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Biosci Rep (2021) BSR20211828.
Published: 09 September 2021
... and inhibition studies. Results: Cinnamic acid inhibited cell viability and cell invasion, as well as decreased ECAR and OCR, in primary endometrial stromal cells. Cinnamic acid suppressed the effects of PKM2 overexpression, and inhibition of PKM2 using Compound 3k mimicked the effects of cinnamic acid...
Ting Tao, Shiyuan Wu, Zheng Sun, Wei Ma, Sichun Zhou, Jun Deng, Qiongli Su, Mei Peng, Gaosheng Xu, Xiaoping Yang
Biosci Rep (2019) 39 (11): BSR20192453.
Published: 12 November 2019
...Ting Tao; Shiyuan Wu; Zheng Sun; Wei Ma; Sichun Zhou; Jun Deng; Qiongli Su; Mei Peng; Gaosheng Xu; Xiaoping Yang Reprogrammed metabolism is an important hallmark of cancer cells. Pyruvate kinase (PK) is one of the major rate-limiting enzymes in glucose metabolism. The M2 isoform of PK (PKM2...
Shi-zhong Cai, Li-na Zhao, Jun Liu, Yi-ting Ji, Xiao-yan Shi, Zhou-rui Ma, Xiao-hua Lv, Ke Chen, Yan Chen
Biosci Rep (2019) 39 (7): BSR20190243.
Published: 05 July 2019
... aging phenotypes in vivo . Lead exposure induced a peroxide condition in HSCs leading to DNA damage, which reduced expression of the glycolytic enzyme pyruvate kinase M2 isoform (PKM2), a phenotype which was significantly ameliorated by allicin treatment. These findings suggested that allicin alleviated...
Zi-Yuan Nie, Xiao-Jun Liu, Ying Zhan, Meng-Han Liu, Xiao-Yan Zhang, Zi-Ye Li, Ya-Qiong Lu, Jian-Min Luo, Lin Yang
Biosci Rep (2019) 39 (4): BSR20190150.
Published: 30 April 2019
... as a transcriptional factor positively regulated pyruvate kinase isozyme type M2 (PKM2) expression and played an important role in the Warburg effect. In addition, these findings indicated that miR-140-5p functions as a tumor suppressor and plays a critical role in CML cell apoptosis and metabolism by targeting SIX1...