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Keywords: caspase
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Biosci Rep (2022) 42 (6): BSR20220119.
Published: 17 June 2022
...Liqi Yao; A. Clay Clark All caspases evolved from a common ancestor and subsequently developed into two general classes, inflammatory or apoptotic caspases. The caspase-hemoglobinase fold has been conserved throughout nearly one billion years of evolution and is utilized for both the monomeric...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20203495.
Published: 29 January 2021
...Liqi Yao; Paul Swartz; Paul T. Hamilton; A. Clay Clark Caspase (or cysteinyl-aspartate specific proteases) enzymes play important roles in apoptosis and inflammation, and the non-identical but overlapping specificity profiles (that is, cleavage recognition sequence) direct cells to different fates...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (1): BSR20180992.
Published: 18 January 2019
... through recruitment of two adaptor proteins: TNF receptor-associated death domain (TRADD) and Fas-associated death domain protein (FADD), and effect programmed cell death through the action of caspases. TNF ligands form homotrimers which bind to TNF receptors on the membrane. Upon binding, adaptor...
Articles
Biosci Rep (2018) 38 (3): BSR20180503.
Published: 31 May 2018
... of apoptosis, which was followed by release of mitochondrial cytochrome c to cytosol, activation of caspase-3 and -9, as well as cleaved PARP. Moreover, Western blot results confirmed that Piperine (8, 16, and 20 μM) decreased phosphorylation of JNK and p38 MAPK in A2780 cells. In addition, caspase-3 inhibitor...
Articles
Articles
Biosci Rep (2012) 32 (4): 401–411.
Published: 28 June 2012
...Jad Walters; Joshua L. Schipper; Paul Swartz; Carla Mattos; A. Clay Clark A mutation in the allosteric site of the caspase 3 dimer interface of Val 266 to histidine abolishes activity of the enzyme, and models predict that the mutation mimics the action of small molecule allosteric inhibitors...
Includes: Supplementary data
Articles