... and immunoproteasome inhibitor, capable of inducing cell death in multiple myeloma, triple-negative breast cancer, (TNBC) and non-small cell lung cancer lines. TIR-199 also effectively inhibits the proteasome in primary myeloma cells of patients, and bypasses the PSMB5 A49T+A50V bortezomib-resistant mutant. TIR-199...

...Xiaohu Li; Xin Zhang; Inam Ullah Khan; Nina N. Guo; Bing Wang; Yifeng Guo; Bufan Xiao; Yueshan Zhang; Yimin Chu; Junsong Chen; Fang Guo Background: Breast cancer is the main lethal disease among females. The combination of lobaplatin and microwave hyperthermia plays a crucial role in several kinds...

...Marcela Manrique-Moreno; Gloria A. Santa-González; Vanessa Gallego Breast cancer continues to affect millions of women worldwide, and the number of new cases dramatically increases every year. The physiological causes behind the disease are still not fully understood. One in every 100 cases can...

...Marcela Manrique-Moreno; Gloria A Santa-González; Vanessa Gallego Breast cancer continues to affect millions of women worldwide, and the number of new cases dramatically increases every year. The physiological causes behind the disease are still not fully understood. One in every 100 cases can...

...Nese Unver The patterns of chemokine expression play a decisive role in both breast cancer prognosis and metastasis. In a recent article published in Bioscience Reports , ‘Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment’, Chen et al...

... to several cancer therapeutics in vitro (Therapy-Induced Senescence, TIS), including agents utilized as neoadjuvant chemotherapy (NAC) in the treatment of invasive breast cancer. TIS has been proposed to contribute to adverse therapy outcomes including relapse. However, there is limited evidence...

...Yomna S. Abd El-Aziz; Andrew J. Spillane; Patric J. Jansson; Sumit Sahni Triple-negative breast cancer (TNBC) is a group of breast cancers which neither express hormonal receptors nor human epidermal growth factor receptor. Hence, there is a lack of currently known targeted therapies and the only...

...Yanwei Wang; Yu Li; Baohong Liu; Ailin Song Breast cancer is the most common form of cancer afflicting women worldwide. Patients with breast cancer of different molecular classifications need varied treatments. Since it is known that the development of breast cancer involves multiple genes...

... with breast cancer has not been systematically evaluated. In the current study, a meta-analysis was conducted to clarify the association between MALAT-1 and the prognosis and clinicopathological features of breast cancer. Relevant literature published in several databases was searched. Hazard ratio (HR...

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Oncolytic adenovirus breast cancers IL-15 E2F-1 Some substantive...

...Mingdi Zhang; Hongliang Chen; Maoli Wang; Fang Bai; Kejin Wu Background: Collagen type X alpha 1 (COL10A1) is overexpressed in diverse tumors and displays vital roles in tumorigenesis. However, the prognostic value of COL10A1 in breast cancer remains unclear. Methods: The expression of COL10A1...

...Ying Xin; Xueqiang Wang; Kexin Meng; Chao Ni; Zhenye Lv; Dandan Guan Accumulated evidence has demonstrated exosomes of cancer cells carry microRNAs (miRNAs) to non-malignant cells to induce metastasis. The present study aimed to identify crucial exosomal miRNAs for breast cancer (BC) using...

...Yang Yan; Hu Xu; Jiandong Wang; Xin Wu; Wei Wen; Yan Liang; Lingdi Wang; Fengyuan Liu; Xiaohui Du The wide application of oncolytic adenovirus presents a novel therapeutic strategy for breast cancer gene therapy. Application of adenovirus alone achieves little curative effects on breast cancer...

...Wei Zheng; Bofeng Duan; Qian Zhang; Linna Ouyang; Wei Peng; Fuyong Qian; Yibin Wang; Shiting Huang Objective: Cancer stem cells (CSCs) are responsible for the drug resistance of breast cancers. Vitamin D deficiency promotes tumor resistance. The present study examined the effect of vitamin D...