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Keywords: PTEN
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Articles
Biosci Rep (2022) 42 (1): BSR-2019-0249_COR.
Published: 18 January 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . 5-fluorouracil colorectal cancer MicroRNA-543 PTEN The authors...
Articles
Biosci Rep (2021) 41 (10): BSR20210486.
Published: 04 October 2021
... through down-regulation of cyclin D1 (CCND1) as well as AKT/mTOR signaling pathway inhibition. Meanwhile, USP25 also suppresses NSCLC progression via enhancing phosphatase and tensin homolog (PTEN) stability in cancer cells, which further indicates the significance/importance of USP52 in NSCLC suppression...
Articles
Biosci Rep (2021) 41 (8): BSR20210952.
Published: 06 August 2021
... xenograft model. WT161 and 5-FU inhibited the growth and weight of osteosarcoma. Previously, the treatment of osteosarcoma with 5-azacytidine significantly increased the expression of PTEN and down-regulated AKT signaling. This process caused apoptosis of osteosarcoma cells [ 28 ]. Dr. Sun et al. found...
Articles
Biosci Rep (2021) 41 (4): BSR20203905.
Published: 30 April 2021
... manner. Mechanistically, we found that WT161 treatment obviously increased the protein level of PTEN and decreased the phosphorylation level of protein kinase-B (AKT). More importantly, WT161 showed synergistic inhibition with 5-FU on osteosarcoma cells in vitro and in vivo . Conclusions: These results...
Articles
Biosci Rep (2020) 40 (10): BSR20201901.
Published: 14 October 2020
... reporter assay. After transfection, cell viability, apoptosis, migration, and invasion were detected by MTT, flow cytometry, wound healing, and transwell assays, respectively. The expressions of PTEN, Bax, Bcl-2, cleaved Caspase-3, p-PI3K, PI3K, p-AKT, and AKT were detected by Western blot. Results: MiR-25...
Articles
Biosci Rep (2020) 40 (6): BSR-20194427_RET.
Published: 25 June 2020
... the Editorial Board to manipulation in Figure 2C, as well as duplicated images in Figures 2B, 4B, 7B and 7D. diabetic nephropathy LncRNA- PVT1 miR-93-5p PTEN PI3K/Akt/mTOR pathway mouse mesangial cells © 2020 The Author(s). 2020 This is an open access article published by Portland Press...
Articles
Biosci Rep (2020) 40 (6): BSR20193991.
Published: 23 June 2020
... and tensin homolog (PTEN), which is a target of miR-486. In cell proliferation assay, overexpression of MIR22HG and PTEN led to decreased rates of BC cell proliferation. Moreover, overexpression of miR-486 played an opposite role and attenuated the effects of overexpression of MIR22HG and PTEN. Therefore...
Articles
Biosci Rep (2020) 40 (6): BSR20200527.
Published: 02 June 2020
... and validated the association between PTEN and miR-22-3p. Results: Our data showed that miR-22-3p was significantly down-regulated in a rat model of sepsis-induced acute kidney injury, in vivo and LPS-induced sepsis model in HK-2 cells, in vitro . Overexpression of miR-22-3p remarkably suppressed...
Articles
Biosci Rep (2020) 40 (3): BSR-20182466_RET.
Published: 13 March 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hepatocellular carcinoma MiR-367 PTEN PI3K/AKT pathway Bioscience...
Articles
Biosci Rep (2019) BSR20182466.
Published: 20 September 2019
...). Knockdown of miR-367 expression could inhibit cell proliferation, migration and invasion in vitro. While, enhanced miR-367 expression exhibited opposite effects. Besides, inhibition of miR-367 might enhance PTEN expression, reduce the levels of p-GSK3β and p-AKT. PTEN might be a target of miR-367 in HCC...
Articles
Biosci Rep (2019) 39 (7): BSR20182192.
Published: 26 July 2019
... promoted cells proliferation, G1/S transition, cells invasion, and resisted apoptosis in RA-FLS, whereas it led to contrary effects when inhibiting the expression of miR-26a-5p. The 3′UTR of tensin homolog (PTEN) was directly targetted by miR-26a-5p and activation of phosphoinositide 3-kinase (PI3K)/AKT...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (7): BSR20190954.
Published: 19 July 2019
...Jian Zhou; Xia Xiao; Wanchun Wang; Yingquan Luo Previous studies indicated the prognostic value of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in osteosarcoma (OS). There was a great degree of inconsistency between these reports. The aim of this meta-analysis was to investigate...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (3): BSR20190249.
Published: 22 March 2019
... studies showed that miR-543 enhanced drug resistance by down-regulating the expression of phosphatase and tensin homolog (PTEN), which negatively regulates protein kinase B (AKT) activation. Additionally, an elevated expression of PTEN reversed the chemoresistance of miR-543-overexpressing HCT8 cells to 5...
Articles
Biosci Rep (2018) 38 (3): BSR20180019.
Published: 15 May 2018
... levels of SP1. Consistently, the abundance of phosphatase and tension homolog deleted on chromosome ten (PTEN), a negative downstream target of SP1, was increased with the ectopic miR-150-3p . Collectively, these results suggested that miR-150-3p suppressed the growth of glioma cells partially via...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (2): BSR20171511.
Published: 13 April 2018
.... The expressions of miR-25, tensin homolog deleted on chromosome 10 (PTEN), Toll-like receptors 4 (TLR4), and p-p65 were analyzed by quantitative real-time PCR (qRT-PCR) and Western blot, respectively. The levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected by ELISA. Cell apoptosis...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (6): BSR20170837.
Published: 15 December 2017
... or inhibitor miR-500a were determined. Luciferase reported assay was used to explore the relationship between miR-500a and phosphatase and tensin homologue (PTEN). Then, the protein expression of PTEN, p-Akt (S473), p-Akt (T308), Akt, p-mTOR, mTOR, p-4E-BP1, 4E-BP1, p-S6K, and S6K in SMMC-7721 cells were also...
Articles
Biosci Rep (2017) 37 (4): BSR20170327.
Published: 04 July 2017
...-time PCR demonstrated that miR-214 negatively regulated PTEN in radioresistance ovarian cancer cell lines and ovarian cancer tissues. Taken together, our data conclude that miR-214 contributes to radioresistance of ovarian cancer by directly targeting PTEN. Ovarian cancer is the fourth most...
Articles
Biosci Rep (2016) 36 (5): e00378.
Published: 16 September 2016
... the related indicators. PTEN expression in HO-H1 cells was higher than those in the parental stem cells and lower than those in parental tumour cells; the growth of OV-H1 (RFP+GFP) hybrid cells with double fluorescence expressions were obviously slower than that of human embryonic stem cells and OVCAR-3...