... (ThT) or HiLyte Fluor 647 (HF647) dye covalently attached to the Aβ 1-42 peptide, the aggregation kinetics of Aβ 1-42 were markedly more rapid in the presence of NQO1*2 than the wild-type (WT) NQO1. Experiments using apo-NQO1 indicate that this increase is linked to the inability of NQO1*2 to bind...

... at multiple levels, including transcription, translation and post-translation levels. In the present study, by using different biophysical techniques, we have investigated the possibility of a direct interaction between the p53 core domain, also referred to as the DNA-binding domain, and UDCA. Our in vitro...

...Alireza Roostaee; Élie Barbar; Pierre Lavigne; Jean-Guy Lehoux Steroidogenesis depends on the delivery of free cholesterol to the inner mitochondrial membrane by StAR (steroidogenic acute regulatory protein). Mutations in the StAR gene leads to proteins with limited cholesterol-binding capacity...