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Keywords: cancer
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Articles
Patrick Ball, Emma Thompson, Simon Anderson, Vanessa Gwenin, Amir Ashoorzadeh, Jeff Smaill, Chris Gwenin
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (4): BSR20230627.
Published: 25 April 2023
...Patrick Ball; Emma Thompson; Simon Anderson; Vanessa Gwenin; Amir Ashoorzadeh; Jeff Smaill; Chris Gwenin Directed enzyme prodrug therapy is a highly promising anti-cancer strategy. However, the current technology is limited by inefficient prodrug activation and the dose-limiting toxicity associated...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (3): BSR20222174.
Published: 29 March 2023
...Jinyou Yang; Shuyu Xu; Shaozhuo Wang; Xuyan Zou; Mingxiu Duan; Qiaoling Zhang; Chao Wang Gastrointestinal cancers are the most common type of cancer affecting humans. High expression of HOX transcript antisense intergenic RNA (HOTAIR), a long noncoding RNA (lncRNA), in various types of different...
Includes: Supplementary data
Articles
In Collection
Bionanotechnology and Synthetic Biology: applications in precision medicine and allied fields
Ayon Chakraborty, Saswati Soumya Mohapatra, Subhashree Barik, Ipsita Roy, Bhavika Gupta, Ashis Biswas
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (2): BSR20220324.
Published: 07 February 2023
... drug delivery issue in leprosy, tuberculosis and cancer. Thus, in this review, the application of different nanoparticles for the treatment of these four important diseases (Alzheimer’s disease, tuberculosis, leprosy and cancer) as well as for the effective delivery of drugs used in these diseases has...
Articles
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (1): BSR20220489.
Published: 30 January 2023
... License 4.0 (CC BY) . acute myeloid leukaemia cancer chromosomal translocation paediatric Figure 1 Epidemiology of paediatric leukaemia ( A ) Total cases of leukaemia in the UK by diagnosis (AML, ALL, CML and CLL) and age group (adult or children). ( B ) Incidence of paediatric...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (12): BSR20222171.
Published: 22 December 2022
... the bloodstream. Apoptosis inhibition is one of the hallmarks of cancer and its induction in tumors is a widely used therapeutic approach. Apoptosis inhibition and induction correlate with decreased and increased serum levels of cyt c , respectively. The quantification of cyt c in the serum is useful...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (11): BSR20221280.
Published: 21 November 2022
... SET splicing, and cellular localization to cancer progression and development of neurodegenerative tauopathies such as Alzheimer’s disease. Molecular biology tools, such as targeted genetic deletion, and pharmacological approaches based on SET antagonist peptides, have contributed to unveil...
Articles
In Collection
Bionanotechnology and Synthetic Biology: applications in precision medicine and allied fields
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (7): BSR20212051.
Published: 08 July 2022
... materials are widely used as molecular transporter for delivering therapeutics and imaging agents. Nanomedicine involving multi-component chemotherapeutic drug-based combination therapy has been found to be an improved promising approach to increase the efficacy of cancer treatment. Next-generation...
Articles
Karla Gisel Calderon-González, Ixaura Medina-Medina, Lucia Haronikova, Lenka Hernychova, Ondrej Bonczek, Lukas Uhrik, Vaclav Hrabal, Borivoj Vojtesek, Robin Fahraeus, Jesús Hernández-Monge, Vanesa Olivares-Illana
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (7): BSR20220186.
Published: 04 July 2022
... The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer HDM2 HDMX Induced fit MDM2 MDMX p53 ubiquitination Despite the high homology...
Includes: Supplementary data
Articles
Swagata Adhikari, Apoorva Bhattacharya, Santanu Adhikary, Vipin Singh, Shrikanth S. Gadad, Siddhartha Roy, Chandrima Das
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (4): BSR20211812.
Published: 19 April 2022
...Swagata Adhikari; Apoorva Bhattacharya; Santanu Adhikary; Vipin Singh; Shrikanth S. Gadad; Siddhartha Roy; Chandrima Das Innate and acquired resistance towards the conventional therapeutic regimen imposes a significant challenge for the successful management of cancer for decades. In patients...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (2): BSR20211248.
Published: 25 February 2022
... in these cellular locations have not been studied in detail yet. In recent years, MMRN1 has been identified as a differentially expressed gene (DEG) in various cancers and it has been proposed as a possible cancer biomarker. Some evidence suggest that MMRN1 expression is regulated by methylation, protein...
Articles
Vasudha Tandon, Ruturajsinh M. Vala, Albert Chen, Robert L. Sah, Hitendra M. Patel, Michael C. Pirrung, Sourav Banerjee
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (2): BSR20212721.
Published: 11 February 2022
... and immunoproteasome inhibitor, capable of inducing cell death in multiple myeloma, triple-negative breast cancer, (TNBC) and non-small cell lung cancer lines. TIR-199 also effectively inhibits the proteasome in primary myeloma cells of patients, and bypasses the PSMB5 A49T+A50V bortezomib-resistant mutant. TIR-199...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (2): BSR20212002.
Published: 04 February 2022
... this extraordinary feat through their unique kinetic parameters, myriad regulatory strategies, and their sensitivity to their surroundings, including substrate concentration and pH. The Cancer Genome Atlas (TCGA) highlights the extraordinary number of ways in which the finely tuned activities of enzymes can...
Articles
Nuzhat Sial, Jalil Ur Rehman, Saba Saeed, Mukhtiar Ahmad, Yasir Hameed, Muhammad Atif, Abdul Rehman, Rizwan Asif, Hamad Ahmed, Muhammad Safdar Hussain, Muhammad Rashid Khan, Atifa Ambreen, Ayesha Ambreen
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (1): BSR20211783.
Published: 06 January 2022
... earlier been examined in only a few human cancers. Objectives: Multi-omics profiling of MTHFD1L as a shared biomarker in distinct subtypes of human cancers. Methods: In the current study, for the multi-omics analysis of MTHFD1L in 24 major subtypes of human cancers, a comprehensive in silico approach...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (12): BSR20211577.
Published: 17 December 2021
... tumorigenesis and cell transformation. In this review, we will focus on the recent advances that shed light on the effects of RPs deregulation in different types of cancer and their roles in regulating the tumor cell fate. In normal conditions, p53 expression is low due to its interaction with MDM-2...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (11): BSR20211994.
Published: 12 November 2021
... tyrosine phosphorylation has been linked to various diseases, including metabolic disorders and cancer. Few years ago, protein tyrosine phosphatases (PTPs) were considered as tumor suppressors, able to block the signals emanating from receptor tyrosine kinases. However, recent evidence demonstrates...
Articles
Chen Qiu, Zuyin Li, Wanyue Cao, Xiaoni Cai, Li Ye, Cheng Zhang, Yuefeng Ma, Xiaoliang Wang, Yulong Yang
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (9): BSR20203978.
Published: 17 September 2021
... the expression of RDM1 and expression of marker genes related to immune infiltration. Immunohistochemistry (IHC) method was used to detect the expression level of RDM1 in 90 cases of hepatocellular carcinoma and adjacent normal liver tissues. Results : RDM1 expression was up-regulated in most cancers...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (8): BSR20181627.
Published: 12 August 2021
...Wei Liu; Qin-Peng Wang; Jia Guo Several studies demonstrated that lncRNA differentiation antagonizing non-protein coding RNA (lncRNA DANCR) expression might have the potential capacity to predict the cancer prognosis; however, definite conclusion has not been obtained. The aim of this meta-analysis...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (6): BSR20210462.
Published: 04 June 2021
.... In cancers, HDAC10 plays crucial roles in regulating various cellular processes through its epigenetic functions or targeting some decisive molecular or signaling pathways. It also has potential clinical utility for targeting tumors and non-tumor diseases, such as renal cell carcinoma, prostate cancer...
Articles
Rongqiang Liu, Shiyang Zheng, Kang Yu, Yajie Yu, Chenyu Yu, Wenqing Shi, Qianmin Ge, Zhiwei Ye, Yi Shao
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (2): BSR20204043.
Published: 26 February 2021
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer meta-analysis miR-142 prognosis Globally, tumors have become a major disease threatening people’s health. Although great progress has been made...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (2): BSR20193877.
Published: 03 February 2021
... of cancer. Materials and methods: The data used in this research were collected from Google Scholar, Web of Science, CNKI, and Wan Fang Data databases. The final retrieval ended on 22 February 2019. The strength of correlation was assessed using odds ratios and 95% confidence intervals. Based...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203995.
Published: 14 January 2021
...Weiwei Chen; Yuting Li; Liliangzi Guo; Chenxing Zhang; Shaohui Tang Background: Several studies have assessed the relationship between long non-coding RNA five prime to Xist (FTX) expression, clinicopathological features, and survival outcomes in patients with cancer with conflicting results...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203559.
Published: 07 January 2021
...Mengqiu Xiong; Ping Wang; Bei Pan; Junjie Nie; Shukui Wang; Bangshun He MicroRNA-196a (miR-196a) was previously reported to be up-regulated in cancers, and it has the diagnostic and prognostic values in cancers. Whereas, the conclusion was still unclear according to the published data. To assess...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203459.
Published: 07 January 2021
...Xiao-Jing Qin; Xu Lin; Gang Xue; Hui-Li Fan; Hao-Yu Wang; Jing-Fang Wu; Da Pei Background: In recent years, the annual incidence of thyroid cancer (TC) has increased, with papillary thyroid cancer (PTC) identified as the most commonwinwordpathological type accounting for approximately 80% of all...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (11): BSR20201820.
Published: 17 November 2020
...Bo Ma; Hui Li; Jia Qiao; Tao Meng; Riyue Yu Background: Head and neck squamous cell carcinoma (HNSCC) is recognised as an immune active cancer, but little is known about the role of microRNAs (miRNAs) in it. In the present study, we aim to determine a prognostic and immune-related miRNAs signature...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (11): BSR20202962.
Published: 13 November 2020
...Zhiding Wang; Mengzhen Wang; Jinghong Chen; Linlin Zhang; Li Zhang; Li Yu Cancer immunotherapy has recently undergone rapid development into a validated therapy for clinical use. The adoptive transfer of engineered autologous T cells, such as chimeric antigen receptor (CAR) T cells, has been...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (10): BSR20192051.
Published: 23 October 2020
...Abdolkarim Moazeni-Roodi; Sahel Sarabandi; Shima Karami; Mohammad Hashemi; Saeid Ghavami Fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor tyrosine kinases (RTKs) for FGFs. Several studies have focused on the association between FGFR4 polymorphisms and cancer development...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20202520.
Published: 02 September 2020
...Xiaoqi Yang; Haoran Liu; Tao Ye; Zhangqun Ye Background: Previously published studies have indicated that lymphoid enhancer-binding factor 1 (LEF1) expression could be recognized as a valuable biomarker to evaluate clinical outcome for various types of malignant cancer, but the results remained...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (7): BSR20194468.
Published: 17 July 2020
...Shi Xu Fang; Cheng Chen; Qiang Guo; Xi Xian Ke; Hong Ling Lu; Gang Xu Background: SNHG15 has been reported to be aberrantly expressed in various tumor tissues and could serve as a promising prognostic cancer biomarker. Previous studies on SNHG15 yielded inconsistent results with insufficient...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (7): BSR20191825.
Published: 09 July 2020
...Guang-Hui Qi; Chun-Hui Wang; Hong-Ge Zhang; Jian-Guo Yu; Fei Ding; Zhi-Chao Song; Qing-Hua Xia There is still no conclusion on the potential effect of the rs2295080 and rs2536 polymorphisms of mTOR (mammalian target of rapamycin) gene on different cancers. Herein, we performed a comprehensive...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20192410.
Published: 26 June 2020
...Li-Fang Wu; Gui-Ping Xu; Qing Zhao; Ding Wang; Li-Jing Zhou; Bin Sun; Wei-Xian Chen Background: The evidence for an association between the adiponectin gene (ADIPOQ) polymorphism rs182052 and cancer risk is inconsistent. We performed a meta-analysis to obtain more precise conclusions. Methods...
Includes: Supplementary data
Articles
Zohreh S. Miripour, Parisa Aghaee, Fereshteh Abbasvandi, Parisa Hoseinpour, Mohammad Parniani, Mohammad Abdolahad
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20200970.
Published: 08 June 2020
...Zohreh S. Miripour; Parisa Aghaee; Fereshteh Abbasvandi; Parisa Hoseinpour; Mohammad Parniani; Mohammad Abdolahad Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells...
Includes: Supplementary data
Articles
The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20192320.
Published: 28 May 2020
...Jingdong Li; Yaxuan Wang; Xueliang Chang; Zhenwei Han Purpose: To provide a comprehensive account of the association of five Lymphotoxin-α ( LTA ) gene polymorphisms (rs1041981, rs2229094, rs2239704, rs746868, rs909253) with susceptibility to cancer. Methods: A literature search for eligible...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (2): BSR20194335.
Published: 28 February 2020
...Dan-dan Hu; Hai-ling Chen; Li-ming Lou; Hong Zhang; Guo-liang Yang The processes that lead to lung adenocarcinoma (LUAD) metastasis are poorly characterized. Spindle and kinetochore associated complex subunit 3 (SKA3) plays a key role in cervical cancer development, but its contribution to LUAD...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (2): BSR20193524.
Published: 07 February 2020
...Yuqin Yu; Dapeng Li; Ji’an Duan; Hongshuang Xu; Li Li; Dengwu Tan; Hong Yan Background: Oxycodone is an opioid medication used for the treatment of pain in cancer patients. However, little is known on the direct effects of oxycodone on cancer cells. Aim: To determine the effects and mechanisms...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (12): BSR20190866.
Published: 17 December 2019
...Guowen Ding; Yu Chen; Huiwen Pan; Hao Qiu; Weifeng Tang; Shuchen Chen Background: Previous case–control studies have suggested that apurinic/apyrimidinic endonuclease 1 ( APE1 ) rs1760944 T>G polymorphism may be associated with cancer risk. Here, we carried out an updated meta-analysis to focus...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (12): BSR20192452.
Published: 04 December 2019
... of clinical cancer. Methods We conducted a group of overall and subgroup pooling analyses after retrieving the data from four databases (updated till September 2019). The P -value of association, OR (odds ratios), and 95% CI (confidence interval) were calculated. Results We selected a total of 71 eligible...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (10): BSR20192274.
Published: 18 October 2019
...Caizhi Chen; Long Shu; Wen Zou Cancer incidence rate has increased so much that it is the second leading cause of deaths worldwide after cardiovascular diseases. Sensitive and specific biomarkers are needed for an early diagnosis of cancer and in-time treatment. Recent studies have found that long...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (10): BSR20190608.
Published: 11 October 2019
...Jing Ye; Haiyan Sun; Zhengquan Feng; Qiqin Zhang; Yongliang Xia; Yunxi Ji; Qiqing Zhang Background: Dysregulated expression of long non-coding RNA gastric carcinoma high expressed transcript 1 (lncRNA GHET1) has been observed in several cancers, however, definite conclusion on the prognostic value...
Articles
Elisangela C.P. Lopes, Layde R. Paim, José R. Matos-Souza, Décio R. Calegari, José I. Gorla, Alberto Cliquet, Jr, Carmen S.P. Lima, John F. McDonald, Wilson Nadruz, Jr, Roberto Schreiber
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (9): BSR20190989.
Published: 20 September 2019
... malignancies compared with the normal population. In the present study, we aimed to identify, through in silico analysis, miRNAs and their target genes related to the three most frequent types of cancer in individuals with SCI. In a previous study, we reported a pattern of expression of miRNAs in 17 sedentary...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20190590.
Published: 28 August 2019
...Jiamin Zhu; Shusen Chen; Baixia Yang; Weidong Mao; Xi Yang; Jing Cai Radiotherapy is one of the main modalities of cancer treatment. However, tumor recurrence following radiotherapy occurs in many cancer patients. A key to solving this problem is the optimization of radiosensitivity. In recent...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20190741.
Published: 23 August 2019
... rs2682818 and overall cancers. Crude odds ratios (ORs) and 95% confidence intervals (CIs) analyzed by Z -test were employed to estimate the potential interrelation in five genetic models. We also prospected how the rs2682818 affects the second structure of miR-618. Finally, 10 independent studies meet...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20182240.
Published: 28 June 2019
... of LEPR rs1137101 variants with susceptibility of cancer, however, the observed results were controversial. We searched literature on the relationship of LEPR rs1137101 G>A polymorphism with cancer risk by using PubMed and Embase databases, covering all publications up to 14 October 2018. In total, 44...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20191298.
Published: 28 June 2019
...Xiaoxia He; Peng Wang; Ying Li; Na Shen Rs189037 (G>A) is an important functional variant with ataxia telangiectasia mutated ( ATM ) gene, which might affect ATM ’s expression involvement in several human cancers. Increasing evidence reveals that smoking-related cancers have distinct molecular...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20190754.
Published: 31 May 2019
... 28 04 2019 01 05 2019 10 05 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarkers cancer FEZF1-AS1...
Articles
Yezhou Liu, Kun Liu, Xueru Zhao, Yidan Sun, Ning Ma, Longmei Tang, Haitao Yang, Xia Gao, Lina Yan, Meina Yuan, Bingshuang Wang, Xiaolin Zhang, Jinhai Jia
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20181785.
Published: 24 May 2019
... (ERCC4) gene and cancer susceptibility has been widely investigated. However, results thus far have remained controversial. A meta-analysis was performed to identify the impact of this polymorphism on cancer susceptibility. PubMed, Embase and Science-Web databases were searched systematically up to May...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20182370.
Published: 14 May 2019
...Yizhong Peng; Donghua Huang; Kaige Ma; Xiangyu Deng; Zengwu Shao MiR-19a was aberrantly expressed in various types of cancers and was observed to be potentially associated with the prognosis of cancer patients. The present analysis aims to elucidate its precise predictive value in various human...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20190456.
Published: 14 May 2019
...Songsong Teng; Chunhui Ma; Yinxian Yu; Chengqing Yi Ten-eleven translocation (TET) proteins are abnormally expressed in various cancers. Osteosarcoma cells were treated with hydroxyurea to investigate the expression pattern of TET proteins in these cells. The expression of TET1 was increased...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20181991.
Published: 10 May 2019
...You Jiang; Jun Lu; Yue-E Wu; Xin Zhao; Liang Li Human leucocyte antigen-G (HLA-G) plays an important role in the progression of human cancers. A growing number of published studies have investigated the correlation between the HLA-G 3′ untranslated region (3′UTR) 14-bp insertion/deletion ( Ins/Del...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20180995.
Published: 26 April 2019
...Congmin Liu; Jing Jin; Jin Shi; Liqun Wang; Zhaoyu Gao; Tiantian Guo; Yutong He Background: Urothelial carcinoma associated 1 (UCA1), a novel long noncoding RNA (lncRNA) which is first discovered in 2006 in human bladder cancer and has become a hot spot in recent years. UCA1 has been demonstrated...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20181709.
Published: 09 April 2019
...-inflammatory conditions, eventually promoting the onset of human malignancies. In this review, we describe the structures and functions of the most well-defined NLR proteins and highlight their association and biological impact on a diverse number of cancers. Correspondence: Fernando J. Velloso...
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