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Keywords: PKM2
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Biosci Rep (2019) 39 (11): BSR20192453.
Published: 12 November 2019
...Ting Tao; Shiyuan Wu; Zheng Sun; Wei Ma; Sichun Zhou; Jun Deng; Qiongli Su; Mei Peng; Gaosheng Xu; Xiaoping Yang Reprogrammed metabolism is an important hallmark of cancer cells. Pyruvate kinase (PK) is one of the major rate-limiting enzymes in glucose metabolism. The M2 isoform of PK (PKM2...
Biosci Rep (2019) 39 (7): BSR20190243.
Published: 05 July 2019
... aging phenotypes in vivo . Lead exposure induced a peroxide condition in HSCs leading to DNA damage, which reduced expression of the glycolytic enzyme pyruvate kinase M2 isoform (PKM2), a phenotype which was significantly ameliorated by allicin treatment. These findings suggested that allicin alleviated...
Biosci Rep (2019) 39 (4): BSR20190150.
Published: 30 April 2019
... as a transcriptional factor positively regulated pyruvate kinase isozyme type M2 (PKM2) expression and played an important role in the Warburg effect. In addition, these findings indicated that miR-140-5p functions as a tumor suppressor and plays a critical role in CML cell apoptosis and metabolism by targeting SIX1...