... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alopecia areata bone JAK1-STAT3 signaling pathway Tgr5 The authors...

... the decreasingly significant in hair area and length, skin thickness, and the ratio of anagen and telogen, collagen, and mast cell number and loss the bone mass than WT group. After treating with INT777, the appearance of alopecia areata and bone microstructure has improved. Immunohistochemistry and qPCR analysis...

... cytoskeleton rearrangements. In addition, natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Although currently, there are reports about the natural product, which could play a therapeutic role in bone loss diseases...

...Jing-sheng Luo; Xinhua Zhao; Yu Yang Inflammatory bowel diseases (IBD) are related to bone loss. Emodin can influence the activity and differentiation of osteoblasts and osteoclasts. However, few studies have shown the effects of emodin on IBD-induced bone damage. The aim of the present study...

... is critical for bone modelling/remodelling, through the production of receptor activator of nuclear factor κ B (RANK)-ligand (RANKL). Despite this, the role of Pdpn in the control of bone remodelling is yet to be established in vivo . Here we utilised bone-specific Pdpn conditional knockout mice (cKO...

.../kg, intraperitoneally (ip), three times/week) combining G15 (160 μg/kg, ip, three times/week) for 6 weeks was found to have prevented OVX-induced effects, including increase in bone turnover rate, decrease in bone mineral content (BMC) and bone mineral density (BMD), damage of bone structure...

...-presenting molecules was not significantly modified by FGFb, PDGF-BB or IL-2 treatment. © 2006 Springer Science+Business Media, LLC 2006 Antigenic phenotype Osteoblasts Growth factors Cytokines Bone Abstract Background/Aims Recent reports demonstrated that osteoblast-like cells can also exert...

...-formation. These data indicate that IGF-I reverses selective effects of hydrocortisone on bone. 2 7 1993 17 8 1993 © 1993 Plenum Publishing Corporation 1993 bone glucocorticoids insulin-like growth factor I osteoblasts collagen osteocalcin Bioscience Reports, Vol. 13, No. 5...

...Mone Zaidi This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion...