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Keywords: asthma
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Biosci Rep (2023) 43 (6): BSR-2019-0397_RET.
Published: 05 June 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . asthma CTLA-4 lncRNA MALAT1 miR-155 T-bet/Gata3 ratio Th1/Th2 balance...
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Biosci Rep (2022) 42 (1): BSR20212461.
Published: 28 January 2022
... and NF-κB inflammatory pathways, which can further reduce Th2 cytokine expression and eosinophilic inflammation. Thus, our findings provide a potential mechanism through which the EPS mitigates asthma, suggesting that the EPS could be a potential source of an anti-asthmatic drug. Correspondence...
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Biosci Rep (2021) 41 (3): BSR20204210.
Published: 19 March 2021
...Hairong Shu; Yong Li; Hangyu Xu; Qing Yin; Jianxin Song; Minqiao Zheng; He Li Interferon (IFN) plays a role in immune and inflammation responses. However, the effect of IFN in asthma is still not fully clear. The present study was conducted to better understand the role of IFN signatures in asthma...
Includes: Supplementary data
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Biosci Rep (2020) 40 (5): BSR20190768.
Published: 04 May 2020
...Robert Foronjy Asthma is a common, allergic respiratory disorder affecting over 350 million people worldwide. One of the key features of asthma is skewing of CD4 + cells toward Th2 responses. This promotes the production of cytokines like IL-4 that induce IgE production resulting...
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Biosci Rep (2020) 40 (2): BSR20192645.
Published: 28 February 2020
...Qi Fan; Yu Jian Asthma is a common chronic airway disease with increasing prevalence. MicroRNAs act as vital regulators in cell progressions and have been identified to play crucial roles in asthma. The objective of the present study is to clarify the molecular mechanism of miR-203a-3p...
Includes: Supplementary data
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Biosci Rep (2020) 40 (2): BSR20190534.
Published: 25 February 2020
... coptisine could also participate in asthma treatment through relaxing abnormal contracted mouse airway smooth muscle (ASM). The present study aimed to characterize the relaxant effects of coptisine on mouse ASM and uncover the underlying molecular mechanisms. Methods: To investigate the role of coptisine...
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Biosci Rep (2020) 40 (2): BSR20190397.
Published: 14 February 2020
...Zhijun Liang; Fenglian Tang Objectives: The present study examined if the metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/miR-155/CTLA-4 axis was involved in modifying Th1/Th2 balance, a critical indicator for asthma progression. Methods: Altogether 772 asthma patients and 441...
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Biosci Rep (2019) 39 (11): BSR20193282.
Published: 22 November 2019
...Chang-Ming Lv; Hui-Mei Wu; Ling Wu; Guang-Hong Xu; Zhi-Lai Yang; Qi-Ying Shen Sevoflurane was found to show protective roles in mice with asthma, however, the mechanism of which needs further exploring. Aquaporins (AQPs) have been demonstrated to be involved in the pathogenesis of asthma, while...
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Biosci Rep (2019) 39 (1): BSR20181117.
Published: 08 January 2019
...Cheng Cheng; Huimei Wu; Muzi Wang; Lixia Wang; Hongyun Zou; Shuai Li; Rongyu Liu Background: Estrogen has been suggested to play a protective role against airway inflammations, such as asthma. In these processes, the inflammasome nucleotide-binding oligomerization domain, leucine-rich repeat...
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Biosci Rep (2018) 38 (6): BSR20180548.
Published: 07 November 2018
...Reem H. Alrashoudi; Isabel J. Crane; Heather M. Wilson; Monther Al-Alwan; Nehad M. Alajez Asthma is a chronic inflammatory disorder associated with airway hyper-responsiveness. Although a number of studies have investigated asthma at the molecular level, the molecular immune signatures associated...
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Biosci Rep (2017) 37 (6): BSR20171071.
Published: 22 December 2017
...Peng Liang; Shao Peng; Man Zhang; Yingying Ma; Xinggang Zhen; Huijuan Li The present study is designed to determine whether Huai Qi Huang has immunoregulatory effects on the (helper T (Th)) Th1/Th2 and regulatory T cell (Treg)/Th17 balance in ovalbumin (OVA)-induced asthma model mice. Asthma model...
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Biosci Rep (2011) 31 (2): 145–150.
Published: 23 November 2010
... in inflammation has been demonstrated extensively. The prevalence of asthma is increasing in many developed nations. Consequently, there is an urgent need for the development of new agents for the treatment of asthma, especially for patients who respond poorly to conventional therapy. Recent studies have...
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Biosci Rep (2006) 26 (1): 55–67.
Published: 15 June 2006
...Gautam Damera; Baoyun Xia; Hanumatha R. Ancha; Goverdhan P. Sachdev Compromised epithelial cell integrity is a common feature associated with chronic lung inflammatory states such as asthma. While epithelial cell damage is largely due to sustained effects of inflammatory mediators localized...