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Keywords: biomarker
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Articles
Biosci Rep (2022) 42 (5): BSR20212543.
Published: 20 May 2022
.... In the present study, we investigated circulating protein biomarkers that can accurately and reliably reflect BAT activation triggered by cold exposure, capsinoids ingestion and thyroid hormone excess in humans. We discovered an exosomal protein, methylene tetrahydrofolate dehydrogenase (NADP + dependent) 1-like...
Articles
Biosci Rep (2022) 42 (1): BSR20212446.
Published: 11 January 2022
...Tao Guo; Ran Wei; Dylan C. Dean; Francis J. Hornicek; Zhenfeng Duan Background: Although weak SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) expression is a known diagnostic and prognostic biomarker in several malignancies, its expression...
Articles
Biosci Rep (2022) 42 (1): BSR20211783.
Published: 06 January 2022
... earlier been examined in only a few human cancers. Objectives: Multi-omics profiling of MTHFD1L as a shared biomarker in distinct subtypes of human cancers. Methods: In the current study, for the multi-omics analysis of MTHFD1L in 24 major subtypes of human cancers, a comprehensive in silico approach...
Articles
Biosci Rep (2021) 41 (12): BSR20211096.
Published: 17 December 2021
..., SERPINA1, SCIN , and SLC28A2 ) were identified to correlate with Th17 cells and COAD prognosis, suggesting one new therapy strategy and some predictive biomarkers of COAD. These findings reported by Li et al. may pave one way to explore the molecular mechanism of COAD further. Correspondence: Hu...
Articles
Biosci Rep (2021) 41 (10): BSR20210908.
Published: 12 October 2021
...Quan Lin; Danli Xie; Liangliang Pan; Yongliang Lou; Mengru Shi Objective: Increasing the efficiency of early diagnosis using noninvasive biomarkers is crucial for enhancing the survival rate of lung cancer patients. We explore the differential expression of non-small cell lung cancer (NSCLC...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (9): BSR20203020.
Published: 03 September 2021
... established novel prognostic biomarkers to predict tamoxifen sensitivity, which may facilitate individualized management of breast cancer. Correspondence: Yujie Zhang ( zycx@zju.edu.cn ) 20 09 2020 29 07 2021 17 08 2021 18 08 2021 © 2021 The Author(s). 2021 This is an open...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (8): BSR20203531.
Published: 05 August 2021
...Anze Yu; Kai Guo; Qilin Qin; Changsheng Xing; Xiongbing Zu Background: Evaluation of the feasibility for osteopontin (OPN) to serve as a biomarker in the prognosis and clinical-pathological features of prostate cancer (PCA) patients. Methods: The original publications related to OPN and PCA were...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (5): BSR-20204210_RET.
Published: 04 May 2021
... the Creative Commons Attribution License 4.0 (CC BY) . asthma biomarker blood diagnosis IFN This article is being retracted from Bioscience Reports at the request of the Editorial Board following receipt of a notification from a reader, alerting the Editorial Office to significant similarity...
Articles
Biosci Rep (2021) 41 (3): BSR20203812.
Published: 19 March 2021
... under the Creative Commons Attribution License 4.0 (CC BY) . autophagy biomarker immune microenvironment prognostic prediction uveal melanoma Uveal melanoma (UM) is a type of malignant intraocular cancer derived from melanocytes with high metastasis rate and poor prognosis [ 1...
Articles
Biosci Rep (2021) 41 (3): BSR20204210.
Published: 19 March 2021
..., and their combination as biomarker exhibited a good diagnostic capacity for asthma (AUC = 0.832). These findings offered more insight into the underlying mechanism of how IFN signatures affected asthma. The use of the easy-to-apply IFN-related genes might serve as a promising blood-based biomarker for early diagnosis...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (2): BSR20202439.
Published: 17 February 2021
...Zhicheng Wang; Meilin Chen; Yanbing Qiu; Yuqin Yang; Yumei Huang; Xiaoxu Li; Wenling Zhang Tumor immune cell infiltration was significantly correlated with the progression and the effect of immunotherapy in cancers including esophageal carcinoma (ESCA). However, no biomarkers were identified which...
Articles
Biosci Rep (2021) 41 (1): BSR20203481.
Published: 27 January 2021
.... The present study aimed to construct regulatory network and seek the potential biomarkers of BC diagnosis and prognosis as well as the molecular therapeutic targets from the perspective of mitochondrial dysfunction. Methods: The microarray data of mitochondria-related encoding genes in BC cell lines were...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20203973.
Published: 22 January 2021
...Yexun Song; Wenfang Tang; Hui Li Background: Lung adenocarcinoma (LUAD) is the most frequent histological type of lung cancer, and its incidence has displayed an upward trend in recent years. Nevertheless, little is known regarding effective biomarkers for LUAD. Methods: The robust rank aggregation...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20202042.
Published: 24 November 2020
... biomarkers in BC microenvironment. Correspondence: Shuyuan Zhang ( zsyuan2020@gmail.com ) * These authors contributed equally to this work. 01 07 2020 05 10 2020 02 11 2020 04 11 2020 © 2020 The Author(s). 2020 This is an open access article published...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20200163.
Published: 13 November 2020
..., it is important to find new biomarkers or therapeutic targets in treatment of NSCLC. Methods : The expression levels of miR-371b-5p were detected by qRT-PCR in NSCLC tissues and cell lines. To evaluate the effect of miR-371b-5p on NSCLC progression, we first transfected the miR-371b-5p inhibitor for construction...
Articles
Biosci Rep (2020) 40 (10): BSR20202812.
Published: 28 October 2020
... 07 10 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarker CD44 glioma prognosis CD44 has been considered...
Articles
Biosci Rep (2020) 40 (9): BSR20201590.
Published: 16 September 2020
...Changfeng Man; Yu Fan; Guangli Yin; Jiayu Huang; Jujuan Wang; Hongxia Qiu Circular RNAs (circRNAs) may be potential biomarkers or therapeutic targets of hemophagocytic syndrome (HPS) due to their high stability, covalently closed structure and implicated roles in gene regulation. The aim...
Articles
Biosci Rep (2020) 40 (9): BSR20192436.
Published: 04 September 2020
... biomarkers. Results: A total of 166 DEGs (101 up-regulated and 65 down-regulated) were identified. The up-regulated DEGs were mainly enriched in regulation of the ERK1 and ERK2 cascade, response to interferon-gamma, cell chemotaxis, and migration in biological processes. In the KEGG pathway analysis, up...
Articles
Biosci Rep (2020) 40 (8): BSR20200963.
Published: 20 August 2020
... the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics biomarker hub genes overall survival primary colorectal cancer Primary colorectal cancer (PCRC) is a common digestive tract cancer in the elderly. The primary lesion can be seen in the left colon, the right colon, the upper...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR20194429.
Published: 27 July 2020
...Peilin Shen; Xuejun He; Lin Lan; Yingkai Hong; Mingen Lin Purpose: As bladder cancer (BC) is very heterogeneous and complicated in the genetic level, exploring genes to serve as biomarkers and therapeutic targets is practical. Materials and methods: We searched Gene Expression Omnibus (GEO...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (6): BSR20200902.
Published: 18 June 2020
...) patients. Circular RNA FUNDC1 (circFUNDC1) has been reported to be the diagnosis and prognosis biomarker of AIS. Therefore, the present study aimed to figure out whether circFUNDC1 could be the potential predictor of SAI that could help to guide preventive treatment. In total, 68 patients were included...
Articles
Biosci Rep (2020) 40 (6): BSR20193808.
Published: 03 June 2020
... signature for prognosis prediction in AML may serve as a prognostic biomarker. Polycomb group gene B-cell-specific Moloney murine leukemia virus integration site-1 (BMI1) is crucial to regulate the proliferative activity of normal and leukemia stem cells. Julie et al. demonstrated that leukemic stem cells...
Articles
Biosci Rep (2020) 40 (4): BSR20194448.
Published: 21 April 2020
... an effective behavior evaluation method. A patient was diagnosed as POCD if Z-values of two or more tests were equal or greater than 1.96 [ 21 ]. biomarker coronary artery bypass grafting postoperative cognitive dysfunction red cell distribution width The red blood cell distribution...
Articles
Biosci Rep (2020) 40 (4): BSR20192813.
Published: 15 April 2020
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancer biomarker prognosis overall survival The breast carcinoma is one of the world’s most common cancer in women [ 1 ]. The incidence of breast...
Articles
Biosci Rep (2020) 40 (3): BSR20193484.
Published: 27 March 2020
...-486-3p, demonstrating that circRNA_0058063 regulated FOXP4 expression by competitively binding to miR-486-3p. Taken together, circRNA_0058063 functions by sponging miR-486-3p in BC progression, which could act as a new biomarker and further developed to be a therapeutic target in BC...
Articles
Biosci Rep (2020) 40 (2): BSR20194405.
Published: 24 February 2020
... reported to be related not only to the occurrence of liver cancer but also to the causes of some ocular lesions. Purpose A diagnostic standard for the levels of serum biomarkers associated with OM derived from liver cancer in men is urgently needed. Material and methods We examined the association between...
Articles
Biosci Rep (2020) 40 (2): BSR20181881.
Published: 24 February 2020
... 4.0 (CC BY) . atrophy biomarker dysplasia H+ K+-ATPase structure-function Warburg effect Metaplasia is the replacement of one differentiated cell type with another mature differentiated cell type that is not normally present in a specific tissue [ 1 ]. On the basis...
Articles
Biosci Rep (2020) 40 (2): BSR20194067.
Published: 20 February 2020
...Yu Jin; Xing Qin Head and neck squamous cell carcinoma (HNSCC) is ranked as one of the most frequent malignancies worldwide with a high risk of lymph node metastasis, which serves as a main reason for cancer deaths. Identification of the potential biomarkers for lymph node metastasis in HNSCC...
Articles
Biosci Rep (2020) 40 (2): BSR20193678.
Published: 18 February 2020
... 2019 24 01 2020 10 02 2020 11 02 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Biomarker BIRC5 Breast...
Articles
Biosci Rep (2020) 40 (1): BSR20193349.
Published: 24 January 2020
... prognostic biomarkers for HNSCC patients. Overall, our study lay a groundwork for further investigation into the underlying molecular mechanisms in HNSCC carcinogenesis, providing potential biomarkers and therapeutic targets for HNSCC. Correspondence: Xing Qin ( xingzaing@foxmail.com ) 25 09...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (1): BSR20191251.
Published: 06 January 2020
... various, important roles in osteosarcoma development. The significant 3-lncRNA set could be a novel prediction biomarker that could aid in treatment and also predict the likelihood of recurrence of osteosarcoma in patients. Correspondence: Qingshan Guo ( guoqingshanroom@163.com ) or Peng Li...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (11): BSR20182224.
Published: 22 November 2019
... between patients with intracranial aneurysm (IA) and healthy control individuals to evaluate their potential use as biomarkers of IA. Arraystar Human lncRNA Microarray v3.0 was performed to identify differentially expressed lncRNAs and mRNAs in plasma samples (4 ml). lncRNAs with the most pronounced...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (11): BSR20190966.
Published: 12 November 2019
..., particularly concentrating on ischemic heart disease, CH, and cardiac fibrosis. We next discuss the predictive value of lncRNAs as diagnostic biomarkers of CVDs. Correspondence: Bimei Jiang ( jiangbimei@163.com ) 18 04 2019 03 10 2019 10 10 2019 10 10 2019 © 2019 The Author(s...
Articles
Biosci Rep (2019) 39 (9): BSR20190903.
Published: 13 September 2019
..., and may be a novel biomarker and potential therapeutic target for cervical cancer patients. Correspondence: Fang Yuan ( ycling2019@163.com ) * Chun-Ling Yu and Xiao-Ling Xu are co-first authors. 06 04 2019 04 07 2019 14 08 2019 21 08 2019 Total 92 cervical...
Articles
Biosci Rep (2019) 39 (8): BSR20190884.
Published: 13 August 2019
... at 450 nm. Each experiment was performed in triplicate. © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarker colorectal...
Articles
Biosci Rep (2019) 39 (8): BSR20190095.
Published: 05 August 2019
... biomarker for predicting favorable overall survival in cervical cancer patients. The TP73 expression profiles in cervical cancer tissues ( n =306) and normal cervical tissues ( n =13) were obtained from The Cancer Genome Atlas (TCGA) database ( https://tcga-data.nci.nih.gov ). The prognostic value of TP73...
Articles
Biosci Rep (2019) 39 (7): BSR20191612.
Published: 29 July 2019
.... Therefore, there is an urgent need to have a better understanding of the molecular mechanisms underlying HNSCC progression and to identify essential genes that could serve as effective biomarkers and potential treatment targets. In the present study, original data of three independent datasets were...
Articles
Biosci Rep (2019) 39 (7): BSR20190476.
Published: 26 July 2019
... level was significantly up-regulated in NSCLC patients compared with healthy control subjects ( P <0.0001), and the postoperative THBS2 level decreased significantly ( P <0.0001). ROC curves analysis demonstrated that THBS2 was a comparable biomarker as Cyfra21-1 to distinguish early stage NSCLC...
Articles
Biosci Rep (2019) 39 (6): BSR20190621.
Published: 25 June 2019
... 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarker Breast cancer (BCa) circRNA miRNA sponge Breast...
Articles
Biosci Rep (2019) 39 (6): BSR20190166.
Published: 20 June 2019
... 1.4 ± 1.0 1.3 ± 0.9 0.51   Symbol digit test 31.5 ± 10.8 32.4 ± 9.7 0.50 * P <0.05. Postoperative cognitive dysfunction hip fracture malondialdehyde oxidative stress biomarker Postoperative cognitive dysfunction (POCD), a condition that has been poorly...
Articles
Biosci Rep (2019) 39 (6): BSR20181644.
Published: 18 June 2019
... aggressive phenotypes of LSCC by regulating cell proliferation, migration, invasion, apoptosis, and cell cycle, indicating FTH1P3 may serve as a promising therapeutic biomarker for the treatment of LSCC. Correspondence: Yameng Dong ( dongym92008@tom.com ) 17 09 2018 09 05 2019 22 05...
Articles
Biosci Rep (2019) 39 (5): BSR20190206.
Published: 31 May 2019
.... However, no useful biomarkers for early detection of renal damage in MM exist. Reports indicate that activin A, a multifunctional cytokine of the TGF-β superfamily, is involved in the development and progression of various kidney diseases. In the present study, we measured urinary activin A levels...
Articles
Biosci Rep (2019) 39 (5): BSR20190602.
Published: 17 May 2019
... population growth is resulting in a large number of new nephroblastoma cases, which cause serious influence on children’s health [ 5 , 6 ]. Thus, a better understanding of nephroblastoma progression would be a substantial advancement for identifying sensitive molecular biomarkers to predict high risk...
Articles
Biosci Rep (2019) 39 (5): BSR20190667.
Published: 14 May 2019
...Elif Pala; Tuba Denkçeken MicroRNAs (miRNAs) have been proven to play a crucial role in postmenopausal osteoporosis (PMO), and studies on their diagnostic value have been increasing. In our study, we aim to identify the key miRNAs in the PMO that might be potential biomarkers. A comprehensive...
Articles
Biosci Rep (2019) 39 (5): BSR20190612.
Published: 03 May 2019
... 03 2019 09 04 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarker large intervening non-coding RNA LSINCT5...
Articles
Biosci Rep (2019) 39 (4): BSR20182506.
Published: 30 April 2019
... expression was markedly elevated in cervical cancer tissue specimens and cell lines compared with adjacent normal cervical tissue specimens and human normal cervical cell line, respectively. Then, we found high expression of GHET1 is a useful biomarker to discriminate cervical cancer tissues from non...
Articles
Biosci Rep (2019) 39 (4): BSR20190447.
Published: 30 April 2019
... the Creative Commons Attribution License 4.0 (CC BY) . biomarker LncRNA LOXL1-AS1 osteosarcoma To initially measure the LOXL1-AS1 expression in osteosarcoma, we collected 96 osteosarcoma tissues specimens and 24 normal bone tissue specimens. Compared with normal bone tissue specimens...
Articles
Biosci Rep (2019) 39 (4): BSR20182062.
Published: 09 April 2019
... that RRM2 might be used as a predictive biomarker for prognosis of breast cancer. Further studies are needed to more precisely elucidate the value of RRM2 in evaluating breast cancer prognosis. Correspondence: Wei-xian Chen ( chenweixian@njmu.edu.cn ) 09 11 2018 08 03 2019 19 03 2019...
Articles
Biosci Rep (2019) 39 (3): BSR20190285.
Published: 22 March 2019
... confirmed a positive correlation between TRIM13 and RAB11FIP2 gene expression. Conclusion: Bioinformatics analysis revealed that TRIM13 may be adopted as a promising predictive biomarker for prognosis of breast cancer. More in-depth experiments and clinical trials are needed to validate the value of TRIM13...
Articles
Biosci Rep (2019) 39 (3): BSR20182355.
Published: 15 March 2019
... studies suggested silencing of TMSB10 expression dramatically reduced cell proliferation, migration, and invasion in HCC. In conclusion, TMSB10 may hold promise as a tumor biomarker for predicting prognosis and a potential target for developing a novel therapeutic strategy. © 2019 The Author(s). 2019...