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Keywords: cancer
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Biosci Rep (2024) 44 (1): BSR20231686.
Published: 09 January 2024
... in the cell walls of fungi, yeasts, bacteria, and cereals. The unique features of β-glucans, such as water solubility, viscosity, molecular weight, and so on, have rendered them to be broadly applied in various food systems as well as in medicine to improve human health. Moreover, inhibition of cancer...
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Biosci Rep (2023) 43 (10): BSR20230489.
Published: 03 October 2023
... distantly placed pathways: amyloid formation and developing cancers in the brain have similarities and are mechanistically intertwined together. Correspondence: Vibhuti Joshi ( vibhuti.Joshi@bennett.edu.in ) or Arun Upadhyay ( arun.upadhyay@northwestern.edu ) 14 03 2023 31 05 2023 13...
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Biosci Rep (2023) 43 (1): BSR20220489.
Published: 30 January 2023
... clusters from other subtypes, denoting a distinct gene expression signature. ( B ) Distinctive genes in t(7;12) patients derived by microarray analyses by Wildenhain et al. [ 42 ] and Balgobind et al. [ 50 ]. ( C ) MNX1 expression levels in the AML cohorts of TARGET (paediatric cancers) and TCGA (adult...
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Biosci Rep (2022) 42 (12): BSR20222171.
Published: 22 December 2022
... the bloodstream. Apoptosis inhibition is one of the hallmarks of cancer and its induction in tumors is a widely used therapeutic approach. Apoptosis inhibition and induction correlate with decreased and increased serum levels of cyt c , respectively. The quantification of cyt c in the serum is useful...
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Biosci Rep (2022) 42 (4): BSR20211812.
Published: 19 April 2022
...Swagata Adhikari; Apoorva Bhattacharya; Santanu Adhikary; Vipin Singh; Shrikanth S. Gadad; Siddhartha Roy; Chandrima Das Innate and acquired resistance towards the conventional therapeutic regimen imposes a significant challenge for the successful management of cancer for decades. In patients...
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Biosci Rep (2022) 42 (2): BSR20211248.
Published: 25 February 2022
... in these cellular locations have not been studied in detail yet. In recent years, MMRN1 has been identified as a differentially expressed gene (DEG) in various cancers and it has been proposed as a possible cancer biomarker. Some evidence suggest that MMRN1 expression is regulated by methylation, protein...
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Biosci Rep (2022) 42 (2): BSR20212721.
Published: 11 February 2022
... and immunoproteasome inhibitor, capable of inducing cell death in multiple myeloma, triple-negative breast cancer, (TNBC) and non-small cell lung cancer lines. TIR-199 also effectively inhibits the proteasome in primary myeloma cells of patients, and bypasses the PSMB5 A49T+A50V bortezomib-resistant mutant. TIR-199...
Includes: Supplementary data
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Biosci Rep (2022) 42 (2): BSR20212002.
Published: 04 February 2022
... this extraordinary feat through their unique kinetic parameters, myriad regulatory strategies, and their sensitivity to their surroundings, including substrate concentration and pH. The Cancer Genome Atlas (TCGA) highlights the extraordinary number of ways in which the finely tuned activities of enzymes can...
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Biosci Rep (2021) 41 (12): BSR20211577.
Published: 17 December 2021
... tumorigenesis and cell transformation. In this review, we will focus on the recent advances that shed light on the effects of RPs deregulation in different types of cancer and their roles in regulating the tumor cell fate. Correspondence: Zeina Nasr ( zeina.nasr@balamand.edu.lb ) 01 07 2021 28...
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Biosci Rep (2021) 41 (11): BSR20211994.
Published: 12 November 2021
... tyrosine phosphorylation has been linked to various diseases, including metabolic disorders and cancer. Few years ago, protein tyrosine phosphatases (PTPs) were considered as tumor suppressors, able to block the signals emanating from receptor tyrosine kinases. However, recent evidence demonstrates...
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Biosci Rep (2021) 41 (9): BSR20203978.
Published: 17 September 2021
... the expression of RDM1 and expression of marker genes related to immune infiltration. Immunohistochemistry (IHC) method was used to detect the expression level of RDM1 in 90 cases of hepatocellular carcinoma and adjacent normal liver tissues. Results : RDM1 expression was up-regulated in most cancers...
Includes: Supplementary data
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Biosci Rep (2021) 41 (8): BSR20181627.
Published: 12 August 2021
...Wei Liu; Qin-Peng Wang; Jia Guo Several studies demonstrated that lncRNA differentiation antagonizing non-protein coding RNA (lncRNA DANCR) expression might have the potential capacity to predict the cancer prognosis; however, definite conclusion has not been obtained. The aim of this meta-analysis...
Includes: Supplementary data
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Biosci Rep (2021) 41 (6): BSR20210462.
Published: 04 June 2021
.... In cancers, HDAC10 plays crucial roles in regulating various cellular processes through its epigenetic functions or targeting some decisive molecular or signaling pathways. It also has potential clinical utility for targeting tumors and non-tumor diseases, such as renal cell carcinoma, prostate cancer...
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Biosci Rep (2021) 41 (2): BSR20204043.
Published: 26 February 2021
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer meta-analysis miR-142 prognosis Globally, tumors have become a major disease threatening people’s health...
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Biosci Rep (2021) 41 (2): BSR20193877.
Published: 03 February 2021
... of cancer. Materials and methods: The data used in this research were collected from Google Scholar, Web of Science, CNKI, and Wan Fang Data databases. The final retrieval ended on 22 February 2019. The strength of correlation was assessed using odds ratios and 95% confidence intervals. Based...
Includes: Supplementary data
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Biosci Rep (2021) 41 (1): BSR20203995.
Published: 14 January 2021
...Weiwei Chen; Yuting Li; Liliangzi Guo; Chenxing Zhang; Shaohui Tang Background: Several studies have assessed the relationship between long non-coding RNA five prime to Xist (FTX) expression, clinicopathological features, and survival outcomes in patients with cancer with conflicting results...
Includes: Supplementary data
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Biosci Rep (2021) 41 (1): BSR20203559.
Published: 07 January 2021
...Mengqiu Xiong; Ping Wang; Bei Pan; Junjie Nie; Shukui Wang; Bangshun He MicroRNA-196a (miR-196a) was previously reported to be up-regulated in cancers, and it has the diagnostic and prognostic values in cancers. Whereas, the conclusion was still unclear according to the published data. To assess...
Includes: Supplementary data
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Biosci Rep (2021) 41 (1): BSR20203459.
Published: 07 January 2021
...Xiao-Jing Qin; Xu Lin; Gang Xue; Hui-Li Fan; Hao-Yu Wang; Jing-Fang Wu; Da Pei Background: In recent years, the annual incidence of thyroid cancer (TC) has increased, with papillary thyroid cancer (PTC) identified as the most commonwinwordpathological type accounting for approximately 80% of all...
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Biosci Rep (2020) 40 (11): BSR20201820.
Published: 17 November 2020
...Bo Ma; Hui Li; Jia Qiao; Tao Meng; Riyue Yu Background: Head and neck squamous cell carcinoma (HNSCC) is recognised as an immune active cancer, but little is known about the role of microRNAs (miRNAs) in it. In the present study, we aim to determine a prognostic and immune-related miRNAs signature...
Includes: Supplementary data
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Biosci Rep (2020) 40 (11): BSR20202962.
Published: 13 November 2020
...Zhiding Wang; Mengzhen Wang; Jinghong Chen; Linlin Zhang; Li Zhang; Li Yu Cancer immunotherapy has recently undergone rapid development into a validated therapy for clinical use. The adoptive transfer of engineered autologous T cells, such as chimeric antigen receptor (CAR) T cells, has been...
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Biosci Rep (2020) 40 (9): BSR20202520.
Published: 02 September 2020
...Xiaoqi Yang; Haoran Liu; Tao Ye; Zhangqun Ye Background: Previously published studies have indicated that lymphoid enhancer-binding factor 1 (LEF1) expression could be recognized as a valuable biomarker to evaluate clinical outcome for various types of malignant cancer, but the results remained...
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Biosci Rep (2020) 40 (7): BSR20191825.
Published: 09 July 2020
...Guang-Hui Qi; Chun-Hui Wang; Hong-Ge Zhang; Jian-Guo Yu; Fei Ding; Zhi-Chao Song; Qing-Hua Xia There is still no conclusion on the potential effect of the rs2295080 and rs2536 polymorphisms of mTOR (mammalian target of rapamycin) gene on different cancers. Herein, we performed a comprehensive...
Includes: Supplementary data
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Biosci Rep (2020) 40 (6): BSR20192410.
Published: 26 June 2020
...Li-Fang Wu; Gui-Ping Xu; Qing Zhao; Ding Wang; Li-Jing Zhou; Bin Sun; Wei-Xian Chen Background: The evidence for an association between the adiponectin gene (ADIPOQ) polymorphism rs182052 and cancer risk is inconsistent. We performed a meta-analysis to obtain more precise conclusions. Methods...
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Biosci Rep (2020) 40 (5): BSR20192320.
Published: 28 May 2020
...Jingdong Li; Yaxuan Wang; Xueliang Chang; Zhenwei Han Purpose: To provide a comprehensive account of the association of five Lymphotoxin-α ( LTA ) gene polymorphisms (rs1041981, rs2229094, rs2239704, rs746868, rs909253) with susceptibility to cancer. Methods: A literature search for eligible...
Includes: Supplementary data
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Biosci Rep (2020) 40 (2): BSR20194335.
Published: 28 February 2020
...Dan-dan Hu; Hai-ling Chen; Li-ming Lou; Hong Zhang; Guo-liang Yang The processes that lead to lung adenocarcinoma (LUAD) metastasis are poorly characterized. Spindle and kinetochore associated complex subunit 3 (SKA3) plays a key role in cervical cancer development, but its contribution to LUAD...
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Biosci Rep (2019) 39 (10): BSR20192274.
Published: 18 October 2019
...Caizhi Chen; Long Shu; Wen Zou Cancer incidence rate has increased so much that it is the second leading cause of deaths worldwide after cardiovascular diseases. Sensitive and specific biomarkers are needed for an early diagnosis of cancer and in-time treatment. Recent studies have found that long...
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Biosci Rep (2019) 39 (9): BSR20190989.
Published: 20 September 2019
... malignancies compared with the normal population. In the present study, we aimed to identify, through in silico analysis, miRNAs and their target genes related to the three most frequent types of cancer in individuals with SCI. In a previous study, we reported a pattern of expression of miRNAs in 17 sedentary...
Includes: Supplementary data
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Biosci Rep (2019) 39 (8): BSR20190590.
Published: 28 August 2019
...Jiamin Zhu; Shusen Chen; Baixia Yang; Weidong Mao; Xi Yang; Jing Cai Radiotherapy is one of the main modalities of cancer treatment. However, tumor recurrence following radiotherapy occurs in many cancer patients. A key to solving this problem is the optimization of radiosensitivity. In recent...
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Biosci Rep (2019) 39 (8): BSR20190741.
Published: 23 August 2019
... rs2682818 and overall cancers. Crude odds ratios (ORs) and 95% confidence intervals (CIs) analyzed by Z -test were employed to estimate the potential interrelation in five genetic models. We also prospected how the rs2682818 affects the second structure of miR-618. Finally, 10 independent studies meet...
Includes: Supplementary data
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Biosci Rep (2019) 39 (6): BSR20182240.
Published: 28 June 2019
... of LEPR rs1137101 variants with susceptibility of cancer, however, the observed results were controversial. We searched literature on the relationship of LEPR rs1137101 G>A polymorphism with cancer risk by using PubMed and Embase databases, covering all publications up to 14 October 2018. In total, 44...
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Biosci Rep (2019) 39 (6): BSR20191298.
Published: 28 June 2019
...Xiaoxia He; Peng Wang; Ying Li; Na Shen Rs189037 (G>A) is an important functional variant with ataxia telangiectasia mutated ( ATM ) gene, which might affect ATM ’s expression involvement in several human cancers. Increasing evidence reveals that smoking-related cancers have distinct molecular...
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Biosci Rep (2019) 39 (5): BSR20190754.
Published: 31 May 2019
.... , Xu H.G. , Jiang Y.H. and Zheng Z.J. ( 2018 ) Highly expressed lncRNA FAL1 promotes the progression of gastric cancer by inhibiting PTEN . Eur. Rev. Med. Pharmacol. Sci. 22 , 8257 – 8264 30556865 13. Wang S. , Liu J. , Yang Y. , Hao F. and Zhang L...
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Biosci Rep (2019) 39 (5): BSR20181785.
Published: 24 May 2019
... (ERCC4) gene and cancer susceptibility has been widely investigated. However, results thus far have remained controversial. A meta-analysis was performed to identify the impact of this polymorphism on cancer susceptibility. PubMed, Embase and Science-Web databases were searched systematically up to May...
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Biosci Rep (2019) 39 (5): BSR20182370.
Published: 14 May 2019
...Yizhong Peng; Donghua Huang; Kaige Ma; Xiangyu Deng; Zengwu Shao MiR-19a was aberrantly expressed in various types of cancers and was observed to be potentially associated with the prognosis of cancer patients. The present analysis aims to elucidate its precise predictive value in various human...
Includes: Supplementary data
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Biosci Rep (2019) 39 (5): BSR20190456.
Published: 14 May 2019
...Songsong Teng; Chunhui Ma; Yinxian Yu; Chengqing Yi Ten-eleven translocation (TET) proteins are abnormally expressed in various cancers. Osteosarcoma cells were treated with hydroxyurea to investigate the expression pattern of TET proteins in these cells. The expression of TET1 was increased...
Includes: Supplementary data