... and NF-κB inflammatory pathways, which can further reduce Th2 cytokine expression and eosinophilic inflammation. Thus, our findings provide a potential mechanism through which the EPS mitigates asthma, suggesting that the EPS could be a potential source of an anti-asthmatic drug. Correspondence...

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . asthma biomarker blood diagnosis IFN This article is being retracted...

...Xiao-Li Chen; Qing-Ling Xiao; Zhong-Hua Pang; Cheng Tang; Qi-Yong Zhu An-Chuan Granule (ACG), a traditional Chinese medicine (TCM) formula, is an effective treatment for asthma but its pharmacological mechanism remains poorly understood. In the present study, network pharmacology was applied...

...Hairong Shu; Yong Li; Hangyu Xu; Qing Yin; Jianxin Song; Minqiao Zheng; He Li Interferon (IFN) plays a role in immune and inflammation responses. However, the effect of IFN in asthma is still not fully clear. The present study was conducted to better understand the role of IFN signatures in asthma...

...Giselmo Pinheiro Lopes; Ítalo Patrick Souza Amorim; Bruna de Oliveira de Melo; Carlos Eduardo Campos Maramaldo; Maria Rosa Quaresma Bomfim; Lídio Gonçalves Lima Neto; Matheus Silva Alves; Fabrício Brito Silva; Paulo Vítor Soeiro-Pereira; Angela Falcai Introduction: Asthma is a disease that has been...

.../T, RsaI_in2, RsaI_ex7, and I181L, and risk of asthma and allergic rhinitis based on available 29 case–control studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association of SNPs in FcεRIβ gene with allergic diseases risk. They found...

...Robert Foronjy Asthma is a common, allergic respiratory disorder affecting over 350 million people worldwide. One of the key features of asthma is skewing of CD4 + cells toward Th2 responses. This promotes the production of cytokines like IL-4 that induce IgE production resulting...

...Qi Fan; Yu Jian Asthma is a common chronic airway disease with increasing prevalence. MicroRNAs act as vital regulators in cell progressions and have been identified to play crucial roles in asthma. The objective of the present study is to clarify the molecular mechanism of miR-203a-3p...

... coptisine could also participate in asthma treatment through relaxing abnormal contracted mouse airway smooth muscle (ASM). The present study aimed to characterize the relaxant effects of coptisine on mouse ASM and uncover the underlying molecular mechanisms. Methods: To investigate the role of coptisine...

...Zhijun Liang; Fenglian Tang Objectives: The present study examined if the metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/miR-155/CTLA-4 axis was involved in modifying Th1/Th2 balance, a critical indicator for asthma progression. Methods: Altogether 772 asthma patients and 441...

...Chang-Ming Lv; Hui-Mei Wu; Ling Wu; Guang-Hong Xu; Zhi-Lai Yang; Qi-Ying Shen Sevoflurane was found to show protective roles in mice with asthma, however, the mechanism of which needs further exploring. Aquaporins (AQPs) have been demonstrated to be involved in the pathogenesis of asthma, while...

...Guo Chen; Miao-Miao Zhang; Yu Wang; Shou-Quan Wu; Ming-Gui Wang; Jian-Qing He Background: Chitinase 3-like 1 ( CHI3L1 ) is involved in the Th2 cell mediated pathway, tissue remodeling and fibrosis. Correlations of CHI3L1 gene polymorphisms with asthma in previous studies have been inconsistent...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . asthma epithelial cells Th2 cells Th17 cells Asthma is a chronic inflammatory disorder of the airways that is characterized by airway hyper-responsiveness and reversible airway obstruction [ 1 ]. Asthma occurs more...

...Cheng Cheng; Huimei Wu; Muzi Wang; Lixia Wang; Hongyun Zou; Shuai Li; Rongyu Liu Background: Estrogen has been suggested to play a protective role against airway inflammations, such as asthma. In these processes, the inflammasome nucleotide-binding oligomerization domain, leucine-rich repeat...

...Reem H. Alrashoudi; Isabel J. Crane; Heather M. Wilson; Monther Al-Alwan; Nehad M. Alajez Asthma is a chronic inflammatory disorder associated with airway hyper-responsiveness. Although a number of studies have investigated asthma at the molecular level, the molecular immune signatures associated...

...Peng Liang; Shao Peng; Man Zhang; Yingying Ma; Xinggang Zhen; Huijuan Li The present study is designed to determine whether Huai Qi Huang has immunoregulatory effects on the (helper T (Th)) Th1/Th2 and regulatory T cell (Treg)/Th17 balance in ovalbumin (OVA)-induced asthma model mice. Asthma model...

...Yueli Xu; Junjuan Li; Zhaolei Ding; Juan Li; Bin Li; Zhengang Yu; Wei Tan Asthma is a serious and hereditary respiratory disorder affecting all age groups. Interleukin-13 (IL-13) is a central regulator of allergic inflammation. The purpose of the present study was to estimate the relationship...

... in inflammation has been demonstrated extensively. The prevalence of asthma is increasing in many developed nations. Consequently, there is an urgent need for the development of new agents for the treatment of asthma, especially for patients who respond poorly to conventional therapy. Recent studies have...

...Gautam Damera; Baoyun Xia; Hanumatha R. Ancha; Goverdhan P. Sachdev Compromised epithelial cell integrity is a common feature associated with chronic lung inflammatory states such as asthma. While epithelial cell damage is largely due to sustained effects of inflammatory mediators localized...