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Keywords: Pirarubicin chemoresistance
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Down-regulating GRP78 reverses pirarubicin resistance of triple negative breast cancer by miR-495-3p mimics and involves the p-AKT/mTOR pathway

Mian Liu, Jiu Yang, Wuwu Lv, Shuanglian Wang, Tao Du, Kejing Zhang, Yuhui Wu, Xueping Feng
Journal: Bioscience Reports
Biosci Rep (2022) 42 (1): BSR20210245.
https://doi.org/10.1042/BSR20210245
Published: 06 January 2022
... reduced GRP78 expression, which restored pirarubicin sensitivity. Besides, transfecting MDA-MB-231R cells with miR-495-3p mimics increased miR-495-3p expression, which also reversed pirarubicin chemoresistance. Cell counting kit-8 (CCK-8), EdU, wound healing, and Transwell assays showed that the miR-495...
View article titled, Down-regulating GRP78 reverses pirarubicin resistance of triple negative breast cancer by miR-495-3p mimics and involves the p-AKT/mTOR pathway
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Includes: Supplementary data