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Limin Zhen, Gang Ning, Lina Wu, Yongyuan Zheng, Fangji Yang, Tongtong Chen, Wenxiong Xu, Ying Liu, Chan Xie, Liang Peng
Biosci Rep (2020) 40 (10): BSR20192593.
Published: 05 October 2020
.... Results: In total, 24 up-hypomethylated oncogenes and 37 down-hypermethylated tumor suppressor genes (TSGs) were identified, and 8 hub genes, including 4 up-hypomethylated oncogenes (CDC5L, MERTK, RHOA and YBX1) and 4 down-hypermethylated TSGs (BCR, DFFA, SCUBE2 and TP63), were selected by PPI. Higher...
Biosci Rep (2020) 40 (1): BSR20193158.
Published: 02 January 2020
... synergistically collaborated to regulate RHOA signaling in the carcinogenesis of thyroid cancer. Materials and methods: Candidate miRs were filtrated using miR microarray assays. Gene and protein expression levels were analyzed using RT-qPCR and Western blotting, respectively. Cell growth was evaluated using CCK8...
Biosci Rep (2017) 37 (2): BSR20160622.
Published: 20 April 2017
... and then investigated the regulatory role of RhoA, a well-recognized apoptosis suppressor, in such process, with gain-of-function strategy. Our results indicated that hypoxia induced apoptosis and inhibited CREB phosphprylation in chondrocytes, meanwhile, the dysfunctional mitochondria with up-regulated mitochondrial...