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Keywords: Ovarian cancer
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Articles
Biosci Rep (2022) 42 (9): BSR20221002.
Published: 07 September 2022
...Xifeng Xiong; Xudong Lai; Jinli Zhang; Qingqi Meng; Pengzhen Wang; Shengnan Qin; Wei Liu; Yongxuan Wang; Zhuo Yao; Di Wang; Xiaojian Li; Zhihe Liu; Haixiong Miao Worldwide, ovarian cancer (OC) is the seventh common cancer and the second most common cause of cancer death in women. Due to high rates...
Articles
Biosci Rep (2022) 42 (2): BSR20212090.
Published: 09 February 2022
...Dan Sun; Xingping Zhao; Yang Yu; Waixing Li; Pan Gu; Zhifu Zhi; Dabao Xu Background: Ovarian cancer (OV) is a serious threat to women’s health. Immunotherapy is a new approach. Alternative splicing (AS) of messenger RNA (mRNA) and its regulation are highly relevant for understanding every cancer...
Articles
Biosci Rep (2021) 41 (9): BSR20210565.
Published: 06 September 2021
... known whether SRA is involved in the regulation of ovarian cancer. The present study investigated the molecular function and association between SRA expression and clinicopathological factors. In ovarian cancer cell lines, SRA knockdown and overexpression regulated cell migration, proliferation...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (5): BSR20210478.
Published: 06 May 2021
...Jiahong Tan; Chunyan Song; Daoqi Wang; Yigang Hu; Dan Liu; Ding Ma; Qinglei Gao High-grade serous ovarian cancer (HGSOC) has abundant expression of hormone receptors, including androgen receptor (AR), estrogen receptor α (ER), and progesterone receptor (PR). The effects of hormone receptors...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (4): BSR-20191041_EOC.
Published: 07 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy mTORC ovarian cancer PD-L1 The Editorial Office has been...
Articles
Biosci Rep (2020) 40 (11): BSR20202911.
Published: 19 November 2020
...Lin Zhao; Yuhui Li; Zhen Zhang; Jing Zou; Jianfu Li; Ran Wei; Qiang Guo; Xiaoxiao Zhu; Chu Chu; Xiaoxiao Fu; Jinbo Yue; Xia Li Background: Ovarian cancer causes high mortality rate worldwide, and despite numerous attempts, the outcome for patients with ovarian cancer are still not well improved...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20202683.
Published: 02 November 2020
...Zhaoxia Wang; Honghong Wang; Hongrui Guo; Fengyan Li; Weiwei Wu; Sanyuan Zhang; Tong Wang Background : Ovarian cancer is the most lethal cancer in the female reproductive system. It has been shown that ‘time chemotherapy’ of ovarian cancer has an important impact on the chemotherapy effect...
Articles
Biosci Rep (2020) 40 (10): BSR20201431.
Published: 28 October 2020
...Juan Liu; Zongjian Tan; Jun He; Tingting Jin; Yuanyuan Han; Li Hu; Jukun Song; Shengwen Huang Background: Increasing studies suggest that tumor immune infiltration is a relative factor of prognosis in ovarian cancer (OvCa). The present study explored the composition of tumor-infiltrating immune...
Articles
Biosci Rep (2020) 40 (9): BSR20201937.
Published: 28 September 2020
... BY) . metabolic-genomic landscape ovarian cancer personalized medicine prognostic index the cancer genome atlas Ovarian cancer is the deadliest malignant tumour of the female reproductive system. Ovarian cancer is the eighth most common cause of lethal malignancies in gynaecology and has a cancer...
Includes: Supplementary data
Articles
Biosci Rep (2020) BSR20200679.
Published: 01 September 2020
...Xiaojia Min; Tingting Zhang; Ying Lin; Bo Wang; Kean Zhu Ovarian cancer is the most lethal diseases among women. The chemo-resistance has been a big challenge for the cancer treatment. It has been reported that metformin may inhibit ovarian cancer and is able to impede the development of drug...
Articles
Biosci Rep (2020) 40 (8): BSR20201261.
Published: 07 August 2020
...Weichun Tang; Jie Li; Xinxia Chang; Lizhou Jia; Qi Tang; Ying Wang; Yanli Zheng; Lizhou Sun; Zhenqing Feng Background : Ovarian cancer (OC) is one of the most lethal gynecological cancers worldwide. The pathogenesis of the disease and outcomes prediction of OC patients remain largely unclear...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (8): BSR20192385.
Published: 07 August 2020
...Yuhang Long; Hui Fei; Sumei Xu; Jianzhen Wen; Lihua Ye; Zhaojuan Su Changes in dietary vitamin C intake have been related to the risks of various cancers. However, the association between dietary vitamin C intake and the risk of ovarian cancer has not been fully determined. A meta-analysis...
Articles
Biosci Rep (2020) 40 (7): BSR20200825.
Published: 24 July 2020
...Fenghua Zhang; Yun Xu; Wenfeng Ye; Jingting Jiang; Changping Wu Background: Ovarian cancer (OC) is one lethal gynecologic cancer, with a 5-year survival rate approximately 47% and localized stage diagnosis of 15%. Circular RNAs are promising biomarkers for malignancies. Methods: CiRS-7 expression...
Articles
Biosci Rep (2020) 40 (7): BSR20200995.
Published: 17 July 2020
...Ying Xiong; Ce Bian; Xiaojuan Lin; Xiaoli Wang; Kehui Xu; Xia Zhao Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) in hormone metabolism pathways might cause metabolic disturbances and contribute to the development of polycystic ovary syndrome (PCOS) and ovarian cancer...
Articles
Biosci Rep (2020) 40 (6): BSR20200800.
Published: 15 June 2020
...Chong Qu; Chunmei Dai; Yahua Guo; Rui Qin; Junbao Liu Purpose: To investigate the regulation mechanism of long non-coding RNA (lncRNA) plasmocytoma variant translocation 1 (PVT1) in ovarian cancer (OC). Methods: The levels of PVT1, microRNA (miR)-543, serpin peptidase inhibitor-clade I (neuroserpin...
Articles
Biosci Rep (2020) 40 (4): BSR20193979.
Published: 07 April 2020
...Qiaoqiao Wang; Chaying He BACKGROUND: Previous studies have demonstrated some associations between dietary vitamin A intake and ovarian cancer risk with an inconsistent relationship. We therefore performed the present study to further explore the association between them. METHODS: Databases...
Articles
Biosci Rep (2020) 40 (4): BSR20192457.
Published: 31 March 2020
...Lanlan Feng; Fangrong Shen; Jinhua Zhou; Yan Li; Rong Jiang; Youguo Chen Ovarian cancer (OC) is a malignant tumor with high mortality in women. Although cancer patients initially respond to paclitaxel chemotherapy following surgery, most patients will relapse after 12–24 months and gradually die...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (3): BSR20193396.
Published: 27 March 2020
... effect on ovarian cancer (OC) remains unknown. In the present study, we tried to elucidate the role and mechanism of APS in OC cells. Our results showed that APS treatment suppressed the proliferation and induced apoptosis in OC cells. Afterward, the microRNA (miRNA) profiles in APS-treated cells were...
Articles
Biosci Rep (2020) 40 (3): BSR20192226.
Published: 18 March 2020
... the efficacy and safety of PARP inhibitors (PARPis) in the maintenance treatment of ovarian cancer. Method: We searched for clinical trials in electronic databases. PARPis efficacy were evaluated by the hazard ratios (HR) and its 95% confidence intervals (95% CI) of overall survival (OS) and progression-free...
Articles
Biosci Rep (2019) 39 (12): BSR20193311.
Published: 23 December 2019
...Youxu Leng; Hairong Zhou; Fanjing Meng; Tian Tian; Jianying Xu; Fengjuan Yan Many researches were conducted to assess the association of vitamin E intake on the risk of ovarian cancer, with conflict results. The current meta-analysis of published observational studies aimed to investigate...
Articles
Biosci Rep (2019) 39 (12): BSR20191041.
Published: 20 December 2019
...Hongmin Gao; Juan Zhang; Xiaohong Ren PD-L1 is a well-known immune co-stimulatory molecule that regulates tumour cell escape from immunity by suppressing the immune response. However, the clinical significance of PD-L1 in the progression of ovarian cancer is unclear. Our study demonstrated that PD...
Articles
Biosci Rep (2019) 39 (8): BSR20190405.
Published: 13 August 2019
...Yan Wu; Qin Cai; Wei Li; Zhensheng Cai; Ying Liu; Hongfan Li; Ji Pang; Yongchang Chen Despite advances in chemotherapy, ovarian cancer (OC) is still the most lethal gynecologic malignancy. So, it is imperative to explore its mechanism and find novel targets to improve the outcome. Type II cyclic...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (7): BSR20182101.
Published: 05 July 2019
...Jin-Tian Miao; Jian-Hua Gao; Yong-Qian Chen; Hong Chen; Hao-Yi Meng; Ge Lou This paper tried to explore ANRIL expression in ovarian cancer and how it affects cisplatin-sensitivity of ovarian cancer cells via regulation of let-7a/high-mobility group protein A2 (HMGA2) axis. qRT-PCR was used...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (5): BSR20181650.
Published: 07 May 2019
... gastric carcinoma high expressed transcript 1 (GHET1) was overexpressed in ovarian cancer tissues and cell lines. Up-regulation of GHET1 was positively correlated with the tumor size and metastasis of the ovarian cancer patients. Overexpression of GEHT1 significantly promoted the proliferation and colony...
Articles
Biosci Rep (2019) 39 (5): BSR20190100.
Published: 02 May 2019
...Yi Hu; Qing Zeng; Chenxi Li; Ying Xie Ovarian cancer is a highly lethal cancer in females. Therefore, it is necessary to explore effective biomarkers for the diagnosis and prognosis of the disease. Stratifin (SFN) is a cell cycle checkpoint protein that has been reported to be involved...
Articles
Biosci Rep (2019) 39 (4): BSR20190016.
Published: 16 April 2019
...Xiaojie Feng; Lei Li; Li Wang; Suxia Luo; Xupeng Bai Ovarian cancer is one of the most common gynecological cancers with a high mortality rate in females. Chromatin target of protein arginine methyltransferase (CHTOP) is an important intracellular protein that regulates the transcriptional...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20181857.
Published: 11 December 2018
...Yanyang Pang; Wu Wang The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of the present study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake...
Articles
Biosci Rep (2018) 38 (4): BSR20180547.
Published: 29 August 2018
...Pengfei Jin; Yanjun Liu; Ruijuan Wang Cisplatin is the first-line treatment for ovarian cancer. However, the clinical outcome of cisplatin treatment in ovarian cancer is hindered by cancer resistance. Here we aim to explore the role and mechanism of miR-216a in the cisplatin resistance of ovarian...
Articles
Biosci Rep (2018) 38 (3): BSR20180114.
Published: 21 June 2018
... investigations have demonstrated that single nucleotide polymorphisms (SNPs) of NER pathway genes were associated with various types of cancer. However, there was no research elucidating the genetic association of entire NER pathway with ovarian cancer susceptibility. Therefore, we conducted genotyping for 17...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (2): BSR20180108.
Published: 27 April 2018
... in various cancer types. However, the prognostic value of AQPs expression in ovarian cancer remains unclear. Using ‘Kaplan–Meier plotter’ (KM plotter) online database, we explored the predictive prognostic value of individual AQPs members’ mRNA expression to overall survival (OS) in different clinical data...
Articles
Biosci Rep (2018) 38 (2): BSR20171150.
Published: 16 March 2018
...Jie Li; Chen Yang; Yinguang Li; Aiyue Chen; Li Li; Zeshan You Objective: Long noncoding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is involved in various kinds of cancer. However, the role of lncGAS5 in the development of ovarian cancer remains unclear. In the present study, we explored...
Articles
Biosci Rep (2018) 38 (1): BSR20170681.
Published: 05 January 2018
... in ovarian cancer is still unclear. In the present study, we found that lncRNA SNHG20 was significantly increased in ovarian cancer. In addition, lncRNA SNHG20 knockdown suppressed the ovarian cancer progression, whereas overexpression of SNHG20 showed the opposite effects. Moreover, our results also...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (4): BSR20170650.
Published: 17 July 2017
... with several biological processes such as cell proliferation, invasion, and metastasis in various cancer types. In addition, the STAT family has been well studied as a prognostic predictor for a considerable number of solid tumors. However, the prognostic value of the STAT family in ovarian cancer patients...
Articles
Biosci Rep (2017) 37 (4): BSR20170327.
Published: 04 July 2017
...Qin Zhang; Shuxiang Zhang Ovarian cancer is one of the leading causes of death among gynecological malignancies. Increasing evidence indicate that dysregulation of microRNAs (miRNAs) plays an important role in tumor radioresistance. The aim of the present study is to investigate whether microRNA...
Articles
Biosci Rep (2017) 37 (2): BSR20160470.
Published: 10 April 2017
... into the tumour microenvironment. In the present study, we firstly isolated CAFs from tumour tissues of the patients with ovarian cancer and demonstrated that the hepatocyte growth factor (HGF) was highly expressed in the supernatants of CAFs. CAF-derived HGF or human recombinant HGF promoted cell proliferation...
Articles
Biosci Rep (2017) 37 (1): BSR20160247.
Published: 10 January 2017
...Shan Qin; Yanfang Li; Xuexia Cao; Jiexian Du; Xianghua Huang A key transcription factor associated with poor prognosis and resistance to chemotherapy in ovarian cancer is NANOG. However, the mechanism by which NANOG functions remains undefined. It has been suggested that epithelial-to-mesenchymal...
Articles
Biosci Rep (2016) 36 (1): e00298.
Published: 19 February 2016
...Qingmei Zhang; Xiufeng Chen; Xuan Zhang; Jingfen Zhan; Jie Chen Transmembrane protein 14A (TMEM14A) is a member of TMEMs. Alterations in TMEMs expression have been identified in several types of cancer, but the expression and function of TMEM14A in ovarian cancer is still unclear. Here, analysis...
Includes: Supplementary data
Articles
Biosci Rep (2014) 34 (3): e00110.
Published: 05 June 2014
... to these structures in transfected HeLa cells. We show that siRNA (small interfering RNA)-mediated knockdown of Nac1 in ovarian cancer cells results in increased levels of the Miz1 target gene product, p21 Cip1 . The interaction of Nac1 with Miz1 may thus be relevant to its mechanism of tumourigenesis in ovarian...