Furthermore, YLT-LL-11 facilitated OCI-LY10 cell apoptosis by up-regulation of pro-apoptotic protein BAX and down-regulation...

View article titled, A novel benzoxazinone derivative YLT-LL-11 inhibits diffuse large B-cell lymphoma growth via inducing cell cycle arrest and apoptosis

Includes: Supplementary data

Articles

Hexokinase II inhibition by 3-bromopyruvate sensitizes myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin

Yogesh Rai, Priyanshu Yadav, Neeraj Kumari, Namita Kalra, Anant Narayan Bhatt

Biosci Rep (2019) 39 (9): BSR20190880.

DOI: https://doi.org/10.1042/BSR20190880

Published: 24 September 2019

... cell cycle Daunorubicin Hexokinase-II Leukemia Glycolytic shift of energy metabolism is one of the fundamental changes that occur in cancer cells. Otto Warburg first described that even in the presence of adequate amount of oxygen, cancer cells increased the glycolytic flux for faster rate...

View article titled, Hexokinase II inhibition by 3-bromopyruvate sensitizes myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin

Articles

Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin

Mingfei Ji, Zhijun Wang, Jie Chen, Liqiong Gu, Ming Chen, Yelei Ding, Tao Liu

Biosci Rep (2019) 39 (9): BSR20190503.

DOI: https://doi.org/10.1042/BSR20190503

Published: 09 September 2019

... revealed that ENO1 was critical for the growth and proliferation of BC cells. ENO1 over-expression also promoted the proliferation of SV-HUC-1 cells. At the molecular level, the cell cycle and apoptosis related genes were regulated by ENO1. β-catenin expression was positively regulated by ENO1. Furthermore...

View article titled, Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin

Articles

miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3

Lan Feng, Kai Cheng, Rongjia Zang, Qingdong Wang, Jianjie Wang

Biosci Rep (2019) 39 (9): BSR20190654.

DOI: https://doi.org/10.1042/BSR20190654

Published: 06 September 2019

... and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the proliferation of GC...

View article titled, miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3

Articles

Circular RNA MYLK serves as an oncogene to promote cancer progression via microRNA-195/cyclin D1 axis in laryngeal squamous cell carcinoma

Xiaohui Duan, Na Shen, Jie Chen, Jing Wang, Qinghua Zhu, Zhihai Zhai

Biosci Rep (2019) 39 (9): BSR20190227.

DOI: https://doi.org/10.1042/BSR20190227

Published: 03 September 2019

... to investigate the expression profile and biological role of circMYLK in LSCC. We found that circMYLK was highly expressed in LSCC tissues and cell lines. circMYLK overexpression promoted LSCC cell proliferation and G 1 /S cell cycle transition; whereas circMYLK knockdown had the contrary effects...

View article titled, Circular RNA MYLK serves as an oncogene to promote cancer progression via microRNA-195/cyclin D1 axis in laryngeal squamous cell carcinoma

Articles

Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase

JiaNan Li, QiuHong Wang, ZhiBin Wang, Na Cui, BingYou Yang, WenYing Niu, HaiXue Kuang

Biosci Rep (2019) 39 (5): BSR20182109.

DOI: https://doi.org/10.1042/BSR20182109

Published: 14 May 2019

... of the cell cycle, apoptosis, targets prediction, molecular docking, and alterations in protein levels were performed to elucidate how Tet functions in colon cancer. We found that Tet robustly induced arrest at the G1 phase in colon cancer cell line HT-29. It induced HT-29 cell apoptosis in a dose-dependent...

View article titled, Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase

Articles

Hydroxyurea promotes TET1 expression and induces apoptosis in osteosarcoma cells

Songsong Teng, Chunhui Ma, Yinxian Yu, Chengqing Yi

Biosci Rep (2019) 39 (5): BSR20190456.

DOI: https://doi.org/10.1042/BSR20190456

Published: 14 May 2019

... in U2OS cells after treatment with hydroxyurea. In addition, hydroxyurea increased cell apoptosis and altered the cell cycle. TET proteins catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC); therefore, 5mC and 5hmC levels were evaluated. Increased 5hmC levels were observed...

View article titled, Hydroxyurea promotes TET1 expression and induces apoptosis in osteosarcoma cells

Includes: Supplementary data

Articles

USP39 regulates the cell cycle, survival, and growth of human leukemia cells

Chunxia Liu, Xiaojian Yao, Ming Li, Yaming Xi, Li Zhao

Biosci Rep (2019) 39 (4): BSR20190040.

DOI: https://doi.org/10.1042/BSR20190040

Published: 05 April 2019

... of the patients with leukemia. Lentivirus-mediated knockdown of USP39 repressed the proliferation and colony formation of human leukemia cell lines HL-60 and Jurkat cells. Mechanism study showed that USP39 knockdown induced the arrest of cell cycle and apoptosis of leukemia cells. In addition, our microarray...

View article titled, USP39 regulates the cell cycle, survival, and growth of human leukemia cells

Includes: Supplementary data

Articles

Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma

Shu Dong, Fei Huang, Hao Zhang, Qiwen Chen

Biosci Rep (2019) 39 (2): BSR20182306.

DOI: https://doi.org/10.1042/BSR20182306

Published: 26 February 2019

... 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell cycle disease-free survival overall survival pancreatic ductal...

View article titled, Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma

Includes: Supplementary data

Articles

The Mycoplasma pneumoniae HapE alters the cytokine profile and growth of human bronchial epithelial cells

Shaoli Li, Guanhua Xue, Hanqing Zhao, Yanling Feng, Chao Yan, Jinghua Cui, Hongmei Sun

Biosci Rep (2019) 39 (1): BSR20182201.

DOI: https://doi.org/10.1042/BSR20182201

Published: 18 January 2019

... pathogenesis. Recombinant HapE was purified for use in downstream assays. MTT and colony formation assays were conducted to determine the effects of HapE on cell viability and growth, while flow cytometry was used to examine changes in cell proliferation and cell cycle function. ELISA was performed to examine...

View article titled, The Mycoplasma pneumoniae HapE alters the cytokine profile and growth of human bronchial epithelial cells

Articles

FEZF1-AS1 is a key regulator of cell cycle, epithelial–mesenchymal transition and Wnt/β-catenin signaling in nasopharyngeal carcinoma cells

Yunzhou Cheng

Biosci Rep (2019) 39 (1): BSR20180906.

DOI: https://doi.org/10.1042/BSR20180906

Published: 08 January 2019

... with poor prognosis of NPC patients. We further observed that knockdown of FEZF1-AS1 inhibited the proliferation of NPC cells in vitro and suppressed NPC xenograft growth in vivo through inducing G2/M cell cycle arrest. The migratory and invasive abilities of NPC cells were also reduced upon FEZF1-AS1...

View article titled, FEZF1-AS1 is a key regulator of cell cycle, epithelial–mesenchymal transition and Wnt/β-catenin signaling in nasopharyngeal carcinoma cells

Articles

Long non-coding RNA SNHG14 exerts oncogenic functions in non-small cell lung cancer through acting as an miR-340 sponge

Zhenhua Zhang, Yong Wang, Wei Zhang, Junyan Li, Weiliang Liu, Wenming Lu

Biosci Rep (2019) 39 (1): BSR20180941.

DOI: https://doi.org/10.1042/BSR20180941

Published: 03 January 2019

... of SNHG14 inhibited NSCLC cell proliferation through inducing cell cycle arrest and apoptosis, whereas SNHG14 overexpression exerted the opposite effects. Animal experiment further revealed that down-regulated SNHG14 greatly inhibited NSCLC tumor growth in vivo . Further studies demonstrated that SNHG14...

View article titled, Long non-coding RNA SNHG14 exerts oncogenic functions in non-small cell lung cancer through acting as an miR-340 sponge

Articles

Effect of miR-495 on lower extremity deep vein thrombosis through the TLR4 signaling pathway by regulation of IL1R1

Ke-Cheng Tang, Zhi-Peng Yang, Qiu Zeng, Jing Wang, Feng Guo, Yu Zhao

Biosci Rep (2018) 38 (6): BSR20180598.

DOI: https://doi.org/10.1042/BSR20180598

Published: 21 December 2018

...-related genes. The expressions of both CD31 and CD34 (markers for endothelial progenitor cells) in the FV endothelial cells as well as the proportion of CD31 + /CD34 + cells in peripheral blood were measured in order to evaluate thrombosis. The effect of miR-495 on cell viability, cell cycle...

View article titled, Effect of miR-495 on lower extremity deep vein thrombosis through the TLR4 signaling pathway by regulation of IL1R1

Includes: Supplementary data

Articles

Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells

Xiong Wang, Lei Zhang, Wenji Wang, Yuchen Wang, Ye Chen, Ruimin Xie, Xiang Li, Yongping Wang

Biosci Rep (2018) 38 (6): BSR20181384.

DOI: https://doi.org/10.1042/BSR20181384

Published: 21 November 2018

... that the level of Rhotekin 2 (RTKN2) was up-regulated in osteosarcoma tissues and cell lines. In addition, silencing of RTKN2 of human osteosarcoma cell lines U2OS, inhibited proliferation, and induced G 1 phase cell cycle arrest via reducing the level of the cyclin-dependent kinase 2 (CDK2). Furthermore, RTKN2...

View article titled, Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells

Articles

Golgi integral membrane protein 4 manipulates cellular proliferation, apoptosis, and cell cycle in human head and neck cancer

Yunfei Bai, Xiaobo Cui, Dongxue Gao, Yaping Wang, Boqian Wang, Wei Wang

Biosci Rep (2018) 38 (4): BSR20180454.

DOI: https://doi.org/10.1042/BSR20180454

Published: 31 August 2018

... and neck cancer cells FaDu (human pharyngeal squamous carcinoma cell) and Tca-8113 (human tongue squamous carcinoma cell) with knockdown of GOLIM4 by lentivirus. And the decreased expression of GOLIM4 induced cellular apoptosis. Further experiments revealed that FaDu cell cycle progression was changed...

View article titled, Golgi integral membrane protein 4 manipulates cellular proliferation, apoptosis, and cell cycle in human head and neck cancer

Includes: Supplementary data

Articles

Carnosic acid impedes cell growth and enhances anticancer effects of carmustine and lomustine in melanoma

Kun-I Lin, Chih-Chien Lin, Shyh-Ming Kuo, Jui-Chi Lai, You-Qi Wang, Huey-Ling You, Mei-Ling Hsu, Chang-Han Chen, Li-Yen Shiu

Biosci Rep (2018) 38 (4): BSR20180005.

DOI: https://doi.org/10.1042/BSR20180005

Published: 03 July 2018

... assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was used for cell cycle detection. p21 and p27 expression was detected by Western blotting. B16F10 cell xenograft model was established, and treated with CA...

View article titled, Carnosic acid impedes cell growth and enhances anticancer effects of carmustine and lomustine in melanoma

Articles

Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis

Chunyan Hao, Hubin Duan, Hao Li, Huan Wang, Yueting Liu, Yimin Fan, Ce Zhang

Biosci Rep (2018) 38 (2): BSR20171456.

DOI: https://doi.org/10.1042/BSR20171456

Published: 27 April 2018

... tissues. Functionally, we silenced MRPL42 in glioma cells and revealed that MRPL42 knockdown largely blunted the proliferation of U251 and A172 cells. Mechanistically, our results suggested that MRPL42 silencing resulted in increased distribution of cell cycle in G 1 and G 2 /M phases, while the S-phase...

View article titled, Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis

Articles

RNAi-mediated TCF-3 gene silencing inhibits proliferation of Eca-109 esophageal cancer cells by inducing apoptosis

Jie Ma, Xian-Bin Wang, Rui Li, Shu-Hong Xuan, Fang Wang, Xin-Hua Li, Zhi-Ping Zhang, Lu Tan, Lian Li

Biosci Rep (2017) 37 (6): BSR20170799.

DOI: https://doi.org/10.1042/BSR20170799

Published: 09 November 2017

...-2, Bax, and caspase-3 were determined using Western blotting. Transfection of siTCF-3 successfully down-regulated TCF-3 gene expression. In addition, siTCF-3, reduced Eca-109 cell viability and proliferation, in a time-dependent manner, and inhibited progression of cell cycle from G 0 /G 1 to S...

View article titled, RNAi-mediated TCF-3 gene silencing inhibits proliferation of Eca-109 esophageal cancer cells by inducing apoptosis

Articles

Up-regulation of ANKDR49, a poor prognostic factor, regulates cell proliferation of gliomas

Chunyan Hao, Hubin Duan, Hao Li, Mingyang Pei, Yueting Liu, Yimin Fan, Ce Zhang

Biosci Rep (2017) 37 (4): BSR20170800.

DOI: https://doi.org/10.1042/BSR20170800

Published: 04 August 2017

... targetting ANKRD49 was constructed in U251 and U87 malignant glioma cells. We demonstrated that ANKRD49 knockdown reduced the proliferation rate of U251 and U87 cells. Further mechanism analysis indicated that depletion of ANKRD49 led to the cell-cycle arrest and induced apoptosis in U251 and U87 cells...

View article titled, Up-regulation of ANKDR49, a poor prognostic factor, regulates cell proliferation of gliomas

Articles

Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/ FBXW7 pathway

Haiwei Zhang, Fanglin Chen, Yongpeng He, Lin Yi, Chuang Ge, Xiaolong Shi, Chao Tang, Donglin Wang, Yongzhong Wu, Weiqi Nian

Biosci Rep (2017) 37 (3): BSR20160478.

DOI: https://doi.org/10.1042/BSR20160478

Published: 21 June 2017

...) was observed among cells transfected with FBXW7 siRNA when compared with cells transfected with an empty vector. Cell cycle Cell apoptosis Erlotinib MicroRNA-223 Non-small cell lung cancer Lung cancer is the most common type of cancer worldwide, and almost 80% of lung cancers are classified...

View article titled, Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/ FBXW7 pathway

Includes: Supplementary data

Articles

Stromal interaction molecule 1 regulates growth, cell cycle, and apoptosis of human tongue squamous carcinoma cells

Xiaobo Cui, Laixiao Song, Yunfei Bai, Yaping Wang, Boqian Wang, Wei Wang

Biosci Rep (2017) 37 (2): BSR20160519.

DOI: https://doi.org/10.1042/BSR20160519

Published: 02 March 2017

... repressed the proliferation of Tca-8113 cells. In addition, we also showed that STIM1 deficiency reduced colony number of Tca-8113 cells. Knockdown of STIM1 repressed cells to enter M phase of cell cycle and induced cellular apoptosis. Furthermore, we performed microarray and bioinformatics analysis...

View article titled, Stromal interaction molecule 1 regulates growth, cell cycle, and apoptosis of human tongue squamous carcinoma cells

Articles

Cucurbitacin E inhibits osteosarcoma cells proliferation and invasion through attenuation of PI3K/AKT/mTOR signalling pathway

Ying Wang, Shumei Xu, Yaochi Wu, Junfeng Zhang

Biosci Rep (2016) 36 (6): e00405.

DOI: https://doi.org/10.1042/BSR20160165

Published: 08 November 2016

...-8 assay. Flow cytometry analysis was employed to measure apoptosis of OS cells. Cell cycle distribution was analysed by propidium iodide staining. Transwell assay was performed to evaluate the effect of CuE on invasion potential of OS cells. The protein levels were measured by western blot...

View article titled, Cucurbitacin E inhibits osteosarcoma cells proliferation and invasion through attenuation of PI3K/AKT/mTOR signalling pathway

Includes: Supplementary data

Articles

APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway

Ajeena Ramanujan, Swati Tiwari

Biosci Rep (2016) 36 (5): e00377.

DOI: https://doi.org/10.1042/BSR20160152

Published: 16 September 2016

...Ajeena Ramanujan; Swati Tiwari The ubiquitin (Ub) ligase anaphase promoting complex/cyclosome (APC/C) and the tumour suppressor retinoblastoma protein (pRB) play key roles in cell cycle regulation. APC/C is a critical regulator of mitosis and G 1 -phase of the cell cycle whereas pRB keeps a check...

View article titled, APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway

Articles

Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Qingmei Zhang, Xiufeng Chen, Xuan Zhang, Jingfen Zhan, Jie Chen

Biosci Rep (2016) 36 (1): e00298.

DOI: https://doi.org/10.1042/BSR20150258

Published: 19 February 2016

... patients. In addition, TMEM14A knockdown in two ovarian cancer cell lines, A2780 and HO-8910, reduced cell proliferation, causes cell cycle arrest and suppressed cell invasion. Moreover, silencing of TMEM14A notably repressed G1/S cell cycle transition and cell invasion via down-regulating the expression...

View article titled, Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Includes: Supplementary data

Articles

The mitotic regulator Hec1 is a critical modulator of prostate cancer through the long non-coding RNA BX647187 in vitro

Haifeng Wang, Xu Gao, Xin Lu, Yan Wang, Chunfei Ma, Zhenkai Shi, Feng Zhu, Biming He, Chuanliang Xu, Yinghao Sun

Biosci Rep (2015) 35 (6): e00273.

DOI: https://doi.org/10.1042/BSR20150003

Published: 26 November 2015

... samples by quantitative real-time (qRT)-PCR. The effects of Hec1 on PCa cells were studied by RNAi approach. Apoptosis and cell cycle were analysed by flow cytometry. Cells viability was evaluated using cell counting Kit-8. Cyclin B1–Cdc2 (cell division cycle 2) activity was measured by ELISA assay. Long...

View article titled, The mitotic regulator Hec1 is a critical modulator of prostate cancer through the long non-coding RNA BX647187 in vitro

Articles

Overexpression of transforming growth factor type III receptor restores TGF-β1 sensitivity in human tongue squamous cell carcinoma cells

Duo Li, Dongyang Xu, Zhiyong Lu, Xingli Dong, Xiaofeng Wang

Biosci Rep (2015) 35 (4): e00243.

DOI: https://doi.org/10.1042/BSR20150141

Published: 28 August 2015

... with uranyl acetate. Grids were examined under a Jeol 1200 EXII electron microscope. The effect of TβRIII transfection on TGF-β1-induced cell cycle arrest was determined by flow cytometric analysis of DNA content of nuclei of cells following propidium iodide (PI) staining. CAL-27 cells (1×10 6 cells...

View article titled, Overexpression of transforming growth factor type III receptor restores TGF-β1 sensitivity in human tongue squamous cell carcinoma cells

Articles

Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR–NF-κB signalling pathway in human epidermoid carcinoma A431 cells

Rong Tian, You Li, Mei Gao

Biosci Rep (2015) 35 (2): e00189.

DOI: https://doi.org/10.1042/BSR20150002

Published: 28 April 2015

... the underlying molecular mechanisms. In the present study, our results showed that shikonin significantly inhibited the growth of A431 cells in a concentration- and time-dependent manner, and caused cell cycle arrest by upregulation of p21 and p27, and downregulation of cyclins and cyclin-dependent kinases...

View article titled, Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR–NF-κB signalling pathway in human epidermoid carcinoma A431 cells

Articles

Vascular smooth muscle cell proliferation depends on caveolin-1-regulated polyamine uptake

Mario Grossi, Catarina Rippe, Ramasri Sathanoori, Karl Swärd, Amalia Forte, David Erlinge, Lo Persson, Per Hellstrand, Bengt-Olof Nilsson

Biosci Rep (2014) 34 (6): e00153.

DOI: https://doi.org/10.1042/BSR20140140

Published: 21 November 2014

... proliferation and migration compared with WT (wild-type) cells. Both Cav-1 KO and WT cells expressed the smooth muscle differentiation markers SM22 and calponin. Cell-cycle phase distribution analysis revealed a higher proportion of Cav-1 KO than WT cells in the S phase. Cav-1 KO cells were hyper-proliferative...

View article titled, Vascular smooth muscle cell proliferation depends on caveolin-1-regulated polyamine uptake

Includes: Supplementary data

Articles

Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates

Randy Suryadinata, Martin Sadowski, Boris Sarcevic

Biosci Rep (2010) 30 (4): 243–255.

DOI: https://doi.org/10.1042/BSR20090171

Published: 17 March 2010

...Randy Suryadinata; Martin Sadowski; Boris Sarcevic The eukaryotic cell cycle is a fundamental evolutionarily conserved process that regulates cell division from simple unicellular organisms, such as yeast, through to higher multicellular organisms, such as humans. The cell cycle comprises several...

View article titled, Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates

Articles

NOBEL LECTURE: Protein Synthesis, Proteolysis, and Cell Cycle Transitions

Tim Hunt

Biosci Rep (2002) 22 (5-6): 465–486.

DOI: https://doi.org/10.1023/A:1022077317801

Published: 01 December 2002

...Tim Hunt The discovery of the role(s) of protein synthesis and degradation in the operation of the cell cycle is described. © 2002 Plenum Publishing Corporation 2002 Translation cell cycle cyclins meiosis mitosic Bioscience Reports, Vol. 22, Nos. 5 and 6, October and December 2002...

View article titled, NOBEL LECTURE: Protein Synthesis, Proteolysis, and Cell Cycle Transitions

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