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Keywords: STAT3
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Biosci Rep (2022) 42 (5): BSR20212418.
Published: 13 May 2022
... results demonstrated that the levels of LCN2 mRNA and protein were markedly up-regulated by interleukin (IL) 6 (IL-6) in human CRC cells. Interestingly, we found LCN2 up-regulation by IL-6 is diminished by nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) inhibition...
Biosci Rep (2020) BSR20192842.
Published: 18 June 2020
... Commons licence. Curcumin Imiquimod Psoriasis IL-6 STAT3 Inflammation WITHDRAWN ARTICLE WITHDRAWN: Curcumin against imiquimod-induced psoriasis of mice through IL-6/STAT3 signaling pathway Yibin Zeng; Hongying Zhao; Tong Zhang; Chao Zhang; Yanni He; Lingbo Du; Fuguo Zuo; Wuqing Wang Biosci...
Biosci Rep (2020) 40 (1): BSR20193299.
Published: 14 January 2020
... assays. As a result, we found that NEAT1 knockdown enhanced the proliferation and impaired the apoptosis of vascular smooth muscle cells (VSMCs). Reversely, overexpressed NEAT1 exerted anti-proliferation and pro-apoptosis effects in VSMCs. Mechanically, we found that STAT3 acted as a transcription factor...
Includes: Supplementary data
Biosci Rep (2019) 39 (9): BSR20191965.
Published: 06 September 2019
..., and the gene encoding signal transducer and activator of transcription 3 (STAT3) was targeted by miR-384. We found that miR-384 was unregulated in PE, and overexpression of miR-384 could inhibit cell proliferation and invasion. In addition, we showed that the expression of STAT3 was decreased with knockdown...
Biosci Rep (2019) 39 (7): BSR20190955.
Published: 23 July 2019
...Heqing Lai; Guochao Xu; Haifeng Meng; Haiying Zhu Objective: To study the association between SP1 rs1353058818 and STAT3 rs1053004 gene polymorphisms and risk of human tongue squamous cell carcinoma (TSCC). Methods: Sanger sequencing was used to determine the genotypes of SP1 rs1353058818 and STAT3...
Biosci Rep (2019) 39 (6): BSR20190783.
Published: 20 June 2019
... for the STAT3 polymorphism, 5902 cases and 7867 controls from nine studies for the STAT4 polymorphism. Our results suggested that STAT3 rs1053004 polymorphism was a significant risk factor of chronic HBV infection (C vs. T: OR = 1.17, 95% CI: 1.07–1.29, P A =0.0007; CC + CT vs. TT: OR = 1.38, 95% CI: 1.09–1.76...
Includes: Supplementary data
Biosci Rep (2018) 38 (6): BSR20181228.
Published: 14 December 2018
... was a direct target of miR-216a-5p, and DANCR regulated the JAK2/STAT3 signal pathway through miR-216a-5p in OA chondrocytes. In the present study, we concluded that DANCR promoted the proliferation, inflammation, and reduced cell apoptosis in OA chondrocytes through regulating miR-216a-5p/JAK2/STAT3 signaling...
Biosci Rep (2018) 38 (6): BSR20181521.
Published: 28 November 2018
.... Moreover, IL-9 stimulation inhibited suppressor of cytokine signaling 3 (SOCS3) expression and wound healing ability in colonic epithelial cells and promoted the phosphorylation level of signal transducers and activators of transcription 3 (STAT3). And IL-9 stimulation promoted claudin-2 expression while...
Includes: Supplementary data
Biosci Rep (2018) 38 (4): BSR20180547.
Published: 29 August 2018
...-promoting function of miR-216a . STAT3 is a regulator of miR-216a , and PTEN is also regulated by STAT3. miR-216a up-regulation is associated with cisplatin resistance in ovarian cancer and this effect is mediated by PTEN. STAT3 is a regulator of miR-216a . Strategies that inhibit miR-216a is a potential...
Biosci Rep (2018) 38 (4): BSR20180532.
Published: 03 July 2018
... was significantly up-regulated during the IL-6-driven EMT process. Additionally, JunB induction occurred at the transcriptional level in a manner dependent on phosphorylated STAT3, during which activated STAT3 directly bound to the JunB promoter. Importantly, the knockdown of STAT3 prevented the IL-6-induced EMT...
Includes: Supplementary data
Biosci Rep (2017) 37 (6): BSR20171038.
Published: 12 December 2017
... and activator of transcription 3 (STAT3) signaling pathway and non-STAT3 pathway in glioma cells. Here, we investigated the molecular mechanisms that regulated GRIM-19 expression in glioma cells. By the TargetScan algorithm, four miRNAs, hsa- miR-17-3p , hsa- miR-423-5p , hsa- miR-3184-5p , and hsa- miR-6743-5p...
Includes: Supplementary data
Biosci Rep (2017) 37 (4): BSR20170181.
Published: 21 July 2017
... in response to treatment of BMSC-CM or recombinant IL-6 in two human HCC cell lines Bel-7404 and HepG2. Then we analyzed the level of key components of the IL-6 signal pathway, including IL-6 receptor and signal transducer (i.e. IL-6R and gp130), a transcription factor STAT3 (signal transducer and activator...
Includes: Supplementary data
Biosci Rep (2016) 36 (3): e00342.
Published: 03 June 2016
...Junrong Wang; Nina Zhang; Haijiang Qu; Guangxian You; Junhui Yuan; Caie Chen; Wenyi Li; Feng Pan To investigate the effects of signal transducer and activator of transcription 3 (STAT3) combined with cisplatin (CDDP) on the growth of human Wilms tumour (WT) SK-NEP-1 cell subcutaneous xenografts...
Biosci Rep (2015) 35 (6): e00276.
Published: 22 December 2015
... lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (BAX). Apigenin reduced the expression of phospho-JAK1, phospho-JAK2 and phospho-STAT3 and decreased signal transducer and activator of transcription 3 (STAT3) dependent luciferase reporter gene activity in BT-474 cells. Apigenin inhibited CoCl 2 -induced...