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Keywords: PI3K/Akt/mTOR
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Effects of UC induction and pretreatment with AA on macroscopic changes  ( ...
Published: 27 May 2024
Figure 1 Effects of UC induction and pretreatment with AA on macroscopic changes ( A ) DAI, ( B ) UI, ( C ) indices, and colon weight ( D ) of rats. Data were presented as the mean ± SE ( n =7). a P <0.05 compared with the control group; b P <0.05 compared with UC group. More about this image found in Effects of UC induction and pretreatment with AA on macroscopic changes ( ...
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Effects of AA on histopathological changes in colitic rats  ( A ) Colon fro...
Published: 27 May 2024
Figure 2 Effects of AA on histopathological changes in colitic rats ( A ) Colon from the control rats. ( B ) Colon from acetic acid-induced experimental colitis group. ( C ) Colon from the 5-ASA treated group (200 mg/kg). ( D ) Colon from AA-20+UC treated group. ( E ) Colon from AA-40+UC treated ... More about this image found in Effects of AA on histopathological changes in colitic rats ( A ) Colon fro...
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Effects of UC induction and pretreatment with AA on levels of oxidant marke...
Published: 27 May 2024
Figure 3 Effects of UC induction and pretreatment with AA on levels of oxidant markers The mRNA expression of iNOS ( A ), NO ( B ), LPO ( C ), and the antioxidant GSH ( D ) in the colon of rat. iNOS was referenced to GAPDH and represented as fold change compared with mRNA expression in the contro... More about this image found in Effects of UC induction and pretreatment with AA on levels of oxidant marke...
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Effects of UC induction and pretreatment with AA on levels of antioxidant e...
Published: 27 May 2024
Figure 4 Effects of UC induction and pretreatment with AA on levels of antioxidant enzymes SOD ( A ), CAT ( B ), GPx ( C ), GR ( D ), and mRNA expression of Nrf2 ( E ) in the colon of rat. Nrf2 was referenced to GAPDH and represented as fold change compared with mRNA expression in the control gro... More about this image found in Effects of UC induction and pretreatment with AA on levels of antioxidant e...
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Effects of UC induction and pretreatment with AA on levels and mRNA express...
Published: 27 May 2024
Figure 5 Effects of UC induction and pretreatment with AA on levels and mRNA expression of pro-inflammatory cytokines IL-1β (A&B) and TNF-α (C&D) in rat colon tissue qRT-PCR findings were referenced to GAPDH and represented as fold change compared to mRNA expression in the control group. ... More about this image found in Effects of UC induction and pretreatment with AA on levels and mRNA express...
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Effects of UC induction and pretreatment with AA on levels of inflammatory ...
Published: 27 May 2024
Figure 6 Effects of UC induction and pretreatment with AA on levels of inflammatory mediators [NF-κB (A), MPO (B), MCP1 (C), and PGE2 (D)] in the colon of rat Data were presented as the mean ± SE (n = 7). ( A ) P < 0.05 compared to the control group; ( B ) P < 0.05 compared to UC group. NF-... More about this image found in Effects of UC induction and pretreatment with AA on levels of inflammatory ...
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Effects of UC induction and pretreatment with AA on levels of apoptotic pro...
Published: 27 May 2024
Figure 7 Effects of UC induction and pretreatment with AA on levels of apoptotic proteins Bax ( A ), caspase-3 ( B ), and Bcl-2 ( C ) in the colon of rat Effects of UC induction and pretreatment with AA on levels of apoptotic proteins Bax ( A ), caspase-3 ( B ), and Bcl-2 ( C ) in the colon of ra... More about this image found in Effects of UC induction and pretreatment with AA on levels of apoptotic pro...
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Non-linear regression on glucose and maltose range for wild-type sGDH and Y...
Published: 24 May 2024
Figure 1 Non-linear regression on glucose and maltose range for wild-type sGDH and Y343F or D143E/Y343F mutants at 37°C The oxidation activities of sGDH wild-type and mutants were determined by spectrometry to follow the reduction of 2,6-dichlorophenolindophenol (DCIP) (ε 600 = 21.6 mM −1 ·cm −1... More about this image found in Non-linear regression on glucose and maltose range for wild-type sGDH and Y...
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Active site of the holo sGDH wild-type with glucose  The figure was prepare...
Published: 24 May 2024
Figure 2 Active site of the holo sGDH wild-type with glucose The figure was prepared by the authors based on the structure factors and refinement, published by Oubrie et al . in 1999 (PDB 1CQ1 ) [ 30 ], obtained from the PDB-REDO [ 31 ] server. The electron density (grey mesh) shown is calculat... More about this image found in Active site of the holo sGDH wild-type with glucose The figure was prepare...
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Dimeric interface of the wild-type sGDH  ( A ) The electrostatic charge was...
Published: 24 May 2024
Figure 3 Dimeric interface of the wild-type sGDH ( A ) The electrostatic charge was calculated with the macromolecular electrostatics calculation plugin Plug-APBS available under PyMOL [ 33 ]. A well ordered and extensive water network (yellow spheres) is present between the two monomers, as seen... More about this image found in Dimeric interface of the wild-type sGDH ( A ) The electrostatic charge was...
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Active site of the holo sGDH wild-type  The active site of PQQ from the wil...
Published: 24 May 2024
Figure 4 Active site of the holo sGDH wild-type The active site of PQQ from the wild-type enzyme at pH 8. The density at 5 σ from a Polder Omit Map (PHENIX) is superimposed onto a model of cleaved PQQ. Residues close to the cofactor are labeled, and show little reorganization compared with the st... More about this image found in Active site of the holo sGDH wild-type The active site of PQQ from the wil...
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Sensitivity of sGDH to H 2 O 2  at pH 7.5 (A) and pH 5.0 (B)  The  k  obs  ...
Published: 24 May 2024
Figure 5 Sensitivity of sGDH to H 2 O 2 at pH 7.5 (A) and pH 5.0 (B) The k obs were calculated from the decreasing exponential fit at pH 7.5 and at pH 5.0; values are reported in Table 2 . More about this image found in Sensitivity of sGDH to H 2 O 2 at pH 7.5 (A) and pH 5.0 (B) The k obs ...
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Evidence of aging and catalase effect  Evidence for the aging of sGDH at 25...
Published: 24 May 2024
Figure 6 Evidence of aging and catalase effect Evidence for the aging of sGDH at 25°C, observed through three different parameters: spectroscopic properties at 340 nm ( A ), retention of activity ( B ), and the relative stability of modified electrodes measured using chronoamperometry at +0.3V vs... More about this image found in Evidence of aging and catalase effect Evidence for the aging of sGDH at 25...
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sFlt-1 reduces neurite growth in RA-differentiated SH-SY5Y cells  RA-differ...
Published: 17 May 2024
Figure 1 sFlt-1 reduces neurite growth in RA-differentiated SH-SY5Y cells RA-differentiated SH-SY5Y cells were treated with 0.1, 1, 10, or 100 ng/ml sFlt-1 or PBS as vehicle control, daily for 72 h. ( A ) Graph and ( B ) representative photomicrographs of neurite length. ( C ) Graph of extracellu... More about this image found in sFlt-1 reduces neurite growth in RA-differentiated SH-SY5Y cells RA-differ...
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sFlt-1 reduces neurite growth in human NPC-derived neurons  ReNcell® VM wer...
Published: 17 May 2024
Figure 2 sFlt-1 reduces neurite growth in human NPC-derived neurons ReNcell® VM were differentiated from human neural progenitor cells into neurons and glia over 15 days while exposed to 0.1, 1, 10, or 100 ng/ml sFlt-1, or PBS as vehicle control. ( A ) Timeline of cell treatments: all cells recei... More about this image found in sFlt-1 reduces neurite growth in human NPC-derived neurons ReNcell® VM wer...
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sFlt-1 reduces βIII tubulin mRNA expression in human NPC-derived neurons  R...
Published: 17 May 2024
Figure 3 sFlt-1 reduces βIII tubulin mRNA expression in human NPC-derived neurons ReNcell® VM were differentiated into neurons and glia over 15 days while exposed to 100 ng/ml sFlt-1 or PBS as vehicle control. On day 15, RNA was extracted, and relative mRNA expression measured by RT-qPCR. Graphs ... More about this image found in sFlt-1 reduces βIII tubulin mRNA expression in human NPC-derived neurons R...
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sFlt-1 reduces neuronal differentiation of human neurospheres  ReNcell® VM ...
Published: 17 May 2024
Figure 4 sFlt-1 reduces neuronal differentiation of human neurospheres ReNcell® VM were grown into neurospheres and exposed to 100 ng/ml sFlt-1 or PBS as vehicle control. ( A ) Timeline of cell treatments: neurospheres were cultured in suspension with neural progenitors kept in a proliferative st... More about this image found in sFlt-1 reduces neuronal differentiation of human neurospheres ReNcell® VM ...
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ReNcell VM express machinery for endogenous VEGFA autocrine and paracrine s...
Published: 17 May 2024
Figure 5 ReNcell VM express machinery for endogenous VEGFA autocrine and paracrine signalling, which is unchanged by sFlt-1 treatment ReNcell® VM were differentiated into neurons and glia over 15 days while exposed to 100 ng/ml sFlt-1, or PBS as vehicle control. ( A ) Timeline of experiment: on d... More about this image found in ReNcell VM express machinery for endogenous VEGFA autocrine and paracrine s...
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VEGFA exerts neurogenic effects only in the absence of sFlt-1  ReNcell® VM ...
Published: 17 May 2024
Figure 6 VEGFA exerts neurogenic effects only in the absence of sFlt-1 ReNcell® VM were differentiated into neurons and glia over 15 days while exposed to 100 ng/ml sFlt-1, 50 ng/ml VEGFA, both sFlt-1 and VEGFA, or PBS as vehicle control. ( A,B ) Graph and representative photomicrographs of neuri... More about this image found in VEGFA exerts neurogenic effects only in the absence of sFlt-1 ReNcell® VM ...
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Summary of findings and proposed mechanism  sFlt-1/VEGFR-1 reduces neurite ...
Published: 17 May 2024
Figure 7 Summary of findings and proposed mechanism sFlt-1/VEGFR-1 reduces neurite growth and neuronal differentiation in human neural progenitor cells, whereas VEGFA increases neurite length and neuronal differentiation, but only in the absence of sFlt-1. ReNcell® VM express VEGFA and VEGFR-2, w... More about this image found in Summary of findings and proposed mechanism sFlt-1/VEGFR-1 reduces neurite ...
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Effect of soluble factors derived from CH-hMSCs and PL-hMSCs on the prolife...
Published: 17 May 2024
Figure 1 Effect of soluble factors derived from CH-hMSCs and PL-hMSCs on the proliferation of human glioblastoma U251 cells ( A ) Graphs show the growth kinetics of U251 cells cultured in 10–75% (v/v) conditioned media derived from CH-hMSCs (CH-CMs) determined by the MTT assay. ( B ) Graphs show ... More about this image found in Effect of soluble factors derived from CH-hMSCs and PL-hMSCs on the prolife...
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Effect of the soluble factors derived from CH-hMSCs and PL-hMSCs on migrati...
Published: 17 May 2024
Figure 2 Effect of the soluble factors derived from CH-hMSCs and PL-hMSCs on migration of human glioblastoma U251 cells ( A ) Representative micrographs of U251 cell migration induced by CH-hMSCs and PL-hMSCs determined by the transwell migration assay. CH-hMSCs were derived from three different ... More about this image found in Effect of the soluble factors derived from CH-hMSCs and PL-hMSCs on migrati...
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The effect of soluble factors derived from CH-hMSCs and PL-hMSCs on the inv...
Published: 17 May 2024
Figure 3 The effect of soluble factors derived from CH-hMSCs and PL-hMSCs on the invasion of human glioblastoma U251 cells ( A ) Representative micrographs of U251 cell invasion induced by CH-hMSCs and PL-hMSCs determined by the transwell invasion assay. CH-hMSCs were derived from three different... More about this image found in The effect of soluble factors derived from CH-hMSCs and PL-hMSCs on the inv...
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The effect of hMSC-derived soluble factors on U251 cell survival  ( A ) Rep...
Published: 17 May 2024
Figure 4 The effect of hMSC-derived soluble factors on U251 cell survival ( A ) Representative flow cytometric dot plot images showing the distribution of U251 cells stained with annexin V and PI after co-culture with various CH-hMSCs and PL-hMSCs. Cells that were positive for annexin V and/or PI... More about this image found in The effect of hMSC-derived soluble factors on U251 cell survival ( A ) Rep...
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The effect of hMSC-derived soluble factors on the gene expression of human ...
Published: 17 May 2024
Figure 5 The effect of hMSC-derived soluble factors on the gene expression of human glioblastoma U251 cells The expression levels of genes in U251 cells treated with 75% (v/v) conditioned media derived from CH-hMSCs (coCH) and 75% (v/v) conditioned media derived from PL-hMSCs (coPL) determined by... More about this image found in The effect of hMSC-derived soluble factors on the gene expression of human ...
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The roles of Wnt/β-catenin, TGF-β, and NF-kB signaling pathways on the prol...
Published: 17 May 2024
Figure 6 The roles of Wnt/β-catenin, TGF-β, and NF-kB signaling pathways on the proliferation of human glioblastoma U251 cells treated with soluble factors derived from CH-hMSCs and PL-hMSCs The graphs show the growth kinetics of U251 cells cultured in 75% (v/v) conditioned medium derived from CH... More about this image found in The roles of Wnt/β-catenin, TGF-β, and NF-kB signaling pathways on the prol...
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The roles of Wnt/β-catenin, TGF-β, and NF-kB signaling pathways on the migr...
Published: 17 May 2024
Figure 7 The roles of Wnt/β-catenin, TGF-β, and NF-kB signaling pathways on the migration of U251 cells treated with soluble factors derived from CH-hMSCs and PL-hMSCs Graphs show the number of migratory U251 cells induced by CH-hMSCs and PL-hMSCs in the presence of ChiR99021 (CH9 + CHIR and PL22... More about this image found in The roles of Wnt/β-catenin, TGF-β, and NF-kB signaling pathways on the migr...
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The roles of Wnt/β-catenin, TGF-β, and NF-kB signaling pathways on the surv...
Published: 17 May 2024
Figure 8 The roles of Wnt/β-catenin, TGF-β, and NF-kB signaling pathways on the survival of U251 cells treated with soluble factors derived from PL-hMSCs Graphs show the percentages of viable, early apoptotic, late apoptotic, and necrotic U251 cells co-cultured with PL-hMSCs in the presence of Ch... More about this image found in The roles of Wnt/β-catenin, TGF-β, and NF-kB signaling pathways on the surv...
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Effect of Q3R and QPS on coagulation time  In the control set, from A to C,...
Published: 15 May 2024
Figure 1 Effect of Q3R and QPS on coagulation time In the control set, from A to C, the green bar represents the negative control having platelet-poor plasma (PPP) only, while the red and yellow bar represents the PPP with Q3R and QPS respectively. Within the wtPDI set, the blue bar represents th... More about this image found in Effect of Q3R and QPS on coagulation time In the control set, from A to C,...
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Purification of wtPDI and its variants  wtPDI and its variants were purifie...
Published: 15 May 2024
Figure 2 Purification of wtPDI and its variants wtPDI and its variants were purified using affinity chromatography, ( A–C ) representing the purified protein fractions on SDS-PAGE and Western blot analysis. All the fractions were eluted in 0.05 M to 1 M imidazole. Lane M is an 11–180 kDa protei... More about this image found in Purification of wtPDI and its variants wtPDI and its variants were purifie...
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Effect of conserved residue mutations on PDI insulin reductase activity, an...
Published: 15 May 2024
Figure 3 Effect of conserved residue mutations on PDI insulin reductase activity, and its secondary and tertiary structures ( A ) Insulin reductase activity of wtPDI and its variants, Cys53Ala and His399Arg. Panel ( B ) represents the change in fluorescence intensity of wtPDI and its variants, at... More about this image found in Effect of conserved residue mutations on PDI insulin reductase activity, an...
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Effect of exogenous PDI and its variants on clotting time  In the control s...
Published: 15 May 2024
Figure 4 Effect of exogenous PDI and its variants on clotting time In the control set from A to C, the blue bar represents the plasma alone in the absence of reduced glutathione (GSH), and the red bar indicates the presence of GSH. While the set of wtPDI, C53A, and H399R having PDI, C53A, and H39... More about this image found in Effect of exogenous PDI and its variants on clotting time In the control s...
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Effect of exogenous PDI and its variants on clotting time with Q3R and QPS ...
Published: 15 May 2024
Figure 5 Effect of exogenous PDI and its variants on clotting time with Q3R and QPS In the control set, from A to C, the green bar represents the negative control with platelet-poor plasma (PPP) only, while the red and yellow bars represent PPP with Q3R and QPS, respectively. Within the wtPDI, C5... More about this image found in Effect of exogenous PDI and its variants on clotting time with Q3R and QPS ...
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Antithrombin–thrombin complex and PDI specificity  Panel ( A ) represents t...
Published: 15 May 2024
Figure 6 Antithrombin–thrombin complex and PDI specificity Panel ( A ) represents the effect of T-ATIII preformed complex on wtPDI, C53A, and H399R insulin reductase activity. Panel ( B ) shows the specificity of wtPDI in antithrombin–thrombin inhibition assay, in which thrombin and antithrombin ... More about this image found in Antithrombin–thrombin complex and PDI specificity Panel ( A ) represents t...
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Activity analysis of ATIII–thrombin–PDI complex  ( A ) Represents the impac...
Published: 15 May 2024
Figure 7 Activity analysis of ATIII–thrombin–PDI complex ( A ) Represents the impact of thrombin–ATIII–vitronectin complex on wt-PDI, C53A, and H399R insulin reductase activity. Panel ( B ) represents the impact of the thrombin–ATIII–vitronectin complex on antithrombin inhibition of thrombin. Pan... More about this image found in Activity analysis of ATIII–thrombin–PDI complex ( A ) Represents the impac...
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Assessment of ATIII–FIIa–wtPDI complex  Panel ( A, D, F ) represent the com...
Published: 15 May 2024
Figure 8 Assessment of ATIII–FIIa–wtPDI complex Panel ( A, D, F ) represent the complex formation between PDI and its variants with thrombin, antithrombin, and vitronectin. Lane M is a protein marker of 11–180 kDa. ATIII-FIIa complexes were formed in the presence of heparin and wtPDI, C53A, and H... More about this image found in Assessment of ATIII–FIIa–wtPDI complex Panel ( A, D, F ) represent the com...
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Mechanistic pathway showing involvement of PDI with thrombin (FIIa) and ATI...
Published: 15 May 2024
Figure 9 Mechanistic pathway showing involvement of PDI with thrombin (FIIa) and ATIII The image depicts the activation of coagulating factors via intrinsic and extrinsic pathways which in turn causes the blood to clot by following the series of activation steps. Overproduced FIIa will be removed... More about this image found in Mechanistic pathway showing involvement of PDI with thrombin (FIIa) and ATI...
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H 2 O 2  reduces cell viability and promotes premature senescence in HUVECs...
Published: 15 May 2024
Figure 1 H 2 O 2 reduces cell viability and promotes premature senescence in HUVECs ( A ) Different concentrations of H 2 O 2 (0, 25, 50, 100, 200, and 400 μM) were applied to cultured HUVECs for 1 h. A CCK-8 assay was used to evaluate cell viability. ( B,C ) Representation and statistics of ce... More about this image found in H 2 O 2 reduces cell viability and promotes premature senescence in HUVECs...
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H 2 O 2  accelerates cellular premature and inhibits cell proliferation in ...
Published: 15 May 2024
Figure 2 H 2 O 2 accelerates cellular premature and inhibits cell proliferation in HUVECs ( A ) Determination of p16 and p21 protein expression by Western Blotting. ( B,C ) Densitometric quantification of p16 and p21 protein expression based on Western Blot assays. ( D,E ) Representation and sta... More about this image found in H 2 O 2 accelerates cellular premature and inhibits cell proliferation in ...
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Relative expression of miR-142-3p and its effect on the cell viability of H...
Published: 15 May 2024
Figure 3 Relative expression of miR-142-3p and its effect on the cell viability of HUVECs ( A ) miR-142-3p expression levels in control and 100 μM H 2 O 2 , revealed by RT-qPCR. ( B ) The relative expression level of miR-142-3p after knocking out miR-142-3p. ( C ) Cell viability of HUVECs between... More about this image found in Relative expression of miR-142-3p and its effect on the cell viability of H...
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Knockdown of miR-142-3p mitigated the degree of premature senescent HUVECs ...
Published: 15 May 2024
Figure 4 Knockdown of miR-142-3p mitigated the degree of premature senescent HUVECs induced by H 2 O 2 ( A–C ) Representation and statistics of p16 and p21 protein relative expression in HUVECs with different miR-142-3p gene modifications. ( D,E ) Representation and statistics of cell proliferat... More about this image found in Knockdown of miR-142-3p mitigated the degree of premature senescent HUVECs ...