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Keywords: Parkinson disease
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Articles
mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition
Claudia Manzoni, Adamantios Mamais, Sybille Dihanich, Marc P.M. Soutar, Helene Plun-Favreau, Rina Bandopadhyay, Rosella Abeti, Paola Giunti, John Hardy, Mark R. Cookson, Sharon A. Tooze, Patrick A. Lewis
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20171669.
Published: 20 April 2018
... and was thought to be exclusively dependent upon mTOR complex 1 kinase activity. In the present study, a novel regulation of Ser758 ULK1 phosphorylation is reported following prolonged inhibition of the Parkinson’s disease linked protein leucine rich repeat kinase 2 (LRRK2). Here, modulation of Ser758 ULK1...
Includes: Supplementary data
