... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics analysis gene mutations poor prognosis thyroid cancer TTN gene Data processing and analysis were mostly achieved using R language, version 4.0.2...

...Yao Song; Meiling Lu; Lijin Feng; Qian Chen; Hua Huang; Qing Lin Breast cancer is a serious malignancy with a high incidence worldwide and a tendency to relapse. We used integrated bioinformatics analysis to identify potential biomarkers in breast carcinoma in the present study. Microarray data...

... of the present study was to apply bioinformatics analysis to explore tumor-educated platelet (TEP) microRNA (miRNA) expression and its potential diagnostic utility in HCC. Methods: Twenty-five HCC patients and 25 healthy controls were included. RNA sequencing was utilized to screen miRNA alterations in platelets...

... BY) . bioinformatics analysis differentially expressed genes gestational diabetes mellitus novel biomarkers small drug molecules Gestational diabetes mellitus (GDM) is the metabolic disorder diagnosed during pregnancy, affecting 2–5% of pregnant women worldwide [ 1 , 2 ]. Risk factors of GDM include...

... established by STRING and Cytoscape software for further study. Finally, miRNAs targeted HSP90AA1 were predicted by miRanda. All in all, based on the data of GSE20479 chip, the molecular mechanism of SFN on hepatocytes was studied by a series of bioinformatics analysis methods, and it indicated that SFN might...

... using GS and MM analyses. bioinformatics analysis gene expression profile microarray Skeletal muscle healing wound age Skeletal muscle tissues, which are widely distributed throughout the body, account for 30–50% of total body mass [ 1 , 2 ]. These tissues have a relatively superficial...

... is not yet clear. Our study aimed to systematically identify the genes and microRNA (miRNA) and explore the potential biomarkers associated with HAR by integrated bioinformatics analysis. The mRNA and miRNA expression profiles were obtained from the Gene Expression Omnibus database. We performed Gene...

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bioinformatics analysis Differentially expressed gene Microarray Pediatric atopic dermatitis Atopic dermatitis (AD) is the most common...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics analysis DEGs non-TNBC survival analysis TNBC Breast cancer (BC) is the most common malignant disease worldwide and remains a major...

... of an efficient treatment strategy, and assessment of patient prognosis. bioinformatics analysis biomarkers Colon adenocarcinoma colorectal cancer Sixty paired primary cancer tissues and adjacent tissues from colon cancer patients who underwent surgery between September 2011 and April 2020, were...

... was captured on an Illumina Flowcell (Illumina, U.S.A.), amplified into clusters in situ , and sequenced in 150 cycles with PE mode on an Illumina HiSeq (Illumina HiSeq 4000, U.S.A.) sequencer. Circular RNA Second-generation sequencing Bioinformatics analysis NK/T-LAHS Biomarker Paired-end...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics analysis prognosis serous ovarian cancer TIMER database analysis tumor metastasis weighted gene coexpression network analysis (WGCNA...

...Xiaoling Ma; Jinhui Liu; Hui Wang; Yi Jiang; Yicong Wan; Yankai Xia; Wenjun Cheng Methylation functions in the pathogenesis of cervical cancer. In the present study, we applied an integrated bioinformatics analysis to identify the aberrantly methylated and differentially expressed genes (DEGS...

...). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bioinformatics analysis Breast cancer CDC20 Prognosis Breast cancer is the most common malignant...

..., including eotaxin-2, eotaxin-3, CCL18, IL-4, IL-5, IL-10, IL-12p70, IL-13, and IL-15. Bioinformatics analysis indicated that these mediators were mainly enriched in leukocyte chemotaxis and proliferation, JAK-STAT cascade, asthma, and Th1 and Th2 cell differentiation. Furthermore, seven mediators were...

...) and disease-free survival (DFS). COL10A1 was positively correlated with metastatic relapse-free survival. GSEA analysis revealed that enrichment of TGF-β signaling pathway. 15-leucine-rich repeat containing membrane protein ( LRRC15 ) is a correlated gene of COL10A1. Conclusion: Bioinformatics analysis...

... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bioinformatics analysis Differentially expressed genes Differentially expressed microRNAs Necrotizing enterocolitis in newborn Necrotizing enterocolitis (NEC) is a devastating...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis bioinformatics analysis icariin long non-coding RNA microarray Atherosclerosis (AS), characterized by progressing atherosclerotic...

... 04 2019 30 05 2019 16 06 2019 18 06 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics...

... migration of cervical cancer cells. Bioinformatics analysis showed that adherens junction was significant for both P -value and enrichment scores, which was consistent with the clinical study. The underlying molecular mechanisms might be the interaction among HMGB1, RAC1, and CDC42. HMGB1 expression...

... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics analysis Diffuse large B cell lymphoma differentially expressed genes protein-protein interaction network survival analysis Diffuse large B-cell lymphoma (DLBCL...

... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancer bioinformatics analysis CD28 polymorphism Breast cancer (BC) is the most frequently diagnosed cancer among women and it is the leading cause of female cancer-related death [ 1 ]. In 2017...

... non-coding (Lnc)RNAs regulated by Hec1 were gained from bioinformatics analysis. The role of LncRNA BX647187, regulated by Hec1, was finally characterized in PCa cells by siRNA. Our results showed that Hec1 mRNA and protein were significantly overexpressed in Human PCa tissues and several PCa cell...