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Keywords: biomarkers
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Biosci Rep (2022) 42 (12): BSR20221053.
Published: 09 December 2022
..., this was a systematic analysis to assess the association between sarcomas and levels of pyroptosis-associated genes, and to provide new therapeutic targets and options for sarcomas. biomarkers pyroptosis sacoma Sarcoma is a kind of rare malignancy of mesenchymal tissues [ 1 ]. The disease tends to occur...
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Biosci Rep (2022) 42 (2): BSR20211248.
Published: 25 February 2022
... in these cellular locations have not been studied in detail yet. In recent years, MMRN1 has been identified as a differentially expressed gene (DEG) in various cancers and it has been proposed as a possible cancer biomarker. Some evidence suggest that MMRN1 expression is regulated by methylation, protein...
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Biosci Rep (2022) 42 (2): BSR20212119.
Published: 18 February 2022
...Xiangpu Wang; Haoyue Xu; Zuo Zhou; Siyuan Guo; Renji Chen Aim: The main of the present study was to investigate the role of insulin-like growth factor 2 mRNA-binding protein 2 ( IGF2BP2 ) in oral squamous cell carcinoma (OSCC) with the overarching of providing new biomarkers or potential...
Includes: Supplementary data
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Biosci Rep (2022) 42 (2): BSR20212304.
Published: 07 February 2022
... methods/therapeutic agents is summarized. In addition, the identification of biomarkers to predict treatment response and the limitations of current ICIs are analyzed, and future directions for ICI treatment are discussed. Correspondence: Wulin Yang ( yangw@cmpt.ac.cn ) * These authors...
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Biosci Rep (2022) 42 (2): BSR20212035.
Published: 04 February 2022
...Yao Song; Meiling Lu; Lijin Feng; Qian Chen; Hua Huang; Qing Lin Breast cancer is a serious malignancy with a high incidence worldwide and a tendency to relapse. We used integrated bioinformatics analysis to identify potential biomarkers in breast carcinoma in the present study. Microarray data...
Includes: Supplementary data
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Biosci Rep (2021) 41 (12): BSR20212218.
Published: 07 December 2021
... and the Biochemical Society under a transformative agreement with JISC. bioinformatics biomarkers breast cancer master regulators surfaceome transcriptomics While advances in therapeutic options and diagnostic tools have significantly improved breast cancer (BRCA) survival, BRCA incidence has...
Includes: Supplementary data
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Biosci Rep (2021) 41 (8): BSR20211532.
Published: 20 August 2021
... as the identification of eight protein clusters with motif analysis. Our findings offered an important reference of potential biomarkers and effective therapeutic targets for ACC. Correspondence: Donge Tang ( donge66@126.com ) or Yong Dai ( daiyong22@aliyun.com ) 28 06 2021 30 07 2021 02 08 2021...
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Biosci Rep (2021) 41 (7): BSR20210033.
Published: 01 July 2021
...Nese Unver The patterns of chemokine expression play a decisive role in both breast cancer prognosis and metastasis. In a recent article published in Bioscience Reports , ‘Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment’, Chen et al...
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Biosci Rep (2021) 41 (6): BSR20210344.
Published: 04 June 2021
...Miji Shin; Sora Mun; Sang Hyun Park; Jiyeong Lee; Hee-Gyoo Kang Acute coronary syndrome (ACS) results from inadequate supply of blood flow from the coronary arteries to the heart or ischemia. ACS has an extremely high morbidity and mortality. The levels of biomarkers currently used for detection...
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Biosci Rep (2021) 41 (5): BSR20211016.
Published: 17 May 2021
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biochemical techniques and resources biomarkers cell cycle genomics molecular basis of health and disease The Biochemical Society is one of the U.K.’s largest single-discipline learned societies...
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Biosci Rep (2021) 41 (3): BSR20204394.
Published: 10 March 2021
... Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed in the DAVID dataset. Using machine learning, the optimal diagnostic mRNA biomarkers for CC were identified. We used qRT-PCR and Human Protein Atlas (HPA) database to exhibit the differences in gene and protein levels...
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Biosci Rep (2021) 41 (1): BSR20202074.
Published: 29 January 2021
... be good biomarkers of COVID-19 activity [ 21 , 22 ]. The associations between (i) the differences in disease severity and prevalence between men and women and (ii) the differences in CD4 + and CD8 + T cell counts between male and female COVID-19 patients remain unclear. Therefore, investigations...
Includes: Supplementary data
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Biosci Rep (2021) 41 (1): BSR20202219.
Published: 19 January 2021
..., proteomic analysis was used to identify the differentially expressed proteins (DEPs) and then evaluate the potential plasma biomarkers between CMS and non-CMS groups. A total of 145 DEPs were detected in CMS Han Chinese people who live in the plateau (CMS-HPu), among which 89 were significantly up-regulated...
Includes: Supplementary data
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Biosci Rep (2021) 41 (1): BSR20203231.
Published: 15 January 2021
... biomarkers hepatocellular carcinoma prognosis TCGA Liver cancer is the sixth most common malignant tumor and the associated mortality rate was ranked fourth among cancer-related deaths in 2018 [ 1 ] and these rates have remained high for nearly 2 years [ 2 ]. Hepatocellular carcinoma (HCC...
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Biosci Rep (2021) 41 (1): BSR20203200.
Published: 08 January 2021
... (CC BY) . Biomarkers breast cancers coexpression modules Breast cancer, which affects approximately one of every nine women globally, is one of the most widespread cancers among female malignant tumors [ 1 ]. It is well known that breast cancer has high heterogeneity at the molecular...
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Biosci Rep (2020) 40 (11): BSR20201704.
Published: 23 November 2020
..., it is urgent to investigate the tumor microenvironment in melanoma as well as to identify efficient biomarkers in the diagnosis and treatments of SKCM patients. A comprehensive analysis was performed based on metastatic melanoma samples from the Cancer Genome Atlas (TCGA) database and ESTIMATE algorithm...
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Biosci Rep (2020) 40 (10): BSR20202711.
Published: 06 October 2020
...Jiajia Chen; Rong Wu; Ying Xuan; Min Jiang; Yuecan Zeng Background: Despite the prominent development of medical technology in recent years, the prognosis of non-small cell lung cancer (NSCLC) is still not optimistic. It is crucial to identify more reliable diagnostic biomarkers for the early...
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Biosci Rep (2020) 40 (7): BSR20200218.
Published: 27 July 2020
... as possible biomarkers for the early diagnosis of patients with ascending TAAs (ATAAs). MiRNA expression was profiled by NanoString nCounter technology using 12 samples including tissue and pre- and post-surgical plasma from ATAA patients. Four miRNAs were selected and further validated by real time...
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Biosci Rep (2020) 40 (7): BSR20200825.
Published: 24 July 2020
...Fenghua Zhang; Yun Xu; Wenfeng Ye; Jingting Jiang; Changping Wu Background: Ovarian cancer (OC) is one lethal gynecologic cancer, with a 5-year survival rate approximately 47% and localized stage diagnosis of 15%. Circular RNAs are promising biomarkers for malignancies. Methods: CiRS-7 expression...
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Biosci Rep (2020) 40 (5): BSR20191188.
Published: 05 May 2020
....-1329A>G and TP53 c.215C>G (Pro72Arg) SNPs may be risk factors for LSCC. Through this research, we identify two low penetrance genetic variants that may be evaluated as novel biomarkers for this disease, in South American Mestizo populations. Correspondence: Nelson Miguel Varela ( nvarela...
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Biosci Rep (2019) 39 (11): BSR20190505.
Published: 15 November 2019
... The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . BCYRN1 biomarkers gastric cancer large intervening non-coding RNA At first, we...
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Biosci Rep (2019) 39 (7): BSR20190770.
Published: 19 July 2019
... 2 ( IGFBP2 ) mRNA in glioblastoma biopsies. The study revealed that patients with high levels of IGFBP2 mRNA had shorter survival and that IGFBP2 transcript level was an independent prognostic factor. It is also of value to determine the prognostic effect of IGFBP2 on established biomarkers...
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Biosci Rep (2019) 39 (5): BSR20190754.
Published: 31 May 2019
... and IGF2BP1 protein . Biomed. Pharmacother. 106 , 1243 – 1249 10.1016/j.biopha.2018.07.052 30119193 16. Hao F. , Mou Y. , Zhang L. , Wang S. and Yang Y. ( 2018 ) LncRNA AFAP1-AS1 is a prognostic biomarker and serves as oncogenic role in retinoblastoma . Biosci...
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Biosci Rep (2019) 39 (5): BSR20190027.
Published: 14 May 2019
.... Currently, serum predictive biomarkers of radioresistance are scare. We enrolled NPC patients, who underwent radiotherapy in the Department of Oncology, Xiangya Hospital, Central Southern University, and analyzed the serum proteins profiles in NPC patients using with quantitative label-free proteomics using...
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Biosci Rep (2019) 39 (4): BSR20190171.
Published: 05 April 2019
... for gastric cancer patient’s overall survival. The study in vitro suggested down-regulation of MIR100HG expression inhibits cell proliferation, migration, and invasion in gastric cancer. In conclusion, MIR100HG is a credible prognostic biomarker and functions as an oncogenic lncRNA in gastric cancer...
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Biosci Rep (2019) 39 (4): BSR20190232.
Published: 02 April 2019
...). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarkers cancer giloma large intervening non-coding RNA LINC00599 prognosis All statistical...
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Biosci Rep (2018) 38 (6): BSR20180537.
Published: 14 December 2018
...% CI = 0.21–0.71). In conclusion, NFKB1 rs28362491, NFKBIA rs2233406 and NFKBIA rs696 polymorphisms may serve as biomarkers for predicting risk of AKI in children. Correspondence: Xinqian Zhao ( zuqkg40@163.com ) 07 04 2018 31 10 2018 06 11 2018 14 11 2018 © 2018...
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Biosci Rep (2018) 38 (5): BSR20180731.
Published: 23 October 2018
... License 4.0 (CC BY) . biomarkers epigenetics methylation 5-methylcytosine metastasis molecular diagnostics Unique interactions between the brain’s micro-environment, blood–brain barrier, and tumor cells are hypothesized to promote distinct molecular features in CNS metastases [ 11...
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Biosci Rep (2018) 38 (5): BSR20181187.
Published: 21 September 2018
...Ibtsam Gheith; Abubakr El-Mahmoudy The present study is aimed at utilization of novel and classical kidney function biomarkers to evaluate the nephroprotective potential of Carica papaya leaf extract (CPLE) in gentamicin nephrotoxicity model in albino rats. The used classical biomarkers were urea...
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Biosci Rep (2018) 38 (5): BSR20181039.
Published: 19 September 2018
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarkers cancer glioma LINC00675 large intervening non-coding RNA prognosis Glioma originates in the glial cells and is the most common primary central nervous system malignant tumor [ 1...
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Biosci Rep (2018) 38 (5): BSR20180660.
Published: 07 September 2018
... metabolites may be non-invasive biomarkers for DM and DM-related complications. Different brain regions presented distinct metabolic signatures, indicating region-specific diabetic brain damages. In addition to serving as biomarkers, MRS data on brain metabolites can also shed light on diabetic treatment...
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Biosci Rep (2018) 38 (4): BSR20180525.
Published: 29 August 2018
...Xiaoyi Zhang; Xiaoyan Wang; Jian Wu; Juan Peng; Xin Deng; Yi Shen; Chunjie Yang; Jie Yuan; Yunzeng Zou Few studies have compared the performances of those reported miRNAs as biomarkers for hypertension in a same cohort, we aimed to comprehensively examine the performances of those reported miRNAs...
Includes: Supplementary data
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Biosci Rep (2018) 38 (3): BSR20180384.
Published: 15 May 2018
... biomarkers large intervening non-coding RNA oncogene retinoblastoma Retinoblastoma has been reported to be a most common intraocular malignant neoplasm in children [ 1 ]. Retinoblastoma accounts for 3% of all childhood cancers and has an incidence of 1 in 14,000–20,000 live births worldwide [ 2...
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Biosci Rep (2018) 38 (1): BSR20171265.
Published: 08 February 2018
... sensitivity and specificity, many studies showed that miR-29a might serve as a potential therapeutic target and promising biomarker in various tumors. In this review, we discussed the functions of miR-29a and its potential application in the diagnosis, treatment and stages of carcinoma, which could provide...
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Biosci Rep (2017) 37 (4): BSR20170852.
Published: 14 August 2017
... carcinoma tissues. Furthermore, high expression of PLK1 protein was correlated with differentiated degree, clinical stage, tumor size, lymph node metastasis, and distant metastasis. The univariate and multivariate analyses showed PLK1 protein high expression was an unfavorable prognostic biomarker for lung...
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