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Keywords: apoptosis
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Articles

MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression

Xinyu Wang, Tingting Zhang, Jianlong Zhai, Zhongli Wang, Yan Wang, Lili He, Sai Ma, Hanying Xing, Yifang Guo
Journal: Bioscience Reports
Biosci Rep (2023) 43 (9): BSR20230014.
https://doi.org/10.1042/BSR20230014
Published: 05 September 2023
... the effects of miR-21 and homeodomain interacting protein kinase 3 (HIPK3) on cardiomyocyte apoptosis induced by hypoxia/reoxygenation (H/R) in vitro . To this end, the rat cardiomyocyte H9C2 cell line was exposed to H/R and the roles of miR-21 and HIPK3 in regulating cell viability and apoptosis were...
View article titled, MiR-21 attenuates FAS-mediated cardiomyocyte <span class="search-highlight">apoptosis</span> by regulating HIPK3 expression
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Includes: Supplementary data
Articles

Expression of Concern: Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA GAS5

Journal: Bioscience Reports
Biosci Rep (2023) 43 (8): BSR-2018-0626_EOC.
https://doi.org/10.1042/BSR-2018-0626_EOC
Published: 31 August 2023
... surrounding the scientific validity of this paper, hence has issued an Expression of Concern to notify readers. apoptosis GAS5 LncRNA rheumatoid arthritis © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society...
View article titled, Expression of Concern: Tanshinone IIA promotes the <span class="search-highlight">apoptosis</span> of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA GAS5
Open the PDF for Expression of Concern: Tanshinone IIA promotes the <span class="search-highlight">apoptosis</span> of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA GAS5 in another window
Articles

Retraction: Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR–NF-κB signalling pathway in human epidermoid carcinoma A431 cells

Journal: Bioscience Reports
Biosci Rep (2023) 43 (4): BSR-2015-0002_RET.
https://doi.org/10.1042/BSR-2015-0002_RET
Published: 06 April 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell cycle epidermal growth factor receptor–nuclear factor-kappa...
View article titled, Retraction: Shikonin causes cell-cycle arrest and induces <span class="search-highlight">apoptosis</span> by regulating the EGFR–NF-κB signalling pathway in human epidermoid carcinoma A431 cells
Open the PDF for Retraction: Shikonin causes cell-cycle arrest and induces <span class="search-highlight">apoptosis</span> by regulating the EGFR–NF-κB signalling pathway in human epidermoid carcinoma A431 cells in another window
Articles

Retraction: Stromal interaction molecule 1 (STIM1) regulates growth, cell cycle and apoptosis of human tongue squamous carcinoma cells

Journal: Bioscience Reports
Biosci Rep (2023) 43 (3): BSR-2016-0519_RET.
https://doi.org/10.1042/BSR-2016-0519_RET
Published: 02 March 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell cycle STIM1 Tca-8113 cells tongue squamous carcinoma...
View article titled, Retraction: Stromal interaction molecule 1 (STIM1) regulates growth, cell cycle and <span class="search-highlight">apoptosis</span> of human tongue squamous carcinoma cells
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Articles

Retraction: In vivo and in vitro effects of hyperplasia suppressor gene on the proliferation and apoptosis of lung adenocarcinoma A549 Cells

Journal: Bioscience Reports
Biosci Rep (2023) 43 (3): BSR-2018-0391_RET.
https://doi.org/10.1042/BSR-2018-0391_RET
Published: 02 March 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . A549 cells Apoptosis Gene silencing Hyperplasia suppressor gene Lung...
View article titled, Retraction: In vivo and in vitro effects of hyperplasia suppressor gene on the proliferation and <span class="search-highlight">apoptosis</span> of lung adenocarcinoma A549 Cells
Open the PDF for Retraction: In vivo and in vitro effects of hyperplasia suppressor gene on the proliferation and <span class="search-highlight">apoptosis</span> of lung adenocarcinoma A549 Cells in another window
Articles

Expression of Concern: LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation

Journal: Bioscience Reports
Biosci Rep (2023) 43 (2): BSR-2017-1150_EOC.
https://doi.org/10.1042/BSR-2017-1150_EOC
Published: 09 February 2023
..., between the first two panels of Figure 4E. apoptosis cell proliferation growth arrest-specific 5 inflammasome long non-coding RNA ovarian cancer © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society...
View article titled, Expression of Concern: LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation
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Articles

Retraction: Long non-coding RNA SNHG1 protects human AC16 cardiomyocytes from doxorubicin toxicity by regulating miR-195/Bcl-2 axis

Journal: Bioscience Reports
Biosci Rep (2023) 43 (1): BSR-2019-1050_RET.
https://doi.org/10.1042/BSR-2019-1050_RET
Published: 30 January 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cardiotoxicity doxorubicin long non-coding RNA SNHG1 niR-195...
View article titled, Retraction: Long non-coding RNA SNHG1 protects human AC16 cardiomyocytes from doxorubicin toxicity by regulating miR-195/Bcl-2 axis
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Articles

Correction: Couplet medicines of leech and centipede granules improves erectile dysfunction via inactivation of the CaSR/PLC/PKC signaling in streptozotocin-induced diabetic rats

Journal: Bioscience Reports
Biosci Rep (2023) 43 (1): BSR-2019-3845_COR.
https://doi.org/10.1042/BSR-2019-3845_COR
Published: 19 January 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis CaSR/PLC/PKC signaling pathway diabetes mellitus endothelial...
View article titled, Correction: Couplet medicines of leech and centipede granules improves erectile dysfunction via inactivation of the CaSR/PLC/PKC signaling in streptozotocin-induced diabetic rats
Open the PDF for Correction: Couplet medicines of leech and centipede granules improves erectile dysfunction via inactivation of the CaSR/PLC/PKC signaling in streptozotocin-induced diabetic rats in another window
Articles

Expression of Concern: Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-κB signalling pathway in human epidermoid carcinoma A431 cells

Journal: Bioscience Reports
Biosci Rep (2023) 43 (1): BSR-2015-0002_EOC.
https://doi.org/10.1042/BSR-2015-0002_EOC
Published: 19 January 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell cycle epidermal growth factor receptor–nuclear factor-kappa...
View article titled, Expression of Concern: Shikonin causes cell-cycle arrest and induces <span class="search-highlight">apoptosis</span> by regulating the EGFR-NF-κB signalling pathway in human epidermoid carcinoma A431 cells
Open the PDF for Expression of Concern: Shikonin causes cell-cycle arrest and induces <span class="search-highlight">apoptosis</span> by regulating the EGFR-NF-κB signalling pathway in human epidermoid carcinoma A431 cells in another window
Articles

Cytochrome c in cancer therapy and prognosis

João Pessoa
Journal: Bioscience Reports
Biosci Rep (2022) 42 (12): BSR20222171.
https://doi.org/10.1042/BSR20222171
Published: 22 December 2022
...João Pessoa Cytochrome c (cyt c ) is an electron transporter of the mitochondrial respiratory chain. Upon permeabilization of the mitochondrial outer membrane, cyt c is released into the cytoplasm, where it triggers the intrinsic pathway of apoptosis. Cytoplasmic cyt c can further reach...
View article titled, Cytochrome c in cancer therapy and prognosis
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Articles

Retraction: Upregulated circular RNA VANGL1 contributes to progression of non-small cell lung cancer through inhibition of miR-195 and activation of Bcl-2

Journal: Bioscience Reports
Biosci Rep (2022) 42 (12): BSR-2018-2433_RET.
https://doi.org/10.1042/BSR-2018-2433_RET
Published: 22 December 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis circular RNA VANGL1 non-small cell lung cancer This article...
View article titled, Retraction: Upregulated circular RNA VANGL1 contributes to progression of non-small cell lung cancer through inhibition of miR-195 and activation of Bcl-2
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Articles

Retraction: Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans

Journal: Bioscience Reports
Biosci Rep (2022) 42 (9): BSR-2019-1062_RET.
https://doi.org/10.1042/BSR-2019-1062_RET
Published: 21 September 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Breast cancer Cosmc Metastasis Proliferation Tn and T glycans...
View article titled, Retraction: Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans
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Articles

Retraction: MiR-182 regulates cell proliferation and apoptosis in laryngeal squamous cell carcinoma by targeting the CRR9

Journal: Bioscience Reports
Biosci Rep (2022) 42 (8): BSR-2019-1348_RET.
https://doi.org/10.1042/BSR-2019-1348_RET
Published: 31 August 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis CRR9 laryngeal squamous cell carcinoma miR-182 proliferation...
View article titled, Retraction: MiR-182 regulates cell proliferation and <span class="search-highlight">apoptosis</span> in laryngeal squamous cell carcinoma by targeting the CRR9
Open the PDF for Retraction: MiR-182 regulates cell proliferation and <span class="search-highlight">apoptosis</span> in laryngeal squamous cell carcinoma by targeting the CRR9 in another window
Articles

Retraction: α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

Dongmei Fang, Hongxin Wang, Min Li, Wenwen Wei
Journal: Bioscience Reports
Biosci Rep (2022) 42 (8): BSR-2019-0696_RET.
https://doi.org/10.1042/BSR-2019-0696_RET
Published: 31 August 2022
...Dongmei Fang; Hongxin Wang; Min Li; Wenwen Wei α-bisabolol apoptosis endometrial cancer radiotherapy XIAP/caspase-3 pathway This Retraction follows an Expression of Concern relating to this article previously published by Portland Press. This article is being retracted from Bioscience...
View article titled, Retraction: α-bisabolol enhances radiotherapy-induced <span class="search-highlight">apoptosis</span> in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3
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Articles

Jolkinolide B induces cell cycle arrest and apoptosis in MKN45 gastric cancer cells and inhibits xenograft tumor growth in vivo

Hao Zhang, Jiayi Qian, Ming Jin, Li Fan, SongJie Fan, Hong Pan, Yang Li, Ningning Wang, Baiyu Jian
Journal: Bioscience Reports
Biosci Rep (2022) 42 (6): BSR20220341.
https://doi.org/10.1042/BSR20220341
Published: 27 June 2022
... hand, JB induced MKN45 cells apoptosis through the mitochondrial pathway, and ultimately effectively inhibited the growth of gastric cancer cells. These results suggest that JB appears to be a promising candidate drug with antigastric cancer activity and warrants further research. 05 03 2022...
View article titled, Jolkinolide B induces cell cycle arrest and <span class="search-highlight">apoptosis</span> in MKN45 gastric cancer cells and inhibits xenograft tumor growth in vivo
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Includes: Supplementary data
Articles

Comparing the folding landscapes of evolutionarily divergent procaspase-3

Liqi Yao, A. Clay Clark
Journal: Bioscience Reports
Biosci Rep (2022) 42 (6): BSR20220119.
https://doi.org/10.1042/BSR20220119
Published: 17 June 2022
... BY) . apoptosis caspase dimerization fluorescence spectroscopy protein folding zebrafish The caspase family is an attractive model to examine the evolution of protein folding landscapes. Caspase genes predate multicellularity and are widely present in eukaryotes [ 1 ]. Caspases are thought to have...
View article titled, Comparing the folding landscapes of evolutionarily divergent procaspase-3
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Includes: Supplementary data
Articles

High glucose represses the proliferation of tendon fibroblasts by inhibiting autophagy activation in tendon injury

Fu-Chen Song, Jia-Qin Yuan, Mei-Dong Zhu, Qi Li, Sheng-Hua Liu, Lei Zhang, Cheng Zhao
Journal: Bioscience Reports
Biosci Rep (2022) 42 (3): BSR20210640.
https://doi.org/10.1042/BSR20210640
Published: 16 March 2022
... healing. However, little is known about the mechanism underlying high glucose (HG)-induced decrease in tendon fibroblasts viability. In the present study, the rat models of DFU were established, and collagen deposition, autophagy activation and cell apoptosis in tendon tissues were assessed using...
View article titled, High glucose represses the proliferation of tendon fibroblasts by inhibiting autophagy activation in tendon injury
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Articles

Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells

Wenbin Wang, Haihua Pan, Feihua Ren, Hongxia Chen, Ping Ren
Journal: Bioscience Reports
Biosci Rep (2022) 42 (3): BSR20212171.
https://doi.org/10.1042/BSR20212171
Published: 16 March 2022
... -nitroanilide (GPNA) and silenced the expression of ASCT2 with specific shRNAs. We found that the growth of PC cells was significantly inhibited. Additionally, knockdown of ASCT2 induced apoptosis through the Akt/mTOR signaling pathway. Furthermore, the loss of ASCT2 in BxPC-3 cell xenografts significantly...
View article titled, Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes <span class="search-highlight">apoptosis</span> of pancreatic cancer cells
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Includes: Supplementary data
Articles

The anti-tumor effects of the combination of microwave hyperthermia and lobaplatin against breast cancer cells in vitro and in vivo

Xiaohu Li, Xin Zhang, Inam Ullah Khan, Nina N. Guo, Bing Wang, Yifeng Guo, Bufan Xiao, Yueshan Zhang, Yimin Chu, Junsong Chen, Fang Guo
Journal: Bioscience Reports
Biosci Rep (2022) 42 (2): BSR20190878.
https://doi.org/10.1042/BSR20190878
Published: 09 February 2022
... assays. Cell migration and invasion were investigated with a transwell assay. Cell apoptosis was probed with flow cytometry. The expression of apoptosis-associated proteins was examined with Western blots. Result: Combination treatment decreased breast cancer cell viability, colony formation, cell...
View article titled, The anti-tumor effects of the combination of microwave hyperthermia and lobaplatin against breast cancer cells in vitro and in vivo
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Includes: Supplementary data
Articles

Overexpression of NMNAT3 improves mitochondrial function and enhances antioxidative stress capacity of bone marrow mesenchymal stem cells via the NAD + -Sirt3 pathway

Tao Wang, Fei Zhang, Wuxun Peng, Lei Wang, Jian Zhang, Wentao Dong, Xiaobin Tian, Chuan Ye, Yanlin Li, Yuekun Gong
Journal: Bioscience Reports
Biosci Rep (2022) 42 (1): BSR20211005.
https://doi.org/10.1042/BSR20211005
Published: 14 January 2022
..., which accelerates senescence and apoptosis of BMSCs, ultimately leading to poor efficacy. Therefore, improving mitochondrial function and enhancing the antioxidative stress capacity of BMSCs may be an effective way of improving the survival rate and curative effect of BMSCs. In the present study, we...
View article titled, Overexpression of NMNAT3 improves mitochondrial function and enhances antioxidative stress capacity of bone marrow mesenchymal stem cells via the NAD + -Sirt3 pathway
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Includes: Supplementary data
Articles

Regucalcin ameliorates doxorubicin-induced cytotoxicity in Cos-7 kidney cells and translocates from the nucleus to the mitochondria

Noor A. Mohammed, Israa J. Hakeem, Nikolas Hodges, Francesco Michelangeli
Journal: Bioscience Reports
Biosci Rep (2022) 42 (1): BSR20211464.
https://doi.org/10.1042/BSR20211464
Published: 06 January 2022
... Cos-7 cells as kidney cell model. Cos-7 cells were exposed to DOX for a period of 24 h over a range of concentrations, and the LC 50 was determined to be 7 µM. Further investigations showed that cell death was mainly via apoptosis involving Ca 2+ and caspase 9, in addition to autophagy. Regucalcin...
View article titled, Regucalcin ameliorates doxorubicin-induced cytotoxicity in Cos-7 kidney cells and translocates from the nucleus to the mitochondria
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Articles

Deregulation of ribosomal proteins in human cancers

Wendy El Khoury, Zeina Nasr
Journal: Bioscience Reports
Biosci Rep (2021) 41 (12): BSR20211577.
https://doi.org/10.1042/BSR20211577
Published: 17 December 2021
... 10 2021 22 11 2021 07 12 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Cancer cell survival...
View article titled, Deregulation of ribosomal proteins in human cancers
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Articles

Retraction: The inhibition of tumor protein p53 by microrna-151a-3p induced cell proliferation, migration and invasion in nasopharyngeal carcinoma

Journal: Bioscience Reports
Biosci Rep (2021) 41 (10): BSR-2019-1357_RET.
https://doi.org/10.1042/BSR-2019-1357_RET
Published: 29 October 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Luciferase reporter assay Matrix metalloproteinases...
View article titled, Retraction: The inhibition of tumor protein p53 by microrna-151a-3p induced cell proliferation, migration and invasion in nasopharyngeal carcinoma
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Articles

Correction: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin

Journal: Bioscience Reports
Biosci Rep (2021) 41 (10): BSR-2019-0503_COR.
https://doi.org/10.1042/BSR-2019-0503_COR
Published: 29 October 2021
... apoptosis bladder cancer cell cycle ENO1 This Correction follows an Expression of Concern relating to this article previously published by Portland Press. The authors of the original article “Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating...
View article titled, Correction: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin
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Articles

Long-chain noncoding RNA-GAS5/hsa-miR-138-5p attenuates high glucose-induced cardiomyocyte damage by targeting CYP11B2

Xiaozhen Zhuo, Kai Bai, Yingxian Wang, Peining Liu, Wen Xi, Jianqing She, Junhui Liu
Journal: Bioscience Reports
Biosci Rep (2021) 41 (9): BSR20202232.
https://doi.org/10.1042/BSR20202232
Published: 03 September 2021
... in the progression of various diseases, including DCM. The purpose of the present study was to explore the role of lncRNA GAS5 in high glucose (HG)-induced cardiomyocyte injury and apoptosis. Materials and methods: We constructed HG-induced AC16 cardiomyocytes and a streptozotocin (STZ)-induced rat diabetes model...
View article titled, Long-chain noncoding RNA-GAS5/hsa-miR-138-5p attenuates high glucose-induced cardiomyocyte damage by targeting CYP11B2
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Articles

Targeting the ‘garbage-bin’ to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU

Consolato M. Sergi
Journal: Bioscience Reports
Biosci Rep (2021) 41 (8): BSR20210952.
https://doi.org/10.1042/BSR20210952
Published: 06 August 2021
... of osteosarcoma with 5-azacytidine significantly increased the expression of PTEN and down-regulated AKT signaling. This process caused apoptosis of osteosarcoma cells [ 28 ]. Dr. Sun et al. found that WT161 increased PTEN expression and inhibited the downstream PI3K/Akt signal pathway, thus inducing apoptosis...
View article titled, Targeting the ‘garbage-bin’ to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU
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Articles

Correction: LncRNA HOTAIR contributes Taxol-resistance of hepatocellular carcinoma cells via activating AKT phosphorylation by down-regulating miR-34a

Journal: Bioscience Reports
Biosci Rep (2021) 41 (8): BSR-2020-1627_COR.
https://doi.org/10.1042/BSR-2020-1627_COR
Published: 02 August 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Taxol-resistance The authors of the original article “LncRNA...
View article titled, Correction: LncRNA HOTAIR contributes Taxol-resistance of hepatocellular carcinoma cells via activating AKT phosphorylation by down-regulating miR-34a
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Articles

LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506-5p expression

Zhiping Chen, Tianyu Zhong, Tao Li, Jinghua Zhong, Yang Tang, Zhanyu Liu, Baodian Ling, Lanfeng Wang
Journal: Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20204177.
https://doi.org/10.1042/BSR20204177
Published: 28 July 2021
... migration, invasion and promoted apoptosis of AGS cells. More importantly, microRNA-506-5p (miR-506-5p) was predicted as a direct target of SNHG15 by binding its 3′-UTR and further verified using luciferase reporter assay. Meanwhile, the results of rescue experiments revealed that knockdown of miR-506-5p...
View article titled, LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506-5p expression
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Includes: Supplementary data
Articles

Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo

Nan-Chieh Huang, Ru-Lai Huang, Xiao-Fan Huang, Kai-Fu Chang, Chien-Ju Lee, Chih-Yen Hsiao, Shan-Chih Lee, Nu-Man Tsai
Journal: Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20211143.
https://doi.org/10.1042/BSR20211143
Published: 12 July 2021
... of J. communis extract (JCo extract) on HCC in vitro and in vivo . In the present study, we found that JCo extract inhibited the growth of human HCC cells by inducing cell cycle arrest at the G 0 /G 1 phase, extensive apoptosis and suppressing metastatic protein expressions in HCC cells. Moreover...
View article titled, Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo
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Articles

Incaspitolide A extracted from Carpesium cernuum induces apoptosis in vitro via the PI3K/AKT pathway in benign prostatic hyperplasia

Xiaoyue Chen, Jingrui Song, Dongbo Yuan, Qing Rao, Kehua Jiang, Shuhui Feng, Guohua Zhu, Chen Yan, Yanmei Li, Jianguo Zhu
Journal: Bioscience Reports
Biosci Rep (2021) 41 (6): BSR20210477.
https://doi.org/10.1042/BSR20210477
Published: 21 June 2021
... investigated the molecular mechanisms underlying the suppressive effect of TMJ-12 specifically on BPH-1 cells. A cytotoxicity assay indicated that TMJ-12 inhibited BPH-1 cell proliferation, while flow cytometry assays showed that TMJ-12 induced G 2 /M phase cell cycle arrest and the apoptosis of BPH-1 cells...
View article titled, Incaspitolide A extracted from Carpesium cernuum induces <span class="search-highlight">apoptosis</span> in vitro via the PI3K&#x2F;AKT pathway in benign prostatic hyperplasia
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Includes: Supplementary data
Articles

HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU

Jun Sun, Wei Wu, Xiaofeng Tang, Feifei Zhang, Cheng Ju, Renfeng Liu, Yiping Liang, Bo Yu, Bin Lv, Yuhong Guo, Duo Zeng, Xuchang Tao, Min Wang, Zhiping Zhang, Changhua Zhang, Xiao-Bin Lv
Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR20203905.
https://doi.org/10.1042/BSR20203905
Published: 30 April 2021
... of cancers. The aim of the present study is to explore the roles of WT161 in osteosarcoma and its underlying mechanisms. Methods: The anti-proliferative effect of WT161 on osteosarcoma cells was examined using MTT assay and colony formation assay. Cell apoptosis was analyzed using flow cytometer...
View article titled, HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU
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Articles

Correction: Protective effects of Fragaria ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20180861_COR.
https://doi.org/10.1042/BSR-20180861_COR
Published: 27 April 2021
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis brain cadmium Fragaria ananassa oxidative stress This Correction follows an Expression of Concern relating to this article previously published by Portland Press. ...
View article titled, Correction: Protective effects of Fragaria ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity
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Articles

Retraction: Effects of microRNA-374 on proliferation, migration, invasion and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20170710_RET.
https://doi.org/10.1042/BSR-20170710_RET
Published: 23 April 2021
... the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Gadd45a MicroRNA-374 P53 signaling pathway Proliferation Squamous carcinoma cells This Retraction follows an Expression of Concern relating to this article previously published by Portland Press. ...
View article titled, Retraction: Effects of microRNA-374 on proliferation, migration, invasion and <span class="search-highlight">apoptosis</span> of human SCC cells by targeting Gadd45a through P53 signaling pathway
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Articles

Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress

Wei Gao, Yongxun Jin, Jindong Hao, Siyi Huang, Dongxu Wang, Fushi Quan, Mingjun Zhang, Jiabao Zhang, Wenzhi Ren, Xianfeng Yu
Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR20203091.
https://doi.org/10.1042/BSR20203091
Published: 22 April 2021
... significantly reduced total blastocyst cell numbers ( P <0.001) and increased apoptosis of blastocyst cells ( P <0.001). Moreover, HU exposure reduced the rate of development of two-celled, four- to eight-celled, blastocyst, and hatching stages after parthenogenetic activation ( P <0.05). Our findings...
View article titled, Hydroxyurea affects in vitro porcine oocyte maturation through increased <span class="search-highlight">apoptosis</span> and oxidative stress
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Includes: Supplementary data
Articles

Retraction: miR-221/222 promote tumor growth and suppress apoptosis by targeting lncRNA GAS5 in breast cancer

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20181859_RET.
https://doi.org/10.1042/BSR-20181859_RET
Published: 19 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis breast cancer GAS5 miR-221/222 This article is being...
View article titled, Retraction: miR-221&#x2F;222 promote tumor growth and suppress <span class="search-highlight">apoptosis</span> by targeting lncRNA GAS5 in breast cancer
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Articles

Retraction: The protective effect of PPARγ in sepsis-induced acute lung injury via inhibiting PTEN/β-catenin pathway

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20192639_RET.
https://doi.org/10.1042/BSR-20192639_RET
Published: 19 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . acute lung injury apoptosis inflammation PPARγ PTEN/β-catenin pathway...
View article titled, Retraction: The protective effect of PPARγ in sepsis-induced acute lung injury via inhibiting PTEN/β-catenin pathway
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Articles

Expression of Concern: Stromal interaction molecule 1 (STIM1) regulates growth, cell cycle and apoptosis of human tongue squamous carcinoma cells

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20160519_EOC.
https://doi.org/10.1042/BSR-20160519_EOC
Published: 19 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell cycle STIM1 Tca-8113 cells tongue squamous carcinoma...
View article titled, Expression of Concern: Stromal interaction molecule 1 (STIM1) regulates growth, cell cycle and <span class="search-highlight">apoptosis</span> of human tongue squamous carcinoma cells
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Articles

Expression of Concern: In vivo and in vitro effects of hyperplasia suppressor gene on the proliferation and apoptosis of lung adenocarcinoma A549 cells

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20180391_EOC.
https://doi.org/10.1042/BSR-20180391_EOC
Published: 19 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . A549 cells Apoptosis Gene silencing Hyperplasia suppressor gene Lung...
View article titled, Expression of Concern: In vivo and in vitro effects of hyperplasia suppressor gene on the proliferation and <span class="search-highlight">apoptosis</span> of lung adenocarcinoma A549 cells
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Articles

2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways

Mengxin Luo, Xiaoxia Shi, Qi Guo, Shuangyue Li, Qing Zhang, Xiuyan Sun, Fengyuan Piao
Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR20204264.
https://doi.org/10.1042/BSR20204264
Published: 09 April 2021
...Mengxin Luo; Xiaoxia Shi; Qi Guo; Shuangyue Li; Qing Zhang; Xiuyan Sun; Fengyuan Piao Increasing evidence suggests that n -hexane induces nerve injury via neuronal apoptosis induced by its active metabolite 2,5-hexanedione (HD). However, the underlying mechanism remains unknown. Studies have...
View article titled, 2,5-Hexanedione induced <span class="search-highlight">apoptosis</span> in rat spinal cord neurons and VSC4.1 cells via the proNGF&#x2F;p75NTR and JNK pathways
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Articles

Expression of Concern: Progesterone receptor antagonist provides palliative effects for uterine leiomyoma through a Bcl-2/Beclin1-dependent mechanism

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20190094_EOC.
https://doi.org/10.1042/BSR-20190094_EOC
Published: 06 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis autophagy mifepristone progesterone receptor antagonist...
View article titled, Expression of Concern: Progesterone receptor antagonist provides palliative effects for uterine leiomyoma through a Bcl-2/Beclin1-dependent mechanism
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Articles

Expression of Concern: miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20193419_EOC.
https://doi.org/10.1042/BSR-20193419_EOC
Published: 31 March 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis inflammation miR-143-3p mycoplasmal pneumonia TLR4/MyD88/NF-κB...
View article titled, Expression of Concern: miR-143-3p impacts on pulmonary inflammatory factors and cell <span class="search-highlight">apoptosis</span> in mice with mycoplasmal pneumonia by regulating TLR4&#x2F;MyD88&#x2F;NF-κB pathway
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Articles

Commentary on: Calpain-2 participates in the process of calpain-1 inactivation

Raniki Kumari, Tushar Kanti Maiti
Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR20203690.
https://doi.org/10.1042/BSR20203690
Published: 31 March 2021
... calcium-dependent cellular pathways including neuronal function, muscle contraction, signal transduction, cell differentiation, proliferation, and apoptosis. Research suggests that C1 and C2 perform similar functions due to their structurally highly similar isoforms. Increasing evidence suggests that C1...
View article titled, Commentary on: Calpain-2 participates in the process of calpain-1 inactivation
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Articles

Expression of Concern: Protective effects of Fragaria ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity

Journal: Bioscience Reports
Biosci Rep (2021) 41 (3): BSR-20180861_EOC.
https://doi.org/10.1042/BSR-20180861_EOC
Published: 26 March 2021
... apoptosis brain cadmium Fragaria ananassa oxidative stress The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. © 2021...
View article titled, Expression of Concern: Protective effects of Fragaria ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity
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Articles

Long non-coding RNA LINC00488 facilitates thyroid cancer cell progression through miR-376a-3p/PON2

Fuyuan Xie, Longgen Li, Yuting Luo, Rensheng Chen, Jinhong Mei
Journal: Bioscience Reports
Biosci Rep (2021) 41 (3): BSR20201603.
https://doi.org/10.1042/BSR20201603
Published: 02 March 2021
... in the view of cell proliferation and apoptosis. Methods: In order to evaluate the effects of LINC00488 on the cellular process of thyroid cancer, we performed a series of in vitro experiments, including cell counting kit-8 (CCK-8) assay, EdU (5-ethynyl-2′-deoxyuridine) assay, flow cytometry, transwell...
View article titled, Long non-coding RNA LINC00488 facilitates thyroid cancer cell progression through miR-376a-3p/PON2
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Articles

Expression of Concern: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin

Journal: Bioscience Reports
Biosci Rep (2021) 41 (2): BSR-20190503_EOC.
https://doi.org/10.1042/BSR-20190503_EOC
Published: 16 February 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . β-catenin apoptosis bladder cancer cell cycle ENO1 The Editorial...
View article titled, Expression of Concern: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin
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Articles

Cyclophilin A inhibits A549 cell oxidative stress and apoptosis by modulating the PI3K/Akt/mTOR signaling pathway

Zhenling Ma, Wenwen Zhang, Yaru Wu, Menghao Zhang, Lei Wang, Yihan Wang, Yi Wang, Wei Liu
Journal: Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203219.
https://doi.org/10.1042/BSR20203219
Published: 29 January 2021
... in A549 cells in response to H 2 O 2 stimulation. Additionally, peptidyl-prolyl isomerase activity was required for PI3K/Akt activation by CypA. The present study showed that CypA protected A549 cells from H 2 O 2 -induced oxidative injury and apoptosis by activating the PI3K/Akt/mTOR pathway. Thus, CypA...
View article titled, Cyclophilin A inhibits A549 cell oxidative stress and <span class="search-highlight">apoptosis</span> by modulating the PI3K&#x2F;Akt&#x2F;mTOR signaling pathway
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Articles

Lamin B2 promotes the progression of triple negative breast cancer via mediating cell proliferation and apoptosis

Cui-Cui Zhao, Jing Chen, Li-Ying Zhang, Hong Liu, Chuan-Gui Zhang, Yan Liu
Journal: Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203874.
https://doi.org/10.1042/BSR20203874
Published: 29 January 2021
... was used to deplete the expression of LMNB2 in human TNBC cell lines including MDA-MB-468 and MDA-MB-231. Alterations in cell proliferation and apoptosis in vitro and the nude mouse tumorigenicity assay in vivo were subsequently analyzed. The human TNBC tissues shown high expression of LMNB2 according...
View article titled, Lamin B2 promotes the progression of triple negative breast cancer via mediating cell proliferation and <span class="search-highlight">apoptosis</span>
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Articles

Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3

In Collection
Protein structure and function
Liqi Yao, Paul Swartz, Paul T. Hamilton, A. Clay Clark
Journal: Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203495.
https://doi.org/10.1042/BSR20203495
Published: 29 January 2021
...Liqi Yao; Paul Swartz; Paul T. Hamilton; A. Clay Clark Caspase (or cysteinyl-aspartate specific proteases) enzymes play important roles in apoptosis and inflammation, and the non-identical but overlapping specificity profiles (that is, cleavage recognition sequence) direct cells to different fates...
View article titled, Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3
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Includes: Supplementary data
Articles

Shikonin inhibits proliferation of melanoma cells by MAPK pathway-mediated induction of apoptosis

Jae Han Lee, So Hee Han, You Min Kim, Sung Hyun Kim, Eun Seon Yoo, Joong Seok Woo, Gi Hwan Jung, Soo Hyun Jung, Bum Seok Kim, Ji Youn Jung
Journal: Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203834.
https://doi.org/10.1042/BSR20203834
Published: 22 January 2021
... bromide) assay, 4′,6-diamidino-2-phenylindole (DAPI) stain, annexin V/ propidium iodide (PI) stain, and protein analysis of apoptosis and mitogen-activated protein kinase (MAPK) pathways). Further, the anticancer effect in vivo was confirmed through a xenograft model. Our results showed that shikonin...
View article titled, Shikonin inhibits proliferation of melanoma cells by MAPK pathway-mediated induction of <span class="search-highlight">apoptosis</span>
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Articles

C1QTNF6 regulates cell proliferation and apoptosis of NSCLC in vitro and in vivo

Wei Zhang, Ganzhu Feng
Journal: Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20201541.
https://doi.org/10.1042/BSR20201541
Published: 12 January 2021
... apoptosis by flow cytometric analysis and TUNEL assay. Furthermore, the capability of migration and invasion was obviously enhanced on C1QTNF6 overexpression. Conclusion: Overall, our results demonstrated that inhibition of C1QTNF6 attenuated cell proliferation, migration, invasion and promoted apoptosis...
View article titled, C1QTNF6 regulates cell proliferation and <span class="search-highlight">apoptosis</span> of NSCLC in vitro and in vivo
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