... phospho ERK which was also inhibited by dapagliflozin. TGF-β1 increased cellular phospho SSXS Smad3 serine 423 and 425, with and without high D-glucose. Glucose alone had no effect. Smad3 serine 204 phosphorylation was significantly raised by a combination of high D-glucose+TGF-β1; this rise...

... Figure 6 Repsox represses translocation of Smad3 and Smad4 into nucleus resulting in attenuation of the effect of TGF-β1 on Cx43 ( D ) Representative IF staining by CLSM showing reduced translocation of Smad4 in osteocytes after pretreatment with 50 μM Repsox for 6 h and then treatment...

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Connexin 43 Gap junction Osteocyte Smad3 Smad4 TGF-β1 The Editorial...

... in the development of asthma. The expression of miR-203a-3p and Sine oculis homeobox homolog 1 (SIX1) were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The protein levels of SIX1, fibronectin, E-cadherin, vimentin, phosphorylated-drosophila mothers against decapentaplegic 3 (p-Smad3...

... we next focussed on the downstream signals of TGF-β and found that TGF-β1-mediated smads, Smad3 and Smad4, to translocate into nucleus. These translocated signal proteins bind to the promoter of Gja1 which was responsible for the changed expression of Cx43. The present study provides evidence...

... osteoarthritis rs12901499 polymorphism SNP SMAD3 Osteoarthritis (OA), a complex and multifactorial disease, is the most common degenerative arthritis characterized by the degeneration of articular cartilage with joint space narrowing, osteophyte formation, and subcondral sclerosis resulting in pain...