... (DSD) enzyme, Ito et al. ( Biosci. Rep. (2021) 41 , BSR20210260) have described abundant levels of l -erythro-β-hydroxyasparagine ( l -β-EHAsn), a non-proteogenic amino acid which is also a newly described substrate for DSD. The data presented support the endogenous production l -β-EHAsn, with its...

...Tomokazu Ito; Mayuka Tono; Yasuyuki Kitaura; Hisashi Hemmi; Tohru Yoshimura In the present study, we identified l - erythro -β-hydroxyasparagine ( l -β-EHAsn) found abundantly in human urine, as a novel substrate of Zn 2+ -dependent d -serine dehydratase (DSD). l -β-EHAsn is an atypical amino acid...

...Junfang Wu; Mingming Zhao; Chenze Li; Yuxuan Zhang; Dao Wen Wang The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has induced an ongoing global health crisis. Here we utilized a combination of targeted amino acids (AAs) and clinical biochemical profiling to analyze the plasma...

... for intestinal cells to sustain life of the whole organism. The TORC is a major protein complex involved in monitoring the nutritional status and is activated by elevated amino acid concentrations. An important feature of haematophagy is that huge amounts of blood are ingested in a single meal, which results...

...Israel Zelikovic; James Wager-Miller Very little is known about the cellular mechanisms controlling renal tubular amino acid transport. cAMP-dependent protein kinase (cAK) modulates the activity of several ion channels and pumps in biological membranes. The direct influence of cAK on transmembrane...

.... The results suggest that although mammary tissue expresses a volume-sensitive amino acid transport system which is inhibited by anion transport blockers the pathway has no identity with volume-activated anion channels. 25 6 1996 © 1996 Plenum Publishing Corporation 1996 Mammary gland amino...

...C. Picó; A. Pons; A. Palou It is well known that the amino acids in the blood are distributed between the plasma and inside the cells. This study was conducted to determine whether amino acids can be located adsorbed on blood cell membranes. The amino acid concentration in the deproteinized...

...Vasek A. Mezl; Jane Wall Amino acid analyses show that while the free amino acids found in the rabbit reticulocyte translation system do not increase during nuclease treatment or during prolonged storage, the endogenous levels of many amino acids are so high that the choice of a radioactive...

...S. Lenzen; W. Schmidt; I. Rustenbeck; U. Panten The various neutral amino acids and aliphatic 2-keto acids exhibit differential effects on insulin secretion. The common denominator for all these effects is the 2-ketoglutarate generation in the pancreatic B-cell mitochondria. The neutral amino acids...

...V. R. Preedy; P. J. Garlick In 12 h fasted rats, rates of muscle protein synthesis were stimulated by refeeding for 1 h and by intragastric or intravenous infusion of an amino acid plus glucose mixture for 1 hr, but not by intravenous infusion of amino acids alone for 1 h. Intravenous injection...